How adding mRNA to code for interleukin-12 markedly increased T cell immune response which could be used for vaccines vs infectious diseases and cancer @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses
IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.
www.science.org
June 7, 2025 at 2:41 PM
How adding mRNA to code for interleukin-12 markedly increased T cell immune response which could be used for vaccines vs infectious diseases and cancer @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A new #ScienceImmunology Review discusses the mechanisms through which dendritic cells influence cytotoxic CD8+ T cell responses against cancer. scim.ag/3PU7hRo
Architects of immunity: How dendritic cells shape CD8+ T cell fate in cancer
DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer.
scim.ag
January 27, 2025 at 5:10 PM
A new #ScienceImmunology Review discusses the mechanisms through which dendritic cells influence cytotoxic CD8+ T cell responses against cancer. scim.ag/3PU7hRo
Tolerance by eviction
"we report that, in mice, CD8 T cell tolerance instead results from premature thymic eviction of immature autoreactive CD8 thymocytes into the periphery, where they differentiate into self-tolerant mature CD8 T cells"
#Immunology #Immunosky
"we report that, in mice, CD8 T cell tolerance instead results from premature thymic eviction of immature autoreactive CD8 thymocytes into the periphery, where they differentiate into self-tolerant mature CD8 T cells"
#Immunology #Immunosky
CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus
Thymic eviction explains CD8 T cell tolerance and why autoreactive CD8 T cells appear in the periphery but not the thymus.
www.science.org
November 15, 2024 at 10:44 PM
Tolerance by eviction
"we report that, in mice, CD8 T cell tolerance instead results from premature thymic eviction of immature autoreactive CD8 thymocytes into the periphery, where they differentiate into self-tolerant mature CD8 T cells"
#Immunology #Immunosky
"we report that, in mice, CD8 T cell tolerance instead results from premature thymic eviction of immature autoreactive CD8 thymocytes into the periphery, where they differentiate into self-tolerant mature CD8 T cells"
#Immunology #Immunosky
i'm told cyndy martin has resigned from ALL of her DFL positions - CD8, CBRC, code of conduct, itasca county DFL, feminist caucus - as of today
she pleaded not guilty to vehicular homicide last month
taylordahlin.com/f/cyndy-mart...
she pleaded not guilty to vehicular homicide last month
taylordahlin.com/f/cyndy-mart...
Cyndy Martin Reportedly Resigns From All DFL Positions
Cyndy Martin, the chair of CD8 DFL, has reportedly resigned from all of her DFL party positions as of Friday, December 12. The news broke after another CD8 party official walked into a labor lunch in ...
taylordahlin.com
December 12, 2025 at 8:43 PM
i'm told cyndy martin has resigned from ALL of her DFL positions - CD8, CBRC, code of conduct, itasca county DFL, feminist caucus - as of today
she pleaded not guilty to vehicular homicide last month
taylordahlin.com/f/cyndy-mart...
she pleaded not guilty to vehicular homicide last month
taylordahlin.com/f/cyndy-mart...
Killer T cells (CD8+) in Long Covid directed to SARS-CoV-2 and Herpes virus antigens are persistent and may have a causal role
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Persistent cytolytic CD8+ T cells recognize SARS-CoV-2 and herpesvirus epitopes in long COVID
Ma et al. perform deep-phenotyping of CD8+ T cells specific for viruses implicated
in LC pathogenesis: SARS-CoV-2, CMV, and EBV. These T cells from LC individuals share
features of terminal differenti...
www.cell.com
July 30, 2026 at 6:50 AM
Killer T cells (CD8+) in Long Covid directed to SARS-CoV-2 and Herpes virus antigens are persistent and may have a causal role
www.cell.com/cell-reports...
www.cell.com/cell-reports...
während der Masseninfektion und nach COVID-19.
