Here's pairsort: github.com/ericflo/pair... ericflo.github.io/pairsort/ (PyPI wouldn't allow jevsort) - created by Opus 5.5
September 23, 2026 at 8:04 AM
Here's pairsort: github.com/ericflo/pair... ericflo.github.io/pairsort/ (PyPI wouldn't allow jevsort) - created by Opus 5.5
Thinking about Jev + PKPD (proceedings.neurips.cc/paper/1994/h...) With the intelligence per dollar being offered now, it becomes feasible to apply this technique to *way more things* For example, ranking ICLR submissions...
Pairwise Neural Network Classifiers with Probabilistic Outputs
proceedings.neurips.cc
September 22, 2026 at 11:08 AM
Thinking about Jev + PKPD (proceedings.neurips.cc/paper/1994/h...) With the intelligence per dollar being offered now, it becomes feasible to apply this technique to *way more things* For example, ranking ICLR submissions...
@pkpd-babe.bsky.social I would like to join this feed. I am a retired nurse scientist (Professor Emerita, U of Tennessee) I completed an NIH R01 study of women abused in childhood. I have 95+ refereed publications. PhD UCSF. Specialties: MH, community health, women’s health, LGBTQ+ health.
September 21, 2026 at 1:15 PM
@pkpd-babe.bsky.social I would like to join this feed. I am a retired nurse scientist (Professor Emerita, U of Tennessee) I completed an NIH R01 study of women abused in childhood. I have 95+ refereed publications. PhD UCSF. Specialties: MH, community health, women’s health, LGBTQ+ health.
📢 Sign up for tomorrow's webinar, and explore how mechanistic pharmacokinetic-pharmacodynamic (PKPD) modeling can advance the development of next-generation antibody-based therapeutics.
Learn more and sign up: <a href="https://ow.ly/14y350ZKFJ3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">https://ow.ly/14y350ZKFJ3 https://ow.ly/14y350ZKFJ3
#pharmsky 🧪
Learn more and sign up: <a href="https://ow.ly/14y350ZKFJ3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">https://ow.ly/14y350ZKFJ3 https://ow.ly/14y350ZKFJ3
#pharmsky 🧪
September 9, 2026 at 11:00 AM
📢 Sign up for tomorrow's webinar, and explore how mechanistic pharmacokinetic-pharmacodynamic (PKPD) modeling can advance the development of next-generation antibody-based therapeutics.
Learn more and sign up: <a href="https://ow.ly/14y350ZKFJ3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">https://ow.ly/14y350ZKFJ3 https://ow.ly/14y350ZKFJ3
#pharmsky 🧪
Learn more and sign up: <a href="https://ow.ly/14y350ZKFJ3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">https://ow.ly/14y350ZKFJ3 https://ow.ly/14y350ZKFJ3
#pharmsky 🧪
📢 Sign up for tomorrow's webinar, and explore how mechanistic pharmacokinetic-pharmacodynamic (PKPD) modeling can advance the development of next-generation antibody-based therapeutics.
Learn more and sign up: <a href="https://ow.ly/14y350ZKFJ3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">https://ow.ly/14y350ZKFJ3 https://ow.ly/14y350ZKFJ3
#pharmsky 🧪
Learn more and sign up: <a href="https://ow.ly/14y350ZKFJ3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">https://ow.ly/14y350ZKFJ3 https://ow.ly/14y350ZKFJ3
#pharmsky 🧪
September 9, 2026 at 11:00 AM
📢 Sign up for tomorrow's webinar, and explore how mechanistic pharmacokinetic-pharmacodynamic (PKPD) modeling can advance the development of next-generation antibody-based therapeutics.
Learn more and sign up: <a href="https://ow.ly/14y350ZKFJ3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">https://ow.ly/14y350ZKFJ3 https://ow.ly/14y350ZKFJ3
#pharmsky 🧪
Learn more and sign up: <a href="https://ow.ly/14y350ZKFJ3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">https://ow.ly/14y350ZKFJ3 https://ow.ly/14y350ZKFJ3
#pharmsky 🧪
🧠 The brain’s response to propofol is fundamentally nonlinear & current linear PKPD models are inadequate for capturing these complex dynamics, potentially leading to a significant discrepancy between predicted & actual anesthetic state after a major disturbance
journals.lww.com/anesthesia-a...
journals.lww.com/anesthesia-a...
August 24, 2026 at 4:01 PM
🧠 The brain’s response to propofol is fundamentally nonlinear & current linear PKPD models are inadequate for capturing these complex dynamics, potentially leading to a significant discrepancy between predicted & actual anesthetic state after a major disturbance
journals.lww.com/anesthesia-a...
journals.lww.com/anesthesia-a...
