New #AI model deciphers the code in #proteins that tells them where to go.
#localization #ProtGPS #compartmentalization
phys.org/news/2025-02...
#localization #ProtGPS #compartmentalization
phys.org/news/2025-02...
New AI model deciphers the code in proteins that tells them where to go
Proteins are the workhorses that keep our cells running, and there are many thousands of types of proteins in our cells, each performing a specialized function. Researchers have long known that the st...
phys.org
February 7, 2025 at 4:36 PM
New #AI model deciphers the code in #proteins that tells them where to go.
#localization #ProtGPS #compartmentalization
phys.org/news/2025-02...
#localization #ProtGPS #compartmentalization
phys.org/news/2025-02...
A protein language model, ProtGPS, was developed that predicts with high performance the compartment localization of human proteins
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
www.science.org
February 8, 2025 at 4:34 AM
A protein language model, ProtGPS, was developed that predicts with high performance the compartment localization of human proteins
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
ProtGPS, a protein language model, cracked cellular localization code of human proteins, predicting their destination and finding pathogenic mutations that disrupt localization. Kudos to scores of wet lab biologists whose real-world data made this possible www.science.org/doi/10.1126/...
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
www.science.org
February 7, 2025 at 7:46 AM
ProtGPS, a protein language model, cracked cellular localization code of human proteins, predicting their destination and finding pathogenic mutations that disrupt localization. Kudos to scores of wet lab biologists whose real-world data made this possible www.science.org/doi/10.1126/...
A protein language model trained to predict subcellular localization for human proteins can generate de novo sequences with the desired localization and identify pathological mutations.
@itamarchinn.bsky.social @pgmikhael.bsky.social
www.science.org/doi/10.1126/...
@itamarchinn.bsky.social @pgmikhael.bsky.social
www.science.org/doi/10.1126/...
February 10, 2025 at 10:28 PM
A protein language model trained to predict subcellular localization for human proteins can generate de novo sequences with the desired localization and identify pathological mutations.
@itamarchinn.bsky.social @pgmikhael.bsky.social
www.science.org/doi/10.1126/...
@itamarchinn.bsky.social @pgmikhael.bsky.social
www.science.org/doi/10.1126/...
アミノ酸配列から細胞内局在を予測する
深層学習モデル(ProtGPS)を開発し、タンパク質が細胞内の特定の区画に集合するためのアミノ酸配列コードを探索。これを用いて核小体に局在する新規タンパク質配列をデザイン。病原性変異により局在の変化もみることができる。ーすごいです
深層学習モデル(ProtGPS)を開発し、タンパク質が細胞内の特定の区画に集合するためのアミノ酸配列コードを探索。これを用いて核小体に局在する新規タンパク質配列をデザイン。病原性変異により局在の変化もみることができる。ーすごいです
www.science.org
February 7, 2025 at 10:00 AM
アミノ酸配列から細胞内局在を予測する
深層学習モデル(ProtGPS)を開発し、タンパク質が細胞内の特定の区画に集合するためのアミノ酸配列コードを探索。これを用いて核小体に局在する新規タンパク質配列をデザイン。病原性変異により局在の変化もみることができる。ーすごいです
深層学習モデル(ProtGPS)を開発し、タンパク質が細胞内の特定の区画に集合するためのアミノ酸配列コードを探索。これを用いて核小体に局在する新規タンパク質配列をデザイン。病原性変異により局在の変化もみることができる。ーすごいです
🧬 AI Decodes Protein Destinations 💡MIT’s ProtGPS accurately predicts protein localization (where proteins travel inside cells) including changes from disease-causing mutations 🏥 This could transform disease research, drug design, even create new proteins from scratch🚀More: tinyurl.com/5e8fhujk
#AI
#AI
AI model deciphers the code in proteins that tells them where to go
A new machine-learning model can predict protein localization to cellular compartments, generate proteins to localize to a desired compartment, and detect disease mutations that alter cellular compart...
tinyurl.com
March 22, 2025 at 10:30 AM
🧬 AI Decodes Protein Destinations 💡MIT’s ProtGPS accurately predicts protein localization (where proteins travel inside cells) including changes from disease-causing mutations 🏥 This could transform disease research, drug design, even create new proteins from scratch🚀More: tinyurl.com/5e8fhujk
#AI
#AI
An exciting advancement in medical research: Machine learning brought us AlphaFold, and now ProtGPS is teaching us to read the "code" in disease mutated proteins, to tell us where they will go. news.mit.edu/2025/ai-mode...
