Crosslinks can sometimes improve AlphaFold3 models. Crosslinking is an experimental method often used as a source of distance restraints in modeling. In AlphaFold3, instead of using restraints, crosslinks can be included as covalent ligands. Thanks to Agnieszka Obarska-Kosinska for the idea.
December 4, 2024 at 9:40 AM
Crosslinks can sometimes improve AlphaFold3 models. Crosslinking is an experimental method often used as a source of distance restraints in modeling. In AlphaFold3, instead of using restraints, crosslinks can be included as covalent ligands. Thanks to Agnieszka Obarska-Kosinska for the idea.
New preprint: We isolate peptide–RNA photo-crosslinks with tunable RNA chains from living cells for mass spec. This maps over 4,700 crosslinking sites across 744 proteins and offers the first glimpse into the RNA sequences in crosslinks by MS. Read here: doi.org/10.1101/2025...
Peptide-RNA photo-crosslinks with tunable RNA chain map protein-RNA interfaces
Photo-crosslinking mass spectrometry enables the identification of protein-RNA interactions in living cells, pinpointing interaction interfaces at single-amino acid resolution. However, current isolat...
doi.org
September 9, 2025 at 11:46 AM
New preprint: We isolate peptide–RNA photo-crosslinks with tunable RNA chains from living cells for mass spec. This maps over 4,700 crosslinking sites across 744 proteins and offers the first glimpse into the RNA sequences in crosslinks by MS. Read here: doi.org/10.1101/2025...
Hydrogels with stimuli-responsive cages as crosslinks. Work by former postdoc Chaolei Hu, with contributions from Damien Chen and Sylvain Sudan. Just published in @chemsci.rsc.org : pubs.rsc.org/en/content/a...
#chemsky #EPFL 🧪
#chemsky #EPFL 🧪
February 27, 2025 at 12:04 PM
Hydrogels with stimuli-responsive cages as crosslinks. Work by former postdoc Chaolei Hu, with contributions from Damien Chen and Sylvain Sudan. Just published in @chemsci.rsc.org : pubs.rsc.org/en/content/a...
#chemsky #EPFL 🧪
#chemsky #EPFL 🧪
Serum IgM crosslinks hepatitis B subviral particles into supramolecular immune complexes https://www.biorxiv.org/content/10.64898/2026.09.30.755772v1
October 2, 2026 at 7:16 AM
Serum IgM crosslinks hepatitis B subviral particles into supramolecular immune complexes https://www.biorxiv.org/content/10.64898/2026.09.30.755772v1
In our latest preprint, we uncover how CMG helicase overcomes covalent DNA-protein crosslinks. Check out our findings here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 7, 2025 at 12:05 PM
In our latest preprint, we uncover how CMG helicase overcomes covalent DNA-protein crosslinks. Check out our findings here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
*ahem*
Crosslinks multi agent support system has claude hooks that prevent claude from pushing software to prod. Human sign off is required by default and with git support manual tests of software are also default.
Crosslinks multi agent support system has claude hooks that prevent claude from pushing software to prod. Human sign off is required by default and with git support manual tests of software are also default.
Amazon’s website and shopping app went down for nearly six hours this month in an incident the company said involved an erroneous “software code deployment.”
After outages, Amazon to make senior engineers sign off on AI-assisted changes
AWS has suffered at least two incidents linked to the use of AI coding assistants.
arstechnica.com
March 10, 2026 at 8:09 PM
*ahem*
Crosslinks multi agent support system has claude hooks that prevent claude from pushing software to prod. Human sign off is required by default and with git support manual tests of software are also default.
Crosslinks multi agent support system has claude hooks that prevent claude from pushing software to prod. Human sign off is required by default and with git support manual tests of software are also default.
📦 mage2kishan/module-crosslinks 1.1.0
Automatic internal crosslinks for Magento 2 (Hyva + Luma). Converts configured keywords in product, category, and CMS content into anchor links to boost internal linking and SEO. Extracted from Pan...
🔗 https://github.com/mage2sk/module-crosslinks
Automatic internal crosslinks for Magento 2 (Hyva + Luma). Converts configured keywords in product, category, and CMS content into anchor links to boost internal linking and SEO. Extracted from Pan...
