Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social @jasperjanssens.bsky.social and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1
July 11, 2025 at 8:59 PM
Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social @jasperjanssens.bsky.social and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1
My postdoc work at Treutlein lab and @graycamplab.bsky.social with @jasperjanssens.bsky.social is out in @science.org ! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. www.science.org/doi/10.1126/...
July 12, 2025 at 10:11 PM
My postdoc work at Treutlein lab and @graycamplab.bsky.social with @jasperjanssens.bsky.social is out in @science.org ! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. www.science.org/doi/10.1126/...
Latest paper in Nature this week: an atlas integrating 36 single-cell datasets spanning 26 protocols for making neural #organoids
Effort led by B. Treutlein, @fabiantheis.bsky.social and @graycamplab.bsky.social
Effort led by B. Treutlein, @fabiantheis.bsky.social and @graycamplab.bsky.social
November 21, 2024 at 7:25 PM
Latest paper in Nature this week: an atlas integrating 36 single-cell datasets spanning 26 protocols for making neural #organoids
Effort led by B. Treutlein, @fabiantheis.bsky.social and @graycamplab.bsky.social
Effort led by B. Treutlein, @fabiantheis.bsky.social and @graycamplab.bsky.social
Learned a lot working with Jonas Fleck, Daniil Bobrovskiy, Dominik Klein, Barbara Treutlein and @fabiantheis.bsky.social on CellFlow: generative single-cell phenotype modeling with flow matching. Virtual protocol screening is particularly innovative!
May 3, 2025 at 8:58 PM
Learned a lot working with Jonas Fleck, Daniil Bobrovskiy, Dominik Klein, Barbara Treutlein and @fabiantheis.bsky.social on CellFlow: generative single-cell phenotype modeling with flow matching. Virtual protocol screening is particularly innovative!
It was fun to learn about blood vessel organoids together with @marinanikolova.bsky.social and Barbara Treutlein! Thanks to Reiner Wimmer and @penningerlab.bsky.social for introducing us to this system! www.cell.com/cell/fulltex... Great support from editors and reviewers @cellpress.bsky.social!
April 28, 2025 at 2:33 PM
It was fun to learn about blood vessel organoids together with @marinanikolova.bsky.social and Barbara Treutlein! Thanks to Reiner Wimmer and @penningerlab.bsky.social for introducing us to this system! www.cell.com/cell/fulltex... Great support from editors and reviewers @cellpress.bsky.social!
Excited to share our latest preprint, presenting a multi-omic human neural organoid cell atlas of the posterior brain! 🧠🔬
doi.org/10.1101/2025...
Great work with @hsiuchuanlin.bsky.social @zhisonghe.bsky.social @graycamplab.bsky.social and Barbara Treutlein!
doi.org/10.1101/2025...
Great work with @hsiuchuanlin.bsky.social @zhisonghe.bsky.social @graycamplab.bsky.social and Barbara Treutlein!
March 24, 2025 at 12:42 PM
Excited to share our latest preprint, presenting a multi-omic human neural organoid cell atlas of the posterior brain! 🧠🔬
doi.org/10.1101/2025...
Great work with @hsiuchuanlin.bsky.social @zhisonghe.bsky.social @graycamplab.bsky.social and Barbara Treutlein!
doi.org/10.1101/2025...
Great work with @hsiuchuanlin.bsky.social @zhisonghe.bsky.social @graycamplab.bsky.social and Barbara Treutlein!
Congratulations to Dr. @akanksha-jain.bsky.social, Gilles Gut, and the Treutlein Lab and @graycamplab.bsky.social on their work live imaging brain #organoid growth!
@nature.com article: go.nature.com/4la2yZh
Episode with discussion: bit.ly/4nzLrCp
@nature.com article: go.nature.com/4la2yZh
Episode with discussion: bit.ly/4nzLrCp
July 11, 2025 at 10:37 PM
Congratulations to Dr. @akanksha-jain.bsky.social, Gilles Gut, and the Treutlein Lab and @graycamplab.bsky.social on their work live imaging brain #organoid growth!
