A three-year-old boy’s liver cancer has been in complete remission for a year after an experimental CAR-T immunotherapy. Researchers engineered the boy’s own T cells to target a protein called glypican-3 on his hepatoblastoma cells. buff.ly/pzm3veU
#ShareGoodNewsToo
#ShareGoodNewsToo
Complete Regression of Hepatoblastoma after Interleukin-15– and Interleukin-21–Coexpressing CAR T-Cell Therapy | NEJM
A 3-year-old boy with chemotherapy-resistant metastatic hepatoblastoma had complete regression lasting at least 12 months after two infusions of glypican-3–specific CAR T cells coexpressing interle...
buff.ly
November 6, 2026 at 1:50 PM
A three-year-old boy’s liver cancer has been in complete remission for a year after an experimental CAR-T immunotherapy. Researchers engineered the boy’s own T cells to target a protein called glypican-3 on his hepatoblastoma cells. buff.ly/pzm3veU
#ShareGoodNewsToo
#ShareGoodNewsToo
A small study found promising results using CAR T-cell therapy to treat autoimmune diseases by targeting Epstein-Barr virus (EBV)-infected immune cells.
• CAR T-cell therapy: 8 of 12 achieved drug-free remission
• Rituximab: 0 of 15 achieved remission
Promising, but more research is needed.
• CAR T-cell therapy: 8 of 12 achieved drug-free remission
• Rituximab: 0 of 15 achieved remission
Promising, but more research is needed.
November 3, 2026 at 4:48 AM
A small study found promising results using CAR T-cell therapy to treat autoimmune diseases by targeting Epstein-Barr virus (EBV)-infected immune cells.
• CAR T-cell therapy: 8 of 12 achieved drug-free remission
• Rituximab: 0 of 15 achieved remission
Promising, but more research is needed.
• CAR T-cell therapy: 8 of 12 achieved drug-free remission
• Rituximab: 0 of 15 achieved remission
Promising, but more research is needed.
CD8+ T cells induce RIPK1-regulated brain endothelial cell death in cerebral malaria
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 6, 2026 at 8:32 PM
CD8+ T cells induce RIPK1-regulated brain endothelial cell death in cerebral malaria
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Stanford researchers studied 27 autoimmune patients and found CD19 CAR T-cell therapy cleared EBV-infected, autoreactive B cells that resisted rituximab.
8 of 12 CAR T-cell patients achieved sustained drug-free remission.
www.biorxiv.org/content/10.6...
8 of 12 CAR T-cell patients achieved sustained drug-free remission.
www.biorxiv.org/content/10.6...
CD19-CAR T-cell therapy resets the EBV+ autoreactive B cell repertoire in autoimmune disease
Epstein-Barr virus (EBV) reprograms autoreactive B cells into activated antigen-presenting cells that drive pathogenic T- and B-cell responses in autoimmune disease. Using EBV B-cell sequencing (EBV-s...
www.biorxiv.org
November 2, 2026 at 6:34 PM
Stanford researchers studied 27 autoimmune patients and found CD19 CAR T-cell therapy cleared EBV-infected, autoreactive B cells that resisted rituximab.
8 of 12 CAR T-cell patients achieved sustained drug-free remission.
www.biorxiv.org/content/10.6...
8 of 12 CAR T-cell patients achieved sustained drug-free remission.
www.biorxiv.org/content/10.6...
Astrocytes are fully competent APC but require IFN-γ & microglial cytokines to drive Ag-specific CD4 T @cp-cellreports.bsky.social
www.cell.com/cell-reports... preview @fchrisbennett.bsky.social
www.cell.com/cell-reports... @liddelowsa.bsky.social @borderbiologist.bsky.social @nyucns.bsky.social
www.cell.com/cell-reports... preview @fchrisbennett.bsky.social
www.cell.com/cell-reports... @liddelowsa.bsky.social @borderbiologist.bsky.social @nyucns.bsky.social
November 4, 2026 at 5:25 PM
Astrocytes are fully competent APC but require IFN-γ & microglial cytokines to drive Ag-specific CD4 T @cp-cellreports.bsky.social
www.cell.com/cell-reports... preview @fchrisbennett.bsky.social
www.cell.com/cell-reports... @liddelowsa.bsky.social @borderbiologist.bsky.social @nyucns.bsky.social
www.cell.com/cell-reports... preview @fchrisbennett.bsky.social
www.cell.com/cell-reports... @liddelowsa.bsky.social @borderbiologist.bsky.social @nyucns.bsky.social
If used properly, I think t cell are a good thing  cell phones
November 4, 2026 at 6:22 PM
If used properly, I think t cell are a good thing  cell phones
Clinical trials of an anti-HIV antibody offer clues to prevent viral escape and resistance, a massive dataset of patient samples accelerates the discovery of T cell receptors for future cancer therapeutics, and more this week in #ScienceTranslationalMedicine. https://scim.ag/4iDmVhX
November 4, 2026 at 10:00 PM
Clinical trials of an anti-HIV antibody offer clues to prevent viral escape and resistance, a massive dataset of patient samples accelerates the discovery of T cell receptors for future cancer therapeutics, and more this week in #ScienceTranslationalMedicine. https://scim.ag/4iDmVhX
An in vivo T cell engager platform induces deep plasma cell depletion in autoimmune dry eye: Cell Reports Medicine www.cell.com/cell-reports...
