#PS19
LightNews LightNews
primavera-sound.bsky.social
🌷 Abrazando la nueva normalidad. #PS19
_

🌷 Abraçant la nova normalitat. #PS19
_

🌷 Embracing the new normal. #PS19

#primaverasound #25primaveras
September 22, 2026 at 9:24 AM
aosasmita.bsky.social
An array of microglia (🔵) and a neuron filled with phospho-tau (🟡) in the cortex of a PS19 mouse.

#FluorescenceFriday
January 10, 2025 at 12:52 PM
sailorrooscout.bsky.social
given to mice bred to express pathological tau they generated antibodies, reduced the extent of the tangles in key brain structures, AND improved their performance on tests to gauge their cognitive disability. Their new paper expands on those exact findings. The vaccine elicited a strong immune
Figure 1. pT181-Qß vaccination induces a robust and long-lasting anti-pT181 tau antibody response. (A) 13-Mer peptides, including the phosphorylated epitope threonine 181 (pT181), were synthesized with two glycines (G) and a cysteine (C) and conjugated to the surface-exposed lysine residues on the coat proteins of a self-assembled Qß RNA bacteriophage (VLP) using a SMPH cross-linker. (B) Conjugation efficiency suggests that up to three peptides could be conjugated per coat protein (≈180 coat proteins/VLP x 3 = max 540 peptides/VLP). (C–D) Anti-pT181 IgG end-point titers (C) and serial dilutions (D) show that anti-pT181 IgGs remain significantly elevated until at least 9 months post-final immunization in PS19 mice. (E) Immune sera from pT181-Qß, but not Qß, vaccinated mice were reactive to pTau—similar to AT8, which was a positive control. LOD = limit of detection. Mean ± SEM, unpaired Student's t-test or one-way ANOVA, *p < .05, ***p < .005; n = 3–4. Scale bar in E – 30 µm. ANOVA, Analysis of Variance; SMPH, Succinimidyl 6-[(beta-maleimidopropionamido) hexanoate]. Figure 2. pT181-Qß vaccination reduces microgliosis, hyperphosphorylated and aggregated tau, and neuroinflammation in PS19 mice. (A–F) pT181-Qß vaccinated PS19 mice show reduced AT180+ (pT231) site tau (A–B), Sarkosyl insoluble tau (D), and Gallyas silver positive NFTs (E) compared to PS19 mice vaccinated with Qβ alone. (G–I) Iba1+ microglial morphology suggests reduced activation in 9-month-old PS19 mice vaccinated with pT181- Qß compared to Qß control. Mean ± SEM, unpaired Student's t-test, *p < .05; n = 3–5. Figure 3. pT181-Qß vaccination reduces brain atrophy in PS19 mice. (A–C) T2-weighted MRI of the separate regions of interest (ROIs—cortical, aqua-cyan; hippocampal, dark blue; ventricle, green; striatum, pink; corpus callosum, light brown; and cerebellar, light blue) volumes shows prevention of brain atrophy in the cortex and a trend in the hippocampus. Corpus callosum quantification is not shown. Ventricle volumes are reduced in pT181-Qß vaccinated PS19 mice. Mean ± SEM, Student's t-test, *p < .05, n = 3–4. Figure 4. pT181-Qß vaccination improves delay-dependent memory and motor function in PS19 mice. (A) Frequency of nose pokes to the novel object (NOV) is increased in pT181-Qß vaccinated PS19 mice compared to controls on the test day (right graph. Left: no preference when tested them on identical objects [OBJ1 and OBJ2] on a training day). (B–C) Catwalk motor function test showing restoration of stride length on all four paws in pT181-Qß vaccinated PS19 mice. RF, right front paw; RH, right hind paw; LF, left front paw; LH, left hind paw. Mean ± SEM, Student's t-test. *p < .05, two-way ANOVA, a Tukey's post hoc analysis was used, ** p < .01; n = 3–4.
May 5, 2025 at 4:06 PM
aosasmita.bsky.social
Some motor neurons (🔵) filled with phospho-tau (🟡) in the spinal cord of one of our PS19 crossbreeds. Taken together with @erinneuro.bsky.social.

