POTS-Symptome haben
Dabei schauen die Forscher besonders auf post-translationale Modifikationen (PTMs). PTMs sind chemische Veränderungen an Proteinen, die nach ihrer Entstehung auftreten und ihre Funktion verändern können. Diese Studie zeigt, dass PTMs innerhalb von
Dabei schauen die Forscher besonders auf post-translationale Modifikationen (PTMs). PTMs sind chemische Veränderungen an Proteinen, die nach ihrer Entstehung auftreten und ihre Funktion verändern können. Diese Studie zeigt, dass PTMs innerhalb von
December 31, 2025 at 6:34 PM
POTS-Symptome haben
Dabei schauen die Forscher besonders auf post-translationale Modifikationen (PTMs). PTMs sind chemische Veränderungen an Proteinen, die nach ihrer Entstehung auftreten und ihre Funktion verändern können. Diese Studie zeigt, dass PTMs innerhalb von
Dabei schauen die Forscher besonders auf post-translationale Modifikationen (PTMs). PTMs sind chemische Veränderungen an Proteinen, die nach ihrer Entstehung auftreten und ihre Funktion verändern können. Diese Studie zeigt, dass PTMs innerhalb von
My neighbors did some cool science: PTMs on top of other PTMs 🤯
New research from the @jnpruneda.bsky.social and @michaelnadbio.bsky.social labs:
In this collaborative work, the groups show that ubiquitin is directly linked to mono-ADP-ribose modifications on proteins, a process called “MARUbylation".
www.embopress.org/doi/full/10....
In this collaborative work, the groups show that ubiquitin is directly linked to mono-ADP-ribose modifications on proteins, a process called “MARUbylation".
www.embopress.org/doi/full/10....
Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose | The EMBO Journal
imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and
ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification
has remained ...
www.embopress.org
March 20, 2025 at 8:51 PM
My neighbors did some cool science: PTMs on top of other PTMs 🤯
Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...
Post-Translational Modifications Remodel Proteome-Wide Ligandability
Post-translational modifications (PTMs) vastly expand the diversity of human proteome, dynamically reshaping protein activity, interactions, and localization in response to environmental, pharmacologi...
www.biorxiv.org
August 3, 2025 at 2:36 PM
Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...
Starter pack here for protein modifications! All PTMs, enzymes, biochemistry, protein fate and function, cell signaling +++ go.bsky.app/HqEcaCw
December 12, 2024 at 9:54 PM
Starter pack here for protein modifications! All PTMs, enzymes, biochemistry, protein fate and function, cell signaling +++ go.bsky.app/HqEcaCw
🚨 Our new paper is out! 🙌
Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs.
We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs.
www.cell.com/chem/fulltex...
1/4
Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs.
We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs.
www.cell.com/chem/fulltex...
1/4
A modular genetic code expansion approach to site-specific lysine acylations
A modular strategy combining genetic code expansion with a selective amide bond-forming
reaction enables the site-specific installation of lysine acylations on folded proteins.
Acylboronates react sel...
www.cell.com
March 11, 2026 at 4:51 PM
🚨 Our new paper is out! 🙌
Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs.
We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs.
www.cell.com/chem/fulltex...
1/4
Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs.
We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs.
www.cell.com/chem/fulltex...
1/4
Great opportunity to present our work @ifink-lab.bsky.social @uni-muenster.de on #proteomics and #PTMs in plants #LCMS #MBP2026
March 17, 2026 at 1:27 PM
Great opportunity to present our work @ifink-lab.bsky.social @uni-muenster.de on #proteomics and #PTMs in plants #LCMS #MBP2026
Thrilled to share the updated video of my paper in Nature with Maciej (under supervision of @simonemattei.bsky.social & @jomaalab.bsky.social) Proud to use Cryo-ET to uncover how hibernation factors are key to translation restart! To model PTMs in situ and render animations fulfilled my PhD dream!🥹🎉
May 14, 2026 at 8:12 AM
Thrilled to share the updated video of my paper in Nature with Maciej (under supervision of @simonemattei.bsky.social & @jomaalab.bsky.social) Proud to use Cryo-ET to uncover how hibernation factors are key to translation restart! To model PTMs in situ and render animations fulfilled my PhD dream!🥹🎉
Excited to share our latest work in expanding AI-based protein design into targeting PTMs! I’m particularly excited in this work as there is so much we don’t know about PTMs despite their central role in signaling and hopefully we can start to decode their rules and functions.
