From ME Research UK:
Research of ten implicates herpesviruses in ME/CFS. Read about a study published this month that analysed antibodies to herpesviruses proteins in a disease cohort vs healthy controls: tinyurl.com/t8tpw8sz
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME
Research of ten implicates herpesviruses in ME/CFS. Read about a study published this month that analysed antibodies to herpesviruses proteins in a disease cohort vs healthy controls: tinyurl.com/t8tpw8sz
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME
February 8, 2026 at 6:23 PM
From ME Research UK:
Research of ten implicates herpesviruses in ME/CFS. Read about a study published this month that analysed antibodies to herpesviruses proteins in a disease cohort vs healthy controls: tinyurl.com/t8tpw8sz
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME
Research of ten implicates herpesviruses in ME/CFS. Read about a study published this month that analysed antibodies to herpesviruses proteins in a disease cohort vs healthy controls: tinyurl.com/t8tpw8sz
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME
Ein Review über die mögliche Rolle von abortiver Replikation von Herpesviren bei #MECFS - und auch eine aktuelle Studie, wo erhöhte Antikörper gegen dUTPase von Herpesviren bzw. HERV mit Symptomschwere korreliert waren.
onlinelibrary.wiley.com/doi/full/10....
www.mdpi.com/1999-4915/17...
onlinelibrary.wiley.com/doi/full/10....
www.mdpi.com/1999-4915/17...
Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV‐6 and VZV and Heightened Anti‐dUTPase IgG Antibodies Are a Recurrent Hallmark in Post‐Infectious ME/CFS and is Associated With Fatigue
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease with unknown etiology and heterogeneous symptomology for which there are no validated tests for definitive diagno...
onlinelibrary.wiley.com
January 4, 2026 at 9:58 PM
Ein Review über die mögliche Rolle von abortiver Replikation von Herpesviren bei #MECFS - und auch eine aktuelle Studie, wo erhöhte Antikörper gegen dUTPase von Herpesviren bzw. HERV mit Symptomschwere korreliert waren.
onlinelibrary.wiley.com/doi/full/10....
www.mdpi.com/1999-4915/17...
onlinelibrary.wiley.com/doi/full/10....
www.mdpi.com/1999-4915/17...
Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious #MECFS & is Associated With Fatigue
onlinelibrary.wiley.com/doi/10.1002/...
Screenshot from Science for ME weekly update
#PwME #CFS
onlinelibrary.wiley.com/doi/10.1002/...
Screenshot from Science for ME weekly update
#PwME #CFS
December 29, 2025 at 11:35 PM
Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious #MECFS & is Associated With Fatigue
onlinelibrary.wiley.com/doi/10.1002/...
Screenshot from Science for ME weekly update
#PwME #CFS
onlinelibrary.wiley.com/doi/10.1002/...
Screenshot from Science for ME weekly update
#PwME #CFS
4) They suspect that dUTPase disrupts the immune system and triggers an antibody response in ME/CFS. They have investigated this using a long-term NIH grant.
Some data supporting their theory:
www.sciencedirect.co...
pmc.ncbi.nlm.nih.gov...
onlinelibrary.wiley....
Some data supporting their theory:
www.sciencedirect.co...
pmc.ncbi.nlm.nih.gov...
onlinelibrary.wiley....
Epstein-Barr Virus dUTPase Induces Neuroinflammatory Mediators: Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Neuroinflammation is a common feature in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), affecting 85%–90% of all patients, yet the under…
www.sciencedirect.com
January 6, 2026 at 9:34 AM
4) They suspect that dUTPase disrupts the immune system and triggers an antibody response in ME/CFS. They have investigated this using a long-term NIH grant.
Some data supporting their theory:
www.sciencedirect.co...
pmc.ncbi.nlm.nih.gov...
onlinelibrary.wiley....
Some data supporting their theory:
www.sciencedirect.co...
pmc.ncbi.nlm.nih.gov...
onlinelibrary.wiley....
So when HIV invades & begins using the "old" cell's DNA base pools, it finds weird or chemically damaged building blocks.
HIV's barnyard cousins, the "non-primate lentiviruses", that infect cats, goats etc., have specialized viral enzymes (dUTPase) that break down weird bases before they get used.
HIV's barnyard cousins, the "non-primate lentiviruses", that infect cats, goats etc., have specialized viral enzymes (dUTPase) that break down weird bases before they get used.
October 19, 2024 at 7:03 PM
So when HIV invades & begins using the "old" cell's DNA base pools, it finds weird or chemically damaged building blocks.
HIV's barnyard cousins, the "non-primate lentiviruses", that infect cats, goats etc., have specialized viral enzymes (dUTPase) that break down weird bases before they get used.