AI model deciphers the code in proteins that tells them where to go
A new machine-learning model can predict protein localization to cellular compartments, generate proteins to localize to a desired compartment, and detect disease mutations that alter cellular compart...
news.mit.edu
February 17, 2025 at 11:56 AM
An exciting advancement in medical research: Machine learning brought us AlphaFold, and now ProtGPS is teaching us to read the "code" in disease mutated proteins, to tell us where they will go. news.mit.edu/2025/ai-mode...
Machine learning has lots of interesting scientific applications
www.technologynetworks.com/informatics/...
www.technologynetworks.com/informatics/...
Machine Learning Predicts Protein Behavior, Aiding Drug Design
Researchers developed ProtGPS, an AI tool that predicts protein localization in cells and how mutations affect disease. The model identifies functional disruptions and designs novel proteins for targe...
www.technologynetworks.com
February 11, 2025 at 7:56 PM
Machine learning has lots of interesting scientific applications
www.technologynetworks.com/informatics/...
www.technologynetworks.com/informatics/...
ProtGPS: Protein codes promote selective subcellular compartmentalization
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
www.science.org
February 7, 2025 at 8:22 AM
ProtGPS: Protein codes promote selective subcellular compartmentalization
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Not apologising for posting this paper twice as really excited about ProtGPS. Logical next step in protein modelling after the success of alphafold2. Not only will help predict pathogenicity of genetic variants but can incorporate elements for subcellular compartmentalisation in gene therapy design
Researchers in the Young Lab at Whitehead Institute and the Barzilay Lab in MIT's CSAIL have developed ProtGPS, a machine learning model that predicts which cellular compartments a protein will reside in.
This tool could inform the development of more effective therapies. shorturl.at/5KdVE
This tool could inform the development of more effective therapies. shorturl.at/5KdVE
February 10, 2025 at 9:12 AM
Not apologising for posting this paper twice as really excited about ProtGPS. Logical next step in protein modelling after the success of alphafold2. Not only will help predict pathogenicity of genetic variants but can incorporate elements for subcellular compartmentalisation in gene therapy design
A new AI model, ProtGPS, predicts protein localization within cells and designs novel proteins for specific compartments, enhancing understanding of protein function and potential therapeutic applications. doi.org/g839gp
New AI model deciphers the code in proteins that tells them where to go
Proteins are the workhorses that keep our cells running, and there are many thousands of types of proteins in our cells, each performing a specialized function.
phys.org
February 7, 2025 at 2:32 PM
A new AI model, ProtGPS, predicts protein localization within cells and designs novel proteins for specific compartments, enhancing understanding of protein function and potential therapeutic applications. doi.org/g839gp
Don't forget our shorter articles:
- a Spotlight on ProtGPS for protein compartmentalization
- a Spotlight on FN3K regulating protein glycation (@oncolab.bsky.social)
- a Forum noting the need for the integration of data for coherent pictures of complex networks
- a Spotlight on ProtGPS for protein compartmentalization
- a Spotlight on FN3K regulating protein glycation (@oncolab.bsky.social)
- a Forum noting the need for the integration of data for coherent pictures of complex networks
May 1, 2025 at 8:56 PM
Don't forget our shorter articles:
- a Spotlight on ProtGPS for protein compartmentalization
- a Spotlight on FN3K regulating protein glycation (@oncolab.bsky.social)
- a Forum noting the need for the integration of data for coherent pictures of complex networks
- a Spotlight on ProtGPS for protein compartmentalization
- a Spotlight on FN3K regulating protein glycation (@oncolab.bsky.social)
- a Forum noting the need for the integration of data for coherent pictures of complex networks
Online now - the Spotlight "Cracking the protein compartmentalization code with #ProtGPS" from Danfeng Cai and colleagues @johnshopkinssph.bsky.social.
#AIModel #ProteinLocalization #BiomolecularCondensates
Read it here: authors.elsevier.com/a/1ksqt_M0e4...
#AIModel #ProteinLocalization #BiomolecularCondensates
Read it here: authors.elsevier.com/a/1ksqt_M0e4...
April 17, 2025 at 2:16 PM
Online now - the Spotlight "Cracking the protein compartmentalization code with #ProtGPS" from Danfeng Cai and colleagues @johnshopkinssph.bsky.social.
#AIModel #ProteinLocalization #BiomolecularCondensates
Read it here: authors.elsevier.com/a/1ksqt_M0e4...
#AIModel #ProteinLocalization #BiomolecularCondensates
Read it here: authors.elsevier.com/a/1ksqt_M0e4...