#FluorescenceFriday
February 7, 2025 at 12:34 PM
steeman.bsky.social
Als je kijkt naar de achtergrond van die partij, vooral ontstaan uit het ineenstorten van FvD na PS19, dan is dat inderdaad een rare vraag. De partij komt van alle kanten uit de rechts radicale hoek, met verledens in de extreme hoeken. Een label verandert niets aan de mensen en gedeelde denkbeelden.
October 31, 2025 at 8:00 AM
aosasmita.bsky.social
Throwback #FluorescenceFriday of large motor neurons filled with phospho-tau in the spinal cord of the PS19 mouse model.

🔵 for phospho-tau
🟡 for axons
April 25, 2025 at 3:44 PM
pryprk.bsky.social
Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice www.sciencedirect.com/science/arti...
Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice
Brain myeloid cells accumulate neutral lipids in multiple human neurodegenerative disorders and relevant mouse models. These lipids are often assumed …
www.sciencedirect.com
January 20, 2026 at 1:44 PM
e-infinity.space
This diagram should win some kind of prize for mathematical illustration. From arxiv.org/abs/2305.08471. 🧮
Figure 6. The quotientope lattice for n = 4: all quotientopes ordered by inclusion (which corresponds to refinement of the lattice congruences). We only consider lattice congruences whose fan is essential. We have highlighted the cube (green), Loday’s associahedron [Lod04] (blue), another one of Hohlweg–Lange’s associahedra [HL07] (purple), the diagonal rectangulation polytope [LR12] (orange), and the permutahedron (red). Adapted from [PS19, Fig. 9].
December 5, 2025 at 10:27 PM
fuliansp.eurosky.social
No te gustaría meterte la ps19(?) en la columna vertebral ⁉️

Rarit@...
February 7, 2025 at 11:11 PM
suditeh.bsky.social
🐧🔥 ¡PODCAST NAVIDEÑO!🔥🐧

Hoy, @rokuso3.bsky.social y Venom Suditeh ( @chatomaltes.bsky.social ) se juntan para hablarnos de Peace Walker, el ¿¡MEJOR!? (no) METAL GEAR:

youtu.be/KcnF7HaaYDw
🚀 DOBLE SECUESTRO, DOBLE DIVERSIÓN 🚀 - Metal Gear Solid: Peace Walker [1/2] - Podcast #PV33 #PS19
YouTube video by Suditeh Juegos
youtu.be
December 22, 2025 at 10:49 AM
cp-cellreports.bsky.social
Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice
Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice
Tabor et al. demonstrated that knocking out microglial DGAT1 and DGAT2 exacerbated hippocampal neurodegeneration, introduced multiple behavioral deficits, and increased the abundance of endolysosomal neutral lipids within brain myeloid cells of 9.5-month-old male PS19 mice. DGAT-dependent microglial lipid droplet biogenesis may be adaptive in mammalian tauopathy.
dlvr.it
February 2, 2026 at 3:39 PM
natrevneurol.nature.com
Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice www.nature.com/articles/s41...
Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice - Nature Neuroscience
In PS19 mice, microglia-derived glycoprotein nonmetastatic melanoma protein B promotes mitochondrial extracellular vesicle secretion, enabling mitochondrial transfer to astrocytes. This improves astro...
www.nature.com
May 27, 2026 at 8:47 AM
molneurodegen.bsky.social
AQP4-dependent enhancement of #glymphatic function attenuates tau pathology and #neurodegeneration in PS19 mice

Kaoru Yamada, Kazuhisa Ishida, Asami Sakamoto...Takeshi Iwatsubo #AlzheimersDisease #aquaporin

link.springer.com/article/10.1...
July 20, 2026 at 6:56 PM
rikvand.bsky.social
Deze peiling laat goed zien hoe hard Wilders nog kan vallen.
Forum was de grootste bij PS19, peilt nu 3 op zetels. BBB was grootste bij PS23, nu op 3 zetels. Omtzigt peilde op een gegeven moment op 40 zetels, kreeg er 20 en peilt nu op 2...