HIV's barnyard cousins, the "non-primate lentiviruses", that infect cats, goats etc., have specialized viral enzymes (dUTPase) that break down weird bases before they get used.
3) One of the viral proteins these Ohio researchers focus on is deoxyuridine triphosphate nucleotidohydrolases (dUTPase), which is encoded by the early genes of Epstein-Barr and other herpesviruses.
January 6, 2026 at 9:33 AM
3) One of the viral proteins these Ohio researchers focus on is deoxyuridine triphosphate nucleotidohydrolases (dUTPase), which is encoded by the early genes of Epstein-Barr and other herpesviruses.
If we take HIV's cousins & delete their dUTPase, they accumulate so many errors they either can't replicate in "old" cells, or it takes months longer for infection to become persistent.
So how does HIV manage without it?!
So how does HIV manage without it?!
October 19, 2024 at 7:04 PM
If we take HIV's cousins & delete their dUTPase, they accumulate so many errors they either can't replicate in "old" cells, or it takes months longer for infection to become persistent.
So how does HIV manage without it?!
So how does HIV manage without it?!
Jan. 2026 study from Ohio State Univ:
'Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious ME/CFS and is Associated With Fatigue'
pubmed.ncbi.nlm.nih.gov/41451845/
'Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious ME/CFS and is Associated With Fatigue'
pubmed.ncbi.nlm.nih.gov/41451845/
Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious ME/CFS and is Associated With Fatigue - PubMed
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease with unknown etiology and heterogeneous symptomology for which there are no validated tests for definitive diagnosis. We examined 873 longitudinal serum samples from ME/CFS patients (n = 40) and 378 from healthy co …
pubmed.ncbi.nlm.nih.gov
December 28, 2025 at 4:24 PM
Jan. 2026 study from Ohio State Univ:
'Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious ME/CFS and is Associated With Fatigue'
pubmed.ncbi.nlm.nih.gov/41451845/
'Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious ME/CFS and is Associated With Fatigue'
pubmed.ncbi.nlm.nih.gov/41451845/
Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious ME/CFS and is Associated With Fatigue.
pubmed.ncbi.nlm.nih.gov/41451845/?ut...
pubmed.ncbi.nlm.nih.gov/41451845/?ut...
Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious ME/CFS and is Associated With Fatigue - PubMed
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease with unknown etiology and heterogeneous symptomology for which there are no validated tests for definitive diagnosis. We examined 873 longitudinal serum samples from ME/CFS patients (n = 40) and 378 from healthy co …
pubmed.ncbi.nlm.nih.gov
December 28, 2025 at 10:47 PM
Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious ME/CFS and is Associated With Fatigue.
pubmed.ncbi.nlm.nih.gov/41451845/?ut...
pubmed.ncbi.nlm.nih.gov/41451845/?ut...
staining of EBV-dUTPase). Also, he mentions organ-specific reactivation of herpes viruses, once again, with a special nod to the bone marrow.
4/6
4/6
September 14, 2024 at 9:57 AM
staining of EBV-dUTPase). Also, he mentions organ-specific reactivation of herpes viruses, once again, with a special nod to the bone marrow.
4/6
4/6
Ohio State researchers studied 40 ME/CFS patients and found that 72.5% had antibodies indicating chronic reactivation of EBV, HHV-6 or VZV.
These antibody levels were also linked to more severe fatigue and pain.
onlinelibrary.wiley.com/doi/10.1002/...
These antibody levels were also linked to more severe fatigue and pain.
onlinelibrary.wiley.com/doi/10.1002/...
Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV‐6 and VZV and Heightened Anti‐dUTPase IgG Antibodies Are a Recurrent Hallmark in Post‐Infectious ME/CFS and is Associated With Fatigue
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease with unknown etiology and heterogeneous symptomology for which there are no validated tests for definitive diagno...
onlinelibrary.wiley.com
December 29, 2025 at 5:42 PM
Ohio State researchers studied 40 ME/CFS patients and found that 72.5% had antibodies indicating chronic reactivation of EBV, HHV-6 or VZV.
These antibody levels were also linked to more severe fatigue and pain.
onlinelibrary.wiley.com/doi/10.1002/...
These antibody levels were also linked to more severe fatigue and pain.
onlinelibrary.wiley.com/doi/10.1002/...