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
September 30, 2025 at 11:42 PM
Excited to share our latest work in expanding AI-based protein design into targeting PTMs! I’m particularly excited in this work as there is so much we don’t know about PTMs despite their central role in signaling and hopefully we can start to decode their rules and functions.
Our lab's latest manuscript led by Emily Zahn to develop a high-throughput approach for quantification of histone PTMs is out in MCP. Come read how you can use rapid and short 10 and even 5 min gradients and still get high quality data on the Sciex 7600 ZenoTOF.
www.mcponline.org/article/S153...
www.mcponline.org/article/S153...
Development of a high-throughput platform for quantitation of histone modifications on a new QTOF instrument
Histone post-translational modifications (PTMs) regulate gene expression patterns through epigenetic mechanisms. The 5 histone proteins (H1, H2A, H2B, H3, and H4) are extensively modified, with over 75 distinct modification types spanning more than 200 sites. Despite strong advances in mass spectrometry-based approaches, identification and quantification of modified histone peptides remains challenging due to factors such as isobaric peptides, pseudo-isobaric PTMs, and low stoichiometry of certain marks.
www.mcponline.org
December 22, 2024 at 4:34 PM
Our lab's latest manuscript led by Emily Zahn to develop a high-throughput approach for quantification of histone PTMs is out in MCP. Come read how you can use rapid and short 10 and even 5 min gradients and still get high quality data on the Sciex 7600 ZenoTOF.
www.mcponline.org/article/S153...
www.mcponline.org/article/S153...
Our new review paper about Pathway-Centric PTM Data Analysis is out this week in #Proteomics!
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
Computational Approaches for Pathway‐Centric Analysis of Protein Post‐Translational Modifications
Protein function is dynamically modulated by post-translational modifications (PTMs). Many different types of PTMs can nowadays be identified and quantified at a large scale using mass spectrometry. ...
doi.org
October 20, 2025 at 7:07 AM
Our new review paper about Pathway-Centric PTM Data Analysis is out this week in #Proteomics!
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
A New Detailed Mass Offset Search in MSFragger for Improved Interpretation of Complex PTMs pubs.acs.org/doi/10....
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#proteomics #prot-paper
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#proteomics #prot-paper
January 14, 2026 at 3:01 PM
A New Detailed Mass Offset Search in MSFragger for Improved Interpretation of Complex PTMs pubs.acs.org/doi/10....
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#proteomics #prot-paper
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#proteomics #prot-paper
Has anyone had success modeling histone peptides (with PTMs) or nuclesomes (with histone tail PTMs) with chromatin reader proteins using Alphafold or Chai1? If so, any tips? Most iterations I try have the histone tail flopping off to the side #Chromatin #Alphafold #Epigenetics
December 12, 2024 at 6:30 PM
Has anyone had success modeling histone peptides (with PTMs) or nuclesomes (with histone tail PTMs) with chromatin reader proteins using Alphafold or Chai1? If so, any tips? Most iterations I try have the histone tail flopping off to the side #Chromatin #Alphafold #Epigenetics
Discover targeted protein control: Nanobody-thioesterase chimeras manipulate palmitoylation, enhancing precision. PTM mis-regulation? Not anymore! #BiotechRevolution PMID:39920166, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56716-x #Medsky 🧪
Nanobody-thioesterase chimeras to specifically target protein palmitoylation | Nature Communications
The complexity of the cellular proteome is massively expanded by a repertoire of chemically distinct reversible post-translational modifications (PTMs) that control protein localisation, interactions, and function. The temporal and spatial control of these PTMs is central to organism physiology, and mis-regulation of PTMs is a hallmark of many diseases. Here we present an approach to manipulate PTMs on target proteins using nanobodies fused to enzymes that control these PTMs. Anti-GFP nanobodies fused to thioesterases (which depalmitoylate protein cysteines) depalmitoylate GFP tagged substrates. A chemogenetic approach to enhance nanobody affinity for its target enables temporal control of target depalmitoylation. Using a thioesterase fused to a nanobody directed against the Ca(v)1.2 beta subunit we reduce palmitoylation of the Ca(v)1.2 alpha subunit, modifying the channel’s voltage dependence and arrhythmia susceptibility in stem cell derived cardiac myocytes. We conclude that nanobod
doi.org
March 6, 2025 at 2:10 AM
Discover targeted protein control: Nanobody-thioesterase chimeras manipulate palmitoylation, enhancing precision. PTM mis-regulation? Not anymore! #BiotechRevolution PMID:39920166, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56716-x #Medsky 🧪
#MusicChallenge
#DavidsMonthOfMusic
24 A song by a band/artist whose name contains X
XTC – Senses Working Overtime
www.youtube.com/watch?v=ptMs...