🔗 https://github.com/mage2sk/module-crosslinks
October 1, 2026 at 6:00 AM
📦 mage2kishan/module-crosslinks 1.1.0
Automatic internal crosslinks for Magento 2 (Hyva + Luma). Converts configured keywords in product, category, and CMS content into anchor links to boost internal linking and SEO. Extracted from Pan...
🔗 https://github.com/mage2sk/module-crosslinks
Automatic internal crosslinks for Magento 2 (Hyva + Luma). Converts configured keywords in product, category, and CMS content into anchor links to boost internal linking and SEO. Extracted from Pan...
🔗 https://github.com/mage2sk/module-crosslinks
Happy to share a review written with the wonderful @jstingele.bsky.social on transcription-coupled DPC repair, featuring an overview of new methods, close comparison with TC-NER, comments on clinical implications and plenty of discussion of the unknowns.
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
Transcription-coupled repair of DNA–protein crosslinks
DNA–protein crosslinks (DPCs) are highly toxic DNA lesions that are relevant to multiple
human diseases. They are caused by various endogenous and environmental agents, and
from the actions of enzymes...
www.cell.com
December 2, 2024 at 7:39 AM
Happy to share a review written with the wonderful @jstingele.bsky.social on transcription-coupled DPC repair, featuring an overview of new methods, close comparison with TC-NER, comments on clinical implications and plenty of discussion of the unknowns.
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
Happy to share our latest work🍾 🥳
PhD student Sophie Dürauer discovered together with many wonderful collaborators that the ubiquitylation of DNA-protein crosslinks promotes their cleavage by SPRTN more than 100-fold 🧬🔧
PhD student Sophie Dürauer discovered together with many wonderful collaborators that the ubiquitylation of DNA-protein crosslinks promotes their cleavage by SPRTN more than 100-fold 🧬🔧
Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability https://www.biorxiv.org/content/10.1101/2024.11.26.625192v1
Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability https://www.biorxiv.org/content/10.1101/2024.11.26.625192v1
The DNA-dependent protease SPRTN maintains genome stability by degrading toxic DNA-protein crosslink
www.biorxiv.org
November 28, 2024 at 6:18 PM
Happy to share our latest work🍾 🥳
PhD student Sophie Dürauer discovered together with many wonderful collaborators that the ubiquitylation of DNA-protein crosslinks promotes their cleavage by SPRTN more than 100-fold 🧬🔧
PhD student Sophie Dürauer discovered together with many wonderful collaborators that the ubiquitylation of DNA-protein crosslinks promotes their cleavage by SPRTN more than 100-fold 🧬🔧
Simonetta Piatti reveals that the yeast anillin complex crosslinks septin filaments into bundles - first septin MAP-like proteins?!?Can we call them SAPs?
#SeptSRC
#SeptSRC
June 17, 2025 at 2:22 PM
Simonetta Piatti reveals that the yeast anillin complex crosslinks septin filaments into bundles - first septin MAP-like proteins?!?Can we call them SAPs?
#SeptSRC
#SeptSRC
📦 mage2kishan/module-crosslinks 1.1.4
Automatic internal crosslinks for Magento 2 (Hyva + Luma). Converts configured keywords in product, category, and CMS content into anchor links to boost internal linking and SEO. Extracted from Pan...
🔗 https://github.com/mage2sk/module-crosslinks
Automatic internal crosslinks for Magento 2 (Hyva + Luma). Converts configured keywords in product, category, and CMS content into anchor links to boost internal linking and SEO. Extracted from Pan...
🔗 https://github.com/mage2sk/module-crosslinks
October 3, 2026 at 4:10 PM
📦 mage2kishan/module-crosslinks 1.1.4
Automatic internal crosslinks for Magento 2 (Hyva + Luma). Converts configured keywords in product, category, and CMS content into anchor links to boost internal linking and SEO. Extracted from Pan...
🔗 https://github.com/mage2sk/module-crosslinks
Automatic internal crosslinks for Magento 2 (Hyva + Luma). Converts configured keywords in product, category, and CMS content into anchor links to boost internal linking and SEO. Extracted from Pan...
🔗 https://github.com/mage2sk/module-crosslinks
July 21, 2025 at 12:59 PM
"Eccentric billionaire does weird theology" completely misses that this is strategic. Saying that it "sounds weird" just means you're not his target audience.
