#PIN1
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sonhita.bsky.social
🔬Early #FluorescenceFriday with one of my favourite #auxin carriers #PIN1, seen here in at the Arabidopsis thaliana root🌱
#plantscience #microscopy #GFP
#sciart #plantscience 🧪🌾🐡PIN1-GFP in Arabidopsis thaliana roots
November 28, 2024 at 7:56 PM
kaikoppel.bsky.social
Täna helistati, et on tähitud kiri. Valida, kas toob kätte või paneb pakiautomaati. Muidugi toimingu jaoks on tarvis pin1 sisetada.
Kui lubasin tagasi helistada, siis huvi kadus, kiri jäi kohale toimetamata ja pin1 sisestamata.
December 2, 2025 at 4:57 PM
orchidfreak.bsky.social
Tricotyledon mutant of Arabidopsis
Arabidopsis pin1 mutant Arabidopsis pin1 mutant Arabidopsis pin1 mutant Arabidopsis pin1 mutant
October 3, 2025 at 10:40 AM
orchidfreak.bsky.social
pin1 mutant flowers

I am not a flower researcher but am curious why it lacks sepals and stamens. B class gene expression shifted outward?
Arabidopsis thaliana pin1 mutant forming odd flowers with extra petals, but lacking stamens and sepals
September 7, 2025 at 4:37 AM
heisler-lab.bsky.social
How does MP influence PIN1 polarity? Here’s our latest preprint …… www.biorxiv.org/content/10.1...
Vascular Transcription Factor TMO5 Regulates PIN1 Polarity and Organogenesis Downstream of MONOPTEROS in the Shoot Meristem
Plants continuously produce lateral organs, such as leaves and flowers, from the shoot apical meristem (SAM). This process is guided by the accumulation of the plant hormone auxin and the polar locali...
www.biorxiv.org
November 11, 2024 at 11:58 AM
pilleriin.bsky.social
Päeva hea: nõusolekuseadus (ja muid asju ka muidugi).
Aga siis loen seda "Helistaja on enda sõnul Omniva kandekeskusest: soovitakse edastada tähitud kiri endise juhatuse ühele liikmele. Selleks pidavat raamatupidaja aga oma telefonis kinnitama Mobiil-ID PIN1 koodi." ja oeh.
June 10, 2026 at 3:12 PM
dev-journal.bsky.social
TMO5 orchestrates organ patterning in plant shoots

This Research Highlight showcases work by Abdul Kareem, Carolyn Ohno and Marcus Heisler (@heisler-lab.bsky.social):

journals.biologists.com/dev/article/...
TMO5 promotes PIN1 polarity convergence and organogenesis independent of MP. (A-C) Activation of PIN1-CFP expression (intensity-based colouring; the look-up table displays the signal intensity range), convergence formation and organ outgrowth in mp mutant shoot meristems after clonal activation of TMO5-2YPET (green). Panels A and B show the same meristem over time, whereas panel C presents a representative meristem (n=27). (D,E) Flower formation on mp pin-like inflorescence meristem following clonal activation of TMO5-2YPET (n=10). (F-J) No effect on PIN1 localization or organ outgrowth in mp mutant meristems with local activation of DOF5.8-YPET (F-H; n=12) or TMO6-YPET (I,J; n=15). Inset in G shows the meristem with the PIN1-CFP channel alone for clearer visualization. (K-M) Time-lapse images of the same mp mutant meristem region from 1 to 6 days after TMO5 clone formation, showing PIN1-GFP polarization in neighbouring cells towards the clones. The dashed box in K marks the area shown in L and M. Arrows indicate polarity (n=13). (N) PIN1-GFP polarization towards a TMO5 clone lacking organ outgrowth (n=9). (O,P) PIN1-CFP convergence in epidermal TMO5-expressing clones and polarized PIN1 in neighbouring cells in the mp mutant meristem at two time points of the same clones. Lower panels show longitudinal sections. Arrows indicate polarity; arrowhead in P marks sub-epidermal PIN1 expression (n=24). (Q) Two distinct organ outgrowths with epidermal PIN1 convergence induced by epidermal (left) or sub-epidermal (right) TMO5 clones. Lower panels show longitudinal sections. White arrowhead marks PIN1 activation in sub-epidermal cells; orange arrowhead marks sub-epidermal TMO5 clones. Dashed line marks the outgrowth boundary (n=5). Scale bars: 20 µm (A-C,F,G,I-Q); 1 mm (D,E,H).
December 23, 2025 at 5:38 AM
newphyt.bsky.social
#LatestIssue cover: Confocal #microscopy image showing DR5:3nucVenus expression in the inflorescence apical meristem of an Arabidopsis thaliana plt3 plt5 plt7 pin1-T600I mutant. Image courtesy of Kerstens and Willemsen.

