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Thermal power plant Penza TPP1 in russia. Smoking accident.
July 10, 2025 at 10:55 PM
koukun107.bsky.social
놀랍게도
코우도 인간 자캐가 있워요우
커미션 귀여움 얏호

kre.pe/TPp1
May 25, 2025 at 12:12 AM
johnthorn.bsky.social
Tommy Leach and Fred Parent, opponents in the 1903 World Series, on "I've Got a Secret" in 1960. Watch from 7-minute mark. www.youtube.com/watch?v=TpP1...
I've Got A Secret! - Jonathan Winters 9/28/1960
YouTube video by I've Got A Secret!
www.youtube.com
July 28, 2025 at 5:58 PM
johnthorn.bsky.social
Tommy Leach and Fred Parent, opponents in the 1903 World Series, on "I've Got a Secret" in 1960. Watch from 7-minute mark. www.youtube.com/watch?v=TpP1...
I've Got A Secret! - Jonathan Winters 9/28/1960
YouTube video by I've Got A Secret!
www.youtube.com
July 28, 2026 at 12:18 PM
areyoucertain.bsky.social
music.youtube.com/watch?v=TpP1...
I Go To The Rock
YouTube video by Whitney Houston - Topic
music.youtube.com
September 8, 2025 at 11:27 PM
effectomics.bsky.social
#2025ISMPMI Youhuang Xiang from Roger Innes lab presents the TPP1 effector of Fusarium graminearum. A protease that localizes specific to the chloroplast and suppresses in its precursor form ETI.
July 15, 2025 at 10:44 AM
areyoucertain.bsky.social
music.youtube.com/watch?v=TpP1...
I Go To The Rock
YouTube video by Whitney Houston - Topic
music.youtube.com
March 24, 2026 at 5:46 PM
janovictom.bsky.social
1/8 Super excited to share my first-author preprint in @jenscs83.bsky.social lab!
We measured the shelterin complex stoichiometry and dynamics at telomeres in living cells. Our results re-envisions the architecture of telomeres in human cancer cells.
www.biorxiv.org/content/10.1...
TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres
The shelterin complex protects chromosome ends from the DNA damage repair machinery and regulates telomerase access to telomeres. Shelterin is composed of six proteins (TRF1, TRF2, TIN2, TPP1, POT1 an...
www.biorxiv.org
December 24, 2024 at 11:41 AM
morgancarterphd.bsky.social
Postdoc Youhuang Xiang is studying the TPP1 effector from Fusarium to learn how it blocks ETI through regulating ROS production.