Whether he even believes it or not doesn't matter. He's building an ideological framework that crosslinks into theology.
Whether he even believes it or not doesn't matter. He's building an ideological framework that crosslinks into theology.
October 20, 2025 at 8:24 PM
"Eccentric billionaire does weird theology" completely misses that this is strategic. Saying that it "sounds weird" just means you're not his target audience.
Whether he even believes it or not doesn't matter. He's building an ideological framework that crosslinks into theology.
Whether he even believes it or not doesn't matter. He's building an ideological framework that crosslinks into theology.
*tries to follow the thread*
*brain crosslinks and short-circuits*
…Buffalo buffalo Buffalo buffalo buffalo buffalo Buffalo buffalo…
*brain crosslinks and short-circuits*
…Buffalo buffalo Buffalo buffalo buffalo buffalo Buffalo buffalo…
May 20, 2024 at 7:47 PM
*tries to follow the thread*
*brain crosslinks and short-circuits*
…Buffalo buffalo Buffalo buffalo buffalo buffalo Buffalo buffalo…
*brain crosslinks and short-circuits*
…Buffalo buffalo Buffalo buffalo buffalo buffalo Buffalo buffalo…
New update to the #renpy Chapter Select plugin! This includes bugfixes and improvements to the way that crosslinks are drawn.
Reminder that Chapter Select is currently 50% off! Get access to this premium plugin for only $2.99!
cross-couloir.itch.io/renpy-chapte...
#gamedev #indiedev #visualnovel
Reminder that Chapter Select is currently 50% off! Get access to this premium plugin for only $2.99!
cross-couloir.itch.io/renpy-chapte...
#gamedev #indiedev #visualnovel
CSS v1.2.0 released
Hi everyone, I'm here with another update for chapter select! This is mainly focused on fixing some rendering issues related to crosslinks. Fixed an issue with tree layout which caused some branches t...
cross-couloir.itch.io
May 7, 2026 at 7:15 PM
New update to the #renpy Chapter Select plugin! This includes bugfixes and improvements to the way that crosslinks are drawn.
Reminder that Chapter Select is currently 50% off! Get access to this premium plugin for only $2.99!
cross-couloir.itch.io/renpy-chapte...
#gamedev #indiedev #visualnovel
Reminder that Chapter Select is currently 50% off! Get access to this premium plugin for only $2.99!
cross-couloir.itch.io/renpy-chapte...
#gamedev #indiedev #visualnovel
Na het grote verlies van Bob Rusche hebben zijn collega-programamakers van de afdeling Crosslinks een nieuwe invulling van de zondagavond voor elkaar gekregen.
www.concertzender.nl/de-nieuwe-zo...
www.concertzender.nl/de-nieuwe-zo...
July 12, 2026 at 3:17 PM
Na het grote verlies van Bob Rusche hebben zijn collega-programamakers van de afdeling Crosslinks een nieuwe invulling van de zondagavond voor elkaar gekregen.
www.concertzender.nl/de-nieuwe-zo...
www.concertzender.nl/de-nieuwe-zo...
Delighted to share my latest work, co-first authored with fantastic undergrad mentee Joshua Lee, on highly entangled hydrogels with photolabile crosslinks. We compare selective crosslink cleavage (which lengthens chains) to non-selective photo-oxidative degradation. pubs.rsc.org/en/content/a...
December 9, 2024 at 4:38 PM
Delighted to share my latest work, co-first authored with fantastic undergrad mentee Joshua Lee, on highly entangled hydrogels with photolabile crosslinks. We compare selective crosslink cleavage (which lengthens chains) to non-selective photo-oxidative degradation. pubs.rsc.org/en/content/a...
... crosslinks. It is expected to operate over Ka band, have stereo coverage and be dynamically networked for simpler hand-offs, greater bandwidth and fault tolerance.
This launch carries 21 satellites manufactured by Northrop Grumman.
This launch carries 21 satellites manufactured by Northrop Grumman.
October 3, 2026 at 12:15 PM
... crosslinks. It is expected to operate over Ka band, have stereo coverage and be dynamically networked for simpler hand-offs, greater bandwidth and fault tolerance.
