#WFS1
New @NatureComms paper: MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers. #Myoblue tinyurl.com/xmdsv5ez
MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers - Nature Communications
The nuclear periphery is linked with transcriptional repression, but MyoD1 remains active during myoblast proliferation despite being in this compartment. Here, the authors show that WFS1 tethers MyoD...
tinyurl.com
March 17, 2025 at 2:03 PM
Endocrine dysfunction and #diabetes is promoted by β cell dedifferentiation and loss of cellular identity in people with Wolfram syndrome, and ameliorated by inhibition of TXNIP #islets #genetics www.science.org/doi/10.1126/...
β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome
β cell dedifferentiation underlies diabetes mellitus in Wolfram syndrome, and Txnip inhibition prevents β cell regression in Wfs1-deficient mice.
www.science.org
February 19, 2025 at 7:19 PM
Defining mutation-specific dysfunctions in WS1 supports targeting the GLP-1/GLP-1R axis as a therapeutic strategy in Wolfram syndrome 1 #diabetes diabetesjournals.org/diabetes/art...
Liraglutide treatment reverses unconventional cellular defects in induced pluripotent stem cell-derived β cells harboring a partially functional WFS1 variant
Wolfram Syndrome 1 (WS1) is a rare genetic disorder caused by WFS1 variants that disrupt Wolframin, an endoplasmic reticulum-associated protein essential f
diabetesjournals.org
April 9, 2025 at 9:00 PM
RRID:Addgene_48138 was used by the authors of the Nature Communications paper "MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers". Thank you for making your methods matter! #RRID #ReproducibleResearch
doi.org
April 4, 2025 at 7:01 AM
Up front & free to read in our Jan issue #editorspicks: AWFS1 variant disrupting acceptor splice site uncovers the impact of alternative splicing on beta cell apoptosis in a patient with Wolfram syndrome tinyurl.com/3ytj5kf4
A WFS1 variant disrupting acceptor splice site uncovers the impact of alternative splicing on beta cell apoptosis in a patient with Wolfram syndrome - Diabetologia
Aims/hypothesis Wolfram syndrome 1 (WS1) is an inherited condition mainly manifesting in childhood-onset diabetes mellitus and progressive optic nerve atrophy. The causative gene, WFS1, encodes wolfra...
tinyurl.com
January 9, 2025 at 2:21 PM
Our commentary is out in Diabetes!
• MODY panels are undergoing refinement in the population-scale genetics era.
• We discuss how the Exeter team provides strong evidence for NEUROD1 and PDX1, but not for APPL1 or WFS1, using data from UK Biobank and gnomAD.
diabetesjournals.org/diabetes/art...
October 21, 2025 at 2:21 PM
Its here ! 👀💋🏈🇨🇦📰👊
World Flag Series 2 will take place in Canada featuring Midnight Ballers debut facing WFS1 Champions Hustle Every Rep (HER) & GlitterBombs
Details below :
September 18, 2026 at 7:51 PM
Wolfram Syndrome (DIDMOAD) is an ultra-rare genetic disorder causing childhood diabetes, progressive optic atrophy, hearing loss, and neurodegeneration. Affects roughly 1 in 700,000 people.

