Científicos del KAIST lograron regenerar tejido retinal y restaurar la visión en ratones al inhibir la proteína PROX1 mediante terapia génica AAV.
DOI: 10.1038/s41467-025-58290-8
Te contamos:
cerebrodigital.net/terapia-...
DOI: 10.1038/s41467-025-58290-8
Te contamos:
cerebrodigital.net/terapia-...
September 26, 2026 at 7:00 AM
Científicos del KAIST lograron regenerar tejido retinal y restaurar la visión en ratones al inhibir la proteína PROX1 mediante terapia génica AAV.
DOI: 10.1038/s41467-025-58290-8
Te contamos:
cerebrodigital.net/terapia-...
DOI: 10.1038/s41467-025-58290-8
Te contamos:
cerebrodigital.net/terapia-...
To watch: UVA team led by Dr. Evan Scott used targeted nanotechnology to probe fluid drainage in the eye; id’ed Prox1 as a potential gene therapy target for glaucoma. Great example of nanotech as a tool for discovery & therapeutic innovation. #AfroBiotech #Nanotech www.uvahealth.com/news/nanotec...
Nanotechnology IDs New Target for Treating Glaucoma
www.uvahealth.com
September 4, 2026 at 3:12 AM
To watch: UVA team led by Dr. Evan Scott used targeted nanotechnology to probe fluid drainage in the eye; id’ed Prox1 as a potential gene therapy target for glaucoma. Great example of nanotech as a tool for discovery & therapeutic innovation. #AfroBiotech #Nanotech www.uvahealth.com/news/nanotec...
☕ @robles-lab.bsky.social & co map chromatin-bound CLOCK/BMAL1 protein complexes across three mouse tissues and uncover PROX1, HNF1B and HOXA5 as homeodomain cofactors that directly bind and co-occupy BMAL1 sites to establish tissue-specific circadian transcription.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CLOCK/BMAL1 interactome uncovers homeodomain factors as tissue regulators - Nature Cell Biology
Aygenli et al. map chromatin-bound CLOCK/BMAL1 protein complexes across three mouse tissues and uncover PROX1, HNF1B and HOXA5 as homeodomain cofactors that directly bind and co-occupy BMAL1 sites to ...
www.nature.com
August 10, 2026 at 10:33 AM
☕ @robles-lab.bsky.social & co map chromatin-bound CLOCK/BMAL1 protein complexes across three mouse tissues and uncover PROX1, HNF1B and HOXA5 as homeodomain cofactors that directly bind and co-occupy BMAL1 sites to establish tissue-specific circadian transcription.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ectopic expression of PROX1 on endothelial cells underlies blood-brain barrier compromise in brain diseases such as tumours & vascular malformation
📷 Sara González-Hernández et al NIH National Heart, Lung, and Blood Institute in @insight.jci.org
➡️ bpod.org.uk/archive/2026...
📷 Sara González-Hernández et al NIH National Heart, Lung, and Blood Institute in @insight.jci.org
➡️ bpod.org.uk/archive/2026...
August 4, 2026 at 8:12 AM
Ectopic expression of PROX1 on endothelial cells underlies blood-brain barrier compromise in brain diseases such as tumours & vascular malformation
📷 Sara González-Hernández et al NIH National Heart, Lung, and Blood Institute in @insight.jci.org
➡️ bpod.org.uk/archive/2026...
📷 Sara González-Hernández et al NIH National Heart, Lung, and Blood Institute in @insight.jci.org
➡️ bpod.org.uk/archive/2026...
Lymphatic Endothelial Cell VEGFR2 in postnatal skin Lymphangiogenesis & Lymphatic valvulogenesis
🐭
Cdh5-CreERT2;Vegfr2 f/f (P1~2,P10~12)
Prox1-CreERT2;Vegfr2 f/f (P1~4,P10~12)
VEGFR2-deficient lymphatic ECs gain hematopoietic transcript traits
#Angiogenesis 2026
link.springer.com/article/10.1...
🐭
Cdh5-CreERT2;Vegfr2 f/f (P1~2,P10~12)
Prox1-CreERT2;Vegfr2 f/f (P1~4,P10~12)
VEGFR2-deficient lymphatic ECs gain hematopoietic transcript traits
#Angiogenesis 2026
link.springer.com/article/10.1...
