Latest from ours: www.cell.com/cell-reports...
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
October 5, 2025 at 10:35 AM
Latest from ours: www.cell.com/cell-reports...
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
Fast-forward to 2022: having established a selection-based gene knockout method for S. rosetta, we set out to study the Hippo pathway - a star pathway of animal development, in which the kinases Hippo and Warts control organ size via the transcription coactivator YAP.
October 5, 2025 at 10:35 AM
Fast-forward to 2022: having established a selection-based gene knockout method for S. rosetta, we set out to study the Hippo pathway - a star pathway of animal development, in which the kinases Hippo and Warts control organ size via the transcription coactivator YAP.
☕Vanni et al. show a role for #microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and degradation, leading to YAP/TAZ activation. #mechanobiology #cytoskeleton
bit.ly/4oS2Ju3
bit.ly/4oS2Ju3
Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signalling - Nature Cell Biology
Vanni et al. show a role for microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and...
bit.ly
November 4, 2025 at 6:35 PM
☕Vanni et al. show a role for #microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and degradation, leading to YAP/TAZ activation. #mechanobiology #cytoskeleton
bit.ly/4oS2Ju3
bit.ly/4oS2Ju3
Exciting paper by Chris Vakoc @cshlaboratory.bsky.social on how to target the YAP/TAZ pathway out in Cancer Discovery! aacrjournals.org/cancerdiscov...
MARK2/MARK3 Kinases Are Catalytic Codependencies of YAP/TAZ in Human Cancer
The kinases MARK2 and MARK3 are identified as requirements for the function of the YAP and TAZ oncogenes, thus providing a druggable vulnerability in Hippo-dysregulated carcinomas and sarcomas.
aacrjournals.org
December 15, 2024 at 9:57 AM
Exciting paper by Chris Vakoc @cshlaboratory.bsky.social on how to target the YAP/TAZ pathway out in Cancer Discovery! aacrjournals.org/cancerdiscov...
Unlock growth control! Targeting the Hippo pathway: Aiming at YAP/TAZ disrupts cancer proliferation. 🚀 #CancerResearch PMID:40588515, Nat Rev Drug Discov 2025, @NatRevDrugDisc https://doi.org/10.1038/s41573-025-01234-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Targeting the Hippo pathway in cancer | Nature Reviews Drug Discovery
The Hippo pathway is a highly conserved signalling network that controls tissue growth and cell fate, responding to physical properties of the tissue microenvironment and cell biological features such as adhesion and polarity. Hippo signalling perturbation is associated with several human diseases, particularly various solid cancers. Hippo pathway-targeted therapies are beginning to emerge for the treatment of cancer, most of which are focused on disrupting the ability of the YAP and TAZ transcription co-activator proteins to promote transcription of genes with their cognate TEAD1–4 DNA binding proteins. Recently, TEAD inhibitors have shown promise in a phase I clinical trial in cancers that are enriched for Hippo pathway mutations, such as mesothelioma. Moreover, Hippo pathway-targeted therapies have great potential to be combined with RAS–MAPK pathway inhibitors, given the close functional relationship that these signalling pathways share in development and disease. The Hippo si
doi.org
November 28, 2025 at 3:10 AM
Unlock growth control! Targeting the Hippo pathway: Aiming at YAP/TAZ disrupts cancer proliferation. 🚀 #CancerResearch PMID:40588515, Nat Rev Drug Discov 2025, @NatRevDrugDisc https://doi.org/10.1038/s41573-025-01234-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Together, this suggests that Hippo/YAP might have already controlled both contractility and ECM secretion before animals evolved. Animals plugged in one additional output: proliferation. Under this hypothesis, the best-known function of YAP would have been the latest innovation.
October 5, 2025 at 10:35 AM
Together, this suggests that Hippo/YAP might have already controlled both contractility and ECM secretion before animals evolved. Animals plugged in one additional output: proliferation. Under this hypothesis, the best-known function of YAP would have been the latest innovation.
