Antigen-independent BCR signals limit differentiation and survival of IgM antibody-secreting cells. New study from Ting-ting Zhang, David J. Rawlings, Richard G. James and colleagues @seattlechildrens.org:
rupress.org/jem/article/...
#LymphocyteBiology #PlasmaCells #Bcells
rupress.org/jem/article/...
#LymphocyteBiology #PlasmaCells #Bcells
October 29, 2026 at 3:15 PM
Antigen-independent BCR signals limit differentiation and survival of IgM antibody-secreting cells. New study from Ting-ting Zhang, David J. Rawlings, Richard G. James and colleagues @seattlechildrens.org:
rupress.org/jem/article/...
#LymphocyteBiology #PlasmaCells #Bcells
rupress.org/jem/article/...
#LymphocyteBiology #PlasmaCells #Bcells
IgD from atypical-like memory #Bcells and #plasmacells targets commensal and environmental antigens. By @rosertp.bsky.social, Bashour, Filipska, @victorgreiff.bsky.social, Cerutti & colleagues: rupress.org/jem/article/...
📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...
📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...
October 25, 2026 at 5:00 AM
IgD from atypical-like memory #Bcells and #plasmacells targets commensal and environmental antigens. By @rosertp.bsky.social, Bashour, Filipska, @victorgreiff.bsky.social, Cerutti & colleagues: rupress.org/jem/article/...
📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...
📘 Part of our Immune #Tolerance collection 👉 rupress.org/jem/collecti...
Ample naïve human #Bcells are still capable of binding to newer variants, and further work is required to determine how much this drop actually impacts a person's ultimate neutralizing antibody response.
October 24, 2026 at 5:45 AM
Ample naïve human #Bcells are still capable of binding to newer variants, and further work is required to determine how much this drop actually impacts a person's ultimate neutralizing antibody response.
New #mRNAFluVaccine 30% more effective than traditional flu shots for adults 50 & older mRNA uses genetic instructions to prompt cells,build proteins, generating broader immune response,training white blood cells/memory Bcells to recognize conserved parts of the virus that don’t change as frequently
New mRNA Flu Vaccine for Older Adults Explained - Washington National Biomedical Research Center
Adults over age 50 face a higher risk of hospitalization and death from influenza each year. Now, a new mRNA flu vaccine coming soon will offer another option for older adults. WaNBRC Director Deborah...
wanbrc.uw.edu
October 18, 2026 at 4:59 PM
New #mRNAFluVaccine 30% more effective than traditional flu shots for adults 50 & older mRNA uses genetic instructions to prompt cells,build proteins, generating broader immune response,training white blood cells/memory Bcells to recognize conserved parts of the virus that don’t change as frequently
KI researchers have mapped how atypical #BCells develop and change function over time. In @embojournal.org, they show that these cells arise from different precursors but converge on a shared late differentiation stage, helping clarify their roles in #Immunity 🧪 news.ki.se/immune-cells...
October 12, 2026 at 3:52 PM
KI researchers have mapped how atypical #BCells develop and change function over time. In @embojournal.org, they show that these cells arise from different precursors but converge on a shared late differentiation stage, helping clarify their roles in #Immunity 🧪 news.ki.se/immune-cells...
📢 New in Discovery Immunology
New open-access research shows a strikingly shared (“public”) antibody response following PRV vaccination and challenge, revealed through porcine BCR repertoire profiling 🧬
🔗 vist.ly/5mz8c
#Immunology #Vaccines #Bcells #OpenAccess
New open-access research shows a strikingly shared (“public”) antibody response following PRV vaccination and challenge, revealed through porcine BCR repertoire profiling 🧬
🔗 vist.ly/5mz8c
#Immunology #Vaccines #Bcells #OpenAccess
Pseudorabies Study Overview
AbstractIntroduction. The antibody repertoire reflects the immune history of an individual. In the present study, we characterised the porcine antibody hea
doi.org
October 12, 2026 at 10:59 AM
📢 New in Discovery Immunology
New open-access research shows a strikingly shared (“public”) antibody response following PRV vaccination and challenge, revealed through porcine BCR repertoire profiling 🧬
🔗 vist.ly/5mz8c
#Immunology #Vaccines #Bcells #OpenAccess
New open-access research shows a strikingly shared (“public”) antibody response following PRV vaccination and challenge, revealed through porcine BCR repertoire profiling 🧬
🔗 vist.ly/5mz8c
#Immunology #Vaccines #Bcells #OpenAccess
These immune-cell changes were most evident in #Bcells in which EBV often lies dormant and were linked to antiviral responses and inflammation.Studies were able to detect these changes in blood samples up to 3 months before people with MS experienced a relapse.
www.sciencealert.com/up-to-3-mont...
www.sciencealert.com/up-to-3-mont...
