Check out our New game coming to y'all this holiday season! If you're a fan of my work you're gonna LOVE this.
www.youtube.com/watch?v=PP2A...
#gaming #gamedev #indiegames #Christmas
www.youtube.com/watch?v=PP2A...
#gaming #gamedev #indiegames #Christmas
SantaCorps: Snow Patrol (2025 REVEAL)
YouTube video by Virtuoso Neomedia
www.youtube.com
December 21, 2025 at 1:57 AM
Check out our New game coming to y'all this holiday season! If you're a fan of my work you're gonna LOVE this.
www.youtube.com/watch?v=PP2A...
#gaming #gamedev #indiegames #Christmas
www.youtube.com/watch?v=PP2A...
#gaming #gamedev #indiegames #Christmas
In this week's mitophagy news 🪫🗑️
biomed.news/bims-tofagi/...
⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡
-Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway
Thanks to @biomednews.bsky.social
biomed.news/bims-tofagi/...
⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡
-Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway
Thanks to @biomednews.bsky.social
October 5, 2025 at 12:09 PM
In this week's mitophagy news 🪫🗑️
biomed.news/bims-tofagi/...
⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡
-Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway
Thanks to @biomednews.bsky.social
biomed.news/bims-tofagi/...
⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡
-Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway
Thanks to @biomednews.bsky.social
Exciting new finding about the role of PP2A molecular glues in overcoming resistant to broad classes of MAPK inhibitors in KRAS driven cancers
JCI - A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer www.jci.org/articles/vie...
JCI - A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer www.jci.org/articles/vie...
JCI -
A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer
www.jci.org
October 21, 2025 at 2:00 PM
Exciting new finding about the role of PP2A molecular glues in overcoming resistant to broad classes of MAPK inhibitors in KRAS driven cancers
JCI - A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer www.jci.org/articles/vie...
JCI - A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer www.jci.org/articles/vie...
Nature research paper: Template-driven scaffolding of SCFFBXO42 regulates PP2A degradation
go.nature.com/4epMbYt
go.nature.com/4epMbYt
Template-driven scaffolding of SCFFBXO42 regulates PP2A degradation - Nature
The E3 ligase SCFFBXO42 degrades holoenzyme-free PP2Ac in complex with the coiled-coil protein CCDC6 to maintain cancer cell fitness
go.nature.com
April 20, 2026 at 10:24 AM
Nature research paper: Template-driven scaffolding of SCFFBXO42 regulates PP2A degradation
go.nature.com/4epMbYt
go.nature.com/4epMbYt
Phosphorylation at the AIS is back! Nice work from @yudonggao.bsky.social and Matt Rasband on the presence and role of the PP2A phosphatase subunit Ppp2r2c using HiUGE tagging www.nature.com/articles/s41...
December 3, 2025 at 12:07 PM
Phosphorylation at the AIS is back! Nice work from @yudonggao.bsky.social and Matt Rasband on the presence and role of the PP2A phosphatase subunit Ppp2r2c using HiUGE tagging www.nature.com/articles/s41...
A PP2A phosphatase-defined transcriptional activity window safeguards male fertility (Zesen Lai , Zhenze Lei , Jianzheng Wang , Yeqiao Liu , Ying Fu , Fang Chang) doi.org/10.1093/plce... #PlantScience @aspbofficial
September 26, 2026 at 5:15 PM
A PP2A phosphatase-defined transcriptional activity window safeguards male fertility (Zesen Lai , Zhenze Lei , Jianzheng Wang , Yeqiao Liu , Ying Fu , Fang Chang) doi.org/10.1093/plce... #PlantScience @aspbofficial
#FERONIA kinase and PP2A antagonistically regulate #salt tolerance in #Arabidopsis
www.cell.com/current-biol...
#PlantScience #StressBiology @currentbiology.bsky.social @cellpress.bsky.social @plantgenomes.bsky.social @plantredox.bsky.social @plantbiotech.bsky.social @agu-scicomm.bsky.social
www.cell.com/current-biol...
#PlantScience #StressBiology @currentbiology.bsky.social @cellpress.bsky.social @plantgenomes.bsky.social @plantredox.bsky.social @plantbiotech.bsky.social @agu-scicomm.bsky.social
FERONIA kinase and PP2A antagonistically regulate salt tolerance in Arabidopsis
Liu et al. show that FER and PP2A engage in reciprocal regulation through phosphorylation
and dephosphorylation. This antagonistic interplay controls the phosphorylation of
downstream substrates, such...
www.cell.com
March 8, 2026 at 7:31 AM
#FERONIA kinase and PP2A antagonistically regulate #salt tolerance in #Arabidopsis
www.cell.com/current-biol...