Während einer Masseninfektion sanken die T-Zellen, CD4 + T-Zellen, CD8 + T-Zellen, NK-Zellen und B-Zellen signifikant. Selbst 20 Monate nach der Infektion lagen die CD8 + T-Zellen noch 9,9 % unter dem Ausgangswert. Die
Während einer Masseninfektion sanken die T-Zellen, CD4 + T-Zellen, CD8 + T-Zellen, NK-Zellen und B-Zellen signifikant. Selbst 20 Monate nach der Infektion lagen die CD8 + T-Zellen noch 9,9 % unter dem Ausgangswert. Die
December 5, 2025 at 10:30 PM
während der Masseninfektion und nach COVID-19.
Während einer Masseninfektion sanken die T-Zellen, CD4 + T-Zellen, CD8 + T-Zellen, NK-Zellen und B-Zellen signifikant. Selbst 20 Monate nach der Infektion lagen die CD8 + T-Zellen noch 9,9 % unter dem Ausgangswert. Die
Während einer Masseninfektion sanken die T-Zellen, CD4 + T-Zellen, CD8 + T-Zellen, NK-Zellen und B-Zellen signifikant. Selbst 20 Monate nach der Infektion lagen die CD8 + T-Zellen noch 9,9 % unter dem Ausgangswert. Die
Vaccination after Covid infection leads to substantial expansion of CD8+ T cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 7, 2023 at 1:33 AM
Vaccination after Covid infection leads to substantial expansion of CD8+ T cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Thank you, CD8!
It was inspiring to join folks in Lindstrom at their convention today. Sometimes democracy is messy (and long), but conventions like these are at the heart of how we organize.
It was inspiring to join folks in Lindstrom at their convention today. Sometimes democracy is messy (and long), but conventions like these are at the heart of how we organize.
May 2, 2026 at 6:25 PM
Thank you, CD8!
It was inspiring to join folks in Lindstrom at their convention today. Sometimes democracy is messy (and long), but conventions like these are at the heart of how we organize.
It was inspiring to join folks in Lindstrom at their convention today. Sometimes democracy is messy (and long), but conventions like these are at the heart of how we organize.
Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis - Nature Immunology
Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...
www.nature.com
February 5, 2026 at 10:20 AM
Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
aufweisen, die nicht nur gegen SARS-CoV-2, sondern auch gegen die Herpesviren Epstein-Barr-Virus (EBV) und Zytomegalievirus (CMV) gerichtet sind. Die Ergebnisse deuten darauf hin, dass Long COVID durch eine anhaltende Immunantwort auf persistierende Virusproteine gekennzeichnet
August 1, 2026 at 8:59 PM
aufweisen, die nicht nur gegen SARS-CoV-2, sondern auch gegen die Herpesviren Epstein-Barr-Virus (EBV) und Zytomegalievirus (CMV) gerichtet sind. Die Ergebnisse deuten darauf hin, dass Long COVID durch eine anhaltende Immunantwort auf persistierende Virusproteine gekennzeichnet
youtube.com/shorts/rSIc0.... I am in a packed auditorium in Duluth Minnesota for a Town Hall meeting. Over 700 people from CD8 are here. Congressman Pete Stauber is a no show. @rachelmaddow.msnbc.com.
March 29, 2025
YouTube video by Joan Peterson
youtube.com
March 29, 2025 at 7:52 PM
youtube.com/shorts/rSIc0.... I am in a packed auditorium in Duluth Minnesota for a Town Hall meeting. Over 700 people from CD8 are here. Congressman Pete Stauber is a no show. @rachelmaddow.msnbc.com.
Happy to be part of @kingofpathogens.bsky.social study showing mRNAs encoding IL-12 enhance CD8 T cell responses to co-administered HA mRNA vaccines. Study led by Emily Aunins and Anthony Phan from the Hunter lab @upenn.edu
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses
IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.
www.science.org
June 6, 2025 at 9:26 PM
Happy to be part of @kingofpathogens.bsky.social study showing mRNAs encoding IL-12 enhance CD8 T cell responses to co-administered HA mRNA vaccines. Study led by Emily Aunins and Anthony Phan from the Hunter lab @upenn.edu
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
"Even 20 months post-infection, CD8+ T cells remained 9.9% below baseline.”
