1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Inge et al. show that human endoderm originates from two converging developmental
routes with distinct dynamics and efficiencies yet similar developmental potential.
Combinatorial activin and BMP4 sig...
www.cell.com
September 9, 2025 at 8:01 PM
1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
It's difficult to succinctly summarize a entire germ layer, but Aaron Zorn, Scott Rankin and I tried recently!
Our "Endoderm at a Glance" review with @dev-journal.bsky.social is out now.
shorturl.at/kHf9Y
Our "Endoderm at a Glance" review with @dev-journal.bsky.social is out now.
shorturl.at/kHf9Y
May 1, 2026 at 2:17 PM
It's difficult to succinctly summarize a entire germ layer, but Aaron Zorn, Scott Rankin and I tried recently!
Our "Endoderm at a Glance" review with @dev-journal.bsky.social is out now.
shorturl.at/kHf9Y
Our "Endoderm at a Glance" review with @dev-journal.bsky.social is out now.
shorturl.at/kHf9Y
A primitive endoderm-centric view of mammalian development
In this Review, @rpkimyip.bsky.social, Denis Faerberg and @eposfai.bsky.social give an overview of mammalian primitive endoderm development, focusing on the mouse and, where appropriate, the human context. 🐭
doi.org/10.1242/dev....
In this Review, @rpkimyip.bsky.social, Denis Faerberg and @eposfai.bsky.social give an overview of mammalian primitive endoderm development, focusing on the mouse and, where appropriate, the human context. 🐭
doi.org/10.1242/dev....
August 18, 2026 at 1:34 PM
A primitive endoderm-centric view of mammalian development
In this Review, @rpkimyip.bsky.social, Denis Faerberg and @eposfai.bsky.social give an overview of mammalian primitive endoderm development, focusing on the mouse and, where appropriate, the human context. 🐭
doi.org/10.1242/dev....
In this Review, @rpkimyip.bsky.social, Denis Faerberg and @eposfai.bsky.social give an overview of mammalian primitive endoderm development, focusing on the mouse and, where appropriate, the human context. 🐭
doi.org/10.1242/dev....
❤️ Endoderm !!
"Endoderm at a Glance" review in @dev-journal.bsky.social from #Zorn Lab at Cincinnati Children's 🎉
journals.biologists.com/dev/article-...
"Endoderm at a Glance" review in @dev-journal.bsky.social from #Zorn Lab at Cincinnati Children's 🎉
journals.biologists.com/dev/article-...
Vertebrate endoderm development
Summary: This Development at a Glance article summarizes current research into the cellular and molecular mechanisms controlling the development of the vertebrate embryonic endoderm into digestive and...
journals.biologists.com
May 3, 2026 at 1:40 PM
❤️ Endoderm !!
"Endoderm at a Glance" review in @dev-journal.bsky.social from #Zorn Lab at Cincinnati Children's 🎉
journals.biologists.com/dev/article-...
"Endoderm at a Glance" review in @dev-journal.bsky.social from #Zorn Lab at Cincinnati Children's 🎉
journals.biologists.com/dev/article-...
☕Moghe et al. show that embryonic primitive #endoderm cells migrate towards the inner cell mass-cavity interface, depositing an #ExtracellularMatrix gradient that may guide migration. Primitive endoderm to epiblast ratios may enable robust patterning across #embryos and sizes.
go.nature.com/4iLjlAP
go.nature.com/4iLjlAP
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness - Nature Cell Biology
Moghe et al. show that mouse embryonic primitive endoderm cells migrate towards the inner cell mass-cavity interface, depositing an extracellular matrix gradient that may guide migration. Primitive en...
go.nature.com
March 22, 2025 at 6:30 AM
☕Moghe et al. show that embryonic primitive #endoderm cells migrate towards the inner cell mass-cavity interface, depositing an #ExtracellularMatrix gradient that may guide migration. Primitive endoderm to epiblast ratios may enable robust patterning across #embryos and sizes.
go.nature.com/4iLjlAP
go.nature.com/4iLjlAP
How do endodermal cells behave during gastrulation? In this paper, the authors found that a gradient of BMP regulates mesoderm and endoderm convergent extension. Endoderm cells also use the mesoderm and Cxcr4a signalling to guide their movement. The imaging is beautiful!
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
October 17, 2025 at 6:27 PM
How do endodermal cells behave during gastrulation? In this paper, the authors found that a gradient of BMP regulates mesoderm and endoderm convergent extension. Endoderm cells also use the mesoderm and Cxcr4a signalling to guide their movement. The imaging is beautiful!
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
Happy to share a new paper, a fun collaboration with, with Kat
Hadjantonakis and Effie Apostolou reminding us that plasticity is central to development and therefore has both drivers and roadblock that underly it ->. www.cell.com/developmenta...
