Sign-trackers vs goal-trackers, not just in rats. 🐀 → 🧑
Across 5 fMRI cohorts (N=1,251), two reproducible human reward phenotypes emerge (ST-like & GT-like). D2/D3 antagonists (risperidone, haloperidol, amisulpride) selectively blunt anticipatory BOLD in ST-like.
#RewardSignals #neuroskyence
Across 5 fMRI cohorts (N=1,251), two reproducible human reward phenotypes emerge (ST-like & GT-like). D2/D3 antagonists (risperidone, haloperidol, amisulpride) selectively blunt anticipatory BOLD in ST-like.
#RewardSignals #neuroskyence
Reproducible Human Reward Imaging Phenotypes Exhibit Differential Sensitivity to Dopamine D2 Receptor Antagonism https://www.biorxiv.org/content/10.64898/2026.05.14.724267v1
May 17, 2026 at 9:46 AM
Sign-trackers vs goal-trackers, not just in rats. 🐀 → 🧑
Across 5 fMRI cohorts (N=1,251), two reproducible human reward phenotypes emerge (ST-like & GT-like). D2/D3 antagonists (risperidone, haloperidol, amisulpride) selectively blunt anticipatory BOLD in ST-like.
#RewardSignals #neuroskyence
Across 5 fMRI cohorts (N=1,251), two reproducible human reward phenotypes emerge (ST-like & GT-like). D2/D3 antagonists (risperidone, haloperidol, amisulpride) selectively blunt anticipatory BOLD in ST-like.
#RewardSignals #neuroskyence
New data on antipsychotics and prolactinemia:
> Highest risk: Amisulpride, risperidone, paliperidone, ziprasidone
> Lowest risk: Quetiapine, clozapine, aripiprazole
From study of 6489 w/ #schizophrenia:
pubmed.ncbi.nlm.nih.gov/40830714/
I treat w/B6, metformin, bromocriptine. What do you use?
> Highest risk: Amisulpride, risperidone, paliperidone, ziprasidone
> Lowest risk: Quetiapine, clozapine, aripiprazole
From study of 6489 w/ #schizophrenia:
pubmed.ncbi.nlm.nih.gov/40830714/
I treat w/B6, metformin, bromocriptine. What do you use?
August 27, 2025 at 12:01 PM
New data on antipsychotics and prolactinemia:
> Highest risk: Amisulpride, risperidone, paliperidone, ziprasidone
> Lowest risk: Quetiapine, clozapine, aripiprazole
From study of 6489 w/ #schizophrenia:
pubmed.ncbi.nlm.nih.gov/40830714/
I treat w/B6, metformin, bromocriptine. What do you use?
> Highest risk: Amisulpride, risperidone, paliperidone, ziprasidone
> Lowest risk: Quetiapine, clozapine, aripiprazole
From study of 6489 w/ #schizophrenia:
pubmed.ncbi.nlm.nih.gov/40830714/
I treat w/B6, metformin, bromocriptine. What do you use?
- Neuroleptiques : amisulpride, chlorpromazine, cyamémazine, dropéridol, flupenthixol, fluphénazine, halopéridol, lévomépromazine, pimozide, pipampérone, pipotiazine, prucalopride, sulpiride, sultopride, tiapride, zuclopenthixol ⤵️
October 23, 2025 at 4:42 PM
- Neuroleptiques : amisulpride, chlorpromazine, cyamémazine, dropéridol, flupenthixol, fluphénazine, halopéridol, lévomépromazine, pimozide, pipampérone, pipotiazine, prucalopride, sulpiride, sultopride, tiapride, zuclopenthixol ⤵️
Forse sarebbe più indicata una dose massiccia di Amisulpride, o di clozapina...
January 9, 2025 at 10:10 AM
Forse sarebbe più indicata una dose massiccia di Amisulpride, o di clozapina...
New analysis ranks meds for #bipolar #depression, homing in on optimal doses for each (on average):
psych-partners.com/ranking-meds...
Some surprises - pindolol, amisulpride, NAC, inositol, ziprasidone - but not all are ready for practice.
#psychiatry #pmhnp
psych-partners.com/ranking-meds...
Some surprises - pindolol, amisulpride, NAC, inositol, ziprasidone - but not all are ready for practice.