July 28, 2026 at 12:12 PM
Lymphatic Endothelial Cell VEGFR2 in postnatal skin Lymphangiogenesis & Lymphatic valvulogenesis
🐭
Cdh5-CreERT2;Vegfr2 f/f (P1~2,P10~12)
Prox1-CreERT2;Vegfr2 f/f (P1~4,P10~12)
VEGFR2-deficient lymphatic ECs gain hematopoietic transcript traits
#Angiogenesis 2026
link.springer.com/article/10.1...
🐭
Cdh5-CreERT2;Vegfr2 f/f (P1~2,P10~12)
Prox1-CreERT2;Vegfr2 f/f (P1~4,P10~12)
VEGFR2-deficient lymphatic ECs gain hematopoietic transcript traits
#Angiogenesis 2026
link.springer.com/article/10.1...
PROX1 loss in adult mouse Schlemm’s canal causes permanent ocular hypertension: doi.org/10.1172/jci....
July 3, 2026 at 11:02 AM
PROX1 loss in adult mouse Schlemm’s canal causes permanent ocular hypertension: doi.org/10.1172/jci....
Achieving tissue-specific & time-dependent genetic manipulation in mice: doi.org/10.1172/jci....
Benjamin R. Thomson @thomsonlab.bsky.social & team report on a nanoparticle-assisted approach in which PROX1 loss in adult mouse Schlemm’s canal causes permanent ocular hypertension
Benjamin R. Thomson @thomsonlab.bsky.social & team report on a nanoparticle-assisted approach in which PROX1 loss in adult mouse Schlemm’s canal causes permanent ocular hypertension
July 3, 2026 at 11:02 AM
Achieving tissue-specific & time-dependent genetic manipulation in mice: doi.org/10.1172/jci....
Benjamin R. Thomson @thomsonlab.bsky.social & team report on a nanoparticle-assisted approach in which PROX1 loss in adult mouse Schlemm’s canal causes permanent ocular hypertension
Benjamin R. Thomson @thomsonlab.bsky.social & team report on a nanoparticle-assisted approach in which PROX1 loss in adult mouse Schlemm’s canal causes permanent ocular hypertension
'Progressive plasticity during colorectal cancer metastasis'
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Progressive plasticity during colorectal cancer metastasis - Nature
Colorectal cancer metastasis involves dramatic plasticity and loss of PROX1-mediated repression of non-intestinal lineages.
www.nature.com
June 19, 2026 at 10:05 AM
'Progressive plasticity during colorectal cancer metastasis'
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Hear Tatiana Petrova at #Angiogenesis26!
Tatiana studies lymphatic vascular development & tissue-specific remodeling, showing how Prox1, organ-specific mechanical forces, & metabolic pathways govern lymphatic endothelial identity & functional maturation.
Register today! www.vwfb.de/start/regist...
Tatiana studies lymphatic vascular development & tissue-specific remodeling, showing how Prox1, organ-specific mechanical forces, & metabolic pathways govern lymphatic endothelial identity & functional maturation.
Register today! www.vwfb.de/start/regist...
June 16, 2026 at 3:32 AM
Hear Tatiana Petrova at #Angiogenesis26!
Tatiana studies lymphatic vascular development & tissue-specific remodeling, showing how Prox1, organ-specific mechanical forces, & metabolic pathways govern lymphatic endothelial identity & functional maturation.
Register today! www.vwfb.de/start/regist...
Tatiana studies lymphatic vascular development & tissue-specific remodeling, showing how Prox1, organ-specific mechanical forces, & metabolic pathways govern lymphatic endothelial identity & functional maturation.
Register today! www.vwfb.de/start/regist...
Hear Tatiana Petrova at #Angioscience26!
Tatiana studies lymphatic vascular development & tissue-specific remodeling, defining how Prox1, organ-specific mechanical forces, and metabolic signaling pathways govern lymphatic endothelial cell identity & maturation in health & disease.
Tatiana studies lymphatic vascular development & tissue-specific remodeling, defining how Prox1, organ-specific mechanical forces, and metabolic signaling pathways govern lymphatic endothelial cell identity & maturation in health & disease.