Het lot van de opvolgende populistische messias is grillig
peterkanne2024.bsky.social Peter Kanne @peterkanne2024.bsky.social · Mar 19
Verse Ipsos I&O-zetelpeiling: verschuivingen a.g.v. geopolitiek.
PVV: 34 > 30, GL-PvdA: 24 > 27, VVD: 20 > 25, CDA: 16 > 18.
Herstel van oude midden?
BBB: 3, NSC: 2.
JA21 en DENK allebei op 4,
@ashervanderschelde.bsky.social
@maartjevdkoppel.bsky.social

www.ipsos-publiek.nl/actueel/ipso...
March 19, 2025 at 3:31 PM
sailorrooscout.bsky.social
The study has been published in Alzheimer’s & Dementia. YES, it is PEER-REVIEWED.
• alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
• hscnews.unm.edu/news/unm-res...
SUMMARY Researchers have developed a tau-targeting vaccine that could help prevent the progression of Alzheimer's disease by generating a strong immune response against abnormal tau proteins. The vaccine showed effectiveness in mice and non-human primates, prompting researchers to pursue human clinical trials. It targets a specific region of the tau protein, pT181, linked to Alzheimer's-related brain damage and cognitive decline. If successful in humans, this approach could complement or even surpass current therapies that only modestly impact disease progression by targeting amyloid beta. KEY FACTS •Tau-Targeting Vaccine: Generates antibodies against pT181, a hallmark of Alzheimer's pathology. • Strong Immune Response: Proven effective in mice and macaques, with long-lasting immunity. •The vaccine improved memory, reduced brain atrophy, and caused NO major side effects. •Clinical Trials Ahead: Researchers are preparing for Phase I human trials pending funding. ABSTRACT INTRODUCTION Pathological accumulation of tau (pTau) contributes to various tauopathies, including Alzheimer's disease (AD), and correlates with cognitive decline. A rapid surge in tau-targeted approaches via anti-sense oligonucleotides, active/passive immunotherapies suggests that targeting p-Tau is a viable strategy against tauopathies. METHOD We describe a multi-species validation of our previously described Qß virus-like particle (VLP)-based vaccine technology targeting phosphorylated tau on threonine 181 (pT181-Qß). RESULTS Two vaccine doses of pT181-Qß, without any adjuvants, elicited robust antibody responses in two different mouse models of tauopathy (PS19 and hTau) and rhesus macaques. In mouse models, vaccination reduced AT180+ hyperphosphorylated, Sarkosyl insoluble, Gallyas silver positive tau, inflammasomes/ neuroinflammation, and improved recognition memory and motor function without inducing adverse T-cell activation. Anti-pT181 antibodies are reactive to pTau in human AD brains, engage pT181+ tau in human brain lysates, and are central nervous system bioavailable. DISCUSSION Our results suggest the translational utility of pT181-QB against tauopathies. Highlights • Icosahedral display of phosphorylated tau at threonine 181 (pT181) Qß virus-like particle surface ("pT181-Qß" vaccine) induces a robust immune response in mice and in non-human primates (NHPs) • pT181-Qß vaccination reduces pathological tau (pTau) and brain atrophy, and improves memory and motor function in PS19 and hTau mice. • pT181-Qß vaccination-induced immunoglobulin Gs (IgGs) are safe, Th2 skewed (anti-inflammatory), specific to pTau in human AD brain, and efficiently engage pT181 in NHPs and human brain lysate. • pT181+ tau in human plasma correlates with the neurofilament light in subjects with mild cognitive impairment (MCI)-suggesting the presence of pT181-Qß vaccine target in the early disease state. RESEARCH IN CONTEXT Systematic review: A literature review of PubMed and other literature sources suggests that the pathological modifications in tau protein strongly correlate with the cognitive decline in Alzheimer's disease (AD) and related dementias. As such, many pre-clinical and clinical trials have been targeting pathological tau to determine if such an approach benefits patients. Emerging clinical trials using monoclonal antibodies (mAbs) against different regions of tau show positive results in secondary outcomes of cognitive stabilization. Even if the mAb is approved for tau, repeated infusions of mAbs may have compliance issues in elderly patients and short-lived antibody responses upon active immunizations. The relevant citations and clinical trials are included where appropriate. Interpretation: Our study suggests that display of phosphorylated tau (on T181) peptide on the virus-like particles (VLPs) from Qß bacteriophage induced a robust immune response, reduced tau pathology, prevented brain atrophy, and improved memory, and that the immunoglobulin Gs (IgGs) from immunized sera engaged the target in vaccinated non-human primates (rhesus macaques) and human AD brains. Future directions: Targeting pT181-positive tau with pT181-Qß vaccination may in Phase 0/1 clinical trials validate the safety, immunogenicity, and therapeutic efficacy of pT181-Qß vaccination in patients with AD and related tauopathies.
May 5, 2025 at 4:02 PM
biorxiv-neursci.bsky.social
BCG vaccination mitigates tau pathology and restores cognitive function in PS19 mice. https://www.biorxiv.org/content/10.64898/2026.05.12.724591v1
May 16, 2026 at 12:15 AM
judyc2401.bsky.social
1 The celestial realms announce God’s Glory . . . testify of His Hands’ Great Work. . . .

