#PROX1
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mb1106.bsky.social
Mouse retina staining with
Kir4.1 ⚪
Prox1🔴
Calbindin D28k🟢
Nuclei 🔵

#bloodretinalbarrier
#FluorescenceFriday
Mouse retina staining with Kir4.1 Prox1 Calbindin D28k Nuclei
December 20, 2024 at 11:26 AM
cerebrodigital.net
Científicos del KAIST lograron regenerar tejido retinal y restaurar la visión en ratones al inhibir la proteína PROX1 mediante terapia génica AAV.

DOI: 10.1038/s41467-025-58290-8

Te contamos:
cerebrodigital.net/terapia-...
September 26, 2026 at 7:00 AM
parahsaramore.bsky.social
Is Fluorescence Friday a thing here?

If so, here’s some embryonic mouse dermal vasculature 😍 (cyan CD31, yellow VegfR3, magenta Prox1)
E15 embryonic dermis stained with CD31, Prox1, and VegfR3
September 15, 2023 at 4:37 PM
haoyin.bsky.social
Neural Guidance of Lymphatics

#SchwannCell CXCL12⏫ Sprouting/Patterning of CXCR4+ #LymphaticEndothelialCell

Prox1-CreERT2:Cxcr4f/f🐭
⬇️ Lymphatic Valve formation
⬇️ VEGF-C-induced #Lymphangiogenesis

Xiaolei Liu lab Development 2024 @biologists.bsky.social
journals.biologists.com/dev/article-...
November 24, 2024 at 8:31 PM
blacoste.bsky.social
New findings suggesting that PROX1 compromises BBB integrity by negatively regulating BBB-associated Wnt signaling. #BBB #BloodBrainBarrier #cerebrovascular
JCI Insight - Endothelial PROX1 induces blood-brain barrier disruption in the central nervous system
insight.jci.org
January 28, 2026 at 3:51 PM
natcellbio.nature.com
☕ @robles-lab.bsky.social & co map chromatin-bound CLOCK/BMAL1 protein complexes across three mouse tissues and uncover PROX1, HNF1B and HOXA5 as homeodomain cofactors that directly bind and co-occupy BMAL1 sites to establish tissue-specific circadian transcription.
www.nature.com/articles/s41...
CLOCK/BMAL1 interactome uncovers homeodomain factors as tissue regulators - Nature Cell Biology
Aygenli et al. map chromatin-bound CLOCK/BMAL1 protein complexes across three mouse tissues and uncover PROX1, HNF1B and HOXA5 as homeodomain cofactors that directly bind and co-occupy BMAL1 sites to ...
www.nature.com
August 10, 2026 at 10:33 AM
devbiol.bsky.social
#DBfeature 👂🐁

PROX1 is necessary for cellular patterning, innervation and differentiation in the mouse ear organ of Corti

By Shubham Kale, Dimitri Traenkner, Ellison Goodrich, Satish Ghimire, Thomas Coate, Michael Deans

tinyurl.com/4catf6vr
PROX1 directs Type II SGN axon turning non-cell autonomously. Peripheral axons of Type II SGNs immunolabeled for Neurofilament (NF-H, green) in Emx2-Cre; Prox1 cKOs or littermate controls, and Bhlhe22-Cre; Prox1 cKOs and littermate controls. Arrowheads indicate incorrectly turning axons.
April 10, 2026 at 8:16 AM
ondinecleaver.bsky.social
Hear Tatiana Petrova at #Angiogenesis26!

Tatiana studies lymphatic vascular development & tissue-specific remodeling, showing how Prox1, organ-specific mechanical forces, & metabolic pathways govern lymphatic endothelial identity & functional maturation.

