🦠🧍♀️From bacterial to human immunity.
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
www.science.org
July 24, 2025 at 6:23 PM
🦠🧍♀️From bacterial to human immunity.
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
Filament formation is a conserved mechanism of Thoeris SIR2 effector activation https://www.biorxiv.org/content/10.64898/2026.03.01.708072v1
March 3, 2026 at 2:17 AM
Filament formation is a conserved mechanism of Thoeris SIR2 effector activation https://www.biorxiv.org/content/10.64898/2026.03.01.708072v1
What if this immune function also exists in humans, but hadn’t been discovered yet?
We analyzed SIR2 from thousands of bacterial, archaeal & eukaryotic genomes. All housekeeping sirtuins group in a clade, whereas all antiphage SIR2 group in another one that we named SIRim, for “SIR” and “immunity”.
We analyzed SIR2 from thousands of bacterial, archaeal & eukaryotic genomes. All housekeeping sirtuins group in a clade, whereas all antiphage SIR2 group in another one that we named SIRim, for “SIR” and “immunity”.
July 24, 2025 at 6:23 PM
What if this immune function also exists in humans, but hadn’t been discovered yet?
We analyzed SIR2 from thousands of bacterial, archaeal & eukaryotic genomes. All housekeeping sirtuins group in a clade, whereas all antiphage SIR2 group in another one that we named SIRim, for “SIR” and “immunity”.
We analyzed SIR2 from thousands of bacterial, archaeal & eukaryotic genomes. All housekeeping sirtuins group in a clade, whereas all antiphage SIR2 group in another one that we named SIRim, for “SIR” and “immunity”.
Akin to bacterial SIR2 antiphage proteins, human SIRal, also known as FAM118b, forms filaments that are essential for its NAD processing activity.
Awesome to see structures of these filaments that differ from bacterial ones.
Congrats to the authors on this beautiful study.
Awesome to see structures of these filaments that differ from bacterial ones.
Congrats to the authors on this beautiful study.
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Filament formation and NAD processing by noncanonical human FAM118 sirtuins
Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...
rdcu.be
November 17, 2025 at 4:52 PM
Akin to bacterial SIR2 antiphage proteins, human SIRal, also known as FAM118b, forms filaments that are essential for its NAD processing activity.
Awesome to see structures of these filaments that differ from bacterial ones.
Congrats to the authors on this beautiful study.
Awesome to see structures of these filaments that differ from bacterial ones.
Congrats to the authors on this beautiful study.
a short and sweet paper in which we use 3D STED and Micro-C analysis to show dramatic changes in large 3D chromatin structures in quiescence. www.biorxiv.org/content/10.1...
Sir2 is required for the quiescence-specific condensed three-dimensional chromatin structure of rDNA
Quiescence in Saccharomyces cerevisiae is a reversible G0 crucial for long-term survival under nutrient-deprived conditions. During quiescence, the genome is hypoacetylated and chromatin undergoes sig...
www.biorxiv.org
December 13, 2024 at 5:30 PM
a short and sweet paper in which we use 3D STED and Micro-C analysis to show dramatic changes in large 3D chromatin structures in quiescence. www.biorxiv.org/content/10.1...
Sir2 is required for the quiescence-specific condensed three-dimensional chromatin structure of rDNA
Quiescence in Saccharomyces cerevisiae is a reversible G0 crucial for long-term survival under nutrient-deprived conditions. During quiescence, the genome is hypoacetylated and chromatin undergoes sig...
www.biorxiv.org
December 13, 2024 at 2:59 PM
a short and sweet paper in which we use 3D STED and Micro-C analysis to show dramatic changes in large 3D chromatin structures in quiescence. www.biorxiv.org/content/10.1...
Evolutionary molecular biology paying dividends again - this time in finding new modulators of innate immunity - www.science.org/doi/10.1126/...
A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway
Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent in...
www.science.org
July 26, 2025 at 1:39 AM
Evolutionary molecular biology paying dividends again - this time in finding new modulators of innate immunity - www.science.org/doi/10.1126/...
Solidarietà e ammirazione per tutti coloro che in questi giorni lavorano lungo i 20 km di cantiere della nuova linea del tram Sir2 a Padova.
June 25, 2026 at 12:50 PM
Solidarietà e ammirazione per tutti coloro che in questi giorni lavorano lungo i 20 km di cantiere della nuova linea del tram Sir2 a Padova.
n a new study, we report the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of mammalian innate immunity!!
Co-led with E. Porier's lab, in collab with @morehouse_ben
www.biorxiv.org/content/10.1...
Co-led with E. Porier's lab, in collab with @morehouse_ben
www.biorxiv.org/content/10.1...