#psychiatry #pmhnp
July 6, 2026 at 12:00 PM
New analysis ranks meds for #bipolar #depression, homing in on optimal doses for each (on average):
psych-partners.com/ranking-meds...
Some surprises - pindolol, amisulpride, NAC, inositol, ziprasidone - but not all are ready for practice.
#psychiatry #pmhnp
psych-partners.com/ranking-meds...
Some surprises - pindolol, amisulpride, NAC, inositol, ziprasidone - but not all are ready for practice.
#psychiatry #pmhnp
Clozapine after 1 failed antipsychotic? Response rates in new open-label RCT of:
▪ Clozapine 63%
▪ Amisulpride 45%
▪ Olanzapine 32%
pubmed.ncbi.nlm.nih.gov/41811299
Guidelines recommend clozapine after 1 failed antipsychotic in #schizophrenia with suicidality/violence
▪ Clozapine 63%
▪ Amisulpride 45%
▪ Olanzapine 32%
pubmed.ncbi.nlm.nih.gov/41811299
Guidelines recommend clozapine after 1 failed antipsychotic in #schizophrenia with suicidality/violence
March 13, 2026 at 12:01 PM
Clozapine after 1 failed antipsychotic? Response rates in new open-label RCT of:
▪ Clozapine 63%
▪ Amisulpride 45%
▪ Olanzapine 32%
pubmed.ncbi.nlm.nih.gov/41811299
Guidelines recommend clozapine after 1 failed antipsychotic in #schizophrenia with suicidality/violence
▪ Clozapine 63%
▪ Amisulpride 45%
▪ Olanzapine 32%
pubmed.ncbi.nlm.nih.gov/41811299
Guidelines recommend clozapine after 1 failed antipsychotic in #schizophrenia with suicidality/violence
Do you know the forgotten drugs that block dopamine receptors and worsen Parkinson's?
Amisulpride (Barhemsys)
Metoclopramide (Reglan, Gimoti)
Droperidol (Inapsine)
Chlorpromazine (Thorazine)
Prochlorperazine (Compazine, Compro).
pubs.acs.org/doi/10.1021/...
Amisulpride (Barhemsys)
Metoclopramide (Reglan, Gimoti)
Droperidol (Inapsine)
Chlorpromazine (Thorazine)
Prochlorperazine (Compazine, Compro).
pubs.acs.org/doi/10.1021/...
October 12, 2023 at 12:03 PM
Do you know the forgotten drugs that block dopamine receptors and worsen Parkinson's?
Amisulpride (Barhemsys)
Metoclopramide (Reglan, Gimoti)
Droperidol (Inapsine)
Chlorpromazine (Thorazine)
Prochlorperazine (Compazine, Compro).
pubs.acs.org/doi/10.1021/...
Amisulpride (Barhemsys)
Metoclopramide (Reglan, Gimoti)
Droperidol (Inapsine)
Chlorpromazine (Thorazine)
Prochlorperazine (Compazine, Compro).
pubs.acs.org/doi/10.1021/...
🔬Molecular Mechanisms of Amisulpride
New cell study reveals the complex molecular footprint of the antipsychotic amisulpride.
📊Scientists treated neuroblastoma cells with amisulpride and discovered it changes the levels of key genes and proteins involved in:👇
New cell study reveals the complex molecular footprint of the antipsychotic amisulpride.
📊Scientists treated neuroblastoma cells with amisulpride and discovered it changes the levels of key genes and proteins involved in:👇
September 19, 2025 at 7:42 PM
🔬Molecular Mechanisms of Amisulpride
New cell study reveals the complex molecular footprint of the antipsychotic amisulpride.
📊Scientists treated neuroblastoma cells with amisulpride and discovered it changes the levels of key genes and proteins involved in:👇
New cell study reveals the complex molecular footprint of the antipsychotic amisulpride.