Register today! www.vwfb.de/start/regist...
June 16, 2026 at 3:32 AM
insight.jci.org
PROX1 loss in adult mouse Schlemm’s canal causes permanent ocular hypertension: doi.org/10.1172/jci....
July 3, 2026 at 11:02 AM
dkfz.bsky.social
Den GSCN 2025 Publication of the Year Award erhält @moritzmall.bsky.social zusammen mit Bryce Lim und weiteren Co-Autoren für ihre Veröffentlichung "Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis". 👏
@gscnoffice.bsky.social
Bild: Jung/DKFZ
August 22, 2025 at 8:37 AM
haoyin.bsky.social
2X #DilatedCardiomyopathy GWAS MATG #NatGenet 2024 reveal novel genes/cellular players

PROX1 - #LymphaticEndothelialCell
ERG - #EndothelialCell
DGKG - #SmoothMuscleCell
MAPT/Tau validated in both studies

>9k case
www.nature.com/articles/s41...

>14k case
www.nature.com/articles/s41...
November 30, 2024 at 1:22 PM
embl.org
In a collaborative study, Group Leaders Judith Zaugg (EMBL) and Moritz Mall (DKFZ) discovered a liver protein, called PROX1, that preserves cell identity and halts cancer formation in preclinical mouse models, paving the way for novel liver cancer therapies. 🧪

www.embl.org/news/science...
A special puppeteer holds the strings to liver cells' identity | EMBL
Scientists at EMBL and DKFZ discovered a protein in liver cells that maintains cell identity and halts tumour formation and progression.
www.embl.org
February 13, 2025 at 10:16 AM
stemcellpodcast.com
Researchers at @uniheidelberg.bsky.social discovered that #PROX1 can block #CellFate plasticity in #hepatocytes, preventing #LiverCancer in mice.

@aryankamal.bsky.social
@moritzmall.bsky.social

📃 @naturegenet.bsky.social - go.nature.com/3D9AYuR
🎤 - bit.ly/4k42YAG
February 19, 2025 at 10:08 PM
bild.bsky.social
PROX1 proteini, karaciğer hücrelerinin kimliğini koruyarak tümörleşmelerini önleyebilir.

Ayrca karaciğer kanseri hastalarında yüksek PROX1 seviyeleri daha iyi bir prognoz ve daha uzun yaşam süresi ile ilişkiliymiş 👇
bild.bsky.social Çağsı @bild.bsky.social · Feb 14
🧬🔬 Koruyucu molekül PROX1, karaciğer hücrelerinin kimliklerini korumalarına yardımcı olur ve tümör hücrelerine dönüşmelerini engelliyormuş. Farelerdeki klinik öncesi karaciğer kanseri modellerinde PROX1, kanser gelişimini durdurmuş ve ilerlemesini yavaşlatmış.
A special puppeteer holds the strings to liver cells' identity | EMBL
Scientists at EMBL and DKFZ discovered a protein in liver cells that maintains cell identity and halts tumour formation and progression.
www.embl.org
February 14, 2025 at 2:06 PM
metastasisresearch.bsky.social
2/Discover how colorectal cancer evolves during metastasis. This study reveals metastases shifting from stem-like to fetal progenitor states, driving squamous & neuroendocrine traits linked to poor outcomes.

@karunamdphd.bsky.social @mskcancercenter.bsky.social

www.nature.com/articles/s41...
Progressive plasticity during colorectal cancer metastasis - Nature
Colorectal cancer metastasis involves dramatic plasticity and loss of PROX1-mediated repression of non-intestinal lineages.
www.nature.com
December 23, 2024 at 3:55 PM
bild.bsky.social
🧬🔬 Koruyucu molekül PROX1, karaciğer hücrelerinin kimliklerini korumalarına yardımcı olur ve tümör hücrelerine dönüşmelerini engelliyormuş. Farelerdeki klinik öncesi karaciğer kanseri modellerinde PROX1, kanser gelişimini durdurmuş ve ilerlemesini yavaşlatmış.
A special puppeteer holds the strings to liver cells' identity | EMBL
Scientists at EMBL and DKFZ discovered a protein in liver cells that maintains cell identity and halts tumour formation and progression.
www.embl.org
February 14, 2025 at 10:35 AM
centinel.bsky.social
Prometedor estudio (aunque todavía en fase experimental) en el que se consigue regeneración de tejido neuronal de la retina:
www.nature.com/articles/s41...
Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer - Nature Communications
Recovery for mammalian retinal degeneration is limited by a lack of Müller glia (MG)-mediated regeneration. Here authors show blocking Prox1 accumulation and intercellular transfer from retinal neuron...
www.nature.com
April 23, 2025 at 9:54 PM
berlinliverlab.bsky.social
interesting.