Hippo signalling regulates the nuclear behaviour and DNA dwell times of YAP and TEAD to control transcription https://www.biorxiv.org/content/10.1101/2025.03.11.642705v1
March 13, 2025 at 8:31 AM
Hippo signalling regulates the nuclear behaviour and DNA dwell times of YAP and TEAD to control transcription https://www.biorxiv.org/content/10.1101/2025.03.11.642705v1
The Hippo pathway is frequently dysregulated in human cancers and represents an ideal therapeutic target. Find out about the advances in targeting the Hippo pathway for cancer treatment this #BiochemSocTrans mini-review from Zhu et al. 🧪
doi.org/10.1042/BST2...
doi.org/10.1042/BST2...
January 23, 2025 at 2:02 PM
The Hippo pathway is frequently dysregulated in human cancers and represents an ideal therapeutic target. Find out about the advances in targeting the Hippo pathway for cancer treatment this #BiochemSocTrans mini-review from Zhu et al. 🧪
doi.org/10.1042/BST2...
doi.org/10.1042/BST2...
Is this YAP/ECM connection a choano oddity? Not necessarily: recently, links between Hippo/YAP and ECM have been emerging in animals. One of the most commonly reported YAP targets is cyr61, a thrombospondin-domain protein that's part of the ECM... www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
October 5, 2025 at 10:35 AM
Is this YAP/ECM connection a choano oddity? Not necessarily: recently, links between Hippo/YAP and ECM have been emerging in animals. One of the most commonly reported YAP targets is cyr61, a thrombospondin-domain protein that's part of the ECM... www.pnas.org/doi/10.1073/...
We are LIVE with more Sly 3: Honor Among Thieves!
THERE'S A RACCOON. AND A HIPPO. AND A TURTLE. AND EVERYONE IS DOIN SNEAKY STUFF!
Come say Hey Hi Hello and listen to me yap to you
www.twitch.tv/blairbears65
THERE'S A RACCOON. AND A HIPPO. AND A TURTLE. AND EVERYONE IS DOIN SNEAKY STUFF!
Come say Hey Hi Hello and listen to me yap to you
www.twitch.tv/blairbears65
September 25, 2025 at 10:03 PM
We are LIVE with more Sly 3: Honor Among Thieves!
THERE'S A RACCOON. AND A HIPPO. AND A TURTLE. AND EVERYONE IS DOIN SNEAKY STUFF!
Come say Hey Hi Hello and listen to me yap to you
www.twitch.tv/blairbears65
THERE'S A RACCOON. AND A HIPPO. AND A TURTLE. AND EVERYONE IS DOIN SNEAKY STUFF!
Come say Hey Hi Hello and listen to me yap to you
www.twitch.tv/blairbears65
Interesting study from Genentech showing previously thought to be TEAD-YAP PPI inhibitors actually work through promoting TEAD interaction with the VGLL4 transcriptional repressor. Shows importance of deep mechanistic understanding of cmpd MOA. 🧪
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway
TEAD proteins are the main transcriptional effectors of the Hippo signaling pathway and a pharmacological target in oncology. Most TEAD-targeting small molecules act by disrupting interaction with the...
www.biorxiv.org
November 18, 2024 at 4:10 AM
Interesting study from Genentech showing previously thought to be TEAD-YAP PPI inhibitors actually work through promoting TEAD interaction with the VGLL4 transcriptional repressor. Shows importance of deep mechanistic understanding of cmpd MOA. 🧪
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Excited to share our new findings: nuclear G-actin directly binds YAP and forms the YAP-TEAD complex to drive transcription. New role of actin in Hippo signalling! @narjournal.bsky.social
Hong's @bdyxwh.bsky.social paper is out with help from @sshamphavi.bsky.social and @archaellum.bsky.social. We discovered a link between nuclear actin and YAP/TAZ: G-actin forms a complex with YAP-TEAD for transcription.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Regulation of YAP activity by nuclear G-actin binding
Abstract. The Yes-associated protein YAP belongs to the TEAD (TEA/ATTS domain) transcriptional co-activators that shuttle between the cytoplasm and the nuc
academic.oup.com
March 19, 2026 at 11:08 AM
Excited to share our new findings: nuclear G-actin directly binds YAP and forms the YAP-TEAD complex to drive transcription. New role of actin in Hippo signalling! @narjournal.bsky.social
This prevents the phosphorylation of YAP, forcing YAP to permanently reside in the nucleus
🧨Promoting Oncogenesis: By continuously forcing YAP/TAZ to stay active, oncogenic (cancer-causing) viruses HPV , EBV ,
www.researchgate.net/figure/Hippo...