#DavidsMonthOfMusic
24 A song by a band/artist whose name contains X
XTC – Senses Working Overtime
www.youtube.com/watch?v=ptMs...
XTC - Senses Working Overtime
YouTube video by egidio sabbadini
www.youtube.com
March 23, 2026 at 9:04 PM
#MusicChallenge
#DavidsMonthOfMusic
24 A song by a band/artist whose name contains X
XTC – Senses Working Overtime
www.youtube.com/watch?v=ptMs...
#DavidsMonthOfMusic
24 A song by a band/artist whose name contains X
XTC – Senses Working Overtime
www.youtube.com/watch?v=ptMs...
I think many Americans fail to understand just how much Trump is hated and vilified. Sadly this will have a deliterious impact on how the world will view America.
No love from across the pond. Good.
January 26, 2025 at 7:21 AM
Group-based Prediction System (GPS) 6.0
gps.biocuckoo.cn
Online server for protein Post-Translational Modifications
Kinase-specific phosphosite prediction across 185 species!
>10 other PTMs
#NucAcidRes 2023
academic.oup.com/nar/article/...
gps.biocuckoo.cn
Online server for protein Post-Translational Modifications
Kinase-specific phosphosite prediction across 185 species!
>10 other PTMs
#NucAcidRes 2023
academic.oup.com/nar/article/...
January 11, 2026 at 12:30 PM
Group-based Prediction System (GPS) 6.0
gps.biocuckoo.cn
Online server for protein Post-Translational Modifications
Kinase-specific phosphosite prediction across 185 species!
>10 other PTMs
#NucAcidRes 2023
academic.oup.com/nar/article/...
gps.biocuckoo.cn
Online server for protein Post-Translational Modifications
Kinase-specific phosphosite prediction across 185 species!
>10 other PTMs
#NucAcidRes 2023
academic.oup.com/nar/article/...
Exciting times in brain calcification research! Check out our Spotlight commentary in @cp-trendsmolecmed.bsky.social
Find it here: authors.elsevier.com/sd/article/S...
Keywords: #astrocyte #diseasemechanisms #membraneproteins #PTMs #neurovascular #neurodegeneration #dementia #brain #aging #newPI
Find it here: authors.elsevier.com/sd/article/S...
Keywords: #astrocyte #diseasemechanisms #membraneproteins #PTMs #neurovascular #neurodegeneration #dementia #brain #aging #newPI
January 10, 2025 at 7:28 AM
Exciting times in brain calcification research! Check out our Spotlight commentary in @cp-trendsmolecmed.bsky.social
Find it here: authors.elsevier.com/sd/article/S...
Keywords: #astrocyte #diseasemechanisms #membraneproteins #PTMs #neurovascular #neurodegeneration #dementia #brain #aging #newPI
Find it here: authors.elsevier.com/sd/article/S...
Keywords: #astrocyte #diseasemechanisms #membraneproteins #PTMs #neurovascular #neurodegeneration #dementia #brain #aging #newPI
PTM’s international campaign cannot be understood without acknowledging its legal status in Pakistan, the court proceedings surrounding its proscription, and the enormous sacrifices made against terrorism.
#Pakistan #PTM #NationalSecurity #Pashtun
Read Full Article: stratheia.com/ptms-interna...
