#TuftCell
LightNews LightNews
immunoeditor.bsky.social
In the latest #Science #Immunology: researchers @ Tsinghua U report that #ILC3 augment group #ILC2 #anthelmintic immune responses in 🐁! Upon N. braziliensis infection, ILC3-derived #RANKL synergizes w/ #IL13 to facilitate intestinal #TuftCell expansion, which amplifies ILC2 responses!
ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling
Gut ILC3s help type 2 immunity by boosting tuft cell differentiation.
www.science.org
May 23, 2025 at 9:51 AM
immunoeditor.bsky.social
The July issue of #Science #Immunology is out now! This week:

• Additional levels of #IL13RA1 gene regulation help explain susceptibility to #allergy!

• Spi-B is a #checkpoint of #type2 immunity by restraining #TuftCell activation in gut!

New content each week!

www.science.org/toc/sciimmun...
Checkpoint on Type 2 Immunity. Tuft cells play key roles in the initiation and propagation of type 2 immune responses in the gut, but whether they have regulatory machinery for constraining these responses is not known. Wang et al. found that the transcription factor Spi-B prevents excessive type 2 immune responses against helminth infection and food allergens by limiting tuft cell activation and proliferation in the small intestine. Spi-B represses c-Kit signaling in tuft cells, which limits their production of the cytokine TSLP and the subsequent activation of T helper 2 (TH2) cells. This month’s cover image features a tuft cell (dark red) within the epithelial lining of the small intestine in which Spi-B has been inactivated, leading to increased production of TSLP by tuft cells and the cytokine interleukin-13 (IL-13) by TH2 cells (white). Credit: A. Fisher/Science Immunology
July 4, 2025 at 10:34 PM
genesndiseases.bsky.social
The latest review suggests #TuftCell-like signatures as promising #Biomarkers and emphasizes the therapeutic potential of the tuft cell-like–POU2F3 axis in lineage-defined #Cancers. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...
November 27, 2025 at 4:34 PM