#RNA-mediated
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erictopol.bsky.social
I wouldn't have anticipated a Lupus self-directed antibody (4H2) might someday turn out to be an anti-cancer treatment
www.science.org/doi/10.1126/...
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells
Delivery of autoimmune disease–associated antibodies activates the immune system to fight glioblastomas.
www.science.org
March 25, 2025 at 6:37 PM
doudna-lab.bsky.social
Out now in Science: Two papers from our lab reveal VIPR, an RNA-guided DNA-targeting system in bacteriophages, providing clues to the origins of CRISPR
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Congrats to Peter Yoon, @kenjmloi.bsky.social @terryzzy.bsky.social, T.Docter & team
A noncontiguous code for RNA-guided DNA recognition at the origin of CRISPR-Cas
CRISPR-Cas provides RNA-mediated adaptive immunity, but how its first RNA-guided effector arose is unclear. In this study, we report the discovery of Viral Interference Programmable Repeat (VIPR) syst...
www.science.org
September 19, 2026 at 1:12 AM
carolynbertozzi.bskyverified.social
Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏

www.nature.com/articles/s41...
Graphic showing modification of mRNA with ADP-ribose mediated by bacterial enzyme cmdTAC
February 6, 2025 at 7:38 PM
olivierduss.bsky.social
First paper of our lab today @natureportfolio.bsky.social by Nussi!

We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!

@embl.org #RNAbiology #RNASky

t.co/a24Xxcxdo0
December 4, 2024 at 8:53 PM
dijiang319.bsky.social
🧬🦠🧫 @science.org RNA-mediated CRISPR-Cas13 inhibition through crRNA structural mimicry | Science www.science.org/doi/10.1126/... meeskelab.org bit.ly/sustecheducnJiaLab #CRISPR #RNA
April 24, 2025 at 6:41 PM
dijiang319.bsky.social
In this week's @science.org from @lucksmith.bsky.social and colleagues @mskcancercenter.bsky.social | Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
#RNA #microRNA #miRNA #siRNA #argonaute🧬🧪
www.science.org/doi/10.1126/...
Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
microRNAs (miRNAs) and small interfering RNAs (siRNAs) are 21- to 22-nucleotide RNAs that guide Argonaute-class effectors to targets for repression. In this work, we uncover 5-aminolevulinic acid synt...
www.science.org
December 20, 2024 at 5:14 PM
chadbourn.bsky.social
Big health breakthrough: a protein from tardigrades can now protect human cells from radiation.

That’s going to lead to better cancer therapies.
Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades - Nature Biomedical Engineering
Radiation-therapy-induced DNA damage in oral and rectal epithelial cells can be reduced via the nanoparticle-mediated local delivery of messenger RNA encoding for a damage-suppressor protein found in ...
www.nature.com
March 5, 2025 at 8:58 PM
nature.com
Nature research paper: Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water

go.nature.com/46cFIvm
Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water - Nature
Aminoacyl-thiols reacting selectively with RNA diols over amine nucleophiles and demonstration of chemically controlled formation of peptidyl-RNA in water at neutral pH suggest an important role for thiol cofactors before the evolution of enzymes.
go.nature.com
August 28, 2025 at 11:48 AM
science.org
Harnessing antibodies found in patients with lupus, researchers test a new #cancer therapy that turns autoimmune responses against tumor cells in mice, suggesting similar approaches could be integrated into immunotherapy regimens.

Learn more in #ScienceSignaling: scim.ag/3FXZQGX
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells
Delivery of autoimmune disease–associated antibodies activates the immune system to fight glioblastomas.
scim.ag
March 28, 2025 at 5:24 PM
natbiotech.nature.com
A pervasive RT–qPCR artifact inflates RNA knockdown by RNA-targeting CRISPR - @binwu1.bsky.social @hopkinsmedicine.bsky.social www.nature.com/articles/s41...
A pervasive RT–qPCR artifact inflates RNA knockdown by RNA-targeting CRISPR - Nature Biotechnology
A quantification artifact confounds CRISPR-mediated RNA knockdown.
www.nature.com
September 1, 2026 at 2:39 PM
zeynepbaharoglu.bsky.social
Acinetobacter baumannii represses type VI secretion system through a manganese-dependent small RNA-mediated regulation - beautiful work of a funky RNA regulation, from Ranjana Pathania lab 🦠 #microsky #rnasky #rnabiology journals.asm.org/doi/10.1128/...
Acinetobacter baumannii represses type VI secretion system through a manganese-dependent small RNA-mediated regulation | mBio
Small RNAs (sRNAs) are identified as critical components within the bacterial regulatory networks involved in fine regulation of virulence-associated factors. The sRNA-mediated regulation of type VI s...
journals.asm.org
February 5, 2025 at 8:35 AM
biorxiv-genomic.bsky.social
Formation of an RNA-mediated nuclear compartment https://www.biorxiv.org/content/10.64898/2026.08.20.746005v1
August 24, 2026 at 2:32 AM
dijiang319.bsky.social
@science.org Mechanism of release factor–mediated peptidyl-tRNA hydrolysis on the ribosome | Science www.science.org/doi/10.1126/...
#ribosome #RNA #hydrolysis
June 25, 2025 at 5:44 AM
evolvedbiofilm.bsky.social
Remodeling of RNA-binding proteome and RNA-mediated regulation as a new layer of control of sporulation
#Bacillussubtilis