Yeah, this is directly what I work on. We can spin up new nanomolar binders much more easily than I could ten years ago.
Doesn’t mean we know what they will do overall, just they likely bind in one spot
But it’s a boon for PKPD when you choose between scaffolds rather than just functional groups.
Doesn’t mean we know what they will do overall, just they likely bind in one spot
But it’s a boon for PKPD when you choose between scaffolds rather than just functional groups.
August 11, 2026 at 6:50 AM
Yeah, this is directly what I work on. We can spin up new nanomolar binders much more easily than I could ten years ago.
Doesn’t mean we know what they will do overall, just they likely bind in one spot
But it’s a boon for PKPD when you choose between scaffolds rather than just functional groups.
Doesn’t mean we know what they will do overall, just they likely bind in one spot
But it’s a boon for PKPD when you choose between scaffolds rather than just functional groups.
@U$t\J<kq)MBXe>CGD[PKPd}Cu:O4f_6
August 6, 2026 at 9:10 AM
@U$t\J<kq)MBXe>CGD[PKPd}Cu:O4f_6
How do you turn complex PK/PD modelling into messages that inform real-world decisions?
Join Dr. Aida Kawuma for a free webinar on communicating Population PK/PD modelling results with clarity.
📅 11 Aug | 🕓 4 PM EAT
🔗 tinyurl.com/pmxuganda15
#Pharmacometrics #PKPD #ClinicalResearch
Join Dr. Aida Kawuma for a free webinar on communicating Population PK/PD modelling results with clarity.
📅 11 Aug | 🕓 4 PM EAT
🔗 tinyurl.com/pmxuganda15
#Pharmacometrics #PKPD #ClinicalResearch
August 5, 2026 at 7:58 AM
How do you turn complex PK/PD modelling into messages that inform real-world decisions?
Join Dr. Aida Kawuma for a free webinar on communicating Population PK/PD modelling results with clarity.
📅 11 Aug | 🕓 4 PM EAT
🔗 tinyurl.com/pmxuganda15
#Pharmacometrics #PKPD #ClinicalResearch
Join Dr. Aida Kawuma for a free webinar on communicating Population PK/PD modelling results with clarity.
📅 11 Aug | 🕓 4 PM EAT
🔗 tinyurl.com/pmxuganda15
#Pharmacometrics #PKPD #ClinicalResearch
Una canción divertida del menda de Coffee Project hacia su gato. Ojalá encuentres a alguien que te quiera igual.
m.youtube.com/watch?v=PKpD...
m.youtube.com/watch?v=PKpD...
Oh Sweet Pickle, by Coffee Project #drumcover
YouTube video by Drumkit Loser
m.youtube.com
August 4, 2026 at 8:00 PM
Una canción divertida del menda de Coffee Project hacia su gato. Ojalá encuentres a alguien que te quiera igual.
m.youtube.com/watch?v=PKpD...
m.youtube.com/watch?v=PKpD...
Harvard University (@harvard.edu) is hiring:
Postdoctoral Fellow – PKPD Modelling, Lung-on-Chip
#postdoc #biology #lungbiology
Postdoctoral Fellow – PKPD Modelling, Lung-on-Chip
#postdoc #biology #lungbiology
August 1, 2026 at 11:07 PM
Harvard University (@harvard.edu) is hiring:
Postdoctoral Fellow – PKPD Modelling, Lung-on-Chip
#postdoc #biology #lungbiology
Postdoctoral Fellow – PKPD Modelling, Lung-on-Chip
#postdoc #biology #lungbiology
Study reveals pharmacokinetics and bactericidal activity in rifampicin-resistant TB treatments. Examined BPaL, BPaLC, BPaLM's impact on TB clearance and toxicity! PMID:42270675, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74335-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Pharmacokinetics, bactericidal activity and toxicity of short oral regimens for rifampicin-resistant tuberculosis treatment | Nature Communications
The exposure and both Mycobacterium tuberculosis clearance rates and toxicity relationships of bedaquiline-pretomanid-linezolid- (BPaL), BPaL-clofazimine (BPaLC) and BPaL-moxifloxacin (BPaLM) for treatment of rifampicin-resistant tuberculosis remain understudied. Therefore, the relationship between the patients’ exposure to anti-TB drugs in TB-PRACTECAL trial investigational regimens and their treatment outcomes was investigated. PRACTECAL-PKPD was a prospective pharmacokinetics and pharmacodynamics study. Patients with rifampicin-resistant tuberculosis were enrolled from Belarus and South Africa. Antimicrobial exposures for bedaquiline, pretomanid, linezolid, moxifloxacin and clofazimine were adequately estimated, were within the ranges of previously published studies but did not correlate with the speed of sputum bacterial clearance. When compared to the standard of care (SoC) arm, a 20% increased bacillary killing rate with BPaLM was observed, whilst BPaL and BPaLC displayed a 15% d
doi.org
July 25, 2026 at 11:00 PM
Peptide chemist here. You should not be injecting yourself with any peptides that have not undergone rigorous preclinical in vitro and animal pkpd studies followed by double-blinded human trials for safety then efficacy!