A human homolog of SIR2 antiphage proteins mediates immunity via the TLR pathway
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
September 23, 2024 at 9:28 AM
n a new study, we report the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of mammalian innate immunity!!
Co-led with E. Porier's lab, in collab with @morehouse_ben
www.biorxiv.org/content/10.1...
Co-led with E. Porier's lab, in collab with @morehouse_ben
www.biorxiv.org/content/10.1...
#USGS #CorridorMappingTeam - #Ungulate #Migrations of #West
-
tinyurl.com/2tt37swu
-
doi.org/10.3133/sir2...
-
#GIS #spatial #mapping #USWest #route #ecosystems #wildlife #publicland #privateland #opendata #fedopendata #fedscience #tracking #GPS #seasonal #habitat #protection #management #USFWS
-
tinyurl.com/2tt37swu
-
doi.org/10.3133/sir2...
-
#GIS #spatial #mapping #USWest #route #ecosystems #wildlife #publicland #privateland #opendata #fedopendata #fedscience #tracking #GPS #seasonal #habitat #protection #management #USFWS
September 5, 2025 at 11:03 PM
#NatMicroPicks
Ancient Proteins, Modern Immune Insights! 🦠
A conserved protein family member activates inflammation via the Toll-like receptor pathway in mammals highlighting new aspects of human immunity.
www.science.org/doi/10.1126/...
Ancient Proteins, Modern Immune Insights! 🦠
A conserved protein family member activates inflammation via the Toll-like receptor pathway in mammals highlighting new aspects of human immunity.
www.science.org/doi/10.1126/...
A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway
Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent in...
www.science.org
August 1, 2025 at 2:22 PM
#NatMicroPicks
Ancient Proteins, Modern Immune Insights! 🦠
A conserved protein family member activates inflammation via the Toll-like receptor pathway in mammals highlighting new aspects of human immunity.
www.science.org/doi/10.1126/...
Ancient Proteins, Modern Immune Insights! 🦠
A conserved protein family member activates inflammation via the Toll-like receptor pathway in mammals highlighting new aspects of human immunity.
www.science.org/doi/10.1126/...
Many components of human immunity evolved from ancient pathways in bacteria. A beautiful story from @audeber.bsky.social @enzopoirier.bsky.social leverages this evolutionary connection to discover SIRal as a signaling protein in animal TLR-mediated innate immunity.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway
Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent in...
www.science.org
July 24, 2025 at 6:22 PM
Many components of human immunity evolved from ancient pathways in bacteria. A beautiful story from @audeber.bsky.social @enzopoirier.bsky.social leverages this evolutionary connection to discover SIRal as a signaling protein in animal TLR-mediated innate immunity.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
I am so happy to share this new paper I co-wrote with colleagues at the USGS. It's a guide to predicting how nonmotorized recreation like hiking, skiing, mountain biking, etc. affects ungulates (hoofed mammals like deer, elk, moose, and pronghorn) to inform NEPA analyses. doi.org/10.3133/sir2...
May 26, 2025 at 1:39 PM
I am so happy to share this new paper I co-wrote with colleagues at the USGS. It's a guide to predicting how nonmotorized recreation like hiking, skiing, mountain biking, etc. affects ungulates (hoofed mammals like deer, elk, moose, and pronghorn) to inform NEPA analyses. doi.org/10.3133/sir2...
#NatMicroPicks
Ancient Immunity Links 🦠💉
A human homolog of SIR2 antiphage protein suggesting shared defense strategies across the tree of life.
#MicroSky #ImmunoSky
www.science.org/doi/10.1126/...
Ancient Immunity Links 🦠💉
A human homolog of SIR2 antiphage protein suggesting shared defense strategies across the tree of life.
#MicroSky #ImmunoSky
www.science.org/doi/10.1126/...
A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway
Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent in...
www.science.org
August 8, 2025 at 1:32 PM
#NatMicroPicks
Ancient Immunity Links 🦠💉
A human homolog of SIR2 antiphage protein suggesting shared defense strategies across the tree of life.
#MicroSky #ImmunoSky
www.science.org/doi/10.1126/...
Ancient Immunity Links 🦠💉
A human homolog of SIR2 antiphage protein suggesting shared defense strategies across the tree of life.
#MicroSky #ImmunoSky
www.science.org/doi/10.1126/...
Could the knowledge of bacterial immunity help us discover new human immune proteins?
One protein family caught our attention: the SIR2 proteins. In humans, they are called sirtuins and notably known to regulate gene expression — but in some bacteria, they defend against viruses.
One protein family caught our attention: the SIR2 proteins. In humans, they are called sirtuins and notably known to regulate gene expression — but in some bacteria, they defend against viruses.
