“During pregnancy, several organs are rewired to support the health of the mother and the offspring. A molecular signalling pathway called RANK–RANKL drives the expansion of the layer that lines the inside of the intestine during pregnancy and lactation.”
#ReproSky 🧪
www.nature.com/articles/d41...
#ReproSky 🧪
www.nature.com/articles/d41...
Gut lining in pregnant and lactating mice expands to ensure offspring health
The RANK–RANKL pathway promotes intestinal epithelial expansion in pregnancy and lactation to meet increased nutritional demands.
www.nature.com
January 1, 2025 at 11:42 PM
“During pregnancy, several organs are rewired to support the health of the mother and the offspring. A molecular signalling pathway called RANK–RANKL drives the expansion of the layer that lines the inside of the intestine during pregnancy and lactation.”
#ReproSky 🧪
www.nature.com/articles/d41...
#ReproSky 🧪
www.nature.com/articles/d41...
Excited to share our 1st post ! Thrilled to share our latest research in Science Translational Medicine ! @science.org
We show that RANKL administration reverses thymic involution and rejuvenates T cell immunity.
@ciml.bsky.social
#Aging #Thymus #Tcells #Immunology #Involution #Rejuvenation
We show that RANKL administration reverses thymic involution and rejuvenates T cell immunity.
@ciml.bsky.social
#Aging #Thymus #Tcells #Immunology #Involution #Rejuvenation
RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice
RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.
www.science.org
December 6, 2024 at 10:16 AM
Excited to share our 1st post ! Thrilled to share our latest research in Science Translational Medicine ! @science.org
We show that RANKL administration reverses thymic involution and rejuvenates T cell immunity.
@ciml.bsky.social
#Aging #Thymus #Tcells #Immunology #Involution #Rejuvenation
We show that RANKL administration reverses thymic involution and rejuvenates T cell immunity.
@ciml.bsky.social
#Aging #Thymus #Tcells #Immunology #Involution #Rejuvenation
'We then found that, whereas RANKL neutralization in young mice mimicked thymic involution, exogenous RANKL treatment in aged mice restored thymic architecture as well as endothelial cell and epithelial cell abundance and functional properties.'
#Immunology #Immunosky
#Immunology #Immunosky
RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice
RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.
www.science.org
December 7, 2024 at 9:00 PM
'We then found that, whereas RANKL neutralization in young mice mimicked thymic involution, exogenous RANKL treatment in aged mice restored thymic architecture as well as endothelial cell and epithelial cell abundance and functional properties.'
#Immunology #Immunosky
#Immunology #Immunosky
Santamaria et al. show that RANKL treatment can restore #thymus function in aged mice, improving #antitumor and #vaccine responses. Could RANKL be the thymic fountain of youth? www.science.org/doi/10.1126/...
RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice
RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.
www.science.org
December 4, 2024 at 8:05 PM
Santamaria et al. show that RANKL treatment can restore #thymus function in aged mice, improving #antitumor and #vaccine responses. Could RANKL be the thymic fountain of youth? www.science.org/doi/10.1126/...
Rankl o. Rankala... Glasklar
June 4, 2024 at 10:57 AM
Rankl o. Rankala... Glasklar
I sure hope that the Carney gov increases the pay for military rankl/file as part of the commitment! Otherwise going to be hard to recruit!
June 25, 2025 at 11:14 PM
I sure hope that the Carney gov increases the pay for military rankl/file as part of the commitment! Otherwise going to be hard to recruit!
In a new study from Tan, Kergaravat, @petterbrodin.bsky.social et al., longitudinal profiling of 136 newborns shows thymic output peaks at 3–4 mo, correlating with plasma RANKL, lymphotoxin-α, and the TCRD variant rs2204985. rupress.org/jhi/article/...
May 4, 2026 at 4:30 PM
In a new study from Tan, Kergaravat, @petterbrodin.bsky.social et al., longitudinal profiling of 136 newborns shows thymic output peaks at 3–4 mo, correlating with plasma RANKL, lymphotoxin-α, and the TCRD variant rs2204985. rupress.org/jhi/article/...
Excited to share my latest paper, published today at @natureportfolio.bsky.social ! A big thank you to all our collaborators.
The paper shows how RANK drives intestinal epithelial expansion during reproduction.
#intestine #stemcells #pregnancy
www.nature.com/articles/s41...
The paper shows how RANK drives intestinal epithelial expansion during reproduction.
#intestine #stemcells #pregnancy
www.nature.com/articles/s41...
RANK drives structured intestinal epithelial expansion during pregnancy - Nature
The RANK–RANKL pathway drives intestinal epithelial expansion in pregnancy and lactation.
www.nature.com
December 4, 2024 at 5:12 PM
Excited to share my latest paper, published today at @natureportfolio.bsky.social ! A big thank you to all our collaborators.
The paper shows how RANK drives intestinal epithelial expansion during reproduction.
#intestine #stemcells #pregnancy
www.nature.com/articles/s41...
The paper shows how RANK drives intestinal epithelial expansion during reproduction.