Does Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Represent a Poly-Herpesvirus Post-Virus Infectious Disease?
by Maria Eugenia Ariza, Irene Mena Palomo and Marshall V. Williams
(December 2025)
#ME/CFS #HHVs #dUTPase
by Maria Eugenia Ariza, Irene Mena Palomo and Marshall V. Williams
(December 2025)
#ME/CFS #HHVs #dUTPase
www.mdpi.com
January 6, 2026 at 5:39 PM
‘The results of this study demonstrate a significant increase in dUTPase IgG antibodies to the
herpesviruses Epstein-Barr virus (EBV),
human herpesvirus-6 (HHV-6) &
varicella zoster virus (VZV)
in ME/CFS compared to healthy-controls (p < 0.001)’
herpesviruses Epstein-Barr virus (EBV),
human herpesvirus-6 (HHV-6) &
varicella zoster virus (VZV)
in ME/CFS compared to healthy-controls (p < 0.001)’
Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious ME/CFS and is Associated With Fatigue.
pubmed.ncbi.nlm.nih.gov/41451845/?ut...
pubmed.ncbi.nlm.nih.gov/41451845/?ut...
Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious ME/CFS and is Associated With Fatigue - PubMed
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease with unknown etiology and heterogeneous symptomology for which there are no validated tests for definitive diagnosis. We examined 873 longitudinal serum samples from ME/CFS patients (n = 40) and 378 from healthy co …
pubmed.ncbi.nlm.nih.gov
December 28, 2025 at 11:02 PM
‘The results of this study demonstrate a significant increase in dUTPase IgG antibodies to the
herpesviruses Epstein-Barr virus (EBV),
human herpesvirus-6 (HHV-6) &
varicella zoster virus (VZV)
in ME/CFS compared to healthy-controls (p < 0.001)’
herpesviruses Epstein-Barr virus (EBV),
human herpesvirus-6 (HHV-6) &
varicella zoster virus (VZV)
in ME/CFS compared to healthy-controls (p < 0.001)’
Chi L. Nguyen et al.: Structural characterization of dUTPase from Legionella pneumophila ##SSGCID##StructuralGenomics##SeattleStructuralGenomicsCenterForInfectiousDisease... ##IUCrhttps://journals.iucr.org/paper?S2053230X25001815
Structural characterization of dUTPase from Legionella pneumophila
L. pneumophila serogroup 1 is the causative agent of Legionnaires' disease. Two crystal structures of apo and dUMP-bound deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase) were determined to 1.80 and 1.95 Å resolution, respectively. dUTPases have been investigated as a potential druggable target in several pathogens.
journals.iucr.org
March 18, 2025 at 1:00 AM
Chi L. Nguyen et al.: Structural characterization of dUTPase from Legionella pneumophila ##SSGCID##StructuralGenomics##SeattleStructuralGenomicsCenterForInfectiousDisease... ##IUCrhttps://journals.iucr.org/paper?S2053230X25001815
All problem statements must be written in the form of a haiku.
HIV in silence,
dUTPase guards the path,
life’s code reshaped, still.
HIV in silence,
dUTPase guards the path,
life’s code reshaped, still.
November 12, 2024 at 1:16 PM
All problem statements must be written in the form of a haiku.
HIV in silence,
dUTPase guards the path,
life’s code reshaped, still.
HIV in silence,
dUTPase guards the path,
life’s code reshaped, still.
A preprint using: PB-TO-hNGN2 (RRID:Addgene_172115) from @addgene.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #methodsmatter
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #methodsmatter
Recognizing dUTPase as a mitotic factor essential for early embryonic development
www.biorxiv.org
January 21, 2026 at 1:01 PM
A preprint using: PB-TO-hNGN2 (RRID:Addgene_172115) from @addgene.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #methodsmatter
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #methodsmatter
Apo and dUMP-bound structures of Legionella pneumophila dUTPase revealed a potential new binding site and active-site structural differences when compared with human dUTPase #SSGCID #StructuralGenomics doi.org/10.1107/S205...
April 14, 2025 at 1:55 PM
Apo and dUMP-bound structures of Legionella pneumophila dUTPase revealed a potential new binding site and active-site structural differences when compared with human dUTPase #SSGCID #StructuralGenomics doi.org/10.1107/S205...
🦠 Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious ME/CFS and is Associated With Fatigue — Palomo et al.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies... 2025 Ariza et al
Full title: Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious ME/CFS and is Associated Wi...
www.s4me.info
December 28, 2025 at 8:36 PM
🦠 Chronic Reactivation of Persistent Human Herpesviruses EBV, HHV-6 and VZV and Heightened Anti-dUTPase IgG Antibodies Are a Recurrent Hallmark in Post-Infectious ME/CFS and is Associated With Fatigue — Palomo et al.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Recognizing dUTPase as a mitotic factor essential for early embryonic development https://www.biorxiv.org/content/10.64898/2026.01.16.699898v1
January 18, 2026 at 1:17 AM
Recognizing dUTPase as a mitotic factor essential for early embryonic development https://www.biorxiv.org/content/10.64898/2026.01.16.699898v1
Recognizing dUTPase as a mitotic factor essential for early embryonic development https://www.biorxiv.org/content/10.64898/2026.01.16.699898v1
January 18, 2026 at 1:17 AM
Recognizing dUTPase as a mitotic factor essential for early embryonic development https://www.biorxiv.org/content/10.64898/2026.01.16.699898v1
‘heightened dUTPase IgG levels cluster with ME/CFS patients exhibiting moderate & severe fatigue.