📖 See @merijnkerstens.bsky.social & Willemsen et al.
doi.org/10.1111/nph....
On the cover of New Phytologist volume 249, issue 1: Confocal microscopy image showing DR5:3nucVenus expression (yellow) in the inflorescence apical meristem (cyan) of an Arabidopsis thaliana plt3 plt5 plt7 pin1-T600I mutant. The DR5:3nucVenus auxin-responsive reporter highlights regions of auxin accumulation and signalling activity within the mutant inflorescence apical meristem. Image courtesy of Merijn Kerstens and Viola Willemsen.
December 4, 2025 at 1:03 PM
marcveld.bsky.social
The proposed biology is compelling. Cancer is characterized by excessive cell survival and proliferation. Alzheimer’s by neuronal death. The same pathways (p53, PIN1, immune regulation) may push risk in opposite directions.
4/8
July 3, 2026 at 5:16 PM
e-social.bsky.social
Ma ikka küsin neilt kas võiksin pin1 neile öelda. Siis vähemalt keegi olemas kelt küsida kui endal meelest peaks minema
kaikoppel.bsky.social Kai @kaikoppel.bsky.social · Dec 2
Täna helistati, et on tähitud kiri. Valida, kas toob kätte või paneb pakiautomaati. Muidugi toimingu jaoks on tarvis pin1 sisetada.
Kui lubasin tagasi helistada, siis huvi kadus, kiri jäi kohale toimetamata ja pin1 sisestamata.
December 2, 2025 at 8:16 PM
bakersm11.bsky.social
Although I doubt you will get a Nobel Prize for discovering an inhibitor of inhibitor of Pin1 (peptidyl-prolyl cis/trans isomerase) that could regulate phosphorylation of Tau, implicating potential effects of juglone in Alzheimer’s disease...
www.jbc.org/article/S002...
Juglone Inactivates Cysteine-rich Proteins Required for Progression through Mitosis *
The parvulin peptidyl-prolyl isomerase Pin1 catalyzes cis-trans isomerization of p(S/T)-P bonds and might alter conformation and function of client proteins. Since the trans conformation of p(S/T)-P b...
www.jbc.org
April 21, 2026 at 1:53 PM
heisler-lab.bsky.social
Our latest on PIN1 polarity…. Congrats Kareem!
(x.com/kareemvk)
journals.biologists.com/dev/article/...
TMO5 regulates PIN1 polarity convergence and organogenesis downstream of MONOPTEROS in the Arabidopsis shoot
Plants continuously produce lateral organs, such as leaves and flowers, from the shoot apical meristem (SAM). This process is guided by the accumulation of the plant hormone auxin and the polar locali...
journals.biologists.com
November 12, 2025 at 7:06 PM
krhornberger.bsky.social
PIN1 degraders. I like papers like this because sometimes it’s just as important, if not more important, to present one’s negative findings. Maybe not as splashy, but important.
Re-Evaluating PIN1 as a Therapeutic Target in Oncology Using Neutral Inhibitors and PROTACs
Peptidyl-prolyl cis–trans isomerase NIMA-interacting 1 (PIN1) has emerged as a promising therapeutic target for cancer treatment. However, the current PIN1 inhibitors have shown limited efficacy in an...
pubs.acs.org
September 20, 2024 at 11:56 AM
pilleriin.bsky.social
Pätsasin FB-st:
Jõululuuletuse asemel on sel aastal küberpettuse harjutus. Helistad sõbrale, telefon valjuhääldi peal, nii et päkapikk ka kuuleks, ja püüad sõbra PIN1 koodi teada saada.
December 19, 2025 at 8:43 PM
frimllab.bsky.social
It is out! A tandem of two papers showing TMK regulation of PIN-dependent auxin transport www.cell.com/cell/fulltex... (PIN2, Friml lab) and www.cell.com/developmenta... (PIN1, Xu lab)
ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism
In gravistimulated roots, gravity perception in the columella redirects the flow of the plant hormone auxin toward the lower root side, where it inhibits cell elongation for downward root bending. Thi...
www.cell.com
October 6, 2025 at 10:41 AM
martisoosaar.bsky.social
Jaa, oskan. kohe tuleb sulle sõnum ja pane siis PIN1 ja PIN2 kohe järgi ja siis tuleb juhend.
May 23, 2025 at 8:02 PM
trevor-lithgow.bsky.social
We have been working on ways to find #phage with long shelf-life and this one is a winner. 12 months freeze-thawing as much as you like, no loss of viability
#phageSky #microSky