#PlantScience #StressBiology @currentbiology.bsky.social @cellpress.bsky.social @plantgenomes.bsky.social @plantredox.bsky.social @plantbiotech.bsky.social @agu-scicomm.bsky.social
www.cell.com/current-biol...
#PlantScience #StressBiology @currentbiology.bsky.social @cellpress.bsky.social @plantgenomes.bsky.social @plantredox.bsky.social @plantbiotech.bsky.social @agu-scicomm.bsky.social
The culmination of a fantastic collaboration between our lab and Bob Yauch’s lab that resulted in the uncovering of a proteosomal regulatory mechanism for PP2A. Congratulations to all the authors!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Template-driven scaffolding of SCFFBXO42 regulates PP2A degradation - Nature
The E3 ligase SCFFBXO42 degrades holoenzyme-free PP2Ac in complex with the coiled-coil protein CCDC6 to maintain cancer cell fitness
www.nature.com
April 16, 2026 at 2:43 PM
The culmination of a fantastic collaboration between our lab and Bob Yauch’s lab that resulted in the uncovering of a proteosomal regulatory mechanism for PP2A. Congratulations to all the authors!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
There is nothing sweeter than the first paper from your former postdoc’s own lab. Huge congratulations to Yudong and his lab!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A distinct PP2A subunit regulates local protein phosphorylation at the axon initial segment - Nature Communications
The existence of phosphatases specialized in regulating the axon initial segment (AIS) was unclear. Here, the authors show that a PP2A-B55 subunit is selectively enriched at the AIS and contributes to...
www.nature.com
December 4, 2025 at 1:57 AM
There is nothing sweeter than the first paper from your former postdoc’s own lab. Huge congratulations to Yudong and his lab!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The existence of specialized phosphatases in regulating the AIS was unclear. In this initial report, we show that a PP2A subunit is enriched at the AIS and contributes to its local phosphoregulation. Fun collaboration with Dr. Matthew Rasband's lab, and thanks to all authors for their contribution!
A distinct PP2A subunit regulates local protein phosphorylation at the axon initial segment - Nature Communications
The existence of phosphatases specialized in regulating the axon initial segment (AIS) was unclear. Here, the authors show that a PP2A-B55 subunit is selectively enriched at the AIS and contributes to...
www.nature.com
December 3, 2025 at 4:43 PM
The existence of specialized phosphatases in regulating the AIS was unclear. In this initial report, we show that a PP2A subunit is enriched at the AIS and contributes to its local phosphoregulation. Fun collaboration with Dr. Matthew Rasband's lab, and thanks to all authors for their contribution!
Published today in Cell Chemical Biology, our Cryo-EM structure of PP2A/B55α with IER5 and identification of IER5 structural homologues SERTADs using structural bioinformatics. Congratulations to Aster and @blacklowlab.bsky.social authors!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Molecular mechanism of PP2A/B55α phosphatase inhibition by IER5
PP2A serine/threonine phosphatases are heterotrimeric complexes that execute many essential physiologic functions. These activities are modulated by a…
www.sciencedirect.com
April 9, 2025 at 3:29 PM
Published today in Cell Chemical Biology, our Cryo-EM structure of PP2A/B55α with IER5 and identification of IER5 structural homologues SERTADs using structural bioinformatics. Congratulations to Aster and @blacklowlab.bsky.social authors!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Please find here our newest research paper on Ebola virus Nucleoprotein phosphorylation, published as christmas present in Emerging Microbes and Infections :-) what a good start into 2025, happy new year!
www.tandfonline.com/doi/10.1080/...
www.tandfonline.com/doi/10.1080/...
To be or not to be phosphorylated: Understanding the role of Ebola virus nucleoprotein in the dynamic interplay with the transcriptional activator VP30 and the host phosphatase PP2A-B56
Ebola virus (EBOV) transcription is essentially regulated via dynamic dephosphorylation of its viral transcription activator VP30 by the host phosphatase PP2A. The nucleoprotein NP has emerged as a...
www.tandfonline.com
January 3, 2025 at 9:23 AM
Please find here our newest research paper on Ebola virus Nucleoprotein phosphorylation, published as christmas present in Emerging Microbes and Infections :-) what a good start into 2025, happy new year!
www.tandfonline.com/doi/10.1080/...
www.tandfonline.com/doi/10.1080/...
Paulo Ribeiro, @aashikasekar.bsky.social et al @qmbci.bsky.social find that protein phosphatase PP2A activates the Hippo pathway in Drosophila, in addition to its role as a Hippo negative regulator as part of the STRIPAK complex
link.springer.com/article/10.1...
link.springer.com/article/10.1...
