Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.

Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.

Two recipients of gene-edited pig kidneys have successfully received human organs, a milestone in the wider effort to advance xenografts.

Patient-derived tumor xenografts from treatment-naïve breast cancer samples can predict patient drug responses and model treatment-induced phenotypic and functional evolution, making them valuable pre...

Cell surface proteins offer significant cancer therapeutic potential attributable to their accessible membrane localization and central role in cellular signaling. Despite this, their promise remains ...

Metastasis causes most cancer deaths, yet no recurrent mutation specifically drives it, raising the possibility that metastatic potential is a non-genetic yet heritable cell state. Classic experiments...

A proposed deep learning method helps to bridge the gap between preclinical cancer models and clinical tumors.

Genetically modified pigs are being developed to address the critical shortage of human organs for transplantation. Although porcine xenografts lacking the three major carbohydrate xenoantigens (3KO) have been considered ideal for human transplantation, the optimal combination of human transgenes (HTGs) to mitigate protein incompatibility remains undefined. In the current study, we evaluate immune responses and transplant outcomes of 3KO kidney xenografts with four different combinations of HTGs in a nonhuman primate model. Here, we show that the addition of HTGs significantly reduces transcripts associated with early immune activation, resulting in markedly prolonged survival of 3KO xenografts. Notably, the inclusion of the anti-inflammatory genes TNFAIP3 and HMOX1 is associated with improved graft survival, significantly reduced T-cell and CD11b⁺ myeloid cell infiltration, and lower expression of rejection-related gene sets in protocol xenograft biopsies. Genetically modified pigs la

Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.

Patient-derived xenografts (PDXs) are frequently used as preclinical models, but their recapitulation of tumour metabolism in patients has not been closely examined. We developed a parallel workflow t...

Triple negative breast cancer (TNBC) that fails to respond to neoadjuvant chemotherapy (NACT) can be

The heterogeneity of breast cancer has a major role in drug response and resistance. In this study, the authors use patient-derived tumour xenografts as a platform for drug testing and correlation wit...

A proposed deep learning method helps to bridge the gap between preclinical cancer models and clinical tumors.

Nature Metabolism, Published online: 29 July 2025; doi:10.1038/s42255-025-01338-2Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.