Background: Repetitive transcranial magnetic stimulation induces neural plasticity, which may be maximized via adjunctive interventions. Objective: This study aimed to examine the feasibility and acceptability of interleaving computerized cognitive training (CCT) with accelerated intermittent theta burst (iTBS) repetitive transcranial magnetic stimulation in 2 open-label phase I trials of amnestic mild cognitive impairment (aMCI; NCT04503096) and poststroke mild cognitive impairment (psMCI; NCT04655963). Methods: Participants (aMCI: n=21; and psMCI: n=14) received 24 sessions of accelerated iTBS over 3 days (8 sessions per day). During the 10‐ to 15-minute intervals between iTBS sessions, participants engaged in CCT via the BrainHQ platform. During the 4-week follow-up period, participants were asked to complete 20 minutes daily of BrainHQ. Both studies offered identical compensation for daily practice, but the aMCI group received weekly reminders, whereas the psMCI group did not. Study-specific questionnaires assessed BrainHQ acceptability (administered post-treatment and at follow-up). Results: During in-laboratory treatment, the groups completed similar amounts of BrainHQ (aMCI: median 107, IQR 92-121 min; and psMCI: median 111, IQR 93-137 min; =.51). However, engagement differed during the unmonitored follow-up (aMCI: median 450, IQR 167-581 min,; and psMCI: median 142, IQR 0-477 min); practice time increased in the aMCI group but decreased in the psMCI group over the 4 weeks (=.001). Both groups generally rated BrainHQ positively at both time points in terms of their experience with the platform, exercises, and perceived benefit for their mood and functioning. Conclusions: Combined treatment with CCT and accelerated iTBS is feasible and acceptable in people with mild cognitive impairment. Standardized dosing of CCT is feasibly achieved when interleaved with iTBS sessions and completed in-laboratory, but ecological adherence to CCT in an unmonitored, self-directed context likely requires additional supports and may be influenced by patient characteristics. Trial Registration: ClinicalTrials.gov NCT04503096; https://clinicaltrials.gov/study/NCT04503096 and NCT04655963; https://clinicaltrials.gov/study/NCT04655963

TikTok video by Dr Jacob | Neuroscientist 🧠

Is Brain Stimulation the Best Treatment for OCD? Obsessive-Compulsive Disorder (OCD) is a complex mental health condition characterized by recurring intrusive thoughts (obsessions) and repetitive behaviors or mental acts (compulsions). Understanding the underlying mechanisms of OCD is essential to exploring treatment options. A recent spotlight on this topic was cast by Dr. Ali R. Rezai, a leading figure in the field of stereotactic and functional restorative neurosurgery at the Cleveland Clinic Foundation.

Declarations Under Perjury Transcranial Magnetic Stimulation Causes Traumatic Brain Injury

October 12-14, 2026

In January, Duke Health opened a transcranial magnetic stimulation (TMS) clinic at Duke Regional Hospital. TMS is primarily used to treat major depressive disorder but has also proven effective in tre...

What I was able to learn about the injury inflicted by TMS is an insight into the treatment itself and the nature of the medical model.

YouTube video by Greenhouse for Mental Health Development