Unpublished data but lots done so looks like a manuscript is in the works.
#2025ISMPMI
A person presenting a scientific talk but the slide is not shown
July 15, 2025 at 10:44 AM
gimopenjournal.bsky.social
Genome-based newborn screening identified CLN2 Batten disease before symptoms appeared, enabling early treatment and demonstrating the promise of genomic screening for treatable rare disorders. bit.ly/4y1a0fK #GIMO #CLN2 #BattenDisease #NewbornScreening #TPP1
August 26, 2026 at 1:52 AM
shihcheng.bsky.social
RPA, crucial for telomere maintenance, boosts telomerase processivity in vitro. Predictive models show RPA and TPP1 bind different sites. PMID:41166495, Science 2025, @ScienceMagazine https://doi.org/10.1126/science.ads5297 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://doi.org/10.1126/science.ads5297
No description available
doi.org
November 2, 2025 at 4:00 PM
excalibear.bsky.social
www.youtube.com/watch?v=Tpp1...
Little Feat - Cold, Cold, Cold
YouTube video by Mark Parker
www.youtube.com
October 10, 2025 at 3:21 PM
gambacl.bsky.social
TPP-11 cumplió dos y no pasó NINGUNA de las imbecilidades que dijo el Frente Amplio www.gamba.cl/2025/03/tpp1...
March 14, 2025 at 7:59 PM
ansibot.bsky.social
AT-TPP1.ANS, 1997-02-02 from dark domain - the artpacks.acid.org collection (CD-ROM)
he unji its Art by : ACID TRiP
January 7, 2026 at 8:45 PM
janovictom.bsky.social
Using single-molecule imaging in living cells, we found that TRF1, TIN2, TPP1 and POT1 subunits display static behavior – tightly bound to telomeres.
August 25, 2025 at 1:33 PM
cp-cellrepmed.bsky.social
Online now: Recreating pathophysiology of CLN2 disease and demonstrating reversion by TPP1 gene therapy in hiPSC-derived retinal organoids and retina-on-chip
Recreating pathophysiology of CLN2 disease and demonstrating reversion by TPP1 gene therapy in hiPSC-derived retinal organoids and retina-on-chip
Corti et al. leverage patient hiPSC-derived retinal organoids and retina-on-chip systems to replicate key CLN2 retinal pathologies, including lipofuscin accumulation and cone dysfunction. AAV9-mediated TPP1 gene therapy restores enzyme expression and reduces pathological hallmarks, offering promise for treating CLN2-associated blindness.
dlvr.it
July 23, 2025 at 7:19 PM
rridrobot.bsky.social
RRID:Addgene_12260, was just reported to be used in "C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation". RRIDs like this improve reproducibility in scientific research. #methodsmatter #OpenScience
doi.org
April 11, 2025 at 7:01 AM
chateaudecolombe.bsky.social
Patrick and Stuart rescue their plum tree from the overgrown ivy that is killing the tree. Patrick also begins the trimming back of their giant fig tree, and they work to get all of the Christmas decor at the chateau put away by Epiphany on January 6.
www.youtube.com/watch?v=Tpp1...
Will This Video Be Our New Chateau Channel Format for 2025?
YouTube video by Journey to the Chateau
www.youtube.com
January 10, 2025 at 8:25 AM
gambacl.bsky.social
TPP-11 cumplió dos y no pasó NINGUNA de las imbecilidades que dijo el Frente Amplio www.gamba.cl/2025/03/tpp1...
Dos años del TPP-11: El Frente Amplio mintió en todo
Sólo por esto, el Frente Amplio debería ser expulsado de cualquier debate democrático.
www.gamba.cl
March 15, 2025 at 6:54 PM
rridrobot.bsky.social
@proteintech.bsky.social's resource, RRID:AB_2207530, was just reported to be used in the paper. We value the author's support of reproducibility. #methodsmatter #ReproducibleResearch #reproducibility
Recreating pathophysiology of CLN2 disease and demonstrating reversion by TPP1 gene therapy in hiPSC-derived retinal organoids and retina-on-chip
doi.org
July 31, 2025 at 7:00 AM
teiflab.bsky.social
Structural organization and function of telomeric chromatin [Review by Ruben van der Lugt & Jacqueline Jacobs] www.nature.com/articles/s41...
Fig. 1: Schematic of the human telomeric chromatin architecture. The human telomere is made up of TTAGGG repeats arranged into nucleosomes, bound by a six-subunit shelterin complex (comprising TRF1, TRF2, RAP1, TIN2, TPP1 and POT1). Some complexes are depicted without TPP1 and POT1, which it has been suggested are less abundant than the other subunits. Recent in vitro structural analyses of telomeric chromatin revealed a columnar stacking of histones on TTAGGG repeats, characterized by face-to-face nucleosome arrangements, as well as an alternative open configuration where two histone octamers are oriented at a nearly 90° angle. These in vitro columnar arrays exhibit an NRL of approximately 130 bp. In vivo, however, the telomeric NRL is 157 bp, longer than the NRL of the proposed columnar histone arrangement, but shorter than the ~197-bp NRL of bulk chromatin. To reconcile this, we depict here a model in which shelterin remodels the telomeric chromatin to integrate features of a columnar nucleosome organization with the nucleosome periodicity observed in vivo. At the telomere terminus, a 3′ single-stranded overhang of TTAGGG repeats invades the duplex telomeric DNA to form a lariat structure known as the T-loop. This loop structure serves a protective function by preventing the telomere from being recognized as damaged DNA. The size of the T-loop is variable and may differ between telomeres, contributing to the structural heterogeneity of the telomere. The extent to which nucleosomes are present within the T-loop remains unclear. Fig. 2: Impact of the TPE on the local and distal chromatin environment. Telomere elongation results in the repression of genes in the vicinity of telomeres, a phenomenon known as the TPE. a, Schematic of the repression of telomere-proximal genes via the classical TPE that has been shown at telomere-adjacent artificial reporter genes in human cells. Upon elongation, telomeres accumulate repressive histone modifications (indicated in red) through the activity of a histone methyltransferase (HMT) and HP1. The repressive heterochromatin environment of elongated telomeres spreads to nearby subtelomeric genes (indicated with red and orange DNA strands), resulting in transcriptional repression. The strength of silencing diminishes as the distance from the telomere increases (indicated with fading arrows). Conversely, upon telomere shortening, the human TPE (at telomere-adjacent transgenes) is characterized by loss of the repressive histone modification H3K9me3 and gain of the activating modification H3K9ac. In contrast to telomere-adjacent artificial reporter genes, at natural subtelomeres, spreading of repressive histone modifications from telomeres is not consistently observed, probably due to the presence of boundary elements. b, Schematic of telomere-mediated repression of telomere-distal genes via TPE-OLD. Elongated telomeres acquire the ability to form long-distance loops between telomeres and interstitial telomere sequences (ITSs; that is, sequences of TTAGGG repeats outside of the telomeres). Looping requires binding of shelterin to an ITS and results in transcriptional repression of the affected gene. Fig. 3: Heterogeneity of (sub)telomeric chromatin and its reorganization upon telomere elongation. a, Telomeric and subtelomeric chromatin are organized into distinct domains. The subtelomeric TAR1 site acts as a TSS for the telomeric non-coding RNA TERRA (depicted in red for UUAGGG and in orange for subtelomere-derived RNA). The canonical TERRA promoter contains a high density of CpG dinucleotides, regulated by the DNA methyltransferases DNMT1 and DNMT3B. In contrast, certain subtelomeres (variable across cell lines) contain non-canonical TERRA promoters that lack CpG-rich regions and escape regulation by DNA methylation. Binding of CTCF and cohesin to the centromeric side of TAR1 maintains transcriptionally competent chromatin at the TSS and facilitates the recruitment of RNA polymerase II. The telomeric tract itself displays a bivalent pattern of histone modifications, with both activating (H3K4me3 and H3K27ac) and repressive marks (H3K9me3, H3K27me3 and H4K20me3). TERRA modulates this environment through the formation of RNA:DNA hybrids (R-loops) and G4s. Furthermore, RNA- or G4-binding chromatin remodellers, including Suv39H1, ORC1, NoRC, PRC2 and FUS, are recruited by TERRA and alter the epigenetic landscape. G4-binding proteins, including CTCF and YY1, mediate long-range interactions between distal G4s, contributing to higher-order chromatin organization. The telomeric shelterin complex itself is heterogeneous and probably assembles into subcomplexes (for example, TRF1–TIN2–TPP1–POT1 or TRF2–RAP1). TRF2 is essential for formation of the terminal T-loop, which requires direct interaction between TRF2 and nucleosomes. TRF2-mediated stabilization of nucleosomes may prevent branch migration at the base of the loop, which would result in cleavage of the loop by resolvases. b, TERT-mediated elongation alters the chromatin of telomeres. The length of TERRA molecules is proportional to the telomere length, allowing increased recruitment of chromatin-modifying enzymes… Fig. 4: Schematic of the ALT pathway. ALT is a telomerase-independent, cancer-specific mechanism of telomere maintenance enabled by alterations to the telomeric chromatin. Between 10 and 15% of cancers activate the ALT pathway to maintain telomere length in a telomerase-independent manner. ALT+ cancers frequently display loss of ATRX–DAXX histone chaperone activity, resulting in reduced deposition of the histone variant H3.3 at telomeres and, consequentially, progressive decompaction of the telomeres. This chromatin disruption promotes increased TERRA transcription, leading to accumulation of R-loops and G4s. ALT+ telomeres also display increased levels of the repressive histone mark H3K9me3, partially due to additional mutations such as those encoding the G34R substitution in H3.3 and the R132H substitution in IDH1, which inhibit the histone demethylase KDM4B. The combined effect of R-loops, G4s and decreased nucleosome occupancy cause persistent replication stress, ultimately giving rise to telomeric breaks. Broken telomeres are further enriched in H3K9me3 due to the break-induced recruitment of the CHAMP1–POGZ–HP1 complex. These telomeric breaks are clustered in APBs, membrane-less condensates formed through HP1- and PML-dependent phase separation. Within APBs, broken telomeres invade homologous telomeric templates to initiate HDR-mediated extension. Invasion of the broken strand is stimulated by RAD51AP1, which promotes the switch from TERRA R-loops to stable telomeric D-loops, where telomere elongation takes place.
January 7, 2026 at 8:41 PM
icag02.bsky.social
New Aging Research!

