November 5, 2026 at 6:13 PM
VCAM1 + niacin
www.nature.com/articles/s41...
VCAM1 + Parkinsons
link.springer.com/article/10.1...
niacin + atopic dermatitis
www.ncbi.nlm.nih.gov/pmc/articles...
VCAM1 + atopic dermatitis
onlinelibrary.wiley.com/doi/abs/10.1...
PD + atopic dermatitis
onlinelibrary.wiley.com/doi/abs/10.1...
www.nature.com/articles/s41...
VCAM1 + Parkinsons
link.springer.com/article/10.1...
niacin + atopic dermatitis
www.ncbi.nlm.nih.gov/pmc/articles...
VCAM1 + atopic dermatitis
onlinelibrary.wiley.com/doi/abs/10.1...
PD + atopic dermatitis
onlinelibrary.wiley.com/doi/abs/10.1...
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk - Nature Medicine
Following the observation that higher circulating levels of metabolites derived from niacin—an essential micronutrient that is fortified in cereals—are associated with a higher risk for cardiovascular...
www.nature.com
November 3, 2026 at 11:45 PM
VCAM1 + niacin
www.nature.com/articles/s41...
VCAM1 + Parkinsons
link.springer.com/article/10.1...
niacin + atopic dermatitis
www.ncbi.nlm.nih.gov/pmc/articles...
VCAM1 + atopic dermatitis
onlinelibrary.wiley.com/doi/abs/10.1...
PD + atopic dermatitis
onlinelibrary.wiley.com/doi/abs/10.1...
www.nature.com/articles/s41...
VCAM1 + Parkinsons
link.springer.com/article/10.1...
niacin + atopic dermatitis
www.ncbi.nlm.nih.gov/pmc/articles...
VCAM1 + atopic dermatitis
onlinelibrary.wiley.com/doi/abs/10.1...
PD + atopic dermatitis
onlinelibrary.wiley.com/doi/abs/10.1...
The association of vitamin C and vitamin D status on bone mineral density and VCAM-1 levels in female diabetic subjects ... [2023]
www.sciencedirect.com/science/arti...
#VCAM1 #BoneHealth #health #VitaminD #VitaminC #diabetes #inflammation #T2D
www.sciencedirect.com/science/arti...
#VCAM1 #BoneHealth #health #VitaminD #VitaminC #diabetes #inflammation #T2D
The association of vitamin C and vitamin D status on bone mineral density and VCAM-1 levels in female diabetic subjects: Is combined supplementation with vitamin C and vitamin D potentially more successful in improving bone health than supplementation with vitamin D alone?
Bone mineral density (BMD), which is used to assess bone health, is often diminished in chronic disease states, such as diabetes, which increases the …
www.sciencedirect.com
November 5, 2026 at 6:13 PM
The association of vitamin C and vitamin D status on bone mineral density and VCAM-1 levels in female diabetic subjects ... [2023]
www.sciencedirect.com/science/arti...
#VCAM1 #BoneHealth #health #VitaminD #VitaminC #diabetes #inflammation #T2D
www.sciencedirect.com/science/arti...
#VCAM1 #BoneHealth #health #VitaminD #VitaminC #diabetes #inflammation #T2D
Excited to share our new paper published today in the journal Development!
Vcam1 in endothelial and stromal cells regulates hematopoietic stem cell contact with the niche journals.biologists.com/dev/article-...
Vcam1 in endothelial and stromal cells regulates hematopoietic stem cell contact with the niche journals.biologists.com/dev/article-...
October 20, 2026 at 4:48 PM
Excited to share our new paper published today in the journal Development!
Vcam1 in endothelial and stromal cells regulates hematopoietic stem cell contact with the niche journals.biologists.com/dev/article-...
Vcam1 in endothelial and stromal cells regulates hematopoietic stem cell contact with the niche journals.biologists.com/dev/article-...
3/ VCAM1+ injured proximal tubule cells are enriched 6.5-fold in AIN compared with acute tubular injury. They aren’t passive bystanders — they produce complement (C3, C4A, C4B, CFB), and C3AR1+ macrophages sit directly against them.
August 27, 2026 at 9:48 PM
3/ VCAM1+ injured proximal tubule cells are enriched 6.5-fold in AIN compared with acute tubular injury. They aren’t passive bystanders — they produce complement (C3, C4A, C4B, CFB), and C3AR1+ macrophages sit directly against them.