This launch carries 21 satellites manufactured by Northrop Grumman.
This launch carries 21 satellites manufactured by Northrop Grumman.
Releasing crosslinks datasets from @pride-ebi.bsky.social to other #omics archives—a big step for #multiomics integration and making proteomics data more #FAIR. You can now find links from PRIDE to @egaarchive.bsky.social, #GEO, & #BioStudies via #identifiers.org & with the help of @europepmc.org
May 14, 2025 at 1:32 PM
Releasing crosslinks datasets from @pride-ebi.bsky.social to other #omics archives—a big step for #multiomics integration and making proteomics data more #FAIR. You can now find links from PRIDE to @egaarchive.bsky.social, #GEO, & #BioStudies via #identifiers.org & with the help of @europepmc.org
Our PhD student Stella @stellamk.bsky.social presented her project on ‘Replication-Coupled Resolution of Formaldehyde-Induced Histone Crosslinks’ yesterday at the #GRS prior to the #GRC on Mammalian DNA Repair.
Huge thanks to everyone for the great questions and discussions afterward at her poster!
Huge thanks to everyone for the great questions and discussions afterward at her poster!
February 3, 2025 at 2:28 PM
Our PhD student Stella @stellamk.bsky.social presented her project on ‘Replication-Coupled Resolution of Formaldehyde-Induced Histone Crosslinks’ yesterday at the #GRS prior to the #GRC on Mammalian DNA Repair.
Huge thanks to everyone for the great questions and discussions afterward at her poster!
Huge thanks to everyone for the great questions and discussions afterward at her poster!
Anillin directly crosslinks microtubules with actin filaments | The EMBO Journal www.embopress.org/doi/full/10....
Anillin directly crosslinks microtubules with actin filaments | The EMBO Journal
imageimageAnillin is an actin-binding and -bundling protein that may also affect microtubules.
Here, in vitro work shows that anillin directly crosslinks microtubules with actin
filaments, enabling it...
www.embopress.org
July 22, 2025 at 7:02 PM
Anillin directly crosslinks microtubules with actin filaments | The EMBO Journal www.embopress.org/doi/full/10....
Serum IgM crosslinks hepatitis B subviral particles into supramolecular immune complexes www.biorxiv.org/content/10.64898/2026.09.30.755772v1 #cryoem
October 3, 2026 at 12:17 PM
Serum IgM crosslinks hepatitis B subviral particles into supramolecular immune complexes www.biorxiv.org/content/10.64898/2026.09.30.755772v1 #cryoem
i have to write all the notes _anyway_ in the process of doing the rewrite, but maybe i can set an environment up for myself where it's easy to have fancy crosslinks to things and notes. it could be really neat. i've thought about using Racket + Pollen for something like that but i'm not decided yet
October 2, 2026 at 4:40 PM
i have to write all the notes _anyway_ in the process of doing the rewrite, but maybe i can set an environment up for myself where it's easy to have fancy crosslinks to things and notes. it could be really neat. i've thought about using Racket + Pollen for something like that but i'm not decided yet
The centriole is crucial for cilia formation, but its molecular architecture is not known. Research from the @Wieczorek Group at ETH Zurich reports structures of the centriole’s A-C linker, revealing how it crosslinks neighboring microtubule triplets. More: biol.ethz.ch/en/news-and-...
October 20, 2025 at 2:57 PM
The centriole is crucial for cilia formation, but its molecular architecture is not known. Research from the @Wieczorek Group at ETH Zurich reports structures of the centriole’s A-C linker, revealing how it crosslinks neighboring microtubule triplets. More: biol.ethz.ch/en/news-and-...
Improving AlphaFold 3 structural modeling by incorporating explicit crosslinks https://www.biorxiv.org/content/10.1101/2024.12.03.626671v1
Improving AlphaFold 3 structural modeling by incorporating explicit crosslinks https://www.biorxiv.org/content/10.1101/2024.12.03.626671v1
AlphaFold 3 has significantly advanced the modeling of macromolecular structures, including proteins
www.biorxiv.org
December 4, 2024 at 2:19 AM
Improving AlphaFold 3 structural modeling by incorporating explicit crosslinks https://www.biorxiv.org/content/10.1101/2024.12.03.626671v1