A Common Virus Shows Signs of Reactivating Up to 3 Months Before a Multiple Sclerosis Attack
We've known for decades that multiple sclerosis (MS) and Epstein-Barr virus (EBV) are linked, and experts think it's probably down to a complex combination of environmental and genetic factors.
www.sciencealert.com
September 26, 2026 at 5:33 AM
These immune-cell changes were most evident in #Bcells in which EBV often lies dormant and were linked to antiviral responses and inflammation.Studies were able to detect these changes in blood samples up to 3 months before people with MS experienced a relapse.
www.sciencealert.com/up-to-3-mont...
www.sciencealert.com/up-to-3-mont...
🧪 The order of immune signals matters. A human B-cell model reproduces germinal-centre features in culture, including somatic hypermutation. A useful research tool—not a complete germinal centre.
doi.org/10.1126/scii...
#Immunology #BCells
doi.org/10.1126/scii...
#Immunology #BCells
In vitro induction of human germinal center B cells
Human induced GC-like B (iGCB) cells are generated in vitro from circulating naive or marginal zone cells.
doi.org
September 24, 2026 at 5:20 AM
🧪 The order of immune signals matters. A human B-cell model reproduces germinal-centre features in culture, including somatic hypermutation. A useful research tool—not a complete germinal centre.
doi.org/10.1126/scii...
#Immunology #BCells
doi.org/10.1126/scii...
#Immunology #BCells
For those of us without a convenient supply of human tonsils, here's another way to generate human GC B cells in culture: #science #immunology #Bcells www.science.org/doi/10.1126/...
In vitro induction of human germinal center B cells
Human induced GC-like B (iGCB) cells are generated in vitro from circulating naive or marginal zone cells.
www.science.org
September 21, 2026 at 7:05 PM
For those of us without a convenient supply of human tonsils, here's another way to generate human GC B cells in culture: #science #immunology #Bcells www.science.org/doi/10.1126/...
ER #proteostasis failure in HYOU1 deficiency alters #Bcells, #neutrophils, and #interferon signaling. New study from Aida Idani, Raphael Carapito, Seiamak Bahram @seiamak.bsky.social @unistra.fr and colleagues:
rupress.org/jhi/article/...
#InbornErrorsOfImmunity
rupress.org/jhi/article/...
#InbornErrorsOfImmunity
September 15, 2026 at 1:45 PM
ER #proteostasis failure in HYOU1 deficiency alters #Bcells, #neutrophils, and #interferon signaling. New study from Aida Idani, Raphael Carapito, Seiamak Bahram @seiamak.bsky.social @unistra.fr and colleagues:
rupress.org/jhi/article/...
#InbornErrorsOfImmunity
rupress.org/jhi/article/...
#InbornErrorsOfImmunity
Better #CancerImmunotherapy requires tackling hidden immune barriers.
This review highlights how dysfunctional #Bcells suppress anti-tumor immunity and outlines strategies to reprogram the #TumorMicroenvironment.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
This review highlights how dysfunctional #Bcells suppress anti-tumor immunity and outlines strategies to reprogram the #TumorMicroenvironment.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
September 11, 2026 at 2:00 AM
Better #CancerImmunotherapy requires tackling hidden immune barriers.
This review highlights how dysfunctional #Bcells suppress anti-tumor immunity and outlines strategies to reprogram the #TumorMicroenvironment.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
This review highlights how dysfunctional #Bcells suppress anti-tumor immunity and outlines strategies to reprogram the #TumorMicroenvironment.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
Michalets, Kohlmeier et al. demonstrate that upper respiratory tract tissue-resident memory #CD8⁺ T cells are sufficient to protect against respiratory virus transmission, even in the absence of #CD4 #Tcells, #Bcells, or lower respiratory tract immune responses. rupress.org/jem/article/...