PP2A phosphatase regulates Hippo signalling in dual manner - The EMBO Journal
Hippo signalling is an evolutionarily conserved pathway that regulates tissue growth. The FERM domain protein Expanded (Ex) integrates polarity cues to activate the Hippo pathway. Previous work has sh...
link.springer.com
July 8, 2026 at 8:30 AM
Paulo Ribeiro, @aashikasekar.bsky.social et al @qmbci.bsky.social find that protein phosphatase PP2A activates the Hippo pathway in Drosophila, in addition to its role as a Hippo negative regulator as part of the STRIPAK complex
link.springer.com/article/10.1...
link.springer.com/article/10.1...
#WeekendRead! #WeAreWhatWeEat! @swagatag.bsky.social Yilmaz &co show @science.org that high fat diet drives ceramide accumulation in colorectal cancer #CRC cells which activate PP2A, driving #YAP regenerative/fetal transcriptional programs required for CRC liver #metastases, not primary tumors!
Ceramide synthesis mediates colorectal cancer metastasis through a YAP-driven regenerative program
Mechanisms by which primary tumor cells acquire metastatic capability through metabolic and signaling adaptations are currently poorly understood. We demonstrate that tumor-intrinsic ceramide metaboli...
doi.org
September 26, 2026 at 3:06 PM
#WeekendRead! #WeAreWhatWeEat! @swagatag.bsky.social Yilmaz &co show @science.org that high fat diet drives ceramide accumulation in colorectal cancer #CRC cells which activate PP2A, driving #YAP regenerative/fetal transcriptional programs required for CRC liver #metastases, not primary tumors!
In our latest issue 16:
Review: Revisiting nerve nets
Telomeric replication inhibition reconstituted
Dual Hippo regulation by PP2A
Transcriptional control of Golgi biogenesis
Cover by Marthiens, Basto and colleagues
link.springer.com/journal/4431...
Review: Revisiting nerve nets
Telomeric replication inhibition reconstituted
Dual Hippo regulation by PP2A
Transcriptional control of Golgi biogenesis
Cover by Marthiens, Basto and colleagues
link.springer.com/journal/4431...
August 18, 2026 at 5:44 PM
In our latest issue 16:
Review: Revisiting nerve nets
Telomeric replication inhibition reconstituted
Dual Hippo regulation by PP2A
Transcriptional control of Golgi biogenesis
Cover by Marthiens, Basto and colleagues
link.springer.com/journal/4431...
Review: Revisiting nerve nets
Telomeric replication inhibition reconstituted
Dual Hippo regulation by PP2A
Transcriptional control of Golgi biogenesis
Cover by Marthiens, Basto and colleagues
link.springer.com/journal/4431...
#PubSaludMurcia Stabilization of the PP2A-B56α complex overcomes venetoclax-azacitidine resistance by impairing OXPHOS in AML @AreaUnoArrixaca @IMIB_RMurcia
JCI Insight - Stabilization of the PP2A-B56α complex overcomes venetoclax-azacitidine resistance by impairing OXPHOS in AML
2Department of Internal Medicine: Division of Genetic Medicine, The University of Michigan Medical School, Ann Arbor, United States of America
doi.org
September 25, 2026 at 10:02 AM
#PubSaludMurcia Stabilization of the PP2A-B56α complex overcomes venetoclax-azacitidine resistance by impairing OXPHOS in AML @AreaUnoArrixaca @IMIB_RMurcia
2 mai 2024, Glucksmann réaffirme son indignation : "Depuis le 7 octobre, je n'ai pas bégayé pour condamner les attentats terroristes de l'organisation Hamas. Je n'ai pas bégayé non plus pour condamner les crimes de l'extrême droite israélienne aujourd'hui au pouvoir" www.youtube.com/watch?v=Pp2a...
Raphaël Glucksmann : «Depuis le 7 octobre, moi je n'ai pas bégayé» (Université Libé)
YouTube video by Libération
www.youtube.com
September 2, 2025 at 12:57 PM
2 mai 2024, Glucksmann réaffirme son indignation : "Depuis le 7 octobre, je n'ai pas bégayé pour condamner les attentats terroristes de l'organisation Hamas. Je n'ai pas bégayé non plus pour condamner les crimes de l'extrême droite israélienne aujourd'hui au pouvoir" www.youtube.com/watch?v=Pp2a...
From MBoC: James B. Moseley (Dartmouth) shows PP2A-B56 preserves Mid1 to keep the division plane centered in fission yeast. B56 loss → rings slide & divisions become asymmetric; restoring Mid1 rescues. Paper: www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
September 29, 2025 at 9:01 PM
From MBoC: James B. Moseley (Dartmouth) shows PP2A-B56 preserves Mid1 to keep the division plane centered in fission yeast. B56 loss → rings slide & divisions become asymmetric; restoring Mid1 rescues. Paper: www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
Proposing a new approach for aggressive, treatment-resistant pediatric brain tumors.