July 24, 2025 at 6:23 PM
Could the knowledge of bacterial immunity help us discover new human immune proteins?
One protein family caught our attention: the SIR2 proteins. In humans, they are called sirtuins and notably known to regulate gene expression — but in some bacteria, they defend against viruses.
One protein family caught our attention: the SIR2 proteins. In humans, they are called sirtuins and notably known to regulate gene expression — but in some bacteria, they defend against viruses.
Skipping some stuff, we found that Sir2 is a key regulator for this structure, as the rDNA loop collapses when Sir2 is gone. We also found that Sir2 is required for proper quiescence entry and exit. So many roles for Sir2 out there!
December 13, 2024 at 2:59 PM
Skipping some stuff, we found that Sir2 is a key regulator for this structure, as the rDNA loop collapses when Sir2 is gone. We also found that Sir2 is required for proper quiescence entry and exit. So many roles for Sir2 out there!
We started thinking about chromatin structure at the nucleosome level (can't help ourselves) & saw that in cells lacking Sir2, chromatin is more repressive based on H3 ChIP-seq. Pol II however was increased across the locus, even in quiescence, when Sir2 was gone.
December 13, 2024 at 2:59 PM
We started thinking about chromatin structure at the nucleosome level (can't help ourselves) & saw that in cells lacking Sir2, chromatin is more repressive based on H3 ChIP-seq. Pol II however was increased across the locus, even in quiescence, when Sir2 was gone.
New research in #GENETICs reveals a crucial role of deacetylase Sir2 in sensing and responding to environmentally relevant changes in NAD+ levels in #yeast Kluyveromyces lactis. buff.ly/TyvXCQq
April 8, 2026 at 1:04 PM
New research in #GENETICs reveals a crucial role of deacetylase Sir2 in sensing and responding to environmentally relevant changes in NAD+ levels in #yeast Kluyveromyces lactis. buff.ly/TyvXCQq
In the hands of Sir2, @renbear.bsky.social
November 18, 2023 at 3:32 AM
In the hands of Sir2, @renbear.bsky.social
SIRim proteins are conserved across highly diverse phyla from bacteria to fish, fungi and protists.🐟🍄🐘
Among this large family of proteins, present in thousands of living organisms, we identified on human protein, which function was previously unknown.
We named it SIRal, for SIR2 antiphage-like.
Among this large family of proteins, present in thousands of living organisms, we identified on human protein, which function was previously unknown.
We named it SIRal, for SIR2 antiphage-like.
July 24, 2025 at 6:23 PM
SIRim proteins are conserved across highly diverse phyla from bacteria to fish, fungi and protists.🐟🍄🐘
Among this large family of proteins, present in thousands of living organisms, we identified on human protein, which function was previously unknown.
We named it SIRal, for SIR2 antiphage-like.
Among this large family of proteins, present in thousands of living organisms, we identified on human protein, which function was previously unknown.
We named it SIRal, for SIR2 antiphage-like.
May 19, 2024 at 4:19 AM
13 May 24: Day 1
Rejoined #TeamLocked after the cage fell off!!
Wonder what Sir2 might choose to do when I get into his hands
@renbear.bsky.social
Rejoined #TeamLocked after the cage fell off!!
Wonder what Sir2 might choose to do when I get into his hands
@renbear.bsky.social
May 14, 2024 at 12:34 AM
13 May 24: Day 1
Rejoined #TeamLocked after the cage fell off!!
Wonder what Sir2 might choose to do when I get into his hands
@renbear.bsky.social
Rejoined #TeamLocked after the cage fell off!!
Wonder what Sir2 might choose to do when I get into his hands
@renbear.bsky.social
8 May 2024 / Day 24 of 28
Reaching record on #TeamLocked.
@renbear.bsky.social , Sir2: here's a locked erection.
Reaching record on #TeamLocked.
@renbear.bsky.social , Sir2: here's a locked erection.
May 9, 2024 at 12:42 AM
8 May 2024 / Day 24 of 28
Reaching record on #TeamLocked.
@renbear.bsky.social , Sir2: here's a locked erection.
Reaching record on #TeamLocked.
@renbear.bsky.social , Sir2: here's a locked erection.
Nucleic acid-induced NADase activation of a short Sir2-associated prokaryotic Argonaute system
Nucleic acid-induced NADase activation of a short Sir2-associated prokaryotic Argonaute system
(Cell Reports 43, 114391; July 23, 2024)
dlvr.it
March 21, 2026 at 7:50 PM
Nucleic acid-induced NADase activation of a short Sir2-associated prokaryotic Argonaute system