September 10, 2026 at 4:02 PM
Michalets, Kohlmeier et al. demonstrate that upper respiratory tract tissue-resident memory #CD8⁺ T cells are sufficient to protect against respiratory virus transmission, even in the absence of #CD4 #Tcells, #Bcells, or lower respiratory tract immune responses. rupress.org/jem/article/...
In @jem.org, Michalets et al. demonstrate that upper respiratory tract tissue-resident memory #CD8⁺ T cells are sufficient to protect against respiratory virus transmission, even in the absence of #CD4 #Tcells, #Bcells, or lower respiratory tract immune responses. rupress.org/jem/article/...
September 10, 2026 at 4:02 PM
#WIMMReads 🧪
A new review from the Bannard Group explores how #BCells are selected in germinal centers and how diverse, lasting antibody immunity develops.
https://onlinelibrary.wiley.com/doi/10.1111/imr.70169
#Immunology #MRCWIMM @medsci.ox.ac.uk @ndm.ox.ac.uk
A new review from the Bannard Group explores how #BCells are selected in germinal centers and how diverse, lasting antibody immunity develops.
https://onlinelibrary.wiley.com/doi/10.1111/imr.70169
#Immunology #MRCWIMM @medsci.ox.ac.uk @ndm.ox.ac.uk
Germinal Center Selection and Plasma Cell Differentiation
Germinal centers (GCs) are specialized microenvironments in which B cells undergo affinity maturation through iterative cycles of somatic hypermutation, proliferation and selection, generating antibo...
onlinelibrary.wiley.com
September 10, 2026 at 9:05 AM
#WIMMReads 🧪
A new review from the Bannard Group explores how #BCells are selected in germinal centers and how diverse, lasting antibody immunity develops.
https://onlinelibrary.wiley.com/doi/10.1111/imr.70169
#Immunology #MRCWIMM @medsci.ox.ac.uk @ndm.ox.ac.uk
A new review from the Bannard Group explores how #BCells are selected in germinal centers and how diverse, lasting antibody immunity develops.
https://onlinelibrary.wiley.com/doi/10.1111/imr.70169
#Immunology #MRCWIMM @medsci.ox.ac.uk @ndm.ox.ac.uk
Molecular Medicine - Journal
Article in press: Expansion of bone marrow Cxcr5⁺ B cells is associated with renal injury in early-stage diabetic kidney disease: potential implications for B-cell-targeted immunotherapy | #MolecularMedicine #DKD #Bcells link.springer.com/article/10.1...
Article in press: Expansion of bone marrow Cxcr5⁺ B cells is associated with renal injury in early-stage diabetic kidney disease: potential implications for B-cell-targeted immunotherapy | #MolecularMedicine #DKD #Bcells link.springer.com/article/10.1...
September 2, 2026 at 7:51 PM
Molecular Medicine - Journal
Article in press: Expansion of bone marrow Cxcr5⁺ B cells is associated with renal injury in early-stage diabetic kidney disease: potential implications for B-cell-targeted immunotherapy | #MolecularMedicine #DKD #Bcells link.springer.com/article/10.1...
Article in press: Expansion of bone marrow Cxcr5⁺ B cells is associated with renal injury in early-stage diabetic kidney disease: potential implications for B-cell-targeted immunotherapy | #MolecularMedicine #DKD #Bcells link.springer.com/article/10.1...
Molecular Medicine - Journal
Article in Press: WHAMM deficiency alters splenic B-cell populations, BCR signaling, and actin remodeling | #MolecularMedicine #WHAMM #Bcells link.springer.com/article/10.1...
Article in Press: WHAMM deficiency alters splenic B-cell populations, BCR signaling, and actin remodeling | #MolecularMedicine #WHAMM #Bcells link.springer.com/article/10.1...
WHAMM deficiency alters splenic B-cell populations, BCR signaling, and actin remodeling - Molecular Medicine
Members of the Wiskott-Aldrich syndrome protein (WASP) family orchestrate cytoskeletal reorganization that modulates B-cell receptor (BCR) signaling and B-cell fate decisions. WHAMM, a WASP-family nuc...
link.springer.com
September 1, 2026 at 5:28 PM
Molecular Medicine - Journal
Article in Press: WHAMM deficiency alters splenic B-cell populations, BCR signaling, and actin remodeling | #MolecularMedicine #WHAMM #Bcells link.springer.com/article/10.1...