Hear hear:
“Perhaps if we called these peptides “experimental hormones", or better yet, “experimental hormones whose functions are not well understood", maybe more people would understand why scientists and physicians want more research done before they are approved as medicine.”
“Perhaps if we called these peptides “experimental hormones", or better yet, “experimental hormones whose functions are not well understood", maybe more people would understand why scientists and physicians want more research done before they are approved as medicine.”
July 24, 2026 at 12:20 PM
Peptide chemist here. You should not be injecting yourself with any peptides that have not undergone rigorous preclinical in vitro and animal pkpd studies followed by double-blinded human trials for safety then efficacy!
PKPD-420: Ruka Itoi Stars in Intimate Day‑Long Dating Doc
Explore PKPD-420, where Ruka Itoi delivers a heartfelt, solo‑work romance captured in vivid POV. Dive into this beautiful, creampie‑filled day of intima…
https://jav.do/videos/pkpd-420-pkpd-420-ruka-itoi-stars-in-intimate-daylong-dating-doc
Explore PKPD-420, where Ruka Itoi delivers a heartfelt, solo‑work romance captured in vivid POV. Dive into this beautiful, creampie‑filled day of intima…
https://jav.do/videos/pkpd-420-pkpd-420-ruka-itoi-stars-in-intimate-daylong-dating-doc
PKPD-420: Ruka Itoi Stars in Intimate Day‑Long Dating Doc
Explore PKPD-420, where Ruka Itoi delivers a heartfelt, solo‑work romance captured in vivid POV. Dive into this beautiful, creampie‑filled day of intimacy.
jav.do
July 18, 2026 at 11:09 AM
PKPD-420: Ruka Itoi Stars in Intimate Day‑Long Dating Doc
Explore PKPD-420, where Ruka Itoi delivers a heartfelt, solo‑work romance captured in vivid POV. Dive into this beautiful, creampie‑filled day of intima…
https://jav.do/videos/pkpd-420-pkpd-420-ruka-itoi-stars-in-intimate-daylong-dating-doc
Explore PKPD-420, where Ruka Itoi delivers a heartfelt, solo‑work romance captured in vivid POV. Dive into this beautiful, creampie‑filled day of intima…
https://jav.do/videos/pkpd-420-pkpd-420-ruka-itoi-stars-in-intimate-daylong-dating-doc
PKPD-421 – Shina Kiki’s Virginity Take in Sensual POV Creampie
Stream PKPD-421, a daring Japanese adult film where Kiki Utana explores virginity in a raw POV creampie. Dive into the intense 2‑hour experienc…
https://jav.do/videos/pkpd-421-pkpd-421-shina-kikis-virginity-take-in-sensual-pov-creampie
Stream PKPD-421, a daring Japanese adult film where Kiki Utana explores virginity in a raw POV creampie. Dive into the intense 2‑hour experienc…
https://jav.do/videos/pkpd-421-pkpd-421-shina-kikis-virginity-take-in-sensual-pov-creampie
PKPD-421 – Shina Kiki’s Virginity Take in Sensual POV Creampie
Stream PKPD-421, a daring Japanese adult film where Kiki Utana explores virginity in a raw POV creampie. Dive into the intense 2‑hour experience now.
jav.do
July 18, 2026 at 8:07 AM
PKPD-421 – Shina Kiki’s Virginity Take in Sensual POV Creampie
Stream PKPD-421, a daring Japanese adult film where Kiki Utana explores virginity in a raw POV creampie. Dive into the intense 2‑hour experienc…
https://jav.do/videos/pkpd-421-pkpd-421-shina-kikis-virginity-take-in-sensual-pov-creampie
Stream PKPD-421, a daring Japanese adult film where Kiki Utana explores virginity in a raw POV creampie. Dive into the intense 2‑hour experienc…
https://jav.do/videos/pkpd-421-pkpd-421-shina-kikis-virginity-take-in-sensual-pov-creampie