#Refereedpreprint
Ordering of cell cycle events by regulated proteolysis is not just for eukaryotes:
@buzzbaum.bsky.social et al define mechanisms underlying switch-like degradation of archaeal ESCRT-III CvdB in Sulfolobus
Thanks to @reviewcommons.org for another #RefereedPreprint
link.springer.com/article/10.1...
January 12, 2026 at 2:19 PM
New #RefereedPreprint c/o @reviewcommons.org:
Daiju Kitagawa, Shoji Hata et al reveal the multimodal, cell cycle-dependent mechanisms coordinating centriole maturation with changes in centriole engagement underlying faithful centrosome duplication
www.embopress.org/doi/full/10....
February 4, 2025 at 11:07 AM
Another #RefereedPreprint ℅ @reviewcommons.org :
Fumiyo Ikeda 池田 史代 and coworkers show that LUBAC subunit HOIL-1 restrains linear ubiquitination to maintain dynamic properties of p62 condensates and promote aggregate clearance
link.springer.com/article/10.1...
Excess Met1-linked ubiquitination leads to solid aggregate formation - The EMBO Journal
The ubiquitin ligase HOIL-1 regulates the formation of Met1-linked (linear) ubiquitin chains through its coordination with the E3 ligase HOIP within the Linear Ubiquitin Chain Assembly Complex (LUBAC)...
link.springer.com
September 28, 2026 at 11:15 AM
How can gut microbes modulate host lifespan?
@jogender-singh.bsky.social & coworkers show that in C. elegans, lifespan extension arises from microbial perturbation of iron homeostasis and oxidative stress response activation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
November 17, 2025 at 1:22 PM
Early coordination of cell migration and cardiac fate determination during mammalian gastrulation, revealed by light-sheet microscopy tracking of individual mesodermal cells
#RefereedPreprint c/o @reviewcommons.org by @kenzoivanovitch.bsky.social and colleagues
www.embopress.org/doi/full/10....
May 13, 2025 at 10:27 AM
Jennifer A Miles, molecularrichard.bsky.social et al model the Aurora A-Bora-Plk1 ternary complex revealing how Bora bridges both kinases
#RefereedPreprint @reviewcommons.org

link.springer.com/article/10.1...
January 28, 2026 at 3:43 PM
E. coli bacteriophage N15 suppresses Mre11-Rad50-mediated end degradation of its linear genome via a telomere-resolution-independent function of its telomere resolvase TelN
#RefereedPreprint c/o @reviewcommons.org by @gruberlab.bsky.social
www.embopress.org/doi/full/10....
October 20, 2025 at 1:19 PM
What is the basis & significance of SUMO1 vs SUMO2/3 conjugation preference? Jo Morris et al find that mitotic deacetylation biases SUMO E1 SAE2 towards #SUMO1 conjugation onto NuMA to ensure faithful chromosome segregation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
August 26, 2025 at 12:49 PM
Neutralizing antibodies promote filamentous morphology of #influenza A virus by inhibiting cellular entry and transmission of spherical viral particles
 #RefereedPreprint c/o @reviewcommons.org by Petr Chlanda @chlandalab.bsky.social and coworkers
www.embopress.org/doi/full/10....
June 10, 2025 at 7:33 AM
Arianna Esposito Verza, @andrea-musacchio.bsky.social et al describe the long-sought-after mechanism of Bora dependency of PLK1 activation by Aurora A kinase during mitotic entry
Another #RefereedPreprint ℅ @reviewcommons.org
link.springer.com/article/10.1...
Molecular requirements for PLK1 activation by T-loop phosphorylation - The EMBO Journal
Activation of PLK1, a master mitotic kinase, requires phosphorylation of its activation segment on Thr210, within a basic consensus sequence for Aurora kinases. Aurora B-dependent phosphorylation of T...
link.springer.com
January 28, 2026 at 2:42 PM
Another #RefereedPreprint c/o @reviewcommons.org:
@leunglab.bsky.social finds that interferon-induced, PARP14-dependent cytoplasmic ADP-ribose condensates contain autophagy receptor p62, but otherwise depend on the ubiquitin-proteasome system rather than autophagy
www.embopress.org/doi/full/10....
April 9, 2025 at 6:11 PM
T-cell smFISH:
@anilevetu.bsky.social, @monikawolkers.bsky.social et al present an optimized workflow for simultaneously quantifying nascent and mature mRNA, and its localization with single-cell resolution in human T-cells
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
October 17, 2025 at 10:26 AM
Drosophila Alms1 proteins are general regulators of #centriolar cartwheel assembly, exhibiting distinct centriolar localization patterns and enabling Plk4-Ana2 interaction
#RefereedPreprint c/o @reviewcommons.org by Véronique Morel, Bénédicte Durand and colleagues
www.embopress.org/doi/full/10....
March 3, 2025 at 5:28 PM
Fibril formation of α-synuclein, central to Parkinson’s disease, is catalyzed by ubiquilin-2 droplets and can be suppressed by small-molecule targeting of UBQLN2
#RefereedPreprint c/o @reviewcommons.org by Masaya Imoto, Nobutaka Hattori and coworkers
www.embopress.org/doi/full/10....
October 14, 2025 at 9:53 AM
AlphaFold modeling & new assays for mitotic kinase activation in E. coli (#MITOKINAC) reveal molecular basis of specific Aurora A & PLK1 activation through Bora during mitotic entry
Lionel Pintard @ccdlab.bsky.social et al
#RefereedPreprint ℅ @reviewcommons.org
link.springer.com/article/10.1...
Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry - The EMBO Journal
The evolutionarily conserved, intrinsically disordered protein Bora is critical for initiating the activation of mitotic kinases. Once phosphorylated at Ser112 by Cyclin A-Cdk1 kinase, phospho-Bora ac...
link.springer.com
January 28, 2026 at 2:44 PM
See-Yeun Ting 陳詩允 @seeyeunting.bsky.social and colleagues exemplify a critical #evolutionary constraint: while LPS deficiency shields bacteria from phage infection, it heightens vulnerability to contact-dependent antagonism
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
March 10, 2025 at 3:13 PM
How do cells curb nutrient uptake during quiescence & does it matter?
@teislab.bsky.social & Co. show TXNIP-dependent endocytosis of amino acid transporter LAT1/SLC7A5 is essential to prevent cell death and human disease
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
October 24, 2025 at 2:57 PM
#RefereedPreprint c/o @reviewcommons.org by Faccioli, Biasini et al:
Transient exposure of cryptic phosphorylation sites buried in protein cores during folding may represent novel regulatory mechanism linking co-translational modification to protein folding control
www.embopress.org/doi/full/10....
October 6, 2025 at 1:04 PM
Saltel and colleagues @univbordeaux.bsky.social explore how invadosomes recruit ER proteins, driving cell invasion and matrix degradation.

