New in #Science #Immunology: Researchers at Sun Yat-Sen University in Guangzhou report that #BloodCancers expressing PSGL-1 can prevent the #integrin signaling #macrophages need for #phagocytosis. Targeting PSGL-1 improved survival in mouse models of #leukemia, #lymphoma, & #MultipleMyeloma!
PSGL-1 is a phagocytosis checkpoint that enables tumor escape from macrophage clearance
PSGL-1 acts as a phagocytosis checkpoint to promote tumor immune escape through impeding LFA-1 activation in macrophages.
www.science.org
June 19, 2025 at 7:34 AM
New in #Science #Immunology: Researchers at Sun Yat-Sen University in Guangzhou report that #BloodCancers expressing PSGL-1 can prevent the #integrin signaling #macrophages need for #phagocytosis. Targeting PSGL-1 improved survival in mouse models of #leukemia, #lymphoma, & #MultipleMyeloma!
Just won my first league race ever on F1 25 🏆
Started P3 and finished P1 in PSGL.
I’m in a low tier but it’s the most competitive league, so competition is very tough.
Feels really amazing after sweating for so many hours. Love sim racing.
Started P3 and finished P1 in PSGL.
I’m in a low tier but it’s the most competitive league, so competition is very tough.
Feels really amazing after sweating for so many hours. Love sim racing.
July 10, 2025 at 8:51 PM
Just won my first league race ever on F1 25 🏆
Started P3 and finished P1 in PSGL.
I’m in a low tier but it’s the most competitive league, so competition is very tough.
Feels really amazing after sweating for so many hours. Love sim racing.
Started P3 and finished P1 in PSGL.
I’m in a low tier but it’s the most competitive league, so competition is very tough.
Feels really amazing after sweating for so many hours. Love sim racing.
November 22, 2024 at 7:44 AM
Crazy, I’m champion in PSGL F13 🏆
It’s been a rollercoaster, with amazing and terrible races, no middle ground.
I need to improve my mental game and make fewer mistakes to race and win in higher tiers.
But it’s PSGL, so proud of this as a rookie in my first season.
It’s been a rollercoaster, with amazing and terrible races, no middle ground.
I need to improve my mental game and make fewer mistakes to race and win in higher tiers.
But it’s PSGL, so proud of this as a rookie in my first season.
September 28, 2025 at 11:39 AM
Crazy, I’m champion in PSGL F13 🏆
It’s been a rollercoaster, with amazing and terrible races, no middle ground.
I need to improve my mental game and make fewer mistakes to race and win in higher tiers.
But it’s PSGL, so proud of this as a rookie in my first season.
It’s been a rollercoaster, with amazing and terrible races, no middle ground.
I need to improve my mental game and make fewer mistakes to race and win in higher tiers.
But it’s PSGL, so proud of this as a rookie in my first season.
🚨 New paper out! PSGL-1 is a 🔥 immune checkpoint in pancreatic cancer. Knocking it out=more CD8+ T cells, less tumor, better PD-1 response. 🧬Major props to @jlhope.bsky.social (Drexel) & Linda Bradley (SBP) for leading this awesome collab! #PDAC #Immunotherapy #Tcells www.biorxiv.org/content/10.1...
Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer for which there is a critical need to identify novel therapeutic targets. Herein we define PSGL-1 as a checkpoint inhibitor using a syngeneic...
www.biorxiv.org
May 28, 2025 at 12:07 AM
🚨 New paper out! PSGL-1 is a 🔥 immune checkpoint in pancreatic cancer. Knocking it out=more CD8+ T cells, less tumor, better PD-1 response. 🧬Major props to @jlhope.bsky.social (Drexel) & Linda Bradley (SBP) for leading this awesome collab! #PDAC #Immunotherapy #Tcells www.biorxiv.org/content/10.1...
The Population Studies Group at LSHTM now has a Bluesky account! Feel free to follow us at Bluesky: bsky.app/profile/psgl...