🩸 Exploring blood biomarkers for genetic FTD: A multiplex CNS panel reveals distinct plasma proteomic signatures, identifying unique alterations like elevated GFAP and VCAM1 in GRN-FTD, and reduced NPTXR in C9orf72-FTD.
📚 onlinelibrary.wiley.com/doi/10.1111/...
@ean.org #WileyNeuro
📚 onlinelibrary.wiley.com/doi/10.1111/...
@ean.org #WileyNeuro
August 18, 2026 at 3:01 PM
🩸 Exploring blood biomarkers for genetic FTD: A multiplex CNS panel reveals distinct plasma proteomic signatures, identifying unique alterations like elevated GFAP and VCAM1 in GRN-FTD, and reduced NPTXR in C9orf72-FTD.
📚 onlinelibrary.wiley.com/doi/10.1111/...
@ean.org #WileyNeuro
📚 onlinelibrary.wiley.com/doi/10.1111/...
@ean.org #WileyNeuro
Single-cell and multi-omic analyses reveal a mito_lysis-like malignant program and a TNFRSF12A-MAP3K14-VCAM1 inflammatory remodeling axis in clear cell renal cell carcinoma #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-9923937/latest
https://www.researchsquare.com/article/rs-9923937/latest
June 25, 2026 at 4:00 PM
Single-cell and multi-omic analyses reveal a mito_lysis-like malignant program and a TNFRSF12A-MAP3K14-VCAM1 inflammatory remodeling axis in clear cell renal cell carcinoma #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-9923937/latest
https://www.researchsquare.com/article/rs-9923937/latest
www.sciencedirect.com/science/arti...
📖 Integrative spatial multiomics analysis reveals regulatory mechanisms of VCAM1+ proximal tubule cells in #lupus nephritis
“We identified VCAM1-expressing proximal tubule cells as components of an LN-specific inflammatory niche localised in the kidney cortex.“
📖 Integrative spatial multiomics analysis reveals regulatory mechanisms of VCAM1+ proximal tubule cells in #lupus nephritis
“We identified VCAM1-expressing proximal tubule cells as components of an LN-specific inflammatory niche localised in the kidney cortex.“
Integrative spatial multiomics analysis reveals regulatory mechanisms of VCAM1+ proximal tubule cells in lupus nephritis
Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE), characterised by kidney inflammation, tubular injury, and interst…
www.sciencedirect.com
September 22, 2025 at 1:20 PM
www.sciencedirect.com/science/arti...
📖 Integrative spatial multiomics analysis reveals regulatory mechanisms of VCAM1+ proximal tubule cells in #lupus nephritis
“We identified VCAM1-expressing proximal tubule cells as components of an LN-specific inflammatory niche localised in the kidney cortex.“
📖 Integrative spatial multiomics analysis reveals regulatory mechanisms of VCAM1+ proximal tubule cells in #lupus nephritis
“We identified VCAM1-expressing proximal tubule cells as components of an LN-specific inflammatory niche localised in the kidney cortex.“
Professor Joanne S. Richards is uncovering the ovary's secrets, shedding light on fertility, hormone regulation, and ovarian health! doi.org/10.1093/biol... Read more: www.scientia.global/professor-jo... #MedicalResearch #Science
Targeted deletion of NR2F2 and VCAM1 in theca cells impacts ovarian follicular development: insights into polycystic ovary syndrome?†
Abstract. Defining features of polycystic ovary syndrome (PCOS) include elevated expression of steroidogenic genes, theca cell androgen biosynthesis, and p
doi.org
February 6, 2025 at 11:05 AM
Professor Joanne S. Richards is uncovering the ovary's secrets, shedding light on fertility, hormone regulation, and ovarian health! doi.org/10.1093/biol... Read more: www.scientia.global/professor-jo... #MedicalResearch #Science
can impair clearance of amyloid-beta (Aβ) peptides and cerebral metabolites, mechanisms central to AD pathology
- BBB disruption is linked to increased expression of VCAM1, a biomarker of AD and dementia severity, which is elevated in severe COVID and decreases during recovery
- BBB disruption is linked to increased expression of VCAM1, a biomarker of AD and dementia severity, which is elevated in severe COVID and decreases during recovery
January 25, 2026 at 7:22 AM
can impair clearance of amyloid-beta (Aβ) peptides and cerebral metabolites, mechanisms central to AD pathology
- BBB disruption is linked to increased expression of VCAM1, a biomarker of AD and dementia severity, which is elevated in severe COVID and decreases during recovery
- BBB disruption is linked to increased expression of VCAM1, a biomarker of AD and dementia severity, which is elevated in severe COVID and decreases during recovery
- Stimulating endothelial cells to produce adhesion molecules like VCAM1, promoting immune cell accumulation in 🫁 .