Article in Press: WHAMM deficiency alters splenic B-cell populations, BCR signaling, and actin remodeling | #MolecularMedicine #WHAMM #Bcells link.springer.com/article/10.1...
B cell deficiency reduces TGF-β1 during exercise, disrupting liver glutamate metabolism, and lowering blood and muscle glutamate, which limits exercise capacity. #BCells #Exercise PMID:41999743, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00340-5 #Medsky #Pharmsky #RNA #ASHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00340-5
No description available
www.cell.com
August 8, 2026 at 11:00 PM
#DiabetesBio
Bcells & islet tolerance wT1D #ChristopherWilson #DanielMoore
Wt loss & glucose disposal #BettinaMittendorfer
Sweet Talk w @stephenorahilly.bsky.social
YT shorturl.at/3Ltq4
🍎 shorturl.at/tnCgH
🎧 shorturl.at/86OIE
🔗 shorturl.at/F1WC1
@runningdar.bsky.social
@kirkhabegger.bsky.social
Bcells & islet tolerance wT1D #ChristopherWilson #DanielMoore
Wt loss & glucose disposal #BettinaMittendorfer
Sweet Talk w @stephenorahilly.bsky.social
YT shorturl.at/3Ltq4
🍎 shorturl.at/tnCgH
🎧 shorturl.at/86OIE
🔗 shorturl.at/F1WC1
@runningdar.bsky.social
@kirkhabegger.bsky.social
February 7, 2026 at 2:58 PM
#DiabetesBio
Bcells & islet tolerance wT1D #ChristopherWilson #DanielMoore
Wt loss & glucose disposal #BettinaMittendorfer
Sweet Talk w @stephenorahilly.bsky.social
YT shorturl.at/3Ltq4
🍎 shorturl.at/tnCgH
🎧 shorturl.at/86OIE
🔗 shorturl.at/F1WC1
@runningdar.bsky.social
@kirkhabegger.bsky.social
Bcells & islet tolerance wT1D #ChristopherWilson #DanielMoore
Wt loss & glucose disposal #BettinaMittendorfer
Sweet Talk w @stephenorahilly.bsky.social
YT shorturl.at/3Ltq4
🍎 shorturl.at/tnCgH
🎧 shorturl.at/86OIE
🔗 shorturl.at/F1WC1
@runningdar.bsky.social
@kirkhabegger.bsky.social
New study highlights local lung-resident IgG1+ MBCs as cellular precursors for IgE-secreting PCs in the respiratory mucosa following allergen challenge in a murine model.
🔗 www.sciencedirect.com/science/arti...
#Immunology #IgE #Asthma #Bcells #immunosky
🔗 www.sciencedirect.com/science/arti...
#Immunology #IgE #Asthma #Bcells #immunosky
Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract
Although allergen-specific immunoglobulin E (IgE) is a key mediator of allergic asthma, IgE-expressing B cells fail to form memory B cells (MBCs). Her…
www.sciencedirect.com
April 10, 2025 at 6:37 AM
New study highlights local lung-resident IgG1+ MBCs as cellular precursors for IgE-secreting PCs in the respiratory mucosa following allergen challenge in a murine model.
🔗 www.sciencedirect.com/science/arti...
#Immunology #IgE #Asthma #Bcells #immunosky
🔗 www.sciencedirect.com/science/arti...
#Immunology #IgE #Asthma #Bcells #immunosky
I had a look at this and for the little I understand the matter, I conclude everybody studying Bcells should be encouraged to think outside the box as their behaviours is "complex and variable, showing inconsistent trend across different diseases or even within the same disease".
June 20, 2025 at 12:42 PM
I had a look at this and for the little I understand the matter, I conclude everybody studying Bcells should be encouraged to think outside the box as their behaviours is "complex and variable, showing inconsistent trend across different diseases or even within the same disease".