📊Scientists treated neuroblastoma cells with amisulpride and discovered it changes the levels of key genes and proteins involved in:👇
The mechanistic test: D₂/D₃ antagonism selectively reduced anticipatory ventral-striatal responses in sign-trackers, not goal-trackers. This appeared after single-dose risperidone/haloperidol and again after 7 days of amisulpride; aripiprazole showed a different pattern. 3/4
September 6, 2026 at 3:36 PM
The mechanistic test: D₂/D₃ antagonism selectively reduced anticipatory ventral-striatal responses in sign-trackers, not goal-trackers. This appeared after single-dose risperidone/haloperidol and again after 7 days of amisulpride; aripiprazole showed a different pattern. 3/4
Null results need a home too... In a recent study that was published as a letter in Schizophrenia Research we tested the effects of 300 mg of Amisulpride on the psychobiological stress response in a randomized controlled trial.
authors.elsevier.com/a/1i0KQ3HQGm...
authors.elsevier.com/a/1i0KQ3HQGm...
November 1, 2023 at 9:10 AM
Null results need a home too... In a recent study that was published as a letter in Schizophrenia Research we tested the effects of 300 mg of Amisulpride on the psychobiological stress response in a randomized controlled trial.
authors.elsevier.com/a/1i0KQ3HQGm...
authors.elsevier.com/a/1i0KQ3HQGm...
In healthy volunteers, short-term (~1 week) antipsychotic use (amisulpride/aripiprazole) transiently increases striatal volume,with no cortical changes, with effects reversing within 1 week of cessation of use
www.nature.com/artic...
www.nature.com/artic...
Antipsychotics cause reversible structural brain changes within one week
Neuropsychopharmacology - Antipsychotics cause reversible structural brain changes within one week
www.nature.com
June 11, 2025 at 3:31 PM
In healthy volunteers, short-term (~1 week) antipsychotic use (amisulpride/aripiprazole) transiently increases striatal volume,with no cortical changes, with effects reversing within 1 week of cessation of use
www.nature.com/artic...
www.nature.com/artic...
[struggle // hair] #2WordPrompt from 12/11
“Your hair has turned as white
as the fur of a snowshoe hare,
communing with a moon as pale
as the skin on your wrists,
paper thin.”
“Your hair has turned as white
as the fur of a snowshoe hare,
communing with a moon as pale
as the skin on your wrists,
paper thin.”
December 29, 2024 at 7:22 PM
[struggle // hair] #2WordPrompt from 12/11
“Your hair has turned as white
as the fur of a snowshoe hare,
communing with a moon as pale
as the skin on your wrists,
paper thin.”
“Your hair has turned as white
as the fur of a snowshoe hare,
communing with a moon as pale
as the skin on your wrists,
paper thin.”
📄New paper from our lab @hhu.de on the role of dopamine in multi-attribute decision making. Increasing DA transmission (L-DOPA) increased, whereas D2 receptor blockade (Amisulpride) reduced the effect of individual attributes on choice.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Bidirectional modulation of reward-guided decision making by dopamine - Psychopharmacology
Rationale The neuromodulator dopamine is known to play a key role in reward-guided decision making, where choice options are often characterized by multiple attributes. Different decision strategies c...
link.springer.com
June 3, 2025 at 9:50 AM
📄New paper from our lab @hhu.de on the role of dopamine in multi-attribute decision making. Increasing DA transmission (L-DOPA) increased, whereas D2 receptor blockade (Amisulpride) reduced the effect of individual attributes on choice.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
#ThisWeekInNPP
🧪 In healthy volunteers, short-term antipsychotic use (amisulpride/aripiprazole) transiently increased striatal volume — with no cortical changes.
🔗 www.nature.com/articles/s41...
🧪 In healthy volunteers, short-term antipsychotic use (amisulpride/aripiprazole) transiently increased striatal volume — with no cortical changes.
🔗 www.nature.com/articles/s41...
Antipsychotics cause reversible structural brain changes within one week - Neuropsychopharmacology
Neuropsychopharmacology - Antipsychotics cause reversible structural brain changes within one week
www.nature.com
May 13, 2025 at 4:46 PM
#ThisWeekInNPP
🧪 In healthy volunteers, short-term antipsychotic use (amisulpride/aripiprazole) transiently increased striatal volume — with no cortical changes.
🔗 www.nature.com/articles/s41...
🧪 In healthy volunteers, short-term antipsychotic use (amisulpride/aripiprazole) transiently increased striatal volume — with no cortical changes.
🔗 www.nature.com/articles/s41...