January 14, 2026 at 11:30 PM
"Even 20 months post-infection, CD8+ T cells remained 9.9% below baseline.”
Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity - Nature Aging
Exploring how aging compromises antitumor immunity, the authors reveal an age-related impairment of cytotoxic CD8+ TRM cells in mouse tumor models and clinical samples. They implicate BFAR signaling a...
www.nature.com
November 27, 2024 at 2:26 AM
Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity
www.nature.com/articles/s43...
www.nature.com/articles/s43...
This study found that within 7 days of a COVID-19 infection:
•rapid increase in aged and exhausted CD4 and CD8 T cells
•accelerated “immune aging”
•this occurred in all cases regardless of illness severity
•this is specifically a SARS-CoV-2 effect not seen in other infections
•rapid increase in aged and exhausted CD4 and CD8 T cells
•accelerated “immune aging”
•this occurred in all cases regardless of illness severity
•this is specifically a SARS-CoV-2 effect not seen in other infections
Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection
Mild to severe COVID-19, but not other respiratory infections, increased cellular senescence and exhaustion in CD4 and CD8 T cells over a 7-d period of inf
academic.oup.com
December 6, 2024 at 1:36 PM
This study found that within 7 days of a COVID-19 infection:
•rapid increase in aged and exhausted CD4 and CD8 T cells
•accelerated “immune aging”
•this occurred in all cases regardless of illness severity
•this is specifically a SARS-CoV-2 effect not seen in other infections
•rapid increase in aged and exhausted CD4 and CD8 T cells
•accelerated “immune aging”
•this occurred in all cases regardless of illness severity
•this is specifically a SARS-CoV-2 effect not seen in other infections
More #evidence for the existence of #CD8 #Regulatory #Tcells www.nature.com/articles/s41... Check our previous paper also> #KIR+CD8+ #T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19 | Science www.science.org/doi/10.1126/...
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma - Nature Immunology
Tumor-antigen-specific CD8+ T cells are generally thought to help fight against cancer, but here the authors identify a subpopulation of CD8+ T cells that are associated with a poor clinical outcome i...
www.nature.com
December 1, 2024 at 12:00 PM
More #evidence for the existence of #CD8 #Regulatory #Tcells www.nature.com/articles/s41... Check our previous paper also> #KIR+CD8+ #T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19 | Science www.science.org/doi/10.1126/...
I am overjoyed to present our latest paper on Autophagy in CD8 Tcells!
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.
I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.
I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology
Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...
www.nature.com
March 1, 2025 at 11:18 AM
I am overjoyed to present our latest paper on Autophagy in CD8 Tcells!
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.
I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.
I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
Our @natrevimmunol.bsky.social review with @abhishekgarglab.bsky.social, @deadoc80.bsky.social and Kellie Smith is out!
We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections!
www.nature.com/articles/s41...
We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections!
www.nature.com/articles/s41...
The diversity of CD8+ T cell dysfunction in cancer and viral infection - Nature Reviews Immunology
Beyond exhaustion, CD8+ T cells can adopt various dysfunctional states, including tolerant, anergic, senescent, ignorant and dying states, that compromise their ability to eradicate viruses or tumours...
www.nature.com
April 14, 2025 at 8:53 AM
Our @natrevimmunol.bsky.social review with @abhishekgarglab.bsky.social, @deadoc80.bsky.social and Kellie Smith is out!
We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections!
www.nature.com/articles/s41...
We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections!
www.nature.com/articles/s41...
Hao Hu's talk is now on YouTube!
Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration
youtu.be/4up0OQQA-wA
Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration
youtu.be/4up0OQQA-wA
[Hao Hu] Priming of CD8+ T cells by peripheral DCs exacerbates tau-mediated neurodegeneration
Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration
*Speaker: Hao Hu (Washington University in St. Louis)
*Moderator: Jerry Lin (Massachusetts General…
youtu.be
September 23, 2026 at 2:01 PM
Hao Hu's talk is now on YouTube!
Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration
youtu.be/4up0OQQA-wA
Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration
youtu.be/4up0OQQA-wA
The rolling billboard truck sponsored by the Democratic Messaging campaign, produced by Mobile Media, rolls through CD8 in Weld County CO. The CD8 Indivisible Coalition provided messaging and stop locations. The truck will visit the CD8 district through Sept 22 #GabesGottaGo #VoteBlue #VoteEarly
September 19, 2026 at 11:19 PM
The rolling billboard truck sponsored by the Democratic Messaging campaign, produced by Mobile Media, rolls through CD8 in Weld County CO. The CD8 Indivisible Coalition provided messaging and stop locations. The truck will visit the CD8 district through Sept 22 #GabesGottaGo #VoteBlue #VoteEarly
Something to keep in mind: “These findings suggest that SARS-CoV-2 infection damages the CD8+ T cell response, an effect akin to that observed in earlier studies showing long-term damage to the immune system after infection w/ viruses such as hepatitis C or HIV.” #COVID
www.nih.gov/news-events/...
www.nih.gov/news-events/...
SARS-CoV-2 infection weakens immune-cell response to vaccination
NIH-funded study suggests need to boost CD8+ T cell response after infection.
www.nih.gov
July 22, 2025 at 7:18 PM
Something to keep in mind: “These findings suggest that SARS-CoV-2 infection damages the CD8+ T cell response, an effect akin to that observed in earlier studies showing long-term damage to the immune system after infection w/ viruses such as hepatitis C or HIV.” #COVID
www.nih.gov/news-events/...
www.nih.gov/news-events/...
Driving around CD8, right now.
Kickass!
Kickass!
September 19, 2026 at 6:20 PM
Driving around CD8, right now.
Kickass!
Kickass!
Putting LIPSTIC on CARTs
"We reasoned that target-induced labelling of CAR molecules within the immunologic synapse, instead of surface CD8 expression levels, could be used to distinguish and characterize first-division proximal- and distal-daughter CARTs"
#Immunology
www.nature.com/articles/s41...
"We reasoned that target-induced labelling of CAR molecules within the immunologic synapse, instead of surface CD8 expression levels, could be used to distinguish and characterize first-division proximal- and distal-daughter CARTs"
#Immunology
www.nature.com/articles/s41...
Fate induction in CD8 CAR T cells through asymmetric cell division - Nature
We show that target-induced proximity labelling enables isolation of first-division CD8 chimeric antigen receptor T cells that asymmetrically distribute their surface proteome and transcriptome, resul...
www.nature.com
November 17, 2024 at 2:20 AM
Putting LIPSTIC on CARTs
"We reasoned that target-induced labelling of CAR molecules within the immunologic synapse, instead of surface CD8 expression levels, could be used to distinguish and characterize first-division proximal- and distal-daughter CARTs"
#Immunology
www.nature.com/articles/s41...
"We reasoned that target-induced labelling of CAR molecules within the immunologic synapse, instead of surface CD8 expression levels, could be used to distinguish and characterize first-division proximal- and distal-daughter CARTs"
#Immunology
www.nature.com/articles/s41...
🚨NEW🧪: TET2 regulates early and late transitions in exhausted CD8+ T cell differentiation and limits CAR T cell function - #CARTCell #immunotherapy #TCell #tcellrx #immunology www.science.org/doi/10.1126/...
TET2 regulates early and late transitions in exhausted CD8+ T cell differentiation and limits CAR T cell function
Modulation of exhausted CD8+ T cell differentiation by targeting TET2 improves therapeutic potential of CAR T cells in cancer.
www.science.org
November 19, 2024 at 12:45 PM
🚨NEW🧪: TET2 regulates early and late transitions in exhausted CD8+ T cell differentiation and limits CAR T cell function - #CARTCell #immunotherapy #TCell #tcellrx #immunology www.science.org/doi/10.1126/...