#SARSCoV2-Proteins
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ralfwittenbrink.bsky.social
„Mehrere Infektionen hintereinander können eine zunehmend tiefgreifende und langwierige #Neuroinflammation verursachen. Die Aktivität des #SARSCoV2-Proteins erhöht die längerfristige Anfälligkeit für eine erneute Infektion und verstärkt physiologische Probleme …

#COVID19 #Corona #LongCovid
ralfwittenbrink.bsky.social Ralf Wittenbrink @ralfwittenbrink.bsky.social · Jul 27
Nachfolgende Immunherausforderungen - wie mehrere Infektionen hintereinander - können eine zunehmend tiefgreifende und langwierige #Neuroinflammation verursachen

Die Aktivität des #SARSCoV2 -Proteins erhöht die längerfristige Anfälligkeit für eine weitere Infektion und …

#COVID19 #Corona
"Multiple hit" model shows that COVID protein potentiates subsequent infection-related neuroinflammation and other physiological problems
July 27, 2024 at 10:16 PM
ralfwittenbrink.bsky.social
Nachfolgende Immunherausforderungen - wie mehrere Infektionen hintereinander - können eine zunehmend tiefgreifende und langwierige #Neuroinflammation verursachen

Die Aktivität des #SARSCoV2 -Proteins erhöht die längerfristige Anfälligkeit für eine weitere Infektion und …

#COVID19 #Corona
"Multiple hit" model shows that COVID protein potentiates subsequent infection-related neuroinflammation and other physiological problems
July 27, 2024 at 10:06 PM
boghuma.bsky.social
I thought it was a joke but it's not. There's an actual study. Researchers at Penn & Finland engineered gum with antiviral bean proteins that ⬇️ viral load in the mouth the main site of replication for many viruses, including SarsCov2, HSV-1 &2, & influenza.
www.discovermagazine.com/the-sciences...
Antiviral Chewing Gum Might Revolutionize How We Tackle Infectious Diseases
Learn why lowering the viral load in the mouth could be a game-changer in fighting viruses like herpes, bird flu, and more.
www.discovermagazine.com
April 10, 2025 at 4:02 PM
toveharris.bsky.social
4/4 Und forscht an Medikamenten, die die Anreicherungen des toxischen SARSCoV2-Spike-Proteins im Gehirn (und natürlich in weiteren Organen) rückgängig machen sollen? Spoiler: Bisher erfolglos. Good luck!

#COVID #CovidIsNotOver #Corona #LongCOVID #COVID19 #TeamVorsicht #SARSCoV2
December 1, 2024 at 10:05 AM
toveharris.bsky.social
2/4 Da die Impfungen die Anreicherung des SARSCoV2-Spike-Proteins im Gehirn nur reduzieren können, aber auch dann noch ein Rest des toxisch wirkenden Spike-Proteins bestehen bleibt, taugen die Impfungen allein nicht zur Prävention. Und überhaupt, wer lässt sich denn noch impfen?
#COVID #LongCOVID
December 1, 2024 at 10:05 AM
ralfwittenbrink.bsky.social
Fragmente des #SARSCoV2-Virus können sich zu "Zombie"-Komplexen (XenoAMP-dsDNA) zusammenfügen und eine starke und anhaltende Immunreaktion auslösen, die gesunde, nicht infizierte Zellen angreift, was bei gewöhnlichen Erkältungscoronaviren nicht der Fall ist.

#COVID19 #LongCovid #Coronavirus #MECFS
Existence of exogenous mimics of pro-inflammatory host antimicrobial peptides (xenoAMPs) in SARS-CoV-2 proteins. (A) SARS-CoV-2 proteins are scanned with a machine learning AMP classifier. Each queried sequence is given a σ score that measures its AMP-ness. Three representative high-scoring sequences are studied: xenoAMP(ORF1ab), xenoAMP(S) and xenoAMP(M). The grey bars mark the location where the corresponding sequences are selected.
February 2, 2024 at 10:36 PM
ralfwittenbrink.bsky.social
Auswirkungen der #JN1 -Auffrischungsimpfung auf die Neutralisierung der #SARSCoV2 -Varianten KP.3.1.1 und #XEC

„Wichtig ist, dass die JN.1-Auffrischungsimpfung die Neutralisierung aller getesteten Linien erheblich verbessert hat und daher …

