Online now - the Spotlight "From disorder to order: cryo-EM reveals RNA-dependent remodeling of #NipahVirus polymerase" from ‪‪@rupeshjayachandran.bsky.social‬ and @maxrenner.bsky.social‬.

#ViralPolymerase #RdRP #ViralReplication

Read it here: authors.elsevier.com/sd/article/S...

Exciting days at the Italian Society for Virology Congress in Turin🇮🇹 to talk about the new frontiers in #viralreplication factory biology. 🔬Inspiring to exchange ideas and build new collaborations with talented early-career virologists 🦠 #SIVISV2025

🦠 Virus arrives with instructions. Cell ends up manufacturing more viruses. Rude. 😂

What does the invader bring, and what does it steal from the host?

sciencescandal.com/scandals/cel...

#StayCurious #Viruses #ViralReplication #Microbiology

#MedSky🧪#IDsky #ImmunoSky Historically, strategies to combat #influenza 🦠 have focused on preventing or reducing #viralreplication. The mechanism for targeting influenza disease that is decoupled from 🦠 replication by harnessing an anti-inflammatory IgG-FcγR signaling pathway.

Pp1ab is a large non-structural protein in #SARSCoV2, crucial for #viralreplication & transcription. It is unique to #SARSCoV2 & not found in uninfected human cells. After being translated from the #viralRNA, Pp1ab is cleaved into 16 nonstructural proteins (nsps)

#MedSky🧪 #IDSky #Drugdevelopment interesting study on An oral non-covalent non-peptidic inhibitor of #SARSCoV2 #Mpro ameliorates #viralreplication & pathogenesis in vivo
www.cell.com/cell-reports...

study shows that lower and upper respiratory tract infection can lead to systemic #viralreplication, 🦠 shedding & pneumonia with varying degrees of disease outcome In contrast, orogastric exposure led to virus infection, reduced 🦠 shedding & subclinical disease

Researchers identify glucosidase alpha, neutral C (GANC) as a host factor in #H7N9; rare variants reduce #ViralReplication, while GANC knockdown limits #InfluenzaA via proteasome‑dependent #hemagglutinin degradation.

#OpenAccess in #STTT: doi.org/10.1038/s413...

New publication: Ixodes ricinus as potential vector for #Usutuvirus, by @ReinaSikkema @HenkvanderJeugd and others. #ticks #mosquitoes #birds #onehealth #viralreplication
https://doi.org/10.1371/journal.pntd.0012172

While people with well-controlled #HIV on effective antiretroviral therapy (ART) generally 🦠 effectively, advanced immunodeficiency can lead to prolonged #viralreplication, shedding, & evolution. This creates a favourable environment for the generation of novel, potentially drug-resistant variants.

As further experiments revealed that they also help redirect carbon flux towards #nucleotidesynthesis, ultimately fuelling #viralreplication.
Viral folate genes are often thought to aid in cofactor biosynthesis. Folate is also used for de novo nucleotide biosynthesis

#IDSky #ImmunoSky there are some central roles of #microRNA in #viralinfection #immunity, #Viralreplication . vR can impress through cellular #miRNAs. Indeed either the antiviral responses or 🦠 infection changes through cellular miRNAs resulting in affecting many regulatory signaling pathways.

#CotM is Eukaryotic translation initiation factor 4F, #eIF4F, that loads m7GTP-capped mRNAs onto the 40S ribosomal subunit.
e.g.structure: #4aza @PDBeurope
pathway: R-HSA-72613 @reactome

May be involved in #viralreplication of #SARSCoV2.

ebi.ac.uk/complexportal/…

PNPase identified as a key host regulator controlling influenza A virus replication and antiviral responses.
#Influenza #HostPathogen #AntiviralTargets #ViralReplication
www.nature.com/articles/s41...

New evidence shows SLBP enhances SARS-CoV-2 replication by promoting –1 ribosomal frameshifting.
#SARSCoV2 #Frameshifting #ViralReplication #HostFactors #CoronavirusResearch
www.nature.com/articles/s41...