Rongze Olivia Lu & team @neurosurgucsf.bsky.social target protein phosphatase 2A (PP2A) to induce tumor cell senescence and boost immune response in medulloblastoma models: doi.org/10.1172/JCI1...
#medulloblastoma
Rongze Olivia Lu & team @neurosurgucsf.bsky.social target protein phosphatase 2A (PP2A) to induce tumor cell senescence and boost immune response in medulloblastoma models: doi.org/10.1172/JCI1...
#medulloblastoma
July 6, 2026 at 5:45 PM
Proposing a new approach for aggressive, treatment-resistant pediatric brain tumors.
Rongze Olivia Lu & team @neurosurgucsf.bsky.social target protein phosphatase 2A (PP2A) to induce tumor cell senescence and boost immune response in medulloblastoma models: doi.org/10.1172/JCI1...
#medulloblastoma
Rongze Olivia Lu & team @neurosurgucsf.bsky.social target protein phosphatase 2A (PP2A) to induce tumor cell senescence and boost immune response in medulloblastoma models: doi.org/10.1172/JCI1...
#medulloblastoma
Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after #mitosis.
https://elifesciences.org/articles/104233?utm_source=bluesky&utm_medium=social&utm_campaign=organic
https://elifesciences.org/articles/104233?utm_source=bluesky&utm_medium=social&utm_campaign=organic
February 24, 2025 at 9:21 AM
Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after #mitosis.
https://elifesciences.org/articles/104233?utm_source=bluesky&utm_medium=social&utm_campaign=organic
https://elifesciences.org/articles/104233?utm_source=bluesky&utm_medium=social&utm_campaign=organic
#IsmuasMonthOfMusic #MusicChallenge #MusicSky
Day 7: A track where rhythm drops out entirely for dramatic effect
Bad Brains “Re-Ignition”
www.youtube.com/watch?v=pp2A...
Day 7: A track where rhythm drops out entirely for dramatic effect
Bad Brains “Re-Ignition”
www.youtube.com/watch?v=pp2A...
Bad Brains - Re-ignition Live The Astoria London 29.09.89
YouTube video by TravisBickle1963
www.youtube.com
May 7, 2026 at 3:08 PM
#IsmuasMonthOfMusic #MusicChallenge #MusicSky
Day 7: A track where rhythm drops out entirely for dramatic effect
Bad Brains “Re-Ignition”
www.youtube.com/watch?v=pp2A...
Day 7: A track where rhythm drops out entirely for dramatic effect
Bad Brains “Re-Ignition”
www.youtube.com/watch?v=pp2A...
Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase reveals a role at metaphase kinetochores - Nature Communications
Phosphatase enzymes are challenging to study due to a lack of specific inhibitors. Here, authors develop a chemical-genetic system to inhibit and characterize a major Ser/Thr phosphatase complex, and ...
www.nature.com
April 1, 2025 at 5:58 PM
Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our new paper describing how mutations to the PP2A gene PPP2R1A drive high-grade uterine cancers is out now in this issue of Cancer Research by @theaacr.bsky.social
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer
Elevated IGFBP2 secretion by uterine cancer cells with heterozygous PPP2R1A mutations supports tumor progression and confers a vulnerability to IGFBP2/IGF1R inhibition as a therapeutic approach for th...
aacrjournals.org
February 5, 2025 at 5:19 PM
Our new paper describing how mutations to the PP2A gene PPP2R1A drive high-grade uterine cancers is out now in this issue of Cancer Research by @theaacr.bsky.social
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
Combination of in vivo and in vitro phosphoproteomics determines the PP2A target repertoire on proteome scale
Combination of in vivo and in vitro phosphoproteomics determines the PP2A target repertoire on proteome scale
Brunner et al. developed an on-bead in vitro phosphatase screen that uses whole-proteome lysates as input. In combination with in vivo phosphoproteomics, they outline the PP2A target repertoire. Focusing on PPP2R5E/B56ε-containing PP2A complexes, they highlight that PP2A negatively affects stress granule formation.
dlvr.it
June 19, 2025 at 6:50 PM
Combination of in vivo and in vitro phosphoproteomics determines the PP2A target repertoire on proteome scale
new out in Nature this week www.nature.com/articles/s41...
PPP2R1A mutations portend improved survival after cancer immunotherapy - Nature
Inactivating PPP2R1A mutations correlate with better survival after immune checkpoint blockade in patients with ovarian clear cell carcinoma, suggesting that targeting the phosphatase 2A (PP2A) pathwa...
www.nature.com
July 3, 2025 at 7:08 AM
new out in Nature this week www.nature.com/articles/s41...