New evidence @nejm.org today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Clonal Hematopoiesis as a Driver of Solid Tumors | NEJM
Clonal hematopoiesis is the expansion of a genetically related population of hematopoietic stem and progenitor cells that disproportionately contribute to blood-cell production.1 Clonal hematopoies...
www.nejm.org
April 23, 2025 at 10:22 PM
New evidence @nejm.org today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Out @nature.com: Clonal tracing with somatic epimutations
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...
doi.org
May 21, 2025 at 3:44 PM
Out @nature.com: Clonal tracing with somatic epimutations
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
Pretty much everything is fucked, but here is some beautiful and exciting science from @archaeon-alex.bsky.social and colleagues.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
www.science.org
April 4, 2025 at 3:40 AM
Pretty much everything is fucked, but here is some beautiful and exciting science from @archaeon-alex.bsky.social and colleagues.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Nature ersearch paper: Sex without crossovers mimics clonal reproduction in Rhynchospora tenuis
go.nature.com/3UXKc6g
go.nature.com/3UXKc6g
Sex without crossovers mimics clonal reproduction in Rhynchospora tenuis - Nature
Rhynchospora tenuis undergoes obligate, genome-wide achiasmy in both male and female meiosis.
go.nature.com
September 22, 2026 at 8:19 AM
Nature ersearch paper: Sex without crossovers mimics clonal reproduction in Rhynchospora tenuis
go.nature.com/3UXKc6g
go.nature.com/3UXKc6g
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
www.science.org
April 3, 2025 at 6:24 PM
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
i really like the deltarune theory that the trees around hometown are all a single clonal colony organism, like a quaking aspen, and that the single organism is connected to roots / the shelter
June 26, 2026 at 4:29 PM
i really like the deltarune theory that the trees around hometown are all a single clonal colony organism, like a quaking aspen, and that the single organism is connected to roots / the shelter
New @science.org today
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in t...
science.org
January 1, 2026 at 7:03 PM
New @science.org today
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
personally i think they should rip up the interstate system and replace it with walkable clonal smooth muscle grafts. great pulsing loops of intestine, self-lubricating and all. get digested there
June 25, 2025 at 4:37 PM
personally i think they should rip up the interstate system and replace it with walkable clonal smooth muscle grafts. great pulsing loops of intestine, self-lubricating and all. get digested there
New preprint up! We sequenced hundreds of samples from across one of Earth's oldest living organisms - the Pando aspen clone - to understand how mutations accumulate and spread in long-lived clonal organisms. Our results were…surprising. 1/30
October 26, 2024 at 5:45 PM
New preprint up! We sequenced hundreds of samples from across one of Earth's oldest living organisms - the Pando aspen clone - to understand how mutations accumulate and spread in long-lived clonal organisms. Our results were…surprising. 1/30
Just in time for thanksgiving our paper is out ☄️
using fluctuating methylation clocks as barcodes we show that the variation in the hematopoietic stem cell pool that (in most of us) leads to clonal hematopoiesis in later life is likely present *before birth*
👉🏼 www.nature.com/articles/s41...
using fluctuating methylation clocks as barcodes we show that the variation in the hematopoietic stem cell pool that (in most of us) leads to clonal hematopoiesis in later life is likely present *before birth*
👉🏼 www.nature.com/articles/s41...
Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life - Nature Communications
Clonal hematopoiesis becomes increasingly common with age. Here the authors track stem cell dynamics in monozygotic twins and provide evidence that clonal hematopoiesis in later life reflects weak sel...
www.nature.com
November 28, 2024 at 5:15 AM
Just in time for thanksgiving our paper is out ☄️
using fluctuating methylation clocks as barcodes we show that the variation in the hematopoietic stem cell pool that (in most of us) leads to clonal hematopoiesis in later life is likely present *before birth*
👉🏼 www.nature.com/articles/s41...
using fluctuating methylation clocks as barcodes we show that the variation in the hematopoietic stem cell pool that (in most of us) leads to clonal hematopoiesis in later life is likely present *before birth*
👉🏼 www.nature.com/articles/s41...
DNA barcoding systems that uniquely label progenitors allow us to trace their fate.