🧨Promoting Oncogenesis: By continuously forcing YAP/TAZ to stay active, oncogenic (cancer-causing) viruses HPV , EBV ,
www.researchgate.net/figure/Hippo...
Hippo pathway is involved in viral infection. Abnormal regulation of...
Download scientific diagram | Hippo pathway is involved in viral infection. Abnormal regulation of the Hippo pathway has been observed during infection with a variety of viruses such as HBV, HCV, MCV,...
www.researchgate.net
September 22, 2026 at 5:23 AM
This prevents the phosphorylation of YAP, forcing YAP to permanently reside in the nucleus
🧨Promoting Oncogenesis: By continuously forcing YAP/TAZ to stay active, oncogenic (cancer-causing) viruses HPV , EBV ,
www.researchgate.net/figure/Hippo...
🧨Promoting Oncogenesis: By continuously forcing YAP/TAZ to stay active, oncogenic (cancer-causing) viruses HPV , EBV ,
www.researchgate.net/figure/Hippo...
A new paper reveals that the nuclear E3 ligase UBR5 ubiquitinates VGLL4 at Lys61 for its degradation and regulates the Hippo-YAP signaling pathway
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nuclear ubiquitination permits Hippo–YAP signal for liver development and tumorigenesis - Nature Chemical Biology
Wei et al. found that the nuclear E3 ligase ubiquitin protein ligase E3 component n-recognin 5 (UBR5) ubiquitinated VGLL4 at Lys61 for its degradation, which permits Hippo–YAP signaling for the develo...
www.nature.com
May 16, 2025 at 4:16 PM
A new paper reveals that the nuclear E3 ligase UBR5 ubiquitinates VGLL4 at Lys61 for its degradation and regulates the Hippo-YAP signaling pathway
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In this study identified a direct cellular mechanism linking dietary fat, lipid metabolism, and the spread of CRC to other organs, primarily the liver. The Hippo/YAP signaling pathway is a 🔑 regulatory network that governs
faseb.onlinelibrary.wiley.com/doi/10.1096/...
faseb.onlinelibrary.wiley.com/doi/10.1096/...
The Regulation and Function of Hippo/<fc>YAP</fc> Pathway in Cancer
Hippo/YAP pathway signaling plays critical roles in the progression of multiple cancer types. This review summarizes current knowledge of Hippo/YAP pathway regulation and function in cancer. We discu...
faseb.onlinelibrary.wiley.com
September 26, 2026 at 6:39 AM
In this study identified a direct cellular mechanism linking dietary fat, lipid metabolism, and the spread of CRC to other organs, primarily the liver. The Hippo/YAP signaling pathway is a 🔑 regulatory network that governs
faseb.onlinelibrary.wiley.com/doi/10.1096/...
faseb.onlinelibrary.wiley.com/doi/10.1096/...
The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signaling
#Drosophila
#Drosophila
The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signaling
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
March 20, 2026 at 7:24 AM
The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signaling
#Drosophila
#Drosophila
Wow! The level of overproliferation that results from activation of the hippo pathway is quite something.
Top row: Tissue with too much active yki(YAP/TAZ). Bottom row: controls.
Hippo signaling was first identified in Drosophila and is deregulated in many cancers. 🧪
Top row: Tissue with too much active yki(YAP/TAZ). Bottom row: controls.
Hippo signaling was first identified in Drosophila and is deregulated in many cancers. 🧪
November 29, 2023 at 5:54 PM
Wow! The level of overproliferation that results from activation of the hippo pathway is quite something.
Top row: Tissue with too much active yki(YAP/TAZ). Bottom row: controls.
Hippo signaling was first identified in Drosophila and is deregulated in many cancers. 🧪
Top row: Tissue with too much active yki(YAP/TAZ). Bottom row: controls.