#ImpfenSchuetzt #Booster #VaccinesSaveLives #COVID19
Figure: Cell entry and neutralisation escape by SARS-CoV-2 variants KP.3.1.1 and XEC. (E) Neutralisation sensitivity of pseudovirus particles bearing JN.1, KP.3.1.1, or XEC S proteins. Two cohorts were analysed: cohort 1 = 33 individuals, sampling was performed before and 21 day after JN.1 booster vaccination; cohort 2 = 14 individuals with recent SARS-CoV-2 infection in the summer of 2024. Pseudovirus particles bearing the indicated S proteins were preincubated with plasma dilutions before being inoculated onto Vero cells. Relative inhibition of pseudovirus entry was calculated using particles incubated in the absence of plasma as control (= 0% inhibition). Individual NT50 (neutralizing titre 50) values were determined for each plasma using a non-linear regression model and geometric mean titres (GMT) were calculated for the respective sample groups. The lowest plasma dilution tested (dashed lines) and the threshold (lower limit of detection, LLOD; grey shaded areas) are indicated. Samples that yielded NTSO values below 12-5 (LLOD) were considered negative and manually assigned a value of 1. Presented are the GMTs (indicated by horizontal black lines and numerical values), response rates and fold changes in neutralisation compared to JN.1pp. Data were derived from a single experiment, performed with four technical replicates. Please also see Supplementary Information Figure S3, S4 and S5 for more information. (F) The donor-matched neutralisation data for cohort 1 before and 21 days after JN.1 booster vaccination are shown (lines connect pre- and post-booster samples from the same plasma donors). Information above the graphs indicate GMTs and the mean fold change in neutralisation between pre- and post-booster samples. Statistical significance was assessed by Wilcoxon matched-pairs signed rank test (p ≤ 0.0001; ****). Please also see Supplementary Information Figure S3, S4 and S5 for more information.
December 3, 2024 at 4:50 PM
ralfwittenbrink.bsky.social
Affen mit #SARSCoV2 infizieren und ähnliche Symptome wie Menschen entwickeln können, haben wir begonnen zu untersuchen, was in den Gehirnen gealterter Affen passiert, wenn sie infiziert sind.

Die Ergebnisse sind überraschend: Wir beobachten einen erheblichen Anstieg des Spike-Proteins im Gehirn,
Screenshot
December 29, 2023 at 11:14 AM
ralfwittenbrink.bsky.social
Auswirkungen der JN.1-Auffrischungsimpfung auf die Neutralisierung der #SARSCoV2-Varianten KP.3.1.1 und XEC

„Die JN.1-Auffrischungsimpfung verbesserte die Neutralisierung aller getesteten Stämme deutlich und wird daher wahrscheinlich den …

#COVID19 #ImpfenSchuetzt #Corona #XEC
(E) Neutralisation sensitivity of pseudovirus particles bearing JN.1, KP.3.1.1, or XEC S proteins. Two cohorts were analysed: cohort 1 = 33 individuals, sampling was performed before and 21 day after JN.1 booster vaccination; cohort 2 = 14 individuals with recent SARS-CoV-2 infection in the summer of 2024. Pseudovirus particles bearing the indicated S proteins were preincubated with plasma dilutions before being inoculated onto Vero cells. Relative inhibition of pseudovirus entry was calculated using particles incubated in the absence of plasma as control (= 0% inhibition). Individual NTSO (neutralizing titre 50) values were determined for each plasma using a non-linear regression model and geometric mean titres (GMT) were calculated for the respective sample groups. The lowest plasma dilution tested (dashed lines) and the threshold (lower limit of detection, LLOD; grey shaded areas) are indicated. Samples that yielded NT50 values below 12'5 (LLOD) were considered negative and manual …
October 5, 2024 at 11:09 AM
castltrastondrs.medsky.network
#MedSky🧪 #IDSky #ImmunoSky #Publichealth In this study shed new light on the behavior of proteins that play 🔑 role in the interaction bw #SARSCoV1 & #SARSCoV2 & human cells. Their findings may help explain why #SARSCoV2 responsible for #COVID19, more infectious & rapidly spread than #SARSCoV1 .
October 20, 2024 at 5:47 AM
castltrastondrs.medsky.network
- Systems-bioinformatics demonstrates auto-reactive epitope similarity between #SARSCoV2 and neuronal proteins (APP, tau, GFAP, NfL, myelin proteins), supporting molecular mimicry. Evidence that 🦠 epitopes have shared linear motifs
May 4, 2026 at 5:36 AM
ralfwittenbrink.bsky.social
ein immunprivilegierter Ort ist, der vom Rest des Körpers geschützt ist, muss aufhören.“

www.thelancet.com/journals/lan...