Marine Secchi highlights a #preprint presenting a novel method to analyse complex clonal patterns @sergeyisaev.bsky.social @alekerickson.bsky.social @adameykolab.bsky.social
prelights.biologists.com/highlights/c...
Marine Secchi highlights a #preprint presenting a novel method to analyse complex clonal patterns @sergeyisaev.bsky.social @alekerickson.bsky.social @adameykolab.bsky.social
prelights.biologists.com/highlights/c...
Clonal embeddings allow exploratory analysis of lineage-resolved single-cell data - preLights
DNA barcoding systems that uniquely label progenitors allow us to trace their fate. This preprint presents a novel method to analyse complex clonal patterns.
prelights.biologists.com
September 24, 2026 at 10:31 AM
DNA barcoding systems that uniquely label progenitors allow us to trace their fate.
Marine Secchi highlights a #preprint presenting a novel method to analyse complex clonal patterns @sergeyisaev.bsky.social @alekerickson.bsky.social @adameykolab.bsky.social
prelights.biologists.com/highlights/c...
Marine Secchi highlights a #preprint presenting a novel method to analyse complex clonal patterns @sergeyisaev.bsky.social @alekerickson.bsky.social @adameykolab.bsky.social
prelights.biologists.com/highlights/c...
📣 New paper! 📣
❓Do clonal fish and their sexually reproducing heterospecifics differ in parasite load?
🤒 We found that clonal Amazon mollies were more likely to be infected than Sailfin mollies, but parasite loads were largely the same.
🤔 Could behavior have something to do with this pattern? 1/3
❓Do clonal fish and their sexually reproducing heterospecifics differ in parasite load?
🤒 We found that clonal Amazon mollies were more likely to be infected than Sailfin mollies, but parasite loads were largely the same.
🤔 Could behavior have something to do with this pattern? 1/3
Differences in Parasite Infection Status and Behavior Between a Clonal Fish and Her Sexually Reproducing Heterospecifics
We found that Amazons and Sailfins differed in their qualitative, but not quantitative, resistance to parasites. Amazons had worse qualitative resistance (i.e., were more likely to be infected with a...
doi.org
September 21, 2026 at 7:23 PM
📣 New paper! 📣
❓Do clonal fish and their sexually reproducing heterospecifics differ in parasite load?
🤒 We found that clonal Amazon mollies were more likely to be infected than Sailfin mollies, but parasite loads were largely the same.
🤔 Could behavior have something to do with this pattern? 1/3
❓Do clonal fish and their sexually reproducing heterospecifics differ in parasite load?
🤒 We found that clonal Amazon mollies were more likely to be infected than Sailfin mollies, but parasite loads were largely the same.
🤔 Could behavior have something to do with this pattern? 1/3
A telltale sign that it’s that time of the year again: festively dressed clonal raider ants are decorating the lab.
December 10, 2025 at 2:14 AM
A telltale sign that it’s that time of the year again: festively dressed clonal raider ants are decorating the lab.
Clonal-aggregative multicellularity tuned by salinity in a choanoflagellate www.nature.com/articles/s41... #jcampubs
Clonal-aggregative multicellularity tuned by salinity in a choanoflagellate - Nature
The choanoflagellate Choanoeca flexa forms motile and contractile cell monolayers purely clonally, purely aggregatively or through a combination of both processes depending on environmental condi...
www.nature.com
February 25, 2026 at 5:06 PM
Clonal-aggregative multicellularity tuned by salinity in a choanoflagellate www.nature.com/articles/s41... #jcampubs
Today in
@currentbiology.bsky.social: a Quick Guide to the wondrous and fascinating biology of the clonal raider ant: authors.elsevier.com/a/1kOXg3QW8S...
@currentbiology.bsky.social: a Quick Guide to the wondrous and fascinating biology of the clonal raider ant: authors.elsevier.com/a/1kOXg3QW8S...
January 6, 2025 at 5:27 PM
Today in
@currentbiology.bsky.social: a Quick Guide to the wondrous and fascinating biology of the clonal raider ant: authors.elsevier.com/a/1kOXg3QW8S...
@currentbiology.bsky.social: a Quick Guide to the wondrous and fascinating biology of the clonal raider ant: authors.elsevier.com/a/1kOXg3QW8S...
