Ceratocone afina a córnea e distorce a visão, em geral entre 10 e 25 anos. Veja os sintomas, o risco de coçar os olhos e quem pode fazer crosslinking no SUS.

Obarska-Kosinska et al. combine cryo-electron tomography, AI-assisted modeling, and crosslinking mass spectrometry to build an extended model of the human nuclear pore. They identify five additional nucleoporins and show how the nuclear basket and TREX-2 complex are attached to the nuclear ring, revealing the spatial organization of mRNP export.

Photoinduced aromatic crosslinking offers a cysteine-independent strategy to expand the chemical space of genetically encoded cyclic peptide libraries. Light-triggered coupling of fluorotryptophan wi...

Obarska-Kosinska et al. combine cryo-electron tomography, AI-assisted modeling, and crosslinking mass spectrometry to build an extended model of the human nuclear pore. They identify five additional n...

Covalent adaptable networks (CANs) are polymer networks in which bond formation and cleavage occur dynamically and reversibly. They are intensively investigated for 3D cell culture, as they model a mo...

Triple-negative breast cancer (TNBC) is an aggressive cancer subtype with limited treatment options. Platinum chemotherapy is incorporated into several therapeutic strategies, but its clinical benefit is constrained by resistance, toxicity, and suboptimal patient stratification. Platinum-induced DNA crosslinking remains the principal mechanism underlying antitumor activity. Recent studies indicate that Pt(IV) prodrugs, multifunctional agents, subcellularly targeted complexes, and tumor-responsive delivery systems can extend platinum pharmacology beyond conventional cytotoxicity. In parallel, studies have revealed emerging vulnerabilities, including homologous recombination deficiency, immunogenic cell death, ferroptosis, and DNA damage response dependencies, that provide new opportunities to enhance efficacy and overcome resistance. Advanced translational models and biomarker-guided stratification may help translate these opportunities into more precise therapeutic strategies. In this article, we review these developments and discuss their implications for advanced platinum therapies in TNBC.

The spindle assembly checkpoint (SAC) is a mechanism executed mainly by the mitotic checkpoint complex (MCC) to monitor the anchoring of mitotic spindle microtubules to ensure correct chromosome segregation. Although knowledge of protein-protein interactions in the plant cell cycle has progressed in recent years, information on the SAC mechanism in this context remains scarce. Here, we used bigBac, chemical crosslinking, mass spectrometry and structural analysis to identify protein-protein interactions (PPIs) among AtCDC20, AtBubR1 (BMF2) and AtMad2, which are components of the core MCC26 in A. thaliana. Fifty-three nonredundant crosslinks were identified, with multiple binding sites in different domains and subdomains of these proteins, such as the {beta}-propeller (AtCDC20), tetratricopeptide domain, and KEN boxes, including a new KET box (AtBubR1) and Horma domain (AtMad2). We also identified a hierarchy of interactions between these three proteins, with the potential to regulate signalling through the SAC molecular mechanism. Interactions that characterize the Mad2 tetramer, with the coupling of two dimers, were also identified. No PPIs were identified for AtBub1 (BMF1) or AtBub3:1, revealing a significant difference in MCC formation compared with that in other eukaryotes. Our findings provide a structural basis for core MCC formation in A. thaliana and offer new insights into the proteins CDC20, BubR1 and Mad2 in the context of the SAC.

The global allyl alcohol market is gaining attention as demand for specialty chemicals and advanced materials increases across the chemical, plastics, coatings, and manufacturing industries. Allyl alcohol is a colorless, water-soluble organic compound used as an intermediate in the production of several industrial chemicals. Its applications include optical resins, polymer crosslinking agents, paints and coatings, and other specialty compounds. Growing industrial requirements for high-performance materials are encouraging manufacturers to strengthen their production capabilities and explore new application opportunities.

The Golgi apparatus is a central hub for protein secretion and endolysosomal biogenesis, coordinating protein and vesicular trafficking pathways that maintain cellular homeostasis. Although hundreds o...

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Nine self-synthesized cationic gel model materials with different topological structures (crosslinker type, crosslinking degree, hybrid units, charge density) were selected to conduct performance analysis experiments for treating microplastics in water. The microplastic removal performance was systematically evaluated, and the structure-activity relationship between material structure and treatment capacity was established. Using nano-polystyrene microspheres (PS-MPs, particle size 200 nm) as model microplastic pollutants, under constant water volume (50 mL), initial concentration (50 mg/L), and pH = 7.0 conditions, the effect of different dosages (0.001–0.01 g) of gel materials on microplastic removal percentage and equilibrium treatment capacity was investigated. As shown in Fig. 1A–I, the removal percentage of microplastics by all nine gel materials increased with increasing dosage, eventually leveling off, displaying a typical dose–response relationship. This phenomenon can be attributed to the increase in the number of cationic electrostatic sites in the system with higher gel dosage, leading to a stronger positive electrostatic field, enhancing the electrostatic attraction force on weakly negative microplastics, and increasing the probability of inducing their aggregation. When the dosage exceeds a threshold, the change in microplastic removal rate tends to level off, and the material treatment capacity becomes excessive. Under saturated treatment conditions, i.e., when the material...

The Crosslinking Fluorocarbon Resin Market was valued at USD 2.5 billion in 2025 and is poised to grow from USD 2.

The HPC Self-Crosslinking Emulsion Paper Products Market was valued at USD 2.5 billion in 2025 and is poised to grow from USD 2.

Nature Biomedical Engineering, Published online: 27 October 2026; doi:10.1038/s41551-026-01846-wAuthor Correction: Advanced glycation end-products as mediators of the aberrant crosslinking of extracellular matrix in scarred liver tissue