YTHDF2 modulates oncogenic transformation and immune evasion across multiple B cell cancers by stabilizing m5C-modified mRNAs and destabilizing m6A-modified mRNAs, thereby serving as a dual reader for both m5C and m6A modifications. Small molecules that target YTHDF2 reduce ATP synthesis and are therapeutic candidates for B cell malignancies, especially when combined with CAR-T therapy or bispecific engagers.

YTHDF2 modulates oncogenic transformation and immune evasion across multiple B cell cancers by stabilizing m5C-modified mRNAs and destabilizing m6A-modified mRNAs, thereby serving as a dual reader for...

Read the full paper: ZNF121 recruits YTHDF2 to modulate mRNA stability

Dysregulation of RNA modifiers is common across cancer types and has essential roles in tumor therapy resistance. Chen and colleagues reported that YTHDF2 played dual roles in B cell malignancies by enhancing cell proliferation and promoting immune…

In this study, we investigated the molecular mechanism through which ZEA regulates pituitary gonadotropin synthesis via N6‑methyladenosine (m6A) modification.

Oncogene - Alcohol-induced C/EBP β-driven VIRMA decreases oxidative stress and promotes pancreatic ductal adenocarcinoma growth and metastasis via the m6A/YTHDF2/SLC43A2 pathway

The dual role of YTHDF2 in binding m<sup />6</sup>A- and m⁵C-modified mRNAs supports the initiation, progression, and immune evasion of B-cell cancers. Find out how YTHDF2 plays a pivotal p...

Here, we identify a novel mechanism by which the m6A-modified circRNA circNfix contributes to the regulation of septic AKI (SAKI).

Liu et al. find that the m6A reader YTHDF2 facilitates translation of microtubule-associated proteins to confer tumor chemotherapy resistance in ovarian cancer through interacting with eIF3F and DDX1. The study demonstrates the RNA-stability-independent function of YTHDF2 in cancer cells.

In this issue of Molecular Cell, Liu et al. uncovered a novel translation initiation mechanism orchestrated by YTHDF2 in ovarian cancer, fundamentally reshaping our understanding of its functional versatility and therapeutic implications and offering a new target to overcome ovarian cancer chemoresistance.