Author summary DDX3X mutations are associated with neurodevelopmental disorders, including DDX3X syndrome and autism spectrum disorder. DDX3X is an RNA binding protein whose loss of function impairs b...

Genetic mutations in the DDX3X gene are associated with a neurodevelopmental disorder primarily affecting females. Here authors show that Ddx3x mediates sexual dimorphisms during brain development at ...

Summary: A subpopulation of cortical neurons is altered in a mouse model of DDX3X syndrome.

A disease-associated mutation blocks Cl− binding from functionally affecting the RNA helicase DDX3X.

Yanas et al. report that RNA helicases DDX3X and DDX3X form nanometer-scale RNA-protein clusters (RPCs) both in vitro and in cells. Differences in RPC size and catalytic activity between DDX3X and DDX...

DDX3X is an X-linked RNA helicases that escapes X chromosome inactivation and is expressed at higher levels in female brains. Mutations in DDX3X are associated with intellectual disability (ID) and au...

Trussina et al. demonstrate that the storage of mRNA molecules inside G3BP1-driven RNP granules facilitates the formation of RNA-RNA interactions, preventing the mRNA from being translated. The DEAD-box helicase DDX3X facilitates RNP granule dissolution by attenuating these inhibitory RNA-RNA interactions to aid restart of mRNA translation.

DDX3X is an X-linked RNA helicases that escapes X chromosome inactivation and is expressed at higher

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Genetic mutations in the DDX3X gene are associated with a neurodevelopmental disorder primarily affecting females. Here authors show that Ddx3x mediates sexual dimorphisms during brain development at ...

European Journal of Human Genetics - DDX3X-related neurodevelopmental disorder in males – presenting a new cohort of 19 males and a literature review

Yanas et al. report that RNA helicases DDX3X and DDX3X form nanometer-scale RNA-protein clusters (RPCs) both in vitro and in cells. Differences in RPC size and catalytic activity between DDX3X and DDX...

DDX3X is an X-linked RNA helicases that escapes X chromosome inactivation and is expressed at higher levels in female brains. Mutations in DDX3X are associated with intellectual disability (ID) and au...

DDX3X is a novel positive regulator of Break-Induced RNA-DNA Hybrids (BIRDHs) formation and Homologous Recombination (HR) repair. DDX3X negatively regulates 53BP1’s recruitment to DSB sites in a dilncRNA/DDRNA-dependent manner. BIRDH formation and 53BP1-dependent CST-Polα-mediated fill-in synthesis at DSB sites antagonize each other. DDX3X’s recruitment to DSB sites is dependent on its interaction with Argonaute 2 (AGO2).