3  . . . silence, their means to convey. 4 . . . to the ends of the earth . . . voices . . . the whole world can hear . . .

Ps19:1-4TheVoiceBible©2012ThomasNelsonInc. Voice™ translation©2012EcclesiaBibleSoc
July 6, 2026 at 8:20 PM
chedspellman.bsky.social
Just some stunning views from San Diego at this year’s #ETS2024 meeting. #Ps19
November 22, 2024 at 6:45 PM
biorxiv-neursci.bsky.social
Synaptic plasticity deficits via aberrant engagement of metaplasticity in the hippocampus of PS19 mice https://www.biorxiv.org/content/10.64898/2026.06.30.734148v1
July 6, 2026 at 3:16 AM
richardtol.bsky.social
She also plays the drums www.youtube.com/watch?v=Ps19...
Sadie Sink/Max from Stranger Things Plays Drums to Master Of Puppets?
YouTube video by Mini Fairhurst
www.youtube.com
January 8, 2026 at 6:56 AM
rridrobot.bsky.social
The authors included RRIDs in their in Molecular & Cellular Proteomics paper! RRIDs improve reproducibility in scientific research. #BetterScience #accelerateopenscience #ReproducibleResearch
An Integrative Proteomic Approach to Reveal Altered Signaling Modules During Alzheimer’s Disease Progression in PS19 Tauopathy Mice
Read the full paper: An Integrative Proteomic Approach to Reveal Altered Signaling Modules During Alzheimer’s Disease Progression in PS19 Tauopathy Mice
doi.org
June 14, 2026 at 7:03 AM
biorxivpreprint.bsky.social
Circadian timing and entrainment properties of the SCN pacemaker in the PS19 mouse model of Tau pathology https://www.biorxiv.org/content/10.1101/2025.06.06.655835v1
June 9, 2025 at 8:15 AM
biorxiv-neursci.bsky.social
A multi-organ spatial metabolomic atlas of exercising mice reveals neuronal Complex I as a convergent and sufficient axis for tau pathology reduction in PS19 https://www.biorxiv.org/content/10.64898/2026.06.16.732673v1
June 23, 2026 at 12:16 AM
shihcheng.bsky.social
Microglia transfer mitochondria to astrocytes via GPNMB-enriched EVs to relieve cognitive deficits in tauopathy mice in AD. PMID:42192197, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02317-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice | Nature Neuroscience
Alzheimer’s disease (AD) is an irreversible neurodegenerative disease characterized by cognitive decline. The precise molecular mechanisms that underlie the pathogenesis of AD remain elusive. Here we show that glycoprotein nonmetastatic melanoma protein B (GPNMB) is produced by microglia and transferred to astrocytes through extracellular vesicles (EVs) in PS19 tau pathology mice. Tau is cleaved in microglia to generate N-terminal fragments that form a complex on mitochondria with Parkin/Nix and GPNMB, promoting the secretion of EVs containing mitochondria. Functional mitochondria transferred to astrocytes via EVs markedly improve astrocytic functions and attenuate the cognitive impairments and pathogenic features in PS19 mice. By contrast, microglial GPNMB deficiency eliminates mitochondrial EV secretion and mitochondrial transfer to astrocytes, thereby impairing astrocytic functions and exacerbating cognitive impairment in PS19-CcKO (CX3CR1 cre Gpnmb floxp) mice. GPNMB-enriched EVs f
doi.org
June 27, 2026 at 7:00 PM
neurowithmelike.bsky.social
GPNMB, a protein produced by microglia, is packaged into extracellular vesicles (EVs) along with functional mitochondria and transferred to astrocytes in Alzheimer's-related tau pathology. This transfer depends on tau fragments forming a complex with Parkin/Nix and
www.nature.com/articles/s41...
Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice - Nature Neuroscience
In PS19 mice, microglia-derived glycoprotein nonmetastatic melanoma protein B promotes mitochondrial extracellular vesicle secretion, enabling mitochondrial transfer to astrocytes. This improves astro...
www.nature.com
May 26, 2026 at 2:04 PM