June 16, 2026 at 3:27 AM
Hear Tatiana Petrova at #Angioscience26!
Tatiana studies lymphatic vascular development & tissue-specific remodeling, defining how Prox1, organ-specific mechanical forces, and metabolic signaling pathways govern lymphatic endothelial cell identity & maturation in health & disease.
Tatiana studies lymphatic vascular development & tissue-specific remodeling, defining how Prox1, organ-specific mechanical forces, and metabolic signaling pathways govern lymphatic endothelial cell identity & maturation in health & disease.
Periaortic Lymphatic Vascular Dysfunction (density & drainage) in Thoracic Aortic Dissection
Evidence🐭+BAPN
Prox1-CreERT2:Vegfr3 f/f
Tracheobronchial lymph node removal
hVEGF-C156S i.p.
-/+ AMD3100 CXCRi✅
Lymphatic vessel density ⬇️in 👤TAD
#CardiovascRes 2025
academic.oup.com/cardiovascre...
Evidence🐭+BAPN
Prox1-CreERT2:Vegfr3 f/f
Tracheobronchial lymph node removal
hVEGF-C156S i.p.
-/+ AMD3100 CXCRi✅
Lymphatic vessel density ⬇️in 👤TAD
#CardiovascRes 2025
academic.oup.com/cardiovascre...
May 10, 2026 at 11:31 AM
Periaortic Lymphatic Vascular Dysfunction (density & drainage) in Thoracic Aortic Dissection
Evidence🐭+BAPN
Prox1-CreERT2:Vegfr3 f/f
Tracheobronchial lymph node removal
hVEGF-C156S i.p.
-/+ AMD3100 CXCRi✅
Lymphatic vessel density ⬇️in 👤TAD
#CardiovascRes 2025
academic.oup.com/cardiovascre...
Evidence🐭+BAPN
Prox1-CreERT2:Vegfr3 f/f
Tracheobronchial lymph node removal
hVEGF-C156S i.p.
-/+ AMD3100 CXCRi✅
Lymphatic vessel density ⬇️in 👤TAD
#CardiovascRes 2025
academic.oup.com/cardiovascre...
#DBfeature 👂🐁
PROX1 is necessary for cellular patterning, innervation and differentiation in the mouse ear organ of Corti
By Shubham Kale, Dimitri Traenkner, Ellison Goodrich, Satish Ghimire, Thomas Coate, Michael Deans
tinyurl.com/4catf6vr
PROX1 is necessary for cellular patterning, innervation and differentiation in the mouse ear organ of Corti
By Shubham Kale, Dimitri Traenkner, Ellison Goodrich, Satish Ghimire, Thomas Coate, Michael Deans
tinyurl.com/4catf6vr
April 10, 2026 at 8:16 AM
#DBfeature 👂🐁
PROX1 is necessary for cellular patterning, innervation and differentiation in the mouse ear organ of Corti
By Shubham Kale, Dimitri Traenkner, Ellison Goodrich, Satish Ghimire, Thomas Coate, Michael Deans
tinyurl.com/4catf6vr
PROX1 is necessary for cellular patterning, innervation and differentiation in the mouse ear organ of Corti
By Shubham Kale, Dimitri Traenkner, Ellison Goodrich, Satish Ghimire, Thomas Coate, Michael Deans
tinyurl.com/4catf6vr
Engineering Human Brain Assembloids by Multiphasic/Multilayered/Micropillar-array Microfluidics🤠
Microcapsule hiPSC➡️region-specific brain spheroids
Fused organoid assembly
TBR1+CTIP2+Cortical
TCF7L2+Thalamic
PROX1+ZBTB20+Hippocampal
#AdvMater 2023
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Microcapsule hiPSC➡️region-specific brain spheroids
Fused organoid assembly
TBR1+CTIP2+Cortical
TCF7L2+Thalamic
PROX1+ZBTB20+Hippocampal
#AdvMater 2023
advanced.onlinelibrary.wiley.com/doi/10.1002/...