#RefereedPreprint by @reviewcommons.org
Referee comments and author's response posted here >> eeb.embo.org/doi/10.1101/2024.07.02.601728
#OpenScience
Early Evidence Base | EMBO
eeb.embo.org
March 20, 2025 at 3:51 PM
Association of orphan nuclear receptors and heterochromatin are involved in Alternative Lengthening of Telomeres – Liuh-Yow Chen and coworkers identify their link as the transcriptional corepressor TRIM28
Thanks to @reviewcommons.org for another #RefereedPreprint
link.springer.com/article/10.1...
Orphan nuclear receptors recruit TRIM28 to promote telomeric H3K9me3 for the ALT pathway - The EMBO Journal
Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism deployed in embryonic stem cells and cancer cells. High levels of the heterochromatin mark H3 lysine 9 trimethylation (H3...
link.springer.com
March 31, 2026 at 2:40 PM
Study by Sarah De Val @saradv.bsky.social @ox.ac.uk and colleagues uncovers key enhancers and regulators of arterial identity! #VascularBiology #GeneRegulation

#RefereedPreprint by @reviewcommons.org
Referee reports and author's response avaliable here >>eeb.embo.org/doi/10.1101/2024.04.30.591717
March 26, 2025 at 3:18 PM
Neuronal remodeling during development: Paola Figueroa Delgado and Shaul Yogev find unexpected genetic specificity in elimination of secondary, tertiary, and quaternary branches during dendritic pruning in C. elegans
Another #RefereedPreprint ℅ @reviewcommons.org!
link.springer.com/article/10.1...
NDR kinase SAX-1 controls dendrite branch-specific elimination during neuronal remodeling in C. elegans - The EMBO Journal
Neuronal remodeling is crucial for proper nervous system development and function. Despite significant advances, the underlying mechanisms that govern this process remain poorly understood. Here, we a...
link.springer.com
June 30, 2026 at 8:27 AM
Using AI and subcellular morphology to predict cell types and molecular traits—no markers needed! Navarro and colleagues explore a new way to understand cell identity and behavior.
#Refereedpreprint at @reviewcommons.org
Reviews and response letter here >>eeb.embo.org/doi/10.1101/2024.08.14.607889
March 20, 2025 at 4:03 PM
Ancient genetics shape modern human traits. 🦧🧬Check out the latest #Refereedpreprint at @reviewcommons.org from the Long lab ‪on #Neanderthal variants influencing #craniofacialdevelopment
@hannahlong.bsky.social

Referee reports and author's response
>> eeb.embo.org/doi/10.1101/2024.09.24.614243
doi.org
March 6, 2025 at 4:10 PM