#demography #population #populationstudies #lshtm
#demography #population #populationstudies #lshtm
bsky.app
February 12, 2025 at 4:24 PM
The Population Studies Group at LSHTM now has a Bluesky account! Feel free to follow us at Bluesky: bsky.app/profile/psgl...
#demography #population #populationstudies #lshtm
#demography #population #populationstudies #lshtm
Thrombocytes are part of the immune system: Activated by immune complexes in SLE – thrombocytes express P-selectin, stick to Tregs via a druggable interaction with PSGL-1 and inhib Treg function.
Scherlinger et al – 2021 in STM
www.science.org/doi/full/10....
Scherlinger et al – 2021 in STM
www.science.org/doi/full/10....
November 1, 2023 at 4:31 PM
Thrombocytes are part of the immune system: Activated by immune complexes in SLE – thrombocytes express P-selectin, stick to Tregs via a druggable interaction with PSGL-1 and inhib Treg function.
Scherlinger et al – 2021 in STM
www.science.org/doi/full/10....
Scherlinger et al – 2021 in STM
www.science.org/doi/full/10....
Toutes nos félicitations à Lok San Wong qui a soutenu sa thèse de doctorat intitulée “PSGL-1 and CD33 form a novel glycoimmune checkpoint that inhibits tumor cell-macrophage conjugate formation and phagocytosis”. Bravo!!
Supervised by Dr. André Veillette
www.ircm.qc.ca/fr/etudes
Supervised by Dr. André Veillette
www.ircm.qc.ca/fr/etudes
January 8, 2025 at 5:03 PM
Toutes nos félicitations à Lok San Wong qui a soutenu sa thèse de doctorat intitulée “PSGL-1 and CD33 form a novel glycoimmune checkpoint that inhibits tumor cell-macrophage conjugate formation and phagocytosis”. Bravo!!
Supervised by Dr. André Veillette
www.ircm.qc.ca/fr/etudes
Supervised by Dr. André Veillette
www.ircm.qc.ca/fr/etudes
unfortunately I'm using my own engine so playstation might be a while off (have to port to PSGL or whatever it is they use, heard nobody can really say because people are under NDA)
July 9, 2025 at 3:56 PM
unfortunately I'm using my own engine so playstation might be a while off (have to port to PSGL or whatever it is they use, heard nobody can really say because people are under NDA)
🎮 Our first Capstone Projects at @agu-pols.bsky.social are now online!
These projects highlight our students’ creativity and our innovative approach to teaching. Dive in and explore the games here: gaminglab.agu.edu.tr?p=97
#AGUPOLS #GamingLab #PSGL #Innovation #StudentCreativity #boardgames
These projects highlight our students’ creativity and our innovative approach to teaching. Dive in and explore the games here: gaminglab.agu.edu.tr?p=97
#AGUPOLS #GamingLab #PSGL #Innovation #StudentCreativity #boardgames
Capstone Project Fair – Political Science Gaming Lab
Abdullah Gül University
gaminglab.agu.edu.tr
September 1, 2025 at 6:16 PM
🎮 Our first Capstone Projects at @agu-pols.bsky.social are now online!
These projects highlight our students’ creativity and our innovative approach to teaching. Dive in and explore the games here: gaminglab.agu.edu.tr?p=97
#AGUPOLS #GamingLab #PSGL #Innovation #StudentCreativity #boardgames
These projects highlight our students’ creativity and our innovative approach to teaching. Dive in and explore the games here: gaminglab.agu.edu.tr?p=97
#AGUPOLS #GamingLab #PSGL #Innovation #StudentCreativity #boardgames
Authors use “Siglec-7 and -15…Fc chimera to demonstrate that CHST1-mediated 6-O-sulfation markedly enhanced binding to select O-glycoproteins, namely MAdCAM1, CD43, and PSGL-1”
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Siglec-7 and -15 recognize repeated clustered sulfo-sialo O-glycan motifs on select O-glycoproteins
Siglecs are key immunoreceptors in immune homeostasis and cancer immunosuppression. Diverse endogenous and exogenous sialoglycan ligands induce Siglec-mediated immunoregulation, but the nature of endo...