- Increasing neutrophil binding to BV walls.
- Disrupting vascular integrity by weakening intercellular junctions.
- Increasing neutrophil binding to BV walls.
- Disrupting vascular integrity by weakening intercellular junctions.
July 30, 2025 at 12:19 PM
- Stimulating endothelial cells to produce adhesion molecules like VCAM1, promoting immune cell accumulation in 🫁 .
- Increasing neutrophil binding to BV walls.
- Disrupting vascular integrity by weakening intercellular junctions.
- Increasing neutrophil binding to BV walls.
- Disrupting vascular integrity by weakening intercellular junctions.
➡️ Die Nature Aging Studie 2022, in der Alterungsmerkmale zudem über eine Hauptkomponente zusammengefasst wurden, um den gemeinsamen genetischen Kern von Lebenslänge und Gesundheitszustand besser zu isolieren und damit die Teststärke zu erhöhen.
nature.com/articles/s43... 3/3
nature.com/articles/s43... 3/3
Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging - Nature Aging
Many aging-related phenotypes share a common genetic component, but to disentangle disease-specific variants from aging-specific ones has been challenging. Here Timmers et al. combined several genetic...
nature.com
December 22, 2025 at 10:47 PM
➡️ Die Nature Aging Studie 2022, in der Alterungsmerkmale zudem über eine Hauptkomponente zusammengefasst wurden, um den gemeinsamen genetischen Kern von Lebenslänge und Gesundheitszustand besser zu isolieren und damit die Teststärke zu erhöhen.
nature.com/articles/s43... 3/3
nature.com/articles/s43... 3/3
➡️ Die Nature Aging Studie 2022, in der Alterungsmerkmale zudem über eine Hauptkomponente zusammengefasst wurden, um den gemeinsamen genetischen Kern von Lebenslänge und Gesundheitszustand besser zu isolieren und damit die Teststärke zu erhöhen.
nature.com/articles/s43... 3/3
nature.com/articles/s43... 3/3
Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging - Nature Aging
Many aging-related phenotypes share a common genetic component, but to disentangle disease-specific variants from aging-specific ones has been challenging. Here Timmers et al. combined several genetic...
nature.com
December 22, 2025 at 10:45 PM
➡️ Die Nature Aging Studie 2022, in der Alterungsmerkmale zudem über eine Hauptkomponente zusammengefasst wurden, um den gemeinsamen genetischen Kern von Lebenslänge und Gesundheitszustand besser zu isolieren und damit die Teststärke zu erhöhen.
nature.com/articles/s43... 3/3
nature.com/articles/s43... 3/3
The talents of humanity are unending: Researchers created nanoparticles that deliver mRNA instructions specifically to inflamed blood vessel cells. This restored protective genes, showing promise in mouse models for treating ARDS & atherosclerosis. Wow.
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
April 3, 2025 at 10:08 PM
The talents of humanity are unending: Researchers created nanoparticles that deliver mRNA instructions specifically to inflamed blood vessel cells. This restored protective genes, showing promise in mouse models for treating ARDS & atherosclerosis. Wow.
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
Vcam1+ Fibro-adipogenic Progenitors Mark Fatty Infiltration in Chronic Limb Threatening Ischemia https://www.biorxiv.org/content/10.1101/2024.07.08.602430v1
Vcam1+ Fibro-adipogenic Progenitors Mark Fatty Infiltration in Chronic Limb Threatening Ischemia https://www.biorxiv.org/content/10.1101/2024.07.08.602430v1
Skeletal muscle health and function is a critical determinant of clinical outcomes in patients with
www.biorxiv.org
July 12, 2024 at 12:35 AM
Vcam1+ Fibro-adipogenic Progenitors Mark Fatty Infiltration in Chronic Limb Threatening Ischemia https://www.biorxiv.org/content/10.1101/2024.07.08.602430v1
タイトル: (2R,6R)-HNKはVcam1/Caspase-1/IL-1β経路を抑制することでLPS誘発性うつ病様行動を改善した
要点1: (2R,6R)-HNKはNLRP3、caspase-1、GSDMD、IL-1βの発現を抑制し、神経損傷が軽減された。
要点2: Vcam1遺伝子の発現を下げることで、(2R,6R)-HNKは神経ピロプトーシスと神経炎症を抑制し、うつ病様行動を改善した。
要点1: (2R,6R)-HNKはNLRP3、caspase-1、GSDMD、IL-1βの発現を抑制し、神経損傷が軽減された。
要点2: Vcam1遺伝子の発現を下げることで、(2R,6R)-HNKは神経ピロプトーシスと神経炎症を抑制し、うつ病様行動を改善した。
(2R,6R)-HNK improved LPS-induced depression-like behavior by inhibiting Vcam1/Caspase-1/IL-1β pathway.
