Nature Communications - The relationship between pancreatic β-cell dysfunction and autoinflammation in T2DM is unclear. Here, the authors show the key role of a UCP2/mtDNA/STING axis in the...

Pancreatic β-cell dysfunction and mass loss are core pathologies of type 2 diabetes mellitus (T2DM), which are closely related to intense autoinflammation. However, the molecular mechanisms regulating β-cell autoinflammation remain unclear. Here, we show that STING is significantly elevated in T2DM β cells. We also clarify the key role of uncoupling protein 2 (UCP2), and reveal that interleukin-1β (IL-1β) drives β cells to produce autoinflammation through the UCP2/mtDNA/STING axis in T2DM. To inhibit UCP2 activity in vivo, we design a tailored nanomedicine, Mito-G, with sequential targeting from islets to β-cell mitochondria. Mito-G is a negatively charged ultra-small nanomedicine synthesized by polymerization of genipin (a potent UCP2 inhibitor) and glycine. It can specifically reach β cells and have a natural mitochondrial targeting. In this work, Mito-G effectively eliminates β-cell auto-inflammation by specifically inhibiting β-cell UCP2 activity in vivo, providing a paradigm for t

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In a groundbreaking study set to redefine therapeutic strategies for type 2 diabetes mellitus (T2DM), researchers have unveiled a novel approach that targets pancreatic β cell autoinflammation through precise mitochondrial intervention. The innovative work, published in Nature Communications, introduces islet-mitochondrial sequential targeting nanomedicines to inhibit Uncoupling Protein 2 (UCP2), a pivotal player in the metabolic dysfunction and inflammatory processes underlying β cell deterioration in T2DM.

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Enavermotide (UCP2) is a synthetic immunological agent developed for active immunization strategies in oncology research. It functions as a tumor-associated peptide, enabling laboratories to investigate immune activation against malignant cells. Supplied in GMP-grade quality, Enavermotide is ideal for research on cancer immunotherapy, vaccine design, and antineoplastic mechanisms. Available for wholesale and retail supply. For laboratory research use only.