@nature.com article: go.nature.com/4la2yZh
Episode with discussion: bit.ly/4nzLrCp
@nature.com article: go.nature.com/4la2yZh
Episode with discussion: bit.ly/4nzLrCp
Congrats @akanksha-jain.bsky.social @graycamplab.bsky.social & Treutlein lab on publishing this @nature.com study on early brain organoid development, with insights into processes underlying brain regionalization 🧪🧠🧬🧫
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Morphodynamics of human early brain organoid development - Nature
Human brain morphodynamics are explored using organoids.
www.nature.com
June 22, 2025 at 11:35 AM
Congrats @akanksha-jain.bsky.social @graycamplab.bsky.social & Treutlein lab on publishing this @nature.com study on early brain organoid development, with insights into processes underlying brain regionalization 🧪🧠🧬🧫
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The #iHOME2025 conference is off to a great start at @dkfz.bsky.social! We're excited for 2 days of organoid science from our speakers, like Barbara Treutlein, Max Reichert, Joep Beumer and @kimbakjensen.bsky.social. With @jackstadt-lab.bsky.social @moritzmall.bsky.social @kimboonekamp.bsky.social
March 20, 2025 at 9:50 AM
The #iHOME2025 conference is off to a great start at @dkfz.bsky.social! We're excited for 2 days of organoid science from our speakers, like Barbara Treutlein, Max Reichert, Joep Beumer and @kimbakjensen.bsky.social. With @jackstadt-lab.bsky.social @moritzmall.bsky.social @kimboonekamp.bsky.social
Where RNA Science Meets AI, May 4–8, 2025, Ascona. Invited speakers: @evamarianovoa.bsky.social @fabiantheis.bsky.social @rivaselenarivas.bsky.social, Sterling Churchman, Barbara Treutlein, Rahul Satijia,
Registration open www.rna-ai.org
@hagentilgner.bsky.social @quaidmorris.bsky.social
Registration open www.rna-ai.org
@hagentilgner.bsky.social @quaidmorris.bsky.social
RNA-AI 2025
www.rna-ai.org
December 18, 2024 at 8:22 AM
Where RNA Science Meets AI, May 4–8, 2025, Ascona. Invited speakers: @evamarianovoa.bsky.social @fabiantheis.bsky.social @rivaselenarivas.bsky.social, Sterling Churchman, Barbara Treutlein, Rahul Satijia,
Registration open www.rna-ai.org
@hagentilgner.bsky.social @quaidmorris.bsky.social
Registration open www.rna-ai.org
@hagentilgner.bsky.social @quaidmorris.bsky.social
Happy to share our resource for blood vessel organoids!
@zhisonghe.bsky.social, Makiko Seimiya, Gustav Jonsson, Wuji Cao, Ryo Okuda, Reiner Wimmer, Ryoko Okamoto
Barbara Treutlein, @graycamplab.bsky.social, @penningerlab.bsky.social
@zhisonghe.bsky.social, Makiko Seimiya, Gustav Jonsson, Wuji Cao, Ryo Okuda, Reiner Wimmer, Ryoko Okamoto
Barbara Treutlein, @graycamplab.bsky.social, @penningerlab.bsky.social
Now online! Fate and state transitions during human blood vessel organoid development
Fate and state transitions during human blood vessel organoid development
Single-cell multiomic reconstruction of the human blood vessel organoid system allows for classifying and modeling disease and cell-type-specific states, demonstrating its potential for translational research.
dlvr.it
April 21, 2025 at 6:39 PM
Happy to share our resource for blood vessel organoids!
@zhisonghe.bsky.social, Makiko Seimiya, Gustav Jonsson, Wuji Cao, Ryo Okuda, Reiner Wimmer, Ryoko Okamoto
Barbara Treutlein, @graycamplab.bsky.social, @penningerlab.bsky.social
@zhisonghe.bsky.social, Makiko Seimiya, Gustav Jonsson, Wuji Cao, Ryo Okuda, Reiner Wimmer, Ryoko Okamoto
Barbara Treutlein, @graycamplab.bsky.social, @penningerlab.bsky.social
Opus magnum of my former #PhD student @akanksha-jain.bsky.social. She brought the power of #lightsheet imaging to the #Treutlein lab. #Organoids #singlecells #bigdata #imageanalysis You have learned much #Akanksha. You are a #JEDI now. ❤️👏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Morphodynamics of human early brain organoid development - Nature
Human brain morphodynamics are explored using organoids.
