Fudan University researchers developed #etBE, an engineered Transformer #BaseEditor with up to 35-fold higher C-to-T editing efficiency that achieved 35.13% in vivo liver editing and a 33% LDL-C reduction in mice without off-target trade-offs. 🧬🤖 #FudanUniversity #GeneTherapy #PCSK9

🚨 Excited to share our latest preprint!
@mgarnett.bsky.social @mattcoelho.bsky.social
We introduce BEstimate, a flexible, comprehensive tool for designing and interpreting CRISPR-based editing experiments.
#CRISPR #BEstimate #BaseEditor

YOLT-101
Another single-infusion #BaseEditor therapy for Heterozygous Familial Hypercholesterolemia
From #YolTech Therapeutics

0.6 mg/kg N=3
Being effective in 1 wk
Sustained 70% ⬇️plasma PCSk9 & 50% ⬇️LDL-C till 16-wk

medRxiv 2025
www.medrxiv.org/content/10.1...

Design & Deliver #CRISPR #BaseEditor #PrimeEditor to your adult👤stem cell-derived (colon/ endometrium/hepatocyte) #Organoids

Plasmids
Electroporation
FACS + PiggyBac selection

Learn "Picking the right genome editing tool in 30 minutes!"😄
#STARProtocols 2024
star-protocols.cell.com/protocols/3589

Check this out if you're interested in #crispr #baseeditor. Congratulations Cansu for creating this wonderful tool.

Scientists engineered a high-precision, near-PAMless cytosine #baseeditor by combining a truncated CDA1 deaminase with an HMGN1-VP64 dual-fusion architecture, tightly locking the conversion window onto the C18 position and achieving a peak editing efficiency of 78.57% in stable #rice lines.

2026 Roadmap: The #PrEditR platform streamlines functional proteomics by allowing researchers to design #baseeditor sgRNAs directly from protein residue coordinates through an automated, isoform-aware mapping architecture. 🧬🛡️