March 24, 2026 at 11:53 AM
Engineering Human Brain Assembloids by Multiphasic/Multilayered/Micropillar-array Microfluidics🤠
Microcapsule hiPSC➡️region-specific brain spheroids
Fused organoid assembly
TBR1+CTIP2+Cortical
TCF7L2+Thalamic
PROX1+ZBTB20+Hippocampal
#AdvMater 2023
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Microcapsule hiPSC➡️region-specific brain spheroids
Fused organoid assembly
TBR1+CTIP2+Cortical
TCF7L2+Thalamic
PROX1+ZBTB20+Hippocampal
#AdvMater 2023
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Check out this highly cited research paper: Penile cavernous sinusoids are Prox1-positive hybrid vessels – by Sarah Schnabellehner et al.
This study reveals unique structure, lymphatic-like function & potential targets for erectile dysfunction.
Read here: doi.org/10.1530/VB-2...
This study reveals unique structure, lymphatic-like function & potential targets for erectile dysfunction.
Read here: doi.org/10.1530/VB-2...
March 4, 2026 at 9:47 AM
Check out this highly cited research paper: Penile cavernous sinusoids are Prox1-positive hybrid vessels – by Sarah Schnabellehner et al.
This study reveals unique structure, lymphatic-like function & potential targets for erectile dysfunction.
Read here: doi.org/10.1530/VB-2...
This study reveals unique structure, lymphatic-like function & potential targets for erectile dysfunction.
Read here: doi.org/10.1530/VB-2...
Mitotic bookmarking by Prox1 preserves mammalian neuronal lineage identity memory via promoting timely H3K27me3 restoration https://www.biorxiv.org/content/10.64898/2026.02.25.707603v1
February 26, 2026 at 11:31 PM
Mitotic bookmarking by Prox1 preserves mammalian neuronal lineage identity memory via promoting timely H3K27me3 restoration https://www.biorxiv.org/content/10.64898/2026.02.25.707603v1
Mitotic bookmarking by Prox1 preserves mammalian neuronal lineage identity memory via promoting timely H3K27me3 restoration https://www.biorxiv.org/content/10.64898/2026.02.25.707603v1
February 26, 2026 at 11:31 PM
Mitotic bookmarking by Prox1 preserves mammalian neuronal lineage identity memory via promoting timely H3K27me3 restoration https://www.biorxiv.org/content/10.64898/2026.02.25.707603v1
Blindness may no longer be irreversible. A discovery in South Korea just changed the science www.futura-sciences.com/en/blindness...
Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer www.nature.com/articles/s41...
Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer www.nature.com/articles/s41...
Blindness may no longer be irreversible. A discovery in South Korea just changed the science - Futura-Sciences
More than 300 million people worldwide live with retinal diseases that medicine cannot yet reverse. Conditions like retinitis pigmentosa and macular degeneration destroy the photoreceptor cells that m...
www.futura-sciences.com
February 24, 2026 at 9:31 AM
Blindness may no longer be irreversible. A discovery in South Korea just changed the science www.futura-sciences.com/en/blindness...
Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer www.nature.com/articles/s41...
Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer www.nature.com/articles/s41...
New findings suggesting that PROX1 compromises BBB integrity by negatively regulating BBB-associated Wnt signaling. #BBB #BloodBrainBarrier #cerebrovascular
JCI Insight -
Endothelial PROX1 induces blood-brain barrier disruption in the central nervous system
insight.jci.org
January 28, 2026 at 3:51 PM
New findings suggesting that PROX1 compromises BBB integrity by negatively regulating BBB-associated Wnt signaling. #BBB #BloodBrainBarrier #cerebrovascular
So I will show you the pinnacle of module assignment (IMO) and I will say that I think this is a very good paper - just not so easy to interpret how they made the figures so easy to interpret...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Progressive plasticity during colorectal cancer metastasis - Nature
Colorectal cancer metastasis involves dramatic plasticity and loss of PROX1-mediated repression of non-intestinal lineages.
www.nature.com
January 22, 2026 at 9:42 AM
So I will show you the pinnacle of module assignment (IMO) and I will say that I think this is a very good paper - just not so easy to interpret how they made the figures so easy to interpret...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Endothelial PROX1 induces blood-brain barrier disruption in the central nervous system
January 9, 2026 at 5:15 PM
Endothelial PROX1 induces blood-brain barrier disruption in the central nervous system
Ready for a tour through vascular permeability
This issue’s cover features work by Sara González-Hernández et al. on the role of endothelial PROX1 (a lymphatic marker) in pathological disruption to the blood brain barrier: doi.org/10.1172/jci....