www.nature.com
June 22, 2025 at 3:32 PM
Opus magnum of my former #PhD student @akanksha-jain.bsky.social. She brought the power of #lightsheet imaging to the #Treutlein lab. #Organoids #singlecells #bigdata #imageanalysis You have learned much #Akanksha. You are a #JEDI now. ❤️👏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Join us at the FENS Single-Cell & Spatial Omics Winter School with:
@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein
@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein
🌟 Registration is now OPEN! 🌟
Join the 2025-2026 #FENS-Hertie #WinterSchool and explore this year's topic – Single-cell and Spatial Omics to Understand Brain Heterogeneity! 🔬
📍 Alicante, Spain
🗓️ 11-17 Jan 2026
🔗 https://loom.ly/RM55lFQ
Join the 2025-2026 #FENS-Hertie #WinterSchool and explore this year's topic – Single-cell and Spatial Omics to Understand Brain Heterogeneity! 🔬
📍 Alicante, Spain
🗓️ 11-17 Jan 2026
🔗 https://loom.ly/RM55lFQ
August 12, 2025 at 11:24 AM
Join us at the FENS Single-Cell & Spatial Omics Winter School with:
@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein
@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein
Yay, we built a thing! With @dominik1klein.bsky.social Daniil, Aviv Regev, Barbara Treutlein @graycamplab.bsky.social @fabiantheis.bsky.social we use flow matching to enable generalised sc phenotype modeling. From cytokine screens to fate programming and organoid engineering tinyurl.com/3xhju7db
CellFlow enables generative single-cell phenotype modeling with flow matching
High-content phenotypic screens provide a powerful strategy for studying biological systems, but the scale of possible perturbations and cell states makes exhaustive experiments unfeasible. Computatio...
www.biorxiv.org
April 18, 2025 at 10:19 AM
Yay, we built a thing! With @dominik1klein.bsky.social Daniil, Aviv Regev, Barbara Treutlein @graycamplab.bsky.social @fabiantheis.bsky.social we use flow matching to enable generalised sc phenotype modeling. From cytokine screens to fate programming and organoid engineering tinyurl.com/3xhju7db
🧬 Only one month until the 2nd meeting on early embryogenesis & epigenetics. #Embryo2026
Barbara Treutlein (@ethz.ch) will speak about her work reconstructing human brain development with organoids and single-cell technologies!
More information: www.molgen.mpg.de/embryo2026
Barbara Treutlein (@ethz.ch) will speak about her work reconstructing human brain development with organoids and single-cell technologies!
More information: www.molgen.mpg.de/embryo2026
January 13, 2026 at 2:13 PM
🧬 Only one month until the 2nd meeting on early embryogenesis & epigenetics. #Embryo2026
Barbara Treutlein (@ethz.ch) will speak about her work reconstructing human brain development with organoids and single-cell technologies!
More information: www.molgen.mpg.de/embryo2026
Barbara Treutlein (@ethz.ch) will speak about her work reconstructing human brain development with organoids and single-cell technologies!
More information: www.molgen.mpg.de/embryo2026
Bit late with this, but super happy that our neural organoid atlas is out in Nature! Really fun collab with @zhisonghe.bsky.social and @le-and-er.bsky.social between the Treutlein lab, @fabiantheis.bsky.social and @graycamplab.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An integrated transcriptomic cell atlas of human neural organoids - Nature
A human neural organoid cell atlas integrating 36 single-cell transcriptomic datasets shows cell types and states and estimates transcriptomic similarity between primary and organoid counterparts, sho...
www.nature.com
December 13, 2024 at 2:27 PM
Bit late with this, but super happy that our neural organoid atlas is out in Nature! Really fun collab with @zhisonghe.bsky.social and @le-and-er.bsky.social between the Treutlein lab, @fabiantheis.bsky.social and @graycamplab.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New work from the Treutlein lab & @graycamplab.bsky.social, examining neural organoid response to morphogens 🧪🧠🧫🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Systematic scRNA-seq screens profile neural organoid response to morphogens - Nature Methods
This Resource provides a detailed atlas of morphogen-induced responses in human neural organoids.
www.nature.com
December 18, 2025 at 6:32 PM
New work from the Treutlein lab & @graycamplab.bsky.social, examining neural organoid response to morphogens 🧪🧠🧫🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Congratulations to first authors Lisa Hansen and Mary Couvillion! This was a COVID-era project dreamed up by
Erik Mcshane and me.
And huge thanks to the Treutlein Lab, especially @nazbukina.bsky.social, for the single-cell collaboration!
Erik Mcshane and me.
And huge thanks to the Treutlein Lab, especially @nazbukina.bsky.social, for the single-cell collaboration!
July 28, 2026 at 5:20 PM
Congratulations to first authors Lisa Hansen and Mary Couvillion! This was a COVID-era project dreamed up by
Erik Mcshane and me.
And huge thanks to the Treutlein Lab, especially @nazbukina.bsky.social, for the single-cell collaboration!
Erik Mcshane and me.
And huge thanks to the Treutlein Lab, especially @nazbukina.bsky.social, for the single-cell collaboration!