#Coronavirus #MultipleSclerose #COVID19 #SARSCoV2 #LongCovid #CovidIsNotOver
Severe acute respiratory syndrome coronavirus and viral mimicry
Viruses have evolved various strategies to counteract host-cell processes, notably our immune responses toward their invasion. Oleszak and colleagues1 reported that the spike proteins of coronaviruses...
www.thelancet.com
January 1, 2024 at 7:10 PM
castltrastondrs.medsky.network
#Medsky🧪 #IDsky #Immunosky #publichealth This study found that the Spike proteins from #SARSCoV2 & other human #coronaviruses directly activate mast cells, initiating a rapid inflammatory response through a well-defined intracellular signaling cascade.

journals.asm.org/doi/10.1128/...
Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade | Journal of Virology
The activation and degranulation of mast cells (MCs), triggered by a variety of viruses, are intricately linked to viral pathogenesis. However, the precise mechanism underlying virus-induced MC degran...
journals.asm.org
May 21, 2025 at 2:01 PM
toveharris.bsky.social
Die Achillesferse von #SARSCoV2 entdeckt? Seine Abhängigkeit von bestimmten menschlichen Proteinen, die auch andere Viren „nutzen“ (Influenza, RSV, Ebola).
 
„The similarities between viruses may enable a whole new class of antiviral medication."
scitechdaily.com/key-weakness...
Key Weakness of COVID-19 Discovered
A research study found that without key proteins, the virus cannot infect people. Recent research from UC Riverside has identified  COVID’s Achilles heel — its dependence on key human proteins fo...
scitechdaily.com
September 16, 2023 at 9:20 AM
drinfosec.bsky.social
🚨🧵 by Dr. @harryspoelstra.bsky.social asking the Q:

"Q: Is SARSCOV2 carcinogenic?

➡️Research highlights several indirect ways a virus might contribute to cancer development or progression:
- Chronic Inflammation
- Immune system dysregulation..."

Full 🧵
threadreaderapp.com/thread/19961...
Q: Is SARSCOV2 carcinogenic? ➡️Research highlights several indirect ways a virus might contribute to cancer development or progression: - Chronic Inflammation - Immune system dysregulation - Manipulation of cell pathways( tumor suppressor proteins like p53 inhibitor!) - Tissue damage and fibrosis - Reactivation of dormant cells/viruses ➡️Cell pathways with p53-gen/TP53 evidence is growing: Let’s dig deeper👇 ➡️SARS-CoV-2 can interact with, inhibit, and promote the degradation of p53 – one of the most important tumor-suppressor proteins in human cells (some like to call it: “guardian of the genome”).
December 3, 2025 at 2:30 PM
tomkindlon.bsky.social
News Release 27-Jan-2026

COVID-19 viral fragments shown to target and kill specific immune cells in UCLA-led study

www.eurekalert.org/news-release...

An interesting angle to me but I'm no immunologist.

They talk about long Covid later on

#LongCovid #COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2
News Release 27-Jan-2026 COVID-19 viral fragments shown to target and kill specific immune cells in UCLA-led study Clues about extreme cases and omicron’s effects come from a cross-disciplinary international research team Peer-Reviewed Publication California NanoSystems Institute FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail Fragments of digested protein image: A UCLA-led international research team showed that fragments of digested proteins from the virus behind COVID-19 can attack certain immune cells that have spiky shapes, such as the T cell above. view more Credit: Figure adapted from Yue Zhang et al, PNAS 2026 New research shows that after the body’s defenses kill the virus behind COVID-19, leftover digested chunks of SARS-CoV-2 spike protein can target specific immune cells based on their shape. The revelations could explain why certain populations of cells that detect and fight infection are depleted in patients with severe COVID-19, and shed light on the omicron variant’s milder symptoms. The study, published in the Proceedings of the National Academy of Sciences, may launch a line of inquiry that informs new strategies for quelling the most serious symptoms of COVID-19. Led by a UCLA team, the scientific collaboration comprises nearly three dozen engineers, microbiologists, immunologists, chemists, physicists, medical researchers and analytical experts.
January 28, 2026 at 5:17 PM
castltrastondrs.medsky.network
#Medsky🧪 #IDsky #immunosky #publichealth The identification of human proteins essential to #SARSCoV2 replication reveals new drug targets. Targeting these host factors could lead to broad #COVID treatments resistant to viral mutation and future outbreaks

