Introduction When a couple has a child with a genetic condition, it raises questions when considering future pregnancies. It has typically been considered an easier genetic test result to receive wh...

Spatial transcriptomics (ST) maps gene expression within intact tissues, but its cost and technical complexity limit broad adoption. A growing body of deep-learning methods now seeks to infer ST direc...

Germinal centers (GCs) are specialized microenvironments in which B cells undergo affinity maturation through iterative cycles of somatic hypermutation, proliferation and selection, generating antibo...

Agonistic antibodies initiate signalling by the receptors they target, mimicking the activities of native ligands. This Review discusses the clinical successes and failures of agonistic antibodies and explains how recent mechanistic insights should broaden the scope and improve the safety and efficacy of immunotherapies based on these agents.

A new study led by the Ho Group has uncovered a striking immune signature that may help explain what happens in the early stages of idiopathic pulmonary fibrosis (IPF), a serious condition that causes scarring of the lungs and makes breathing difficult.

MDA5 detects double-stranded RNA during viral infections. This work shows that MDA5 binds aberrant host RNA induced during viral infection. Rescue of aberrant cytoplasmic RNA during infection abrogate...

During embryonic development, the specification of hematopoietic stem cells (HSCs) and progenitor cells (HPCs) critically depends on the transcription factor Runx1. Anselmi et al. describe a Runx1 enh...

High-grade serous ovarian cancers (HGSC) are refractory to immunotherapy, and a comprehensive characterization of the immune landscape at these lesions is lacking. Here, the authors employ single-cell RNA and TCR sequencing of patient-derived tissues to characterize T cell clonality and differentiation during tumor evolution. Tissue-resident memory-like T cells in early lesions display tumor reactivity, exhibit reduced exhaustion, and are implicated in early immune surveillance, and could be leveraged for the design of immunomodulatory therapeutic approaches.

Here, Zhang et al. identify a transgene-independent marker combination that prospectively isolates platelet-biased hematopoietic stem cells with high purity, overcoming a key limitation in the field, ...

Poly(ADP-ribose) polymerase inhibitors (PARPi) exploit homologous recombination deficiency (HRD) in BRCA1/2-mutated cancers to induce synthetic lethality[1][1]–[3][2]. PARPi also kill cancer cells lac...

Congenital dyserythropoietic anaemia type I is caused by mutations in CDAN1 or CDIN1, but the molecular basis of disease is unclear. Here, the authors show that Codanin-1 and CDIN1 form an RNA nucleas...

A new form of CAR T cell therapy has been designed to find and destroy the cancer-driving cells responsible for a group of blood cancers known as myeloproliferative neoplasms (MPNs), while leaving hea...

Key PointsMYB binding is sufficient to generate enhancers de novo, including the formation of enhancer-promoter contacts.MYB loss in acute lymphoblastic le

The muscle nicotinic acetylcholine receptor (AChR) is the key mediator of neuromuscular signal transmission and is essential for all voluntary move...

Key Points. LIN28B, a fetal specific oncogene, is necessary for fetal B lymphopoiesis and KMT2A::AFF1 initiation of infant B ALLLIN28B stabilizes key fetal

Platelets are produced via a canonical pathway emanating from multi-lineage hematopoietic stem cells (ML-HSCs), and a faster, direct pathway used by platelet-biased (P-)HSCs where the latter circumven...

Researchers have discovered that some human blood stem cells retain a lasting “memory” of inflammation, a finding that could help explain links between ageing, chronic disease, and blood cancers

Researchers at the Icahn School of Medicine at Mount Sinai, Bristol Myers Squibb (BMS), and the University of Oxford have discovered a way to give worn-out immune cells a second wind in the fight agai...

Researchers from the University of Oxford, the Stowers Institute for Medical Research, Helmholtz Munich, and the Technical University of Munich have developed a new artificial intelligence framework t...