Is PROX1 —a well established factor in liver development— also maintaining liver cell identity long after birth?

www.nature.com/articles/s41...
Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis - Nature Genetics
This study identifies candidate safeguard repressor transcription factors that repress alternate lineages in mature cell types and provides functional evidence that Prox1 performs such a function in h...
www.nature.com
February 13, 2025 at 3:35 PM
haoyin.bsky.social
🫀 #Lymphangiogenesis
#BranchedChainAminoAcid Catabolism
#HeartFailure

Prox1+ #LymphaticEndothelialCell BCKDK (kinase ⏬BCAA degradation) KO➡️
⏫Lymphangiogenesis
⏫Diastolic function
🐭HFpEF (L-NAME+HFD 12 wk)

Src-VEGFR3 axis

#CircAHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/full/10....
May 24, 2025 at 7:25 PM
haoyin.bsky.social
Lymphatic Endothelial Cell VEGFR2 in postnatal skin Lymphangiogenesis & Lymphatic valvulogenesis

🐭
Cdh5-CreERT2;Vegfr2 f/f (P1~2,P10~12)
Prox1-CreERT2;Vegfr2 f/f (P1~4,P10~12)

VEGFR2-deficient lymphatic ECs gain hematopoietic transcript traits

#Angiogenesis 2026
link.springer.com/article/10.1...
July 28, 2026 at 12:12 PM
moritzmall.bsky.social
If you enjoyed our @naturegenet.bsky.social paper on how PROX1 safeguards hepatocyte identity, check out the behind-the-scenes Research Briefing—both free to read:
Paper: rdcu.be/d9IFg
Briefing: rdcu.be/eaLYL
#CellPlasticity #CancerResearch
February 21, 2025 at 1:23 PM
moritzmall.bsky.social
Our findings show that active repression preserves cell identity. PROX1 is just one example—uncovering more #SafeguardRepressors could reshape regenerative medicine & cancer therapy. Stay tuned for what’s next! 🚀 #CancerTherapy #StemCells www.embopress.org/doi/full/10....
February 13, 2025 at 12:16 PM
degrainger.bsky.social
HCR (@hcrimaging.bsky.social) stainings suggest VEGFC/VEGFR3 signaling acts upstream of PROX1

In the absence of VEGFC/VEGFR3 signaling, specification of LECs from PXM stalls at the angioblast stage with Vegfc-/- embryos having more Etv2+Prox1- cells in the HDM.
January 13, 2025 at 2:31 PM
nanoappsmedical.bsky.social
Breakthrough Drug Restores Vision: Researchers Successfully Reverse Retinal Damage

www.nanoappsmedical.com/breakthrough...

@cellrep7.bsky.social
@heinzvhoenen.bsky.social
@amandascott2023.bsky.social
Breakthrough Drug Restores Vision: Researchers Successfully Reverse Retinal Damage
Blocking the PROX1 protein allowed
www.nanoappsmedical.com
April 23, 2025 at 9:48 AM
trevorgraham.bsky.social
Here is the link to @karunamdphd.bsky.social's lovely @nature.com paper that the commentary is about: www.nature.com/articles/s41...
Progressive plasticity during colorectal cancer metastasis - Nature
Colorectal cancer metastasis involves dramatic plasticity and loss of PROX1-mediated repression of non-intestinal lineages.
www.nature.com
January 20, 2025 at 5:45 PM