【Int Immunopharmacol】<AbstractText>Depression-like behavior is closely associated with neuroinflammation. Lipopolysaccharide (L...
pubmed.ncbi.nlm.nih.gov
May 23, 2026 at 11:49 AM
タイトル: (2R,6R)-HNKはVcam1/Caspase-1/IL-1β経路を抑制することでLPS誘発性うつ病様行動を改善した
要点1: (2R,6R)-HNKはNLRP3、caspase-1、GSDMD、IL-1βの発現を抑制し、神経損傷が軽減された。
要点2: Vcam1遺伝子の発現を下げることで、(2R,6R)-HNKは神経ピロプトーシスと神経炎症を抑制し、うつ病様行動を改善した。
要点1: (2R,6R)-HNKはNLRP3、caspase-1、GSDMD、IL-1βの発現を抑制し、神経損傷が軽減された。
要点2: Vcam1遺伝子の発現を下げることで、(2R,6R)-HNKは神経ピロプトーシスと神経炎症を抑制し、うつ病様行動を改善した。
Four inflammatory markers tracked with kidney function decline in patients at 12+ months post-infection.
IL-6 rose progressively with lower kidney function. IL-17, IL-10, and VCAM-1 were markedly elevated in severe decline (<30 eGFR) in Italian obs study. #LongCovid
IL-6 rose progressively with lower kidney function. IL-17, IL-10, and VCAM-1 were markedly elevated in severe decline (<30 eGFR) in Italian obs study. #LongCovid
Inflammatory biomarkers in the assessment of kidney function decline in Long Covid syndrome - PubMed
According to our results, IL-6, IL-17, IL-10 and VCAM1 constitute a biomarker signature associated with poorer renal prognosis in LC patients. The rise in IL-6 could drive the increase in IL-17, IL-10 and VCAM1 rise, contributing to kidney function decline. These findings may help establish a clinic …
pubmed.ncbi.nlm.nih.gov
June 8, 2026 at 6:16 AM
Four inflammatory markers tracked with kidney function decline in patients at 12+ months post-infection.
IL-6 rose progressively with lower kidney function. IL-17, IL-10, and VCAM-1 were markedly elevated in severe decline (<30 eGFR) in Italian obs study. #LongCovid
IL-6 rose progressively with lower kidney function. IL-17, IL-10, and VCAM-1 were markedly elevated in severe decline (<30 eGFR) in Italian obs study. #LongCovid
New preprint from our lab! We integrate proteomics-informed candidate selection with targeted spatial transcriptomics and protein-level validation to identify astrocytic VCAM1 as a novel regulator of hippocampal synapses.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
March 19, 2026 at 8:28 AM
New preprint from our lab! We integrate proteomics-informed candidate selection with targeted spatial transcriptomics and protein-level validation to identify astrocytic VCAM1 as a novel regulator of hippocampal synapses.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
It became apparent that PTBP1, a splice factor we had identified as critical for EC activation through in vitro CRISPR KO screens, and in vivo in atherogenesis (www.pnas.org/doi/10.1073/...) was linked to CAV EC dysfunction, but lacked mechanistic insight.
Splice factor polypyrimidine tract-binding protein 1 (Ptbp1) primes endothelial inflammation in atherogenic disturbed flow conditions | PNAS
NF-κB–mediated endothelial activation drives leukocyte recruitment and atherosclerosis,
in part through adhesion molecules Icam1 and Vcam1. The end...
www.pnas.org
February 20, 2026 at 3:58 PM
It became apparent that PTBP1, a splice factor we had identified as critical for EC activation through in vitro CRISPR KO screens, and in vivo in atherogenesis (www.pnas.org/doi/10.1073/...) was linked to CAV EC dysfunction, but lacked mechanistic insight.