These findings highlight the importance of examining herpesvirus dUTPase IgG across severity groups in aiding..current challenges in stratifying ME/CFS patients due to the heterogeneity in symptomology’
These findings highlight the importance of examining herpesvirus dUTPase IgG across severity groups in aiding..current challenges in stratifying ME/CFS patients due to the heterogeneity in symptomology’
December 28, 2025 at 11:04 PM
‘heightened dUTPase IgG levels cluster with ME/CFS patients exhibiting moderate & severe fatigue.
These findings highlight the importance of examining herpesvirus dUTPase IgG across severity groups in aiding..current challenges in stratifying ME/CFS patients due to the heterogeneity in symptomology’
These findings highlight the importance of examining herpesvirus dUTPase IgG across severity groups in aiding..current challenges in stratifying ME/CFS patients due to the heterogeneity in symptomology’
‘CMI’
‘..evidence suggesting aberrant antiviral response & immune dysfunction in CMI veterans & supports the premise that decreased serum levels of IFN-γ together with heightened MCP-1 & dUTPase antibodies to multiple herpesviruses may be useful to identify CMI.. pubmed.ncbi.nlm.nih.gov/40392130/
‘..evidence suggesting aberrant antiviral response & immune dysfunction in CMI veterans & supports the premise that decreased serum levels of IFN-γ together with heightened MCP-1 & dUTPase antibodies to multiple herpesviruses may be useful to identify CMI.. pubmed.ncbi.nlm.nih.gov/40392130/
Reactivation of Latent Herpesviruses and a Faulty Antiviral Response may Contribute to Chronic Multi-Symptom and Multi-System Illnesses in U.S. Military Veterans - PubMed
Chronic multi-symptom illness (CMI) is a broad term utilized by the Department of Veterans Affairs to refer to complex conditions of unknown etiology where individuals experience symptoms that lack a ...
pubmed.ncbi.nlm.nih.gov
September 30, 2025 at 7:55 AM
‘CMI’
‘..evidence suggesting aberrant antiviral response & immune dysfunction in CMI veterans & supports the premise that decreased serum levels of IFN-γ together with heightened MCP-1 & dUTPase antibodies to multiple herpesviruses may be useful to identify CMI.. pubmed.ncbi.nlm.nih.gov/40392130/
‘..evidence suggesting aberrant antiviral response & immune dysfunction in CMI veterans & supports the premise that decreased serum levels of IFN-γ together with heightened MCP-1 & dUTPase antibodies to multiple herpesviruses may be useful to identify CMI.. pubmed.ncbi.nlm.nih.gov/40392130/
It seems plausible that herpesvirus dUTPase could stimulate the activation of matrix metalloproteinases (MMPs), leading to the mobilization of fibronectin from the extracellular matrix into blood plasma.
Hence, Doxycycline and Minocycline worth trialling
#MEcfs #LongCovid
chatgpt.com/share/6753db...
Hence, Doxycycline and Minocycline worth trialling
#MEcfs #LongCovid
chatgpt.com/share/6753db...
ChatGPT - MMPs in Pathogen Response
Shared via ChatGPT
chatgpt.com
December 7, 2024 at 5:27 AM
It seems plausible that herpesvirus dUTPase could stimulate the activation of matrix metalloproteinases (MMPs), leading to the mobilization of fibronectin from the extracellular matrix into blood plasma.
Hence, Doxycycline and Minocycline worth trialling
#MEcfs #LongCovid
chatgpt.com/share/6753db...
Hence, Doxycycline and Minocycline worth trialling
#MEcfs #LongCovid
chatgpt.com/share/6753db...
dUTPase is essential in zebrafish development and possesses several single-nucleotide variants with pronounced structural and functional consequences
buff.ly/TEKZy16
#zebrafish #GenomeStability
buff.ly/TEKZy16
#zebrafish #GenomeStability
December 23, 2025 at 10:58 AM
dUTPase is essential in zebrafish development and possesses several single-nucleotide variants with pronounced structural and functional consequences
buff.ly/TEKZy16
#zebrafish #GenomeStability
buff.ly/TEKZy16
#zebrafish #GenomeStability