"[...] this new system, dubbed ProtGPS, allows scientists to predict not just how a protein is built, but where it belongs inside the cell. It also empowers scientists to engineer proteins with defined distributions, directing them to cellular locations with surgical precision."
AI Reveals Hidden Interior Design Rules of the Cell
A new tool predicts where proteins fit, opening new frontiers in drug discovery
spectrum.ieee.org
February 18, 2025 at 7:16 PM
"[...] this new system, dubbed ProtGPS, allows scientists to predict not just how a protein is built, but where it belongs inside the cell. It also empowers scientists to engineer proteins with defined distributions, directing them to cellular locations with surgical precision."
Proteins don’t just fold—they navigate. A hidden sequence code dictates their subcellular destinations. ProtGPS, a deep learning model, deciphers this code, revealing how mutations disrupt localization and drive disease.
Science: www.science.org/doi/10.1126/...
Science: www.science.org/doi/10.1126/...
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. In this study, we demonstrate t...
www.science.org
March 6, 2025 at 11:58 PM
Proteins don’t just fold—they navigate. A hidden sequence code dictates their subcellular destinations. ProtGPS, a deep learning model, deciphers this code, revealing how mutations disrupt localization and drive disease.
Science: www.science.org/doi/10.1126/...
Science: www.science.org/doi/10.1126/...
ProtGPS can predict protein location based on sequence and guide the design for novel protein with precise compartmentalisation - new AI tool for protein biology beyond the AlphaFold!! 👏| Science www.science.org/doi/10.1126/...
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
www.science.org
February 8, 2025 at 10:13 AM
ProtGPS can predict protein location based on sequence and guide the design for novel protein with precise compartmentalisation - new AI tool for protein biology beyond the AlphaFold!! 👏| Science www.science.org/doi/10.1126/...
Generative biology helps us understand the location of proteins in cells
Generative biology helps us understand the location of proteins in cells
#biology #protgps
kocka.news
March 1, 2025 at 8:11 PM
Generative biology helps us understand the location of proteins in cells
Proteins with shared functions use sequence codes for precise compartmentalization. ProtGPS predicts localization with high accuracy! #CellBiology PMID:39913643, Science 2025, @ScienceMagazine https://doi.org/10.1126/science.adq2634 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://doi.org/10.1126/science.adq2634
No description available
doi.org
April 11, 2025 at 11:10 AM
Proteins with shared functions use sequence codes for precise compartmentalization. ProtGPS predicts localization with high accuracy! #CellBiology PMID:39913643, Science 2025, @ScienceMagazine https://doi.org/10.1126/science.adq2634 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
@whiteheadinstitute.bsky.social has been chosen by @statnews.com again for this year's #STATMadness! Vote for ProtGPS, our #AI tool developed by the Young Lab and Regina Barzilay at @csail.mit.edu that predicts protein localization in health/disease. Please vote now!
#WhiteheadInstitute #ResearchSky
#WhiteheadInstitute #ResearchSky
@statnews.com has selected us to compete in this year’s #STATMadness!
Cast your vote today for ProtGPS, an AI tool developed in the Young Lab in collaboration with Regina Barzilay at @csail.mit.edu, that predicts protein localization in health and disease.
🗳️ shorturl.at/dxYjA
Cast your vote today for ProtGPS, an AI tool developed in the Young Lab in collaboration with Regina Barzilay at @csail.mit.edu, that predicts protein localization in health and disease.
🗳️ shorturl.at/dxYjA
March 2, 2026 at 3:39 PM
@whiteheadinstitute.bsky.social has been chosen by @statnews.com again for this year's #STATMadness! Vote for ProtGPS, our #AI tool developed by the Young Lab and Regina Barzilay at @csail.mit.edu that predicts protein localization in health/disease. Please vote now!
#WhiteheadInstitute #ResearchSky
#WhiteheadInstitute #ResearchSky
Researchers from the Young Lab at #WhiteheadInstitute, in collaboration with @csail.mit.edu, made a major breakthrough! Their #AI model, ProtGPS, deciphers how proteins move in cells, which could improve disease understanding. An exciting step for AI in #biology! #ProtGPS #MIT #ResearchSky
Researchers in the Young Lab at Whitehead Institute and the Barzilay Lab in MIT's CSAIL have developed ProtGPS, a machine learning model that predicts which cellular compartments a protein will reside in.