An in vivo T cell engager platform induces deep plasma cell depletion in autoimmune dry eye
Ling et al. develop T-IDLESTCE, a T cell-targeted integration-deficient lentiviral
vector that programs endogenous T cells to secrete TCEs in situ. TCE-secreting T cells
infiltrate disease-relevant ti...
www.cell.com
November 6, 2026 at 3:01 PM
An in vivo T cell engager platform induces deep plasma cell depletion in autoimmune dry eye: Cell Reports Medicine www.cell.com/cell-reports...
Temporal dynamics of antigen-specific T cell expansion in primary SARS-CoV-2 infection
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 6, 2026 at 8:33 PM
Temporal dynamics of antigen-specific T cell expansion in primary SARS-CoV-2 infection
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
new out in Nature www.nature.com/articles/s41...
In vivo CAR-T double knockout screen maps synergistic antitumour gene pairs - Nature
Using high-throughput in vivo CAR-T double knockout screening, synergistic gene combinations to improve CAR-T cell therapy are revealed.
www.nature.com
November 5, 2026 at 10:01 AM
new out in Nature www.nature.com/articles/s41...
Polygenic polymorphisms cooperate to drive expansion of HCMV adaptive NK cell and NK-like T cell populations @biorxivpreprint.bsky.social @mskcancercenter.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
November 5, 2026 at 3:23 PM
Polygenic polymorphisms cooperate to drive expansion of HCMV adaptive NK cell and NK-like T cell populations @biorxivpreprint.bsky.social @mskcancercenter.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
CD19-CAR T cells clear the EBV-infected B cells that carry autoreactive antibodies. Rituximab doesn’t. That may be why only one of them produces lasting remission.
New Robinson Lab preprint led by me and Mahesh Pandit. 🧵
www.biorxiv.org/content/10.6...
New Robinson Lab preprint led by me and Mahesh Pandit. 🧵
www.biorxiv.org/content/10.6...
CD19-CAR T-cell therapy resets the EBV+ autoreactive B cell repertoire in autoimmune disease
Epstein-Barr virus (EBV) reprograms autoreactive B cells into activated antigen-presenting cells that drive pathogenic T- and B-cell responses in autoimmune disease. Using EBV B-cell sequencing (EBV-s...
www.biorxiv.org
November 2, 2026 at 9:33 PM
CD19-CAR T cells clear the EBV-infected B cells that carry autoreactive antibodies. Rituximab doesn’t. That may be why only one of them produces lasting remission.
New Robinson Lab preprint led by me and Mahesh Pandit. 🧵
www.biorxiv.org/content/10.6...
New Robinson Lab preprint led by me and Mahesh Pandit. 🧵
www.biorxiv.org/content/10.6...
Why is long-read-based genotyping important when working with T-DNA lines?
Have a look at this example: doi.org/10.1007/s002...
@puckerlab.bsky.social
#Genomics #LongReads #PlantSciences
Have a look at this example: doi.org/10.1007/s002...
@puckerlab.bsky.social
#Genomics #LongReads #PlantSciences
A hidden T-DNA-linked inversion-duplication is associated with a light-dependent Arabidopsis mutant phenotype - Plant Cell Reports
Key message A hidden T-DNA-linked genomic rearrangement alters gene dosage and exacerbates light-dependent phenotypes in Arabidopsis, highlighting the importance of structural genome validation for re...
doi.org
November 7, 2026 at 3:47 PM
Why is long-read-based genotyping important when working with T-DNA lines?
Have a look at this example: doi.org/10.1007/s002...
@puckerlab.bsky.social
#Genomics #LongReads #PlantSciences
Have a look at this example: doi.org/10.1007/s002...
@puckerlab.bsky.social
#Genomics #LongReads #PlantSciences
Cysteine's sulfur directs T cell fate: Kelly et al. reveal that its partitioning fuels CD8⁺ T cell growth, function, and anti-tumor immunity. 1 key element, 2 pathways! PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2
No description available
www.cell.com
November 6, 2026 at 12:00 AM
Konkuk University researchers reviewed evidence that COVID-19 can reactivate dormant herpesviruses, including EBV, CMV and HSV.
Impaired T-cell and NK cell defenses may allow these viruses to reactivate, potentially contributing to Long COVID.
www.frontiersin.org/journals/imm...