🥛 💊 Un écoulement de lait par les seins (galactorrhée) peut survenir si vous avez un traitement neuroleptique ( = antipsychotique) comme risperidone, aripiprazole, clozapine, amisulpride etc. Un effet secondaire bien connu. N’hésitez pas à en parler à votre psychiatre. 🧠
November 7, 2023 at 10:49 AM
🥛 💊 Un écoulement de lait par les seins (galactorrhée) peut survenir si vous avez un traitement neuroleptique ( = antipsychotique) comme risperidone, aripiprazole, clozapine, amisulpride etc. Un effet secondaire bien connu. N’hésitez pas à en parler à votre psychiatre. 🧠
JAMA Psych study: LB-102, N-methyl amisulpride, shows promise for acute schizophrenia. 28-day double-blind trial. PMID:42018313, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.0428 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://doi.org/10.1001/jamapsychiatry.2026.0428
No description available
doi.org
May 23, 2026 at 7:00 PM
Always like a good sequential trial 😍 jamanetwork.com/journals/jam...
Clozapine After Failed Drug Trial in First-Episode Psychosis
This randomized clinical trial investigates if clozapine is more efficacious than olanzapine or amisulpride in patients who fail to respond to an initial antipsychotic drug trial.
jamanetwork.com
March 12, 2026 at 3:44 AM
Always like a good sequential trial 😍 jamanetwork.com/journals/jam...
Antipsychotics by efficacy in #schizophrenia, from new analysis:
1. Clozapine
2. Amisulpride, olanzapine, risperidone
Cobenfy also high efficacy, and lacks long-term risks, but short-term high drop-out rates due to GI SE.
See how they rank across 7 side effects:
psych-partners.com/antipsychoti...
1. Clozapine
2. Amisulpride, olanzapine, risperidone
Cobenfy also high efficacy, and lacks long-term risks, but short-term high drop-out rates due to GI SE.
See how they rank across 7 side effects:
psych-partners.com/antipsychoti...
March 25, 2026 at 12:03 PM
Antipsychotics by efficacy in #schizophrenia, from new analysis:
1. Clozapine
2. Amisulpride, olanzapine, risperidone
Cobenfy also high efficacy, and lacks long-term risks, but short-term high drop-out rates due to GI SE.
See how they rank across 7 side effects:
psych-partners.com/antipsychoti...
1. Clozapine
2. Amisulpride, olanzapine, risperidone
Cobenfy also high efficacy, and lacks long-term risks, but short-term high drop-out rates due to GI SE.
See how they rank across 7 side effects:
psych-partners.com/antipsychoti...
Le potentiel hyperprolactinémiant des antipsychotiques est lié à la capacité à bloquer les récepteurs D2 (dopamine) de l'hypophyse, avec ≠ entre 💊:
-fort potentiel: risperidone, amisulpride (SOLIAN)
-faible: aripiprazole(ABILIFY), quetiapine, olanzapine(ZYPREXA), clozapine
8/12
-fort potentiel: risperidone, amisulpride (SOLIAN)
-faible: aripiprazole(ABILIFY), quetiapine, olanzapine(ZYPREXA), clozapine
8/12
November 19, 2023 at 7:33 PM
Le potentiel hyperprolactinémiant des antipsychotiques est lié à la capacité à bloquer les récepteurs D2 (dopamine) de l'hypophyse, avec ≠ entre 💊:
-fort potentiel: risperidone, amisulpride (SOLIAN)
-faible: aripiprazole(ABILIFY), quetiapine, olanzapine(ZYPREXA), clozapine
8/12
-fort potentiel: risperidone, amisulpride (SOLIAN)
-faible: aripiprazole(ABILIFY), quetiapine, olanzapine(ZYPREXA), clozapine
8/12
For patients with #FirstEpisodePsychosis unresponsive to initial antipsychotic therapy, clozapine improved symptom response rates and reduced discontinuation due to insufficient efficacy vs olanzapine or amisulpride. ja.ma/49JXqYR
June 7, 2026 at 11:00 AM
For patients with #FirstEpisodePsychosis unresponsive to initial antipsychotic therapy, clozapine improved symptom response rates and reduced discontinuation due to insufficient efficacy vs olanzapine or amisulpride. ja.ma/49JXqYR