rdcu.be/ewnzT
Highly stable bacteriophages PIN1 and PIN2 have hallmarks of flagellotropic phages but infect immotile bacteria
npj Viruses - Bacteriophages (phages) are viruses that kill bacteria, with potential as antibacterial agents in industrial settings, agriculture, and human health. Here, we identified two phages,...
rdcu.be
July 17, 2025 at 1:20 PM
stvanneste.bsky.social
#auxin

TMK vs PIN1
Goes with the Rodrigues paper

doi.org/10.1016/j.de...
Redirecting
doi.org
October 6, 2025 at 12:29 PM
zerblat.bsky.social
Üks moment ... liitumiseks peaks su telefoni jõudma hetke pärast PIN1 ja PIN2 päringud. Palun ära teavita sellest sõpru või tuttavaid, sest liitumine muutub muidu kehtetuks.
August 30, 2026 at 5:32 PM
drstroh.bsky.social
Jabur:) Järgneb laviin kõnesid, soovime teile pakkuda paremaid lepingutingimusi, nõusolekuks andke pin1 ja pin2.
Tore on ka väide, et tavaliselt klient kes soovib lepingut lõpetada ei soovi tegelikult elisa arvates lepingut lõpetada, sellepärast tuleb kohtuda esinduses veenmisteenendajaga.
November 13, 2025 at 12:47 PM
trevor-lithgow.bsky.social
Because of the forces they have to withstand being whizzed around on #flagellae, flagellotropic #phages are super stable. It turns out that the same super-stability remains long after you adapt to a host bacterium without a #flagellum

rdcu.be/ewnzT
Highly stable bacteriophages PIN1 and PIN2 have hallmarks of flagellotropic phages but infect immotile bacteria
npj Viruses - Bacteriophages (phages) are viruses that kill bacteria, with potential as antibacterial agents in industrial settings, agriculture, and human health. Here, we identified two phages,...
rdcu.be
July 16, 2025 at 5:08 AM
sciencex.bsky.social
Protein-degrading drugs targeting Pin1 have demonstrated the ability to suppress pancreatic cancer peritoneal metastases in preclinical models, suggesting potential for new therapeutic strategies. doi.org/g996pp
Halting pancreatic cancer spread: Protein-degrading drugs show promise in preclinical models
Last year, researchers at the University of California, Riverside, developed a novel "molecular crowbar" strategy to degrade the oncogenic enzyme Pin1, a protein that is overexpressed in many tumors, including pancreatic cancer.
medicalxpress.com
November 12, 2025 at 9:35 PM
kaikoppel.bsky.social
Need sellid on eriti libedad ja enne, kui arugi saad, võibki tehing tehtud olla. Mul on õhtul toidupoes vähe teised mõtted juba peas ega soovi nendega oma pin1 ja pin2 jagama hakata.
Küll ma hommikul värske peaga vaatan ja toimetan ise, kui tarvis.
November 3, 2025 at 7:56 PM
bild.bsky.social
Antiviral ilaçlar dudak herpesine, uçuğuna karşı umut vaat ediyor.

Yeni bir antiviral ilaç sınıfı, enfekte olmuş hücrelerdeki virüsü hapsederek herpes virüsünün ortaya çıkışını durdurabilir.

Pin1 👇

www.hiroshima-u.ac.jp/en/news/93258
October 18, 2025 at 10:14 AM
womenintpd.bsky.social
Work out led by Giulia Alboreggia along with colleagues at UC Riverside detailing a covalent binder which causes a conformation change that leads to target (Pin1) loss. Is it a glue? Chaperone recruiter? Quite curious given the dependency on proteasome.
doi.org/10.1073/pnas...
Targeted degradation of Pin1 by protein-destabilizing compounds | PNAS
The concept of targeted protein degradation is at the forefront of modern drug discovery, which aims to eliminate disease-causing proteins using sp...
doi.org
November 20, 2024 at 1:45 AM