🩸 Additional insights on myeloma biology and microenvironment
#MultipleMyeloma #EquilibriumPhase #Immunotherapy #HEMEHUB #EscapePhase #PD1 #CTLA4 #BCells #HemeOnc #Hematology
#MultipleMyeloma #EquilibriumPhase #Immunotherapy #HEMEHUB #EscapePhase #PD1 #CTLA4 #BCells #HemeOnc #Hematology
February 26, 2026 at 10:40 PM
🩸 Additional insights on myeloma biology and microenvironment
#MultipleMyeloma #EquilibriumPhase #Immunotherapy #HEMEHUB #EscapePhase #PD1 #CTLA4 #BCells #HemeOnc #Hematology
#MultipleMyeloma #EquilibriumPhase #Immunotherapy #HEMEHUB #EscapePhase #PD1 #CTLA4 #BCells #HemeOnc #Hematology
Tomorrow at noon @institutcochin.bsky.social seminar by Chris Mueller @cnrs.fr @unistra.fr on "Differentiation of B cell-associated mesenchymal cells in the lymph node" #Bcells #immunity #macrophages #mesenchyme
November 5, 2025 at 6:23 PM
Tomorrow at noon @institutcochin.bsky.social seminar by Chris Mueller @cnrs.fr @unistra.fr on "Differentiation of B cell-associated mesenchymal cells in the lymph node" #Bcells #immunity #macrophages #mesenchyme
www.cell.com/cell-reports...
“These findings validate IgA2 anti-dsDNA antibodies as a theragnostic biomarker of response and provide mechanistic insight into the selective targeting of IgA2+ B cells by combination belimumab after rituximab in SLE.”
#lupus #Bcells #antibody #Rheumsky
“These findings validate IgA2 anti-dsDNA antibodies as a theragnostic biomarker of response and provide mechanistic insight into the selective targeting of IgA2+ B cells by combination belimumab after rituximab in SLE.”
#lupus #Bcells #antibody #Rheumsky
IgA2+ B cells and IgA2 anti-dsDNA antibodies are selectively targeted by belimumab after rituximab therapy in systemic lupus erythematosus
McCluskey et al. show that baseline serum IgA2 anti-dsDNA antibody levels are a companion
biomarker of response to belimumab after rituximab in systemic lupus erythematosus.
Increased BAFF receptor ex...
www.cell.com
July 23, 2025 at 9:36 PM
www.cell.com/cell-reports...
“These findings validate IgA2 anti-dsDNA antibodies as a theragnostic biomarker of response and provide mechanistic insight into the selective targeting of IgA2+ B cells by combination belimumab after rituximab in SLE.”
#lupus #Bcells #antibody #Rheumsky
“These findings validate IgA2 anti-dsDNA antibodies as a theragnostic biomarker of response and provide mechanistic insight into the selective targeting of IgA2+ B cells by combination belimumab after rituximab in SLE.”
#lupus #Bcells #antibody #Rheumsky
www.science.org/doi/10.1126/...
📖Noncanonical functions of T follicular helper cells
#Tfh #germinalcenter #Bcells
📖Noncanonical functions of T follicular helper cells
#Tfh #germinalcenter #Bcells
Noncanonical functions of T follicular helper cells
We review the roles TFH cells play in regulating immune responses and maintaining homeostasis that extend beyond helping B cell responses.
www.science.org
June 17, 2025 at 10:35 AM
www.science.org/doi/10.1126/...
📖Noncanonical functions of T follicular helper cells
#Tfh #germinalcenter #Bcells
📖Noncanonical functions of T follicular helper cells
#Tfh #germinalcenter #Bcells
www.nature.com/articles/s41...
📖 Immunometabolism in systemic #lupus erythematosus
“Altered glucose metabolism influences the function and activation of #Tcells, #Bcells and macrophages, contributing to #SLE pathogenesis.”
📖 Immunometabolism in systemic #lupus erythematosus
“Altered glucose metabolism influences the function and activation of #Tcells, #Bcells and macrophages, contributing to #SLE pathogenesis.”
Immunometabolism in systemic lupus erythematosus - Nature Reviews Rheumatology
Systemic lupus erythematosus is characterized by altered metabolic profiles and changes in immune cell metabolism. The authors review these changes and discuss how interventions that target metab...
www.nature.com
June 17, 2025 at 12:56 AM
www.nature.com/articles/s41...
📖 Immunometabolism in systemic #lupus erythematosus
“Altered glucose metabolism influences the function and activation of #Tcells, #Bcells and macrophages, contributing to #SLE pathogenesis.”
📖 Immunometabolism in systemic #lupus erythematosus
“Altered glucose metabolism influences the function and activation of #Tcells, #Bcells and macrophages, contributing to #SLE pathogenesis.”