www.biorxiv.org
January 8, 2026 at 5:37 AM
Authors use “Siglec-7 and -15…Fc chimera to demonstrate that CHST1-mediated 6-O-sulfation markedly enhanced binding to select O-glycoproteins, namely MAdCAM1, CD43, and PSGL-1”
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer https://www.biorxiv.org/content/10.1101/2025.05.22.655365v1
May 27, 2025 at 6:17 PM
Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer https://www.biorxiv.org/content/10.1101/2025.05.22.655365v1
The decameric repeat (DR) of PSGL-1 functions as a basic antiviral unit in restricting HIV-1 infectivity https://www.biorxiv.org/content/10.1101/2025.05.14.654117v1
May 18, 2025 at 7:15 PM
The decameric repeat (DR) of PSGL-1 functions as a basic antiviral unit in restricting HIV-1 infectivity https://www.biorxiv.org/content/10.1101/2025.05.14.654117v1
Before MMOs I also covered sim racing so if you ever watched Lamborghini The Real Race, rFactor 2 GT Challenge or PSGL, you might recognise me too!
November 22, 2024 at 11:23 AM
Before MMOs I also covered sim racing so if you ever watched Lamborghini The Real Race, rFactor 2 GT Challenge or PSGL, you might recognise me too!
Antibody targeting of surface PSGL-1 glycoprotein leads to lymphoma apoptosis and tumorigenesis inhibition https://www.biorxiv.org/content/10.1101/2024.01.18.576249v1
Antibody targeting of surface PSGL-1 glycoprotein leads to lymphoma apoptosis and tumorigenesis inhibition https://www.biorxiv.org/content/10.1101/2024.01.18.576249v1
Lymphomas are a heterogeneous group of diseases that originate from T, B or natural killer (NK) cell
www.biorxiv.org
January 22, 2024 at 9:54 PM
Antibody targeting of surface PSGL-1 glycoprotein leads to lymphoma apoptosis and tumorigenesis inhibition https://www.biorxiv.org/content/10.1101/2024.01.18.576249v1
Also the usage of Asahi Super Dry as one of the beers is a direct nod to this.
www.youtube.com/watch?v=psgL...
www.youtube.com/watch?v=psgL...
Poputepipikku: Masashi Super Dry! Male VA
YouTube video by PTE Unoffical
www.youtube.com
December 11, 2024 at 12:52 AM
Also the usage of Asahi Super Dry as one of the beers is a direct nod to this.
www.youtube.com/watch?v=psgL...
www.youtube.com/watch?v=psgL...
📣 Seminar + Game Session Alert!
Join us for the next session of the Ideas in Play Seminar Series hosted by the Political Science Gaming Lab (PSGL) and AGU POLS!
Let’s play with ideas. Let’s rethink history.
#IdeasInPlay #OttomanEmpire #HistoricalGaming #PoliticalScience #InteractiveLearning
Join us for the next session of the Ideas in Play Seminar Series hosted by the Political Science Gaming Lab (PSGL) and AGU POLS!
Let’s play with ideas. Let’s rethink history.
#IdeasInPlay #OttomanEmpire #HistoricalGaming #PoliticalScience #InteractiveLearning
October 4, 2025 at 5:25 PM
📣 Seminar + Game Session Alert!
Join us for the next session of the Ideas in Play Seminar Series hosted by the Political Science Gaming Lab (PSGL) and AGU POLS!
Let’s play with ideas. Let’s rethink history.
#IdeasInPlay #OttomanEmpire #HistoricalGaming #PoliticalScience #InteractiveLearning
Join us for the next session of the Ideas in Play Seminar Series hosted by the Political Science Gaming Lab (PSGL) and AGU POLS!
Let’s play with ideas. Let’s rethink history.