Systematic scRNA-seq screens profile neural organoid response to morphogens. Collab. with Treutlein Lab! @natmethods.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Systematic scRNA-seq screens profile neural organoid response to morphogens - Nature Methods
This Resource provides a detailed atlas of morphogen-induced responses in human neural organoids.
nature.com
December 17, 2025 at 12:50 AM
Systematic scRNA-seq screens profile neural organoid response to morphogens. Collab. with Treutlein Lab! @natmethods.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An integrated neural organoid atlas helps us all stand on the shoulders of great scientists! Led by Barbara Treutlein and Fabian Theis labs, we explore coverage and fidelity, provide tools to assess new protocols, and use the diverse cohort to assess disease models. www.nature.com/articles/s41...
November 21, 2024 at 4:59 PM
An integrated neural organoid atlas helps us all stand on the shoulders of great scientists! Led by Barbara Treutlein and Fabian Theis labs, we explore coverage and fidelity, provide tools to assess new protocols, and use the diverse cohort to assess disease models. www.nature.com/articles/s41...
Drs. Marina Nikolova, Barbara Treutlein, the @graycamplab.bsky.social, and a team at @ethzurich.bsky.social used multiomic #SingleCell analysis to reconstruct blood vessel organoid development! 🩸
@cellpress.bsky.social paper: bit.ly/3GstKTZ
Discussion: bit.ly/4jWDX9T
@cellpress.bsky.social paper: bit.ly/3GstKTZ
Discussion: bit.ly/4jWDX9T
May 7, 2025 at 3:39 PM
Drs. Marina Nikolova, Barbara Treutlein, the @graycamplab.bsky.social, and a team at @ethzurich.bsky.social used multiomic #SingleCell analysis to reconstruct blood vessel organoid development! 🩸
@cellpress.bsky.social paper: bit.ly/3GstKTZ
Discussion: bit.ly/4jWDX9T
@cellpress.bsky.social paper: bit.ly/3GstKTZ
Discussion: bit.ly/4jWDX9T
See Organoids Organise: Tracking brain organoid development from fluorescent human induced pluripotent stem cells over weeks using live light-sheet microscopy
📹 @akanksha-jain.bsky.social, Gilles Gut et al Treutlein lab
@ethz.ch in @natcomms.nature.com
➡️ bpod.org.uk/archive/2025...
📹 @akanksha-jain.bsky.social, Gilles Gut et al Treutlein lab
@ethz.ch in @natcomms.nature.com
➡️ bpod.org.uk/archive/2025...
June 28, 2025 at 9:50 AM
See Organoids Organise: Tracking brain organoid development from fluorescent human induced pluripotent stem cells over weeks using live light-sheet microscopy
📹 @akanksha-jain.bsky.social, Gilles Gut et al Treutlein lab
@ethz.ch in @natcomms.nature.com
➡️ bpod.org.uk/archive/2025...
📹 @akanksha-jain.bsky.social, Gilles Gut et al Treutlein lab
@ethz.ch in @natcomms.nature.com
➡️ bpod.org.uk/archive/2025...
Join iHOME 2025 (Mar 20–21 in Heidelberg) for cutting-edge organoid research spanning basic to clinical science! One of many highlights is the keynote speaker, Barbara Treutlein, ETH Zurich, discussing using single-cell tech to map organoid development. Register by Feb 28: indico.dkfz.de/event/1249/
February 18, 2025 at 12:01 PM
Join iHOME 2025 (Mar 20–21 in Heidelberg) for cutting-edge organoid research spanning basic to clinical science! One of many highlights is the keynote speaker, Barbara Treutlein, ETH Zurich, discussing using single-cell tech to map organoid development. Register by Feb 28: indico.dkfz.de/event/1249/
@chatgtp.bsky.social, Manuel, A. Regev, B. Treutlein, @graycamplab.bsky.social, @fabiantheis.bsky.social
April 23, 2025 at 9:26 AM
@chatgtp.bsky.social, Manuel, A. Regev, B. Treutlein, @graycamplab.bsky.social, @fabiantheis.bsky.social
5th day for the @institutcurie.bsky.social Dark Genome course, and it is a tasty one! @perielab.bsky.social, Sidney Shaffer and @alejofraticelli.bsky.social in the morning, Yours truly, @arjunraj.bsky.social and Barbara Treutlein in the afternoon! On the menu clonal memory, cell identity and lineage
April 1, 2025 at 5:40 AM
5th day for the @institutcurie.bsky.social Dark Genome course, and it is a tasty one! @perielab.bsky.social, Sidney Shaffer and @alejofraticelli.bsky.social in the morning, Yours truly, @arjunraj.bsky.social and Barbara Treutlein in the afternoon! On the menu clonal memory, cell identity and lineage