'Here, we show that a specialized population of VCAM1+CD163+CCR3+ macrophages, normally essential for erythropoiesis by transporting iron to erythroblasts, are highly enriched in the bone metastatic niche in mouse models. Tumor cells hijack these macrophages for iron supply'
Tumors hijack macrophages for iron supply to promote bone metastasis and anemia
Tumor cells mimic erythroblasts by hijacking a specialized macrophage population for
iron supply, thereby promoting metastasis through enhanced adaptation to hypoxia and
contributing to anemia by impa...
www.cell.com
November 18, 2025 at 5:59 PM
'Here, we show that a specialized population of VCAM1+CD163+CCR3+ macrophages, normally essential for erythropoiesis by transporting iron to erythroblasts, are highly enriched in the bone metastatic niche in mouse models. Tumor cells hijack these macrophages for iron supply'
University of Campania 78 Long COVID patients found falling kidney filtration tracked with higher IL-6, IL-17, IL-10 and VCAM1, a signal of inflammation and blood vessel stress tied to poorer renal outlook.
karger.com/kbr/article/...
karger.com/kbr/article/...
Inflammatory biomarkers in the assessment of kidney function decline in Long Covid syndrome
Abstract. Introduction: Long Covid (LC) is an inflammatory condition, affecting multiple organs, including kidneys. This study aims to identify a signature of inflammatory biomarkers that can predict,...
karger.com
June 6, 2026 at 4:03 PM
University of Campania 78 Long COVID patients found falling kidney filtration tracked with higher IL-6, IL-17, IL-10 and VCAM1, a signal of inflammation and blood vessel stress tied to poorer renal outlook.
karger.com/kbr/article/...
karger.com/kbr/article/...
RRIDs were included in this None paper. Thanks for making your methods matter! #OpenScience #ReproducibleResearch #methodsmatter
Vcam1 in endothelial and stromal cells regulates hematopoietic stem cell contact with the niche
doi.org
September 10, 2025 at 7:00 AM
RRIDs were included in this None paper. Thanks for making your methods matter! #OpenScience #ReproducibleResearch #methodsmatter
Check out our new preprint titled, "Vcam1 in endothelial and stromal cells regulates hematopoietic stem cell contact with the niche"! www.biorxiv.org/content/10.1...
Vcam1 in endothelial and stromal cells regulates hematopoietic stem cell contact with the niche
Hematopoietic stem and progenitor cells (HSPCs) are essential for differentiation into all blood cell types. In mammals, the interaction between HSPCs and the fetal liver niche during development is c...
www.biorxiv.org
September 4, 2025 at 8:56 PM
Check out our new preprint titled, "Vcam1 in endothelial and stromal cells regulates hematopoietic stem cell contact with the niche"! www.biorxiv.org/content/10.1...
This is a fabulous paper by Dr. Kristy Zera in my lab. She shows how critical the interaction between VCAM1 on endothelium & VLA4 on immune cells is late after stroke. Blocking either prevents post-stroke cognitive decline & drives mature vessel formation, including pericytes and normal BBB function
Blockade of VCAM1 or VLA4 preserves cerebrovasculature and prevents cognitive decline late after stroke https://www.biorxiv.org/content/10.1101/2025.06.25.661593v1
June 30, 2025 at 4:47 AM
This is a fabulous paper by Dr. Kristy Zera in my lab. She shows how critical the interaction between VCAM1 on endothelium & VLA4 on immune cells is late after stroke. Blocking either prevents post-stroke cognitive decline & drives mature vessel formation, including pericytes and normal BBB function
Great talks at our recent seminar! Featuring:
Kristy Zera - Blocking the VLA4/VCAM1 axis prevents infarct-induced neurodegeneration by reducing neuroinflammation & promoting vascular integrity
Carla Shatz - Convergence of signals for pruning at a synaptic receptor implicated in Alzheimer's Disease
Kristy Zera - Blocking the VLA4/VCAM1 axis prevents infarct-induced neurodegeneration by reducing neuroinflammation & promoting vascular integrity
Carla Shatz - Convergence of signals for pruning at a synaptic receptor implicated in Alzheimer's Disease
October 8, 2025 at 6:46 PM
Great talks at our recent seminar! Featuring:
Kristy Zera - Blocking the VLA4/VCAM1 axis prevents infarct-induced neurodegeneration by reducing neuroinflammation & promoting vascular integrity
Carla Shatz - Convergence of signals for pruning at a synaptic receptor implicated in Alzheimer's Disease
Kristy Zera - Blocking the VLA4/VCAM1 axis prevents infarct-induced neurodegeneration by reducing neuroinflammation & promoting vascular integrity
Carla Shatz - Convergence of signals for pruning at a synaptic receptor implicated in Alzheimer's Disease