#IdeasInPlay #OttomanEmpire #HistoricalGaming #PoliticalScience #InteractiveLearning
This week’s Esports calendar looks like this…
𝗧𝗪𝗜𝗧𝗖𝗛 𝗦𝗧𝗥𝗘𝗔𝗠𝗦
🗓️ 22/10 -
@iRacing
with
@_JonathanRiley
- 19:00 CEST
🗓️ 23/10 - #PSGL R11 with
@BariBroumand
- 20:00 CEST
🗓️ 25/10- #F1Manager 24 with
@inphratic
- 20:00 CEST
𝗧𝗪𝗜𝗧𝗖𝗛 𝗦𝗧𝗥𝗘𝗔𝗠𝗦
🗓️ 22/10 -
@iRacing
with
@_JonathanRiley
- 19:00 CEST
🗓️ 23/10 - #PSGL R11 with
@BariBroumand
- 20:00 CEST
🗓️ 25/10- #F1Manager 24 with
@inphratic
- 20:00 CEST
October 22, 2024 at 2:17 PM
This week’s Esports calendar looks like this…
𝗧𝗪𝗜𝗧𝗖𝗛 𝗦𝗧𝗥𝗘𝗔𝗠𝗦
🗓️ 22/10 -
@iRacing
with
@_JonathanRiley
- 19:00 CEST
🗓️ 23/10 - #PSGL R11 with
@BariBroumand
- 20:00 CEST
🗓️ 25/10- #F1Manager 24 with
@inphratic
- 20:00 CEST
𝗧𝗪𝗜𝗧𝗖𝗛 𝗦𝗧𝗥𝗘𝗔𝗠𝗦
🗓️ 22/10 -
@iRacing
with
@_JonathanRiley
- 19:00 CEST
🗓️ 23/10 - #PSGL R11 with
@BariBroumand
- 20:00 CEST
🗓️ 25/10- #F1Manager 24 with
@inphratic
- 20:00 CEST
Some past examples of work I have done;
- Multiple FFXIV World First Races on MogTalk
- Raider.io Break The Meta Dragonflight Season 1 & Nerub’ar Palace RWF for Dungeon Dojo
- Lamborghini The Real Race
- Multiple PSGL F3 Seasons
- rFactor 2 GT Challenge & Formula Pro
Always looking to add more!
- Multiple FFXIV World First Races on MogTalk
- Raider.io Break The Meta Dragonflight Season 1 & Nerub’ar Palace RWF for Dungeon Dojo
- Lamborghini The Real Race
- Multiple PSGL F3 Seasons
- rFactor 2 GT Challenge & Formula Pro
Always looking to add more!
October 18, 2024 at 7:17 AM
Some past examples of work I have done;
- Multiple FFXIV World First Races on MogTalk
- Raider.io Break The Meta Dragonflight Season 1 & Nerub’ar Palace RWF for Dungeon Dojo
- Lamborghini The Real Race
- Multiple PSGL F3 Seasons
- rFactor 2 GT Challenge & Formula Pro
Always looking to add more!
- Multiple FFXIV World First Races on MogTalk
- Raider.io Break The Meta Dragonflight Season 1 & Nerub’ar Palace RWF for Dungeon Dojo
- Lamborghini The Real Race
- Multiple PSGL F3 Seasons
- rFactor 2 GT Challenge & Formula Pro
Always looking to add more!
sexta-feira eu vou correr na psgl e-series, o melhor campeonato de equipes no mundo. vou correr com um monte de pilotos que correm no e-sports, incluindo o jarno opmeer.
me desejem sorte 😃
me desejem sorte 😃
September 19, 2024 at 1:09 PM
sexta-feira eu vou correr na psgl e-series, o melhor campeonato de equipes no mundo. vou correr com um monte de pilotos que correm no e-sports, incluindo o jarno opmeer.
me desejem sorte 😃
me desejem sorte 😃
𝟐𝟎𝟐𝟒 𝐒𝐔𝐌𝐌𝐄𝐑 𝐒𝐇𝐎𝐖𝐑𝐄𝐄𝐋 𝐎𝐔𝐓 𝐍𝐎𝐖
A collection of my best commentary moments from the summer season. Included are :
- PSGL F1
- AMX Global
- Irish Karting GP
- And more!