Impaired T-cell and NK cell defenses may allow these viruses to reactivate, potentially contributing to Long COVID.
www.frontiersin.org/journals/imm...
Frontiers | Herpesvirus reactivation in COVID-19: clinical evidence, mechanistic insights, and research gaps
Herpesviruses establish lifelong latency and can reactivate when antiviral immune surveillance is compromised. Since the onset of COVID-19 pandemic, reactiva...
www.frontiersin.org
November 5, 2026 at 11:55 AM
Konkuk University researchers reviewed evidence that COVID-19 can reactivate dormant herpesviruses, including EBV, CMV and HSV.
Impaired T-cell and NK cell defenses may allow these viruses to reactivate, potentially contributing to Long COVID.
www.frontiersin.org/journals/imm...
Impaired T-cell and NK cell defenses may allow these viruses to reactivate, potentially contributing to Long COVID.
www.frontiersin.org/journals/imm...
MerTK mediates dexamethasone-induced suppression of antiviral CD8+ T cell immunity and exacerbates chronic LCMV infection @frontiersin.bsky.social
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
November 5, 2026 at 3:18 PM
MerTK mediates dexamethasone-induced suppression of antiviral CD8+ T cell immunity and exacerbates chronic LCMV infection @frontiersin.bsky.social
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
T an B Cell training montage let’s go
November 7, 2026 at 2:46 PM
T an B Cell training montage let’s go
A new bispecific antibody targets both CCR8 to deplete regulatory T cells and CD3 to revitalize the broader anti-tumor T cell armada. It combated multiple tumor types and potentiated immunotherapy in mice while being safe in large animals. #ScienceTranslationalMedicine https://scim.ag/4BxHDZ9
T cell–mediated depletion of intratumoral regulatory T cells using a CCR8xCD3 T cell–engaging bispecific antibody (TCB) promotes antitumor immunity in preclinical mouse models
CCR8xCD3 bispecific antibody potently boosts antitumor immunity by engaging T cells for the depletion of immunosuppressive intratumoral Treg cells.
scim.ag
November 2, 2026 at 7:00 PM
A new bispecific antibody targets both CCR8 to deplete regulatory T cells and CD3 to revitalize the broader anti-tumor T cell armada. It combated multiple tumor types and potentiated immunotherapy in mice while being safe in large animals. #ScienceTranslationalMedicine https://scim.ag/4BxHDZ9
EBV is involved in more than just MS, we are learning, and we suddenly have the tools to kill problem b-cells with some precision.
(Car-T cells, borrowed from cancer treatment, and an even cheaper better technology called t cell engagers).
Are we on the brink of solving autoimmune disease?
(Car-T cells, borrowed from cancer treatment, and an even cheaper better technology called t cell engagers).
Are we on the brink of solving autoimmune disease?
November 6, 2026 at 9:43 AM
EBV is involved in more than just MS, we are learning, and we suddenly have the tools to kill problem b-cells with some precision.
(Car-T cells, borrowed from cancer treatment, and an even cheaper better technology called t cell engagers).
Are we on the brink of solving autoimmune disease?
(Car-T cells, borrowed from cancer treatment, and an even cheaper better technology called t cell engagers).
Are we on the brink of solving autoimmune disease?
Panciera, T., Azzolin, L., Cordenonsi, M., & Piccolo, S. (2017). Mechanobiology of YAP and TAZ in physiology and disease. Nature Reviews Molecular Cell Biology, 18(12), 758–770. #EpithelialMechanicsReview
doi.org/10.1038/nrm....
doi.org/10.1038/nrm....
November 5, 2026 at 8:02 AM
Panciera, T., Azzolin, L., Cordenonsi, M., & Piccolo, S. (2017). Mechanobiology of YAP and TAZ in physiology and disease. Nature Reviews Molecular Cell Biology, 18(12), 758–770. #EpithelialMechanicsReview
doi.org/10.1038/nrm....
doi.org/10.1038/nrm....
AI-driven discovery identifies GPNMB CAR T cells as a promising multi-cancer therapy, enhancing target selection via refined single-cell RNA sequencing analysis. PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3
No description available
www.cell.com
November 5, 2026 at 7:00 AM
My arms aren’t long enough to show just how high I want to raise my hand. That sniveling little fvcker needs to be ousted, tried, and convicted for war crimes. Then he should spend the rest of his days sharing a cell with his boss who will be busy super glueing gold sh!t to the walls of their cell.
November 5, 2026 at 8:35 PM
My arms aren’t long enough to show just how high I want to raise my hand. That sniveling little fvcker needs to be ousted, tried, and convicted for war crimes. Then he should spend the rest of his days sharing a cell with his boss who will be busy super glueing gold sh!t to the walls of their cell.