#mSystems from @clemdf.bsky.social

journals.asm.org/doi/10.1128/...
August 17, 2025 at 8:47 AM
biorxivpreprint.bsky.social
SON-mediated circular RNA suppression promotes PKR signaling and radiation resistance in glioblastoma https://www.biorxiv.org/content/10.64898/2026.09.28.755153v1
September 29, 2026 at 3:50 PM
biorxivpreprint.bsky.social
RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing https://www.biorxiv.org/content/10.64898/2025.12.16.694471v1
December 17, 2025 at 3:21 AM
hennig-lab.bsky.social
Just published: My (Janosch Hennig) view on the current capabilities of AF3 and similar for RNA and protein-RNA complex structure prediction plus a bit of forward looking: doi.org/10.1002/cbic...
Structural biology of RNA and protein‐RNA complexes after AlphaFold3
Recent breakthroughs in AI-mediated protein structure prediction have significantly accelerated research and generated valuable hypotheses within the field of structural biology and beyond. Notably, ...
doi.org
February 13, 2025 at 10:23 AM
koenig-lab.bsky.social
Check out our recent work on CDS #m6A mediated RNA decay (CMD)! Decay relies on ribosome pausing at m6A containing codons. Great collab with the Zarnack lab & colleagues. Thank you @uniwuerzburg.bsky.social , @imbmainz.bsky.social and RMap🥳

www.cell.com/molecular-ce...
January 15, 2025 at 10:00 AM
loverna.bsky.social
📢1/12 Happy to share our first bluetutorial & our latest preprint. In this work, we discovered RSRC2 as a novel RNA-binding protein (RBP) with a dual function in cell division whose activity can be (lnc)RNA-mediated. #lncRNA #RBP #Mitosis
www.biorxiv.org/content/10.1...
The RNA-binding protein RSRC2 promotes mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1
Mitotic fidelity depends on proper chromosome alignment at the spindle equator, a process known as chromosome congression, driven by well-established protein networks. Whereas RNA-binding proteins and...
www.biorxiv.org
January 23, 2025 at 5:26 PM
ctmurphy1.bsky.social
🧪#Celegans - I am very excited to announce the publication of our latest finding in transgenerational epigenetic inheritance (TEI) of learned pathogen avoidance - • C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1 www.science.org/doi/10.1126/...
C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1
C. elegans’ TEI of learned pathogen avoidance is induced by a third bacterial small RNA, Pfs1, from P. fluorescens 15.
www.science.org
April 23, 2025 at 8:31 PM
jackiheraudfarlow.bsky.social
Time for a 🧵 on our new paper from the Walkley lab in @scienceimmuno.bsky.social.

If you're into RNA editing by ADARs, double-stranded RNA (dsRNA) sensing, post-transcriptional gene regulation and CRISPR screening, then read on! 1/X

www.science.org/doi/10.1126/...

#RNASky #ImmunoSky
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing
GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.
www.science.org
December 6, 2024 at 1:31 AM
molbioinfo.bsky.social
RNA-mediated DNA damage repair:
www.nature.com/articles/s41...
#RNAbiology
#RNAsky
RNA-mediated double-strand break repair by end-joining mechanisms - Nature Communications
Double-strand breaks (DSBs) in DNA are challenging to repair. Here, the authors show that transcript RNAs impact the DSB repair outcomes in human and yeast cells by promoting NHEJ or MMEJ in a sequenc...
www.nature.com
November 23, 2024 at 8:35 AM
anilevetu.bsky.social
www.biorxiv.org/content/10.1...
Perturbing RNA localization for functional study in neurons
Spatial RNA organization plays a pivotal role in diverse cellular processes and diseases, but the functional implications of spatial RNA localization remain underexplored. We present CRISPR-mediated t...
www.biorxiv.org
April 12, 2025 at 10:27 PM
science.org
Harnessing antibodies found in patients with lupus, researchers test a new #cancer therapy that turns autoimmune responses against tumor cells in mice, suggesting similar approaches could be integrated into immunotherapy regimens.

Learn more in #ScienceSignaling: https://scim.ag/4plX8MG
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells
Delivery of autoimmune disease–associated antibodies activates the immune system to fight glioblastomas.
scim.ag
December 31, 2025 at 4:11 PM
labwaggoner.bsky.social
Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance
www.pnas.org/doi/10.1073/...
February 14, 2025 at 4:49 AM