This issue’s cover features work by Sara González-Hernández et al. on the role of endothelial PROX1 (a lymphatic marker) in pathological disruption to the blood brain barrier: doi.org/10.1172/jci....
January 9, 2026 at 5:15 PM
Ready for a tour through vascular permeability
This issue’s cover features work by Sara González-Hernández et al. on the role of endothelial PROX1 (a lymphatic marker) in pathological disruption to the blood brain barrier: doi.org/10.1172/jci....
This issue’s cover features work by Sara González-Hernández et al. on the role of endothelial PROX1 (a lymphatic marker) in pathological disruption to the blood brain barrier: doi.org/10.1172/jci....
This study demonstrates that #Prox1 suppresses #Retinoblastoma (RB) #CellProliferation and #DrugResistance through regulation of #Notch1, positioning Prox1 as a promising therapeutic target in RB and opening new avenues for #TranslationalOncology. #medsky
Read: link.springer.com/article/10.1...
Read: link.springer.com/article/10.1...
January 8, 2026 at 12:05 PM
This study demonstrates that #Prox1 suppresses #Retinoblastoma (RB) #CellProliferation and #DrugResistance through regulation of #Notch1, positioning Prox1 as a promising therapeutic target in RB and opening new avenues for #TranslationalOncology. #medsky
Read: link.springer.com/article/10.1...
Read: link.springer.com/article/10.1...
Just published in Cancer Research!
We show that PROX1+ colorectal cancer stem cells drive therapy resistance: they self-renew, survive irradiation via enhanced DNA damage repair, and could be targeted with NHEJ inhibitors.
Check out details: doi.org/10.1158/0008...
We show that PROX1+ colorectal cancer stem cells drive therapy resistance: they self-renew, survive irradiation via enhanced DNA damage repair, and could be targeted with NHEJ inhibitors.
Check out details: doi.org/10.1158/0008...
A Multipotent PROX1+ Tumor Stem/Progenitor Cell Population Emerges during Intestinal Tumorigenesis and Mediates Radioresistance in Colorectal Cancer
Colorectal cancer stem/progenitor cells expressing the PROX1 transcription factor display increased radiation resistance, which may be targeted by small-molecule inhibitors of the nonhomologous end-jo...
doi.org
December 12, 2025 at 4:58 PM
Just published in Cancer Research!
We show that PROX1+ colorectal cancer stem cells drive therapy resistance: they self-renew, survive irradiation via enhanced DNA damage repair, and could be targeted with NHEJ inhibitors.
Check out details: doi.org/10.1158/0008...
We show that PROX1+ colorectal cancer stem cells drive therapy resistance: they self-renew, survive irradiation via enhanced DNA damage repair, and could be targeted with NHEJ inhibitors.
Check out details: doi.org/10.1158/0008...
RRIDs were included in this paper. We value the author's support of reproducibility. #accelerateopenscience #methodsmatter #accelerateopenscience
A Multipotent PROX1+ Tumor Stem/Progenitor Cell Population Emerges during Intestinal Tumorigenesis and Mediates Radioresistance in Colorectal Cancer
doi.org
December 4, 2025 at 8:00 AM
RRIDs were included in this paper. We value the author's support of reproducibility. #accelerateopenscience #methodsmatter #accelerateopenscience
South Korea figuring out how to fix the Muller Glia. What's that? Eye structures www.nature.com/nature-index... KAIST is combining bioprinting, stem-cell therapy, and advanced neuro-integration technologies to help with all sorts of vision problems.
Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer | Articles | Nature Index
The Nature Index tracks the affiliations of high-quality scientific articles. Updated monthly, the Nature Index presents research outputs by institution and country. Use the Nature Index to interrogat...
www.nature.com
November 29, 2025 at 8:27 AM
South Korea figuring out how to fix the Muller Glia. What's that? Eye structures www.nature.com/nature-index... KAIST is combining bioprinting, stem-cell therapy, and advanced neuro-integration technologies to help with all sorts of vision problems.