Hippo signaling was first identified in Drosophila and is deregulated in many cancers. 🧪
Targeting the Hippo pathway in cancer www.nature.com/articles/s41...
rdcu.be/et8aj
This new Review discusses emerging Hippo pathway-targeted therapies for cancer, particularly those that target TEAD DNA binding proteins and their interaction with the YAP/TAZ transcription co-activators
rdcu.be/et8aj
This new Review discusses emerging Hippo pathway-targeted therapies for cancer, particularly those that target TEAD DNA binding proteins and their interaction with the YAP/TAZ transcription co-activators
June 30, 2025 at 2:26 PM
Targeting the Hippo pathway in cancer www.nature.com/articles/s41...
rdcu.be/et8aj
This new Review discusses emerging Hippo pathway-targeted therapies for cancer, particularly those that target TEAD DNA binding proteins and their interaction with the YAP/TAZ transcription co-activators
rdcu.be/et8aj
This new Review discusses emerging Hippo pathway-targeted therapies for cancer, particularly those that target TEAD DNA binding proteins and their interaction with the YAP/TAZ transcription co-activators
PM #Carney already blinked when he removed retaliatory tariffs. You cannot reason with a hippo when your head is in its big yap! 🪶😡🇨🇦🏳️🌈🏳️⚧️ #cdnpoli www.cbc.ca/news/world/l...
July 21, 2026 at 3:31 AM
PM #Carney already blinked when he removed retaliatory tariffs. You cannot reason with a hippo when your head is in its big yap! 🪶😡🇨🇦🏳️🌈🏳️⚧️ #cdnpoli www.cbc.ca/news/world/l...
🫁 Could Maresin1 help protect transplanted lungs? This study found that Maresin1 reduced lung ischemia-reperfusion injury in a model by suppressing ferroptosis through PKA-Hippo-YAP signaling.
www.mdpi.com/2227-9059/13...
www.mdpi.com/2227-9059/13...
September 28, 2026 at 8:23 AM
🫁 Could Maresin1 help protect transplanted lungs? This study found that Maresin1 reduced lung ischemia-reperfusion injury in a model by suppressing ferroptosis through PKA-Hippo-YAP signaling.
www.mdpi.com/2227-9059/13...
www.mdpi.com/2227-9059/13...
Mesenchymal SLMAP coordinates with MST3 to govern gut elongation during development
Read this #LifelongDevSI Research Article by Yuwei Pan, Cong Lv, Lu Yu, Zhengquan Yu and colleagues:
journals.biologists.com/dev/article/...
Read this #LifelongDevSI Research Article by Yuwei Pan, Cong Lv, Lu Yu, Zhengquan Yu and colleagues:
journals.biologists.com/dev/article/...
October 21, 2025 at 12:42 PM
Mesenchymal SLMAP coordinates with MST3 to govern gut elongation during development
Read this #LifelongDevSI Research Article by Yuwei Pan, Cong Lv, Lu Yu, Zhengquan Yu and colleagues:
journals.biologists.com/dev/article/...
Read this #LifelongDevSI Research Article by Yuwei Pan, Cong Lv, Lu Yu, Zhengquan Yu and colleagues:
journals.biologists.com/dev/article/...
#InterferonFriendsOrFoes? Another cool one @ellenfoxman.bsky.social &friends out @plosbiology.org about how excessive #IFNs delay repair by activating LATS & degrading YAP/TAZ in the Hippo 🦛 pathway! journals.plos.org/plosbiology/... 👇👇👇
January 27, 2026 at 8:33 PM
#InterferonFriendsOrFoes? Another cool one @ellenfoxman.bsky.social &friends out @plosbiology.org about how excessive #IFNs delay repair by activating LATS & degrading YAP/TAZ in the Hippo 🦛 pathway! journals.plos.org/plosbiology/... 👇👇👇
organ size, tissue homeostasis, cell proliferation, and cell polarity. Aberrant Hippo/YAP signaling contributes to the initiation and progression of multiple cancers…
September 26, 2026 at 6:39 AM
organ size, tissue homeostasis, cell proliferation, and cell polarity. Aberrant Hippo/YAP signaling contributes to the initiation and progression of multiple cancers…
because Long COVID studies repeatedly show endothelial dysfunction and these markers map onto the tissue-remodeling environment in which Hippo/YAP-TAZ is biologically relevant.
September 22, 2026 at 5:23 AM
because Long COVID studies repeatedly show endothelial dysfunction and these markers map onto the tissue-remodeling environment in which Hippo/YAP-TAZ is biologically relevant.