TPP1 activates hair stem cells, promoting regeneration.

Join ICAG 2027
📅Apr 14–15, 2027 |📍Tokyo, Japan

Register: agingcongress.com/registrations

#Aging #Longevity #StemCells
August 31, 2026 at 12:11 PM
insight.jci.org
CLN2 disease is a childhood-onset neurodegenerative lysosomal storage disorder caused by TPP1 deficiency, but little is known about the cellular cause.

Takahashi et al. show GABAergic interneurons contribute to the fatal seizure phenotype in CLN2 disease mice: insight.jci.org/articles/vie...
October 10, 2025 at 1:04 PM
realbiomassspec.bsky.social
Proteomics method for identifying POT1-associated complexes at telomeres using ChIP-Mass spectrometry #Methods www.sciencedirect.com/science/arti...
Proteomics method for identifying POT1-associated complexes at telomeres using ChIP-Mass spectrometry
POT1 is the only single stranded telomere binding protein in the shelterin complex. Together with TPP1, POT1 plays a crucial role in regulating telome…
www.sciencedirect.com
January 24, 2026 at 10:31 AM
arar55.bsky.social
Cold, Cold, Cold - Little Feat
www.youtube.com/watch?v=Tpp1...
Little Feat - Cold, Cold, Cold
YouTube video by Mark Parker
www.youtube.com
August 27, 2025 at 3:50 PM