This tool could inform the development of more effective therapies. shorturl.at/5KdVE
This tool could inform the development of more effective therapies. shorturl.at/5KdVE
February 7, 2025 at 4:00 PM
Researchers from the Young Lab at #WhiteheadInstitute, in collaboration with @csail.mit.edu, made a major breakthrough! Their #AI model, ProtGPS, deciphers how proteins move in cells, which could improve disease understanding. An exciting step for AI in #biology! #ProtGPS #MIT #ResearchSky
For @ieeespectrum.bsky.social, Elie Dolgin spoke with #JameelClinic researchers @itamarchinn.bsky.social and @pgmikhael.bsky.social on how the protein language model ProtGPS has pulled back the curtain on how ~10B protein molecules get distributed in cells. spectrum.ieee.org/ai-protein-l...
AI Reveals Hidden Interior Design Rules of the Cell
A new tool predicts where proteins fit, opening new frontiers in drug discovery
spectrum.ieee.org
February 11, 2025 at 7:41 PM
For @ieeespectrum.bsky.social, Elie Dolgin spoke with #JameelClinic researchers @itamarchinn.bsky.social and @pgmikhael.bsky.social on how the protein language model ProtGPS has pulled back the curtain on how ~10B protein molecules get distributed in cells. spectrum.ieee.org/ai-protein-l...
Researchers @aihealthmit.bsky.social & @whiteheadinstitute.bsky.social introduce ProtGPS. Whereas AlphaFold predicts protein structure, ProtGPS predicts protein localization. Their results suggest previously unrecognized code telling proteins where to go. @science.org: science.org/doi/10.1126/...
February 10, 2025 at 9:03 PM
Researchers @aihealthmit.bsky.social & @whiteheadinstitute.bsky.social introduce ProtGPS. Whereas AlphaFold predicts protein structure, ProtGPS predicts protein localization. Their results suggest previously unrecognized code telling proteins where to go. @science.org: science.org/doi/10.1126/...
"ProtGPS can predict a protein’s selective assembly into specific condensates and guide generation of novel protein sequences whose cellular compartmentalization can be experimentally validated." @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
www.science.org
February 6, 2025 at 9:02 PM
"ProtGPS can predict a protein’s selective assembly into specific condensates and guide generation of novel protein sequences whose cellular compartmentalization can be experimentally validated." @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Help ProtGPS win #STATMadness by casting your vote today!
This AI tool developed at Whitehead Institute and Massachusetts Institute of Technology predicts which parts of the cell a protein will reside in, helping researchers develop effective therapies for a range of diseases.
🗳️ shorturl.at/dxYjA
This AI tool developed at Whitehead Institute and Massachusetts Institute of Technology predicts which parts of the cell a protein will reside in, helping researchers develop effective therapies for a range of diseases.
🗳️ shorturl.at/dxYjA
@statnews.com has selected us to compete in this year’s #STATMadness!
Cast your vote today for ProtGPS, an AI tool developed in the Young Lab in collaboration with Regina Barzilay at @csail.mit.edu, that predicts protein localization in health and disease.
🗳️ shorturl.at/dxYjA
Cast your vote today for ProtGPS, an AI tool developed in the Young Lab in collaboration with Regina Barzilay at @csail.mit.edu, that predicts protein localization in health and disease.
🗳️ shorturl.at/dxYjA
March 6, 2026 at 2:16 PM
Help ProtGPS win #STATMadness by casting your vote today!
This AI tool developed at Whitehead Institute and Massachusetts Institute of Technology predicts which parts of the cell a protein will reside in, helping researchers develop effective therapies for a range of diseases.
🗳️ shorturl.at/dxYjA
This AI tool developed at Whitehead Institute and Massachusetts Institute of Technology predicts which parts of the cell a protein will reside in, helping researchers develop effective therapies for a range of diseases.
🗳️ shorturl.at/dxYjA
@statnews.com has selected us to compete in this year’s #STATMadness!
Cast your vote today for ProtGPS, an AI tool developed in the Young Lab in collaboration with Regina Barzilay at @csail.mit.edu, that predicts protein localization in health and disease.
🗳️ shorturl.at/dxYjA
Cast your vote today for ProtGPS, an AI tool developed in the Young Lab in collaboration with Regina Barzilay at @csail.mit.edu, that predicts protein localization in health and disease.
🗳️ shorturl.at/dxYjA
March 2, 2026 at 3:16 PM
@statnews.com has selected us to compete in this year’s #STATMadness!
Cast your vote today for ProtGPS, an AI tool developed in the Young Lab in collaboration with Regina Barzilay at @csail.mit.edu, that predicts protein localization in health and disease.
🗳️ shorturl.at/dxYjA
Cast your vote today for ProtGPS, an AI tool developed in the Young Lab in collaboration with Regina Barzilay at @csail.mit.edu, that predicts protein localization in health and disease.
🗳️ shorturl.at/dxYjA