Nature research paper: Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
go.nature.com/4op9KDO
go.nature.com/4op9KDO
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis - Nature
Sleep and exercise can slow clonal haematopoiesis and limit mutant cell-driven atherosclerosis.
go.nature.com
June 16, 2026 at 10:06 AM
Nature research paper: Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
go.nature.com/4op9KDO
go.nature.com/4op9KDO
#Blueskypoet #haiku #poetry #photography
Ancient clonal aspens
Wise whisperings underground
Forest watchdog
Ancient clonal aspens
Wise whisperings underground
Forest watchdog
January 20, 2025 at 4:37 PM
#Blueskypoet #haiku #poetry #photography
Ancient clonal aspens
Wise whisperings underground
Forest watchdog
Ancient clonal aspens
Wise whisperings underground
Forest watchdog
That's dramatic (and cool): "archaea species can also form multicellular tissue–like structures when compressive forces are applied... ... These results establish multicellularity as a feature of all three domains of life" www.science.org/doi/10.1126/...
Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
www.science.org
April 4, 2025 at 10:39 AM
That's dramatic (and cool): "archaea species can also form multicellular tissue–like structures when compressive forces are applied... ... These results establish multicellularity as a feature of all three domains of life" www.science.org/doi/10.1126/...
Sometimes I am surprised by how many crops are (mostly) sterile plants that are hanging on just by clonal propagation.
Potato, banana, pandan, yams...
Potato, banana, pandan, yams...
July 26, 2025 at 4:28 AM
Sometimes I am surprised by how many crops are (mostly) sterile plants that are hanging on just by clonal propagation.
Potato, banana, pandan, yams...
Potato, banana, pandan, yams...
This fish shouldn’t exist — the weird genetics of clonal vertebrates idp.nature.com/authorize?re... 🧪🌎🦑🐠
This fish shouldn’t exist — the weird genetics of clonal vertebrates
Hear the biggest stories from the world of science | 11 March 2026
idp.nature.com
March 11, 2026 at 6:21 PM
This fish shouldn’t exist — the weird genetics of clonal vertebrates idp.nature.com/authorize?re... 🧪🌎🦑🐠
The final version of the clonal raider ant reference brain is now out OA in @currentbiology.bsky.social:
🐜 🧠 🐜 🧠 🐜 🧠 🐜 🧠 🐜 🧠 🐜
www.sciencedirect.com/science/arti...
🐜 🧠 🐜 🧠 🐜 🧠 🐜 🧠 🐜 🧠 🐜
www.sciencedirect.com/science/arti...
December 5, 2025 at 4:30 PM
The final version of the clonal raider ant reference brain is now out OA in @currentbiology.bsky.social:
🐜 🧠 🐜 🧠 🐜 🧠 🐜 🧠 🐜 🧠 🐜
www.sciencedirect.com/science/arti...
🐜 🧠 🐜 🧠 🐜 🧠 🐜 🧠 🐜 🧠 🐜
www.sciencedirect.com/science/arti...
Nature research paper: Clonal tracing with somatic epimutations reveals dynamics of blood ageing
https://go.nature.com/43NOe1R
https://go.nature.com/43NOe1R
Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing through cellular differentiation at scale.
go.nature.com
May 21, 2025 at 5:52 PM
Nature research paper: Clonal tracing with somatic epimutations reveals dynamics of blood ageing
https://go.nature.com/43NOe1R
https://go.nature.com/43NOe1R
Sex without crossovers mimics clonal reproduction in Rhynchospora tenuis @Nature.com
Sex without crossovers mimics clonal reproduction in Rhynchospora tenuis
Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11057-7Rhynchospora tenuis undergoes obligate, genome-wide achiasmy in both male and female meiosis.
dlvr.it
September 18, 2026 at 9:44 AM
Sex without crossovers mimics clonal reproduction in Rhynchospora tenuis @Nature.com
Clonal raider ants finding their communities on bluesky 🩵🐜🩷
November 21, 2024 at 9:40 PM
Clonal raider ants finding their communities on bluesky 🩵🐜🩷
Read our latest preprint. A window into GC clonal evolution upon boost.
May 29, 2026 at 6:50 PM
Read our latest preprint. A window into GC clonal evolution upon boost.