www.genengnews.com/topics/infec...
Host Proteins Identified in SARS-CoV-2 Replication Pathways Reveal Drug Targets
New research reveals promising drug targets to block coronaviruses at multiple stages of infection—even across different strains.
www.genengnews.com
September 8, 2025 at 10:08 PM
castltrastondrs.medsky.network
More than 50% of proteins in the MAPK pathway are targeted by different #SARSCoV2 proteins, making it one of the most affected pathways during infection
The MAPK pathway is involved in the immune response to #COVID , including the activation of inflammatory responses & cytokine production
January 17, 2026 at 6:13 AM
castltrastondrs.medsky.network
#Medsky🧪#IDsky #jmmunosky #neurosky #Neurocovid #Publichealth Overview the #Pathophysiology of #SARSCoV2 in #CerebrovascularDisease & the effects #SARSCoV2 has on the #carotid & #vertebralvasculatures

link.springer.com/chapter/10.1...
pdf
link.springer.com/content/pdf/...
Carotid and Vertebrobasilar Manifestations of COVID-19
Coronaviruses are enveloped viruses with a positive-sense single-stranded RNA genome with spikelike proteins projecting from the surface of the virus, hence the name of the virus. Most coronaviruses t...
link.springer.com
April 19, 2025 at 9:21 PM
christinavirgil.bsky.social
One of SARSCOV2’s proteins binds to a human protein called G3BP

This binding promotes viral replication by preventing the formation of stress granules, which would usually have an antiviral effect

Simultaneously
•Promote viral replication
•Suppress the cell's defense mechanisms

Potential 💊 target
SARS-CoV-2 N protein recruits G3BP to double membrane vesicles to promote translation of viral mRNAs - Nature Communications
This study explores how G3BP proteins influence SARS-CoV-2 infection, revealing their interaction with the viral nucleocapsid protein to enhance the translation of viral RNAs produced by membrane boun...
www.nature.com
December 6, 2024 at 2:25 PM
castltrastondrs.medsky.network
While an initial proinflammatory cytokine surge is a standard antiviral defence, #SARSCoV2 possesses specific viral proteins that effectively suppress the critical early IFN-I response.
August 30, 2025 at 5:30 AM
embers1.bsky.social
"The MAPK pathway is activated by #SARSCoV2 proteins and is central to the pathogenesis of long COVID, contributing to inflammation, thrombosis, organ dysfunction, & neurological symptoms."
Impressive thread. Long Covid inflammatory causes ⬇️
castltrastondrs.medsky.network TRAstonDrs @castltrastondrs.medsky.network · Jan 17
#Medsky🧪 #IDsky #immunosky #virosky #Publichealth Role of MAPK in #LongCOVID Pathophysiology . The mitogen-activated protein kinase (MAPK) pathway is a critical intracellular signaling network that regulates inflammation, cell survival & stress responses.
castltrastondrs.medsky.network TRAstonDrs @castltrastondrs.medsky.network · Jan 17
#Medsky🧪 #immunosky New preclinical work in @science.org reveals how #Tcells respond in real time to signaling inputs of varying intensities & could shed further light on how these cells become activated in the context of #immunity & inflammation.
January 17, 2026 at 10:35 AM
castltrastondrs.medsky.network
Summaries 🔑 points
The MAPK pathway is activated by #SARSCoV2 proteins and is central to the pathogenesis of long COVID,
January 17, 2026 at 6:54 AM
gesundheitspiraten.de
Die Auswirkungen des #Corona #SARSCoV2 sind vielfältig. Besonders aber auf unser #Gehirn . Impfungen können das Risiko minimieren, leider aber nicht gänzlich verhindern. Darum: #MaskUp #GibCoronaKeineChance #GibLongCovidKeineChance #CleanAir

nachrichten.idw-online.de/2024/11/29/l...
Long COVID: Ansammlung des SARS-CoV-2-Spike-Proteins mit dauerhaften Auswirkungen auf das Gehirn verbunden
nachrichten.idw-online.de
November 29, 2024 at 7:01 PM
empathy1st.bsky.social
“Through hijacking these 3 proteins, #SARSCoV2 can evade all three complement pathways, resulting in reduced or delayed viral clearance by the infected host...and can also cause significant inflammation, a core feature of both severe #COVID19 and #LongCOVID."

www.meduniwien.ac.at/web/en/about...
SARS-CoV-2 “steals” our proteins to protect itself from the immune system | MedUni Vienna
www.meduniwien.ac.at
November 11, 2024 at 4:05 PM