#intestine #stemcells #pregnancy
www.nature.com/articles/s41...
Revitalizing the Human Immune System by Using RANKL - Thailand Medical News
www.thailandmedical.news
January 18, 2025 at 3:20 AM
Epigenetics-focused CRISPR screening for novel genes in #SmoothMuscleCell #Calcification
Human Epigenetic Knockout Library 2509 genes @Addgene 162256
Sorted RANKL+/Calcified vs RANKL-/Non-Calcified SMCs +high-Piz
122⏫vs 116⏬
#JASN 2025
journals.lww.com/jasn/abstrac...
Human Epigenetic Knockout Library 2509 genes @Addgene 162256
Sorted RANKL+/Calcified vs RANKL-/Non-Calcified SMCs +high-Piz
122⏫vs 116⏬
#JASN 2025
journals.lww.com/jasn/abstrac...
July 22, 2025 at 1:24 PM
Epigenetics-focused CRISPR screening for novel genes in #SmoothMuscleCell #Calcification
Human Epigenetic Knockout Library 2509 genes @Addgene 162256
Sorted RANKL+/Calcified vs RANKL-/Non-Calcified SMCs +high-Piz
122⏫vs 116⏬
#JASN 2025
journals.lww.com/jasn/abstrac...
Human Epigenetic Knockout Library 2509 genes @Addgene 162256
Sorted RANKL+/Calcified vs RANKL-/Non-Calcified SMCs +high-Piz
122⏫vs 116⏬
#JASN 2025
journals.lww.com/jasn/abstrac...
Glia!? We work on glia now?
Awesome work by @anavivinetto.bsky.social modulating conserved mechanisms of wound healing in the spinal cord. But please, take the astrocytes with you to your own lab.
urldefense.com/v3/__http://...
Awesome work by @anavivinetto.bsky.social modulating conserved mechanisms of wound healing in the spinal cord. But please, take the astrocytes with you to your own lab.
urldefense.com/v3/__http://...
Acute Extrinsic Activation of the RANKL Pathway Decreases Wound Healing and Functional Recovery After Spinal Cord Injury in Mice
Acute, intrathecal delivery of RANK ligand (RANKL) negatively impacts wound healing after spinal cord injury. Intrathecal RANKL disrupts tissue remodeling, locomotor recovery, and alters reactive...
urldefense.com
January 20, 2025 at 3:22 PM
Glia!? We work on glia now?
Awesome work by @anavivinetto.bsky.social modulating conserved mechanisms of wound healing in the spinal cord. But please, take the astrocytes with you to your own lab.
urldefense.com/v3/__http://...
Awesome work by @anavivinetto.bsky.social modulating conserved mechanisms of wound healing in the spinal cord. But please, take the astrocytes with you to your own lab.
urldefense.com/v3/__http://...
wow ich HASSE jeden vorgeschlagenen ausdruck dafür
June 4, 2024 at 10:50 AM
wow ich HASSE jeden vorgeschlagenen ausdruck dafür
Reseña de Assault: Silicy’43 – Gela Beachhead
@assaultgames.bsky.social
@soundofdrumsgames.bsky.social
#wargames #tacticalwargames eldesafiodelasaguilas.wordpress.com/2025/07/15/r...
@assaultgames.bsky.social
@soundofdrumsgames.bsky.social
#wargames #tacticalwargames eldesafiodelasaguilas.wordpress.com/2025/07/15/r...
Reseña de Assault: Silicy’43 – Gela Beachhead (Sound of Drums, 2025)
Reseña del juego Assault: Silicy’43 – Gela Beachhead, de Wolfgang Klein y Erich Rankl (Sound of Drums, 2025)
eldesafiodelasaguilas.wordpress.com
July 15, 2025 at 4:48 PM
Reseña de Assault: Silicy’43 – Gela Beachhead
@assaultgames.bsky.social
@soundofdrumsgames.bsky.social
#wargames #tacticalwargames eldesafiodelasaguilas.wordpress.com/2025/07/15/r...
@assaultgames.bsky.social
@soundofdrumsgames.bsky.social
#wargames #tacticalwargames eldesafiodelasaguilas.wordpress.com/2025/07/15/r...
Crazy hot stuff by Magali Irla @ciml.bsky.social - RANKL treatment reverts thymic involution and boosts T cell function in aged mice
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice
RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.
www.science.org
December 5, 2024 at 2:24 PM
Crazy hot stuff by Magali Irla @ciml.bsky.social - RANKL treatment reverts thymic involution and boosts T cell function in aged mice
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@irlalab.bsky.social and collaborators reveals that RANKL therapy reverses age-related thymic decline, recovering immune health in older adults by restoring youthful T-cell responses to vaccines and tumors. Check their study in
Science Translational Medicine. www.science.org/doi/10.1126/...
.
Science Translational Medicine. www.science.org/doi/10.1126/...
.
RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice
RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.
www.science.org
December 13, 2024 at 3:52 PM
@irlalab.bsky.social and collaborators reveals that RANKL therapy reverses age-related thymic decline, recovering immune health in older adults by restoring youthful T-cell responses to vaccines and tumors. Check their study in
Science Translational Medicine. www.science.org/doi/10.1126/...
.
Science Translational Medicine. www.science.org/doi/10.1126/...
.
Rankl was entertaining this morning. In case anyone is interested in an online challenge that’s often quite irritating.
July 24, 2026 at 7:41 AM
Rankl was entertaining this morning. In case anyone is interested in an online challenge that’s often quite irritating.
Not so easy; anti-RANKL (denosumab) is a treatment for osteoporosis: would administration of RANKL cause bone resorption and osteoporosis?
December 4, 2024 at 9:45 PM
Not so easy; anti-RANKL (denosumab) is a treatment for osteoporosis: would administration of RANKL cause bone resorption and osteoporosis?
radentscheid.infreising.de/zwischenbila...
Die Halbzeitbilanz des Radentscheid Freising zur Mitte der fünfjährigen Laufzeit ist zur Zeit im Schaufenster des Friseurgeschäfts von Tommi Rankl in der Ziegelgasse ausgestellt.
#radentscheidfreising
#tommirankl
Die Halbzeitbilanz des Radentscheid Freising zur Mitte der fünfjährigen Laufzeit ist zur Zeit im Schaufenster des Friseurgeschäfts von Tommi Rankl in der Ziegelgasse ausgestellt.
#radentscheidfreising
#tommirankl
Zwischenbilanz im Schaufenster von Tommi Rankl - Radentscheid Freising
Zwischenbilanz Im Schaufenster von Tommi Rankl Die Halbzeitbilanzdes im Frühjahr 2022 geschlossenen Vertrags der Stadt Freising mit dem Radentscheid Freising bei der sowohl ERREICHTE als auch noch AUS...
radentscheid.infreising.de
September 25, 2024 at 5:36 AM
radentscheid.infreising.de/zwischenbila...
Die Halbzeitbilanz des Radentscheid Freising zur Mitte der fünfjährigen Laufzeit ist zur Zeit im Schaufenster des Friseurgeschäfts von Tommi Rankl in der Ziegelgasse ausgestellt.
#radentscheidfreising
#tommirankl
Die Halbzeitbilanz des Radentscheid Freising zur Mitte der fünfjährigen Laufzeit ist zur Zeit im Schaufenster des Friseurgeschäfts von Tommi Rankl in der Ziegelgasse ausgestellt.
#radentscheidfreising
#tommirankl
This looks potentially very cool www.nature.com/articles/s41...
RANK drives structured intestinal epithelial expansion during pregnancy - Nature
The RANK–RANKL pathway drives intestinal epithelial expansion in pregnancy and lactation.
www.nature.com
December 4, 2024 at 4:32 PM
This looks potentially very cool www.nature.com/articles/s41...
In the latest #Science #Immunology: researchers @ Tsinghua U report that #ILC3 augment group #ILC2 #anthelmintic immune responses in 🐁! Upon N. braziliensis infection, ILC3-derived #RANKL synergizes w/ #IL13 to facilitate intestinal #TuftCell expansion, which amplifies ILC2 responses!
ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling
Gut ILC3s help type 2 immunity by boosting tuft cell differentiation.
www.science.org
May 23, 2025 at 9:51 AM
In the latest #Science #Immunology: researchers @ Tsinghua U report that #ILC3 augment group #ILC2 #anthelmintic immune responses in 🐁! Upon N. braziliensis infection, ILC3-derived #RANKL synergizes w/ #IL13 to facilitate intestinal #TuftCell expansion, which amplifies ILC2 responses!
and now explored in mice, see also www.nature.com/articles/s41...
RANK drives structured intestinal epithelial expansion during pregnancy - Nature
The RANK–RANKL pathway drives intestinal epithelial expansion in pregnancy and lactation.
www.nature.com
March 19, 2025 at 5:39 PM
and now explored in mice, see also www.nature.com/articles/s41...
We found that RANK-RANKL signaling promotes the survival of the gut epithelia and controls the stem cell niche by increasing BMP receptor signaling, resulting in the elongation of villi.
December 4, 2024 at 5:16 PM
We found that RANK-RANKL signaling promotes the survival of the gut epithelia and controls the stem cell niche by increasing BMP receptor signaling, resulting in the elongation of villi.
On December 5, @helmholtzhzi.bsky.social Director Josef Penninger will give a lecture at the HIRI. His talk, supported by Physico-Medica Würzburg, is titled: “RANKL – Bones, Sex, and Mammalian Evolution.” More at: www.helmholtz-hiri.de/en/events/ev...
December 2, 2024 at 4:43 PM
On December 5, @helmholtzhzi.bsky.social Director Josef Penninger will give a lecture at the HIRI. His talk, supported by Physico-Medica Würzburg, is titled: “RANKL – Bones, Sex, and Mammalian Evolution.” More at: www.helmholtz-hiri.de/en/events/ev...