Please check it out! Any shares are greatly appreciated
🔗 youtu.be/Ex05yIXkjQE?si…
A collection of my best commentary moments from the summer season. Included are :
- PSGL F1
- AMX Global
- Irish Karting GP
- And more!
Please check it out! Any shares are greatly appreciated
🔗 youtu.be/Ex05yIXkjQE?si…
Evan Dalton Summer 2024 Commentator Showreel!
YouTube video by Evan Dalton Commentary and Media
https://youtu.be/Ex05yIXkjQE?si…
November 14, 2024 at 5:11 PM
𝟐𝟎𝟐𝟒 𝐒𝐔𝐌𝐌𝐄𝐑 𝐒𝐇𝐎𝐖𝐑𝐄𝐄𝐋 𝐎𝐔𝐓 𝐍𝐎𝐖
A collection of my best commentary moments from the summer season. Included are :
- PSGL F1
- AMX Global
- Irish Karting GP
- And more!
Please check it out! Any shares are greatly appreciated
🔗 youtu.be/Ex05yIXkjQE?si…
A collection of my best commentary moments from the summer season. Included are :
- PSGL F1
- AMX Global
- Irish Karting GP
- And more!
Please check it out! Any shares are greatly appreciated
🔗 youtu.be/Ex05yIXkjQE?si…
The Political Science Gaming Lab at AGÜ POLS is kicking off events this September. Explore how games & simulations bring world politics to life. 🌍♟️
Stay tuned 👉 gaminglab.agu.edu.tr
#PSGL #PoliticalScience #SeriousGames
Stay tuned 👉 gaminglab.agu.edu.tr
#PSGL #PoliticalScience #SeriousGames
Political Science Gaming Lab – Abdullah Gül University
We are an experimental lab at Abdullah Gül University where Political Science meets computer games and simulations. Our lab explores how play can inspire new ways of learning, teaching, and thinking about politics.
gaminglab.agu.edu.tr
August 20, 2025 at 8:23 PM
The Political Science Gaming Lab at AGÜ POLS is kicking off events this September. Explore how games & simulations bring world politics to life. 🌍♟️
Stay tuned 👉 gaminglab.agu.edu.tr
#PSGL #PoliticalScience #SeriousGames
Stay tuned 👉 gaminglab.agu.edu.tr
#PSGL #PoliticalScience #SeriousGames
ganhei na PSGL PC F3, um dos grids de base mais renomados do mundo.
eu tenho pace sufiiciente pra F2, mas do jeito que minha temporada foi ruim por azares, não sei se estarei lá. mas bom saber que posso ser um dos prospectos do futuro. 👍🏻
eu tenho pace sufiiciente pra F2, mas do jeito que minha temporada foi ruim por azares, não sei se estarei lá. mas bom saber que posso ser um dos prospectos do futuro. 👍🏻
September 26, 2024 at 7:54 PM
ganhei na PSGL PC F3, um dos grids de base mais renomados do mundo.
eu tenho pace sufiiciente pra F2, mas do jeito que minha temporada foi ruim por azares, não sei se estarei lá. mas bom saber que posso ser um dos prospectos do futuro. 👍🏻
eu tenho pace sufiiciente pra F2, mas do jeito que minha temporada foi ruim por azares, não sei se estarei lá. mas bom saber que posso ser um dos prospectos do futuro. 👍🏻
📃Scientific paper: PSGL-1 excludes HIV Env from virion surface through spatial hindrance involving structural folding of the decameric repeats (DR)
Ref.: Cold Spring Harbor Laboratory, 2024
➡️ Continued on ES/IODE
Ref.: Cold Spring Harbor Laboratory, 2024
➡️ Continued on ES/IODE
September 14, 2026 at 8:00 AM
📃Scientific paper: PSGL-1 excludes HIV Env from virion surface through spatial hindrance involving structural folding of the decameric repeats (DR)
Ref.: Cold Spring Harbor Laboratory, 2024
➡️ Continued on ES/IODE
Ref.: Cold Spring Harbor Laboratory, 2024
➡️ Continued on ES/IODE