Learn more: thesnowfoundation.org

You may be rare, but you're not alone!
#rareDisease #rareDiseaseAwareness
August 18, 2026 at 2:00 PM
Are these MRI findings in people with multiple sclerosis? Shockingly, NO! They actually have Wolfram syndrome (WFS), a rare genetic disorder associated with pathogenic variants in WFS1 and is linked to optic atrophy, hearing loss and diabetes. www.frontiersin.org/journals/neu...
November 18, 2025 at 3:59 AM
β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome | Science Translational Medicine www.science.org/doi/10.1126/...
β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome
β cell dedifferentiation underlies diabetes mellitus in Wolfram syndrome, and Txnip inhibition prevents β cell regression in Wfs1-deficient mice.
www.science.org
February 19, 2025 at 8:26 PM
A WFS1 variant disrupting acceptor splice site uncovers the impact of alternative splicing on ER-stress independent β cell apoptosis in a patient with Wolfram syndrome. https://www.biorxiv.org/content/10.1101/2023.12.29.573188v1
A WFS1 variant disrupting acceptor splice site uncovers the impact of alternative splicing on ER-stress independent β cell apoptosis in a patient with Wolfram syndrome. https://www.biorxiv.org/content/10.1101/2023.12.29.573188v1
Wolfram Syndrome 1 is an inherited condition manifesting in childhood-onset diabetes mellitus and pr
www.biorxiv.org
December 30, 2023 at 11:35 PM
Ham, S. J., Yoon, E., Lee, D. H., Kim, S., Yoo, H., Chung, J. (2025). Reciprocal rescue of Wolfram syndrome by two causative genes.EMBO Rep, 26(9):2459-2482 link.springer.com/article/10.1...
Reciprocal rescue of Wolfram syndrome by two causative genes - EMBO Reports
Wolfram syndrome (WS) is marked by juvenile-onset diabetes mellitus, optic atrophy, diabetes insipidus, and sensorineural hearing loss. The causative genes, WFS1 and CISD2, correspond to WS types 1 an...
link.springer.com
February 23, 2026 at 11:23 PM
Molecular Medicine - Article in press:
ER Stress and Structural Changes Induced by Rare WFS1 Variant Identified in Autosomal Dominant Form of WFS1-related disorder #MolecularMedicine #WFS1 #WolframSyndrome #DiabetesInsipidus
link.springer.com/article/10.1...
August 26, 2026 at 3:21 PM
Its here WFS1 Womens Flag Series inaugural event in Tampa Florida July 25th via You Tube
Watch history made. Get access and details here www.worldflagseries.com
July 25, 2026 at 4:25 PM
Its here. The first pro flag series featuring players globally. World Flag Series 1 event will feature 3 teams and over 30 athletes competing for the inaugural WFS1 Championship on July 25th '26
Get the details here : www.worldflagseries.com
July 21, 2026 at 2:37 AM
🏈🔥 THE FUTURE OF PRO FLAG FOOTBALL ARRIVES JULY 25 2026! 🔥🏈 History is about to be made at WFS1, the inaugural World Flag Series eventthe world's first professional women's flag football series. 🌎 30 elite athletes. 🏆 3 professional teams. Details here www.worldflagseries.com
📸 @yoursportsbff on IG
July 15, 2026 at 5:10 AM
2026 World Flag Series announced the three teams and official rosters that will compete at WFS1. WFS1 will take place at Suncoast Credit Union Stadium in Tampa, Florida, on Saturday, July 25, 2026. The WFS1 event will run from 6 to 9 PM Eastern Time.
www.collegiateflagfootball.com/world-flag-s...
World Flag Series Announces Teams and Athletes for First Event
World Flag Series announced the three teams and official rosters that will compete at WFS1 later this month. WFS1 will take place at Suncoast Credit Union Stadium in Tampa, Florida, on Saturday, July ...
www.collegiateflagfootball.com
July 14, 2026 at 9:38 PM
2026: 🚨 30 elite women. More than 10 countries.
World Flag Series has announced WFS1 - a first-of-its-kind pro women’s flag football event - July 25, 2026 in Tampa, FL

A fast-paced 5v5 format built for fans, broadcast, and the Olympic era of the sport.
www.worldflagseries.com
📸 FlagFootballFinder
July 8, 2026 at 2:46 AM
April 26, 2026 at 10:02 AM
We’ve been exploring the potential of GLP-1 receptor agonists for treating Wolfram Syndrome, a rare form of diabetes.
#WolframSyndrome #GLP1 diabetesjournals.org/diabetes/art...
Liraglutide treatment reverses unconventional cellular defects in induced pluripotent stem cell-derived β cells harboring a partially functional WFS1 variant
Wolfram Syndrome 1 (WS1) is a rare genetic disorder caused by WFS1 variants that disrupt Wolframin, an endoplasmic reticulum-associated protein essential f
diabetesjournals.org
April 9, 2025 at 8:00 PM