#Pakistan #PTM #NationalSecurity #Pashtun
Read Full Article: stratheia.com/ptms-interna...
September 26, 2026 at 6:38 PM
PTM’s international campaign cannot be understood without acknowledging its legal status in Pakistan, the court proceedings surrounding its proscription, and the enormous sacrifices made against terrorism.
#Pakistan #PTM #NationalSecurity #Pashtun
Read Full Article: stratheia.com/ptms-interna...
#Pakistan #PTM #NationalSecurity #Pashtun
Read Full Article: stratheia.com/ptms-interna...
Using expansion microscopy, we re-examined MT organization and mapped PTMs in the human airway multiciliated cells during differentiation. Basal bodies seem to serve the role of main MTOCs (2/N)
September 5, 2025 at 3:43 PM
Using expansion microscopy, we re-examined MT organization and mapped PTMs in the human airway multiciliated cells during differentiation. Basal bodies seem to serve the role of main MTOCs (2/N)
Great #NMR work on PTMs of histones by @roesslph.bsky.social and colleagues at @lek-lab.bsky.social!
Fresh off the press from the @lek-lab.bsky.social: Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and PARylation
#NMRchat
www.pnas.org/doi/10.1073/...
#NMRchat
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
July 22, 2025 at 11:20 AM
Great #NMR work on PTMs of histones by @roesslph.bsky.social and colleagues at @lek-lab.bsky.social!
XTC - Senses Working Overtime
YouTube video by egidio sabbadini
www.youtube.com
August 10, 2026 at 12:15 AM
Understanding posttranslational modifications (PTMs) is often key to mechanistically understanding human health and disease.
At #AdvancesChemBio Pavel Kielkowski talked about his group's impressive work on chemical proteomics to study complex PTMs such as AMPylation. www.biorxiv.org/content/10.1...
At #AdvancesChemBio Pavel Kielkowski talked about his group's impressive work on chemical proteomics to study complex PTMs such as AMPylation. www.biorxiv.org/content/10.1...
January 22, 2025 at 9:14 AM
Understanding posttranslational modifications (PTMs) is often key to mechanistically understanding human health and disease.
At #AdvancesChemBio Pavel Kielkowski talked about his group's impressive work on chemical proteomics to study complex PTMs such as AMPylation. www.biorxiv.org/content/10.1...
At #AdvancesChemBio Pavel Kielkowski talked about his group's impressive work on chemical proteomics to study complex PTMs such as AMPylation. www.biorxiv.org/content/10.1...
Excited to share Modanovo, our transformer-based method for de novo peptide sequencing, which supports a broad range of post-translational modifications (PTMs)!
www.biorxiv.org/content/10.1...
#proteomics #massspectrometry #PTM
www.biorxiv.org/content/10.1...
#proteomics #massspectrometry #PTM
Modanovo: A Unified Model for Post-Translational Modification-Aware de Novo Sequencing Using Experimental Spectra from In Vivo and Synthetic Peptides
Post-translational modifications (PTMs) play a central role in cellular regulation and are implicated in numerous diseases. Database searching remains the standard for identifying modified peptides fr...
www.biorxiv.org
September 18, 2025 at 7:59 AM
Excited to share Modanovo, our transformer-based method for de novo peptide sequencing, which supports a broad range of post-translational modifications (PTMs)!
www.biorxiv.org/content/10.1...
#proteomics #massspectrometry #PTM
www.biorxiv.org/content/10.1...
#proteomics #massspectrometry #PTM
@cnicproteomics.bsky.social is finally in Bluesky!!
Follow us to learn about our quest to advance proteomics research with a special focus on open search strategies and the study of post-translational modifications (PTMs).
Follow us to learn about our quest to advance proteomics research with a special focus on open search strategies and the study of post-translational modifications (PTMs).
September 11, 2025 at 1:55 PM
@cnicproteomics.bsky.social is finally in Bluesky!!
Follow us to learn about our quest to advance proteomics research with a special focus on open search strategies and the study of post-translational modifications (PTMs).
Follow us to learn about our quest to advance proteomics research with a special focus on open search strategies and the study of post-translational modifications (PTMs).