Hadjantonakis and Effie Apostolou reminding us that plasticity is central to development and therefore has both drivers and roadblock that underly it ->. www.cell.com/developmenta...
Single-cell analysis of bidirectional reprogramming between early embryonic states identify mechanisms of differential lineage plasticities in mice
Garg et al. use bidirectional reprogramming between embryonic stem (ES) cells and extra-embryonic endoderm (XEN) stem cells to probe transcriptional and epigenetic factors that direct lineage specification in vivo and facilitate or prevent lineage interconversions. A strong endoderm transcriptional program and distinct epigenetic state accompany extra-embryonic endoderm specification and prevent lineage conversion.
www.cell.com
December 29, 2024 at 4:45 PM
Happy to share a new paper, a fun collaboration with, with Kat
Hadjantonakis and Effie Apostolou reminding us that plasticity is central to development and therefore has both drivers and roadblock that underly it ->. www.cell.com/developmenta...
Hadjantonakis and Effie Apostolou reminding us that plasticity is central to development and therefore has both drivers and roadblock that underly it ->. www.cell.com/developmenta...
Emoticons: E9.5 mouse embryo sections through otocyst, hindbrain and pharyngeal endoderm resemble eyes, nose, and smile of an emoticon.
📸 Image credit: Ankita Thawani (Baylor College of Medicine)
#FluorescenceFriday #Embryology #DevelopmentalBiology #Microscopy #ScienceArt✨ 🧬
📸 Image credit: Ankita Thawani (Baylor College of Medicine)
#FluorescenceFriday #Embryology #DevelopmentalBiology #Microscopy #ScienceArt✨ 🧬
June 5, 2026 at 1:31 PM
Emoticons: E9.5 mouse embryo sections through otocyst, hindbrain and pharyngeal endoderm resemble eyes, nose, and smile of an emoticon.
📸 Image credit: Ankita Thawani (Baylor College of Medicine)
#FluorescenceFriday #Embryology #DevelopmentalBiology #Microscopy #ScienceArt✨ 🧬
📸 Image credit: Ankita Thawani (Baylor College of Medicine)
#FluorescenceFriday #Embryology #DevelopmentalBiology #Microscopy #ScienceArt✨ 🧬
Evidence collected by successive lab members over many years that neural cells in the Clytia larva have two origins: From 'i-cells' located in endoderm and by delamination of the gastrula ectoderm. doi.org/10.1242/dev.... @biodev-vlfr.bsky.social @annaferraioli.bsky.social
September 19, 2026 at 6:24 PM
Evidence collected by successive lab members over many years that neural cells in the Clytia larva have two origins: From 'i-cells' located in endoderm and by delamination of the gastrula ectoderm. doi.org/10.1242/dev.... @biodev-vlfr.bsky.social @annaferraioli.bsky.social
Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: nature.com/articles/s41... Lead by @quanxu.bsky.social, in collaboration with Lennard Halle and @fabiantheis.bsky.social
An integrated transcriptomic cell atlas of human endoderm-derived organoids - Nature Genetics
The human endoderm-derived organoid cell atlas (HEOCA) presents an integrative analysis of single-cell transcriptomes across different conditions, sources and protocols. It compares cell types and sta...
nature.com
May 12, 2025 at 9:23 PM
Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: nature.com/articles/s41... Lead by @quanxu.bsky.social, in collaboration with Lennard Halle and @fabiantheis.bsky.social
Finally, the excellent postdoc work of Emmanuel Haillot is out, where he dissected the integration of Wnt, MAPK and Notch signaling in defining mesoderm and endoderm identities in the diploblast Nematostella. Strikingly similar to sea urchins. www.nature.com/articles/s41...
August 29, 2025 at 9:04 PM
Finally, the excellent postdoc work of Emmanuel Haillot is out, where he dissected the integration of Wnt, MAPK and Notch signaling in defining mesoderm and endoderm identities in the diploblast Nematostella. Strikingly similar to sea urchins. www.nature.com/articles/s41...
Animal embryos in their earliest stages comprise three “germ layers”: ectoderm (outer), mesoderm (middle), and endoderm (inner)
It has been known since the ~1950s that these three layers are already fated to develop into certain specific organ systems
It has been known since the ~1950s that these three layers are already fated to develop into certain specific organ systems
September 22, 2026 at 12:55 PM
Animal embryos in their earliest stages comprise three “germ layers”: ectoderm (outer), mesoderm (middle), and endoderm (inner)
It has been known since the ~1950s that these three layers are already fated to develop into certain specific organ systems
It has been known since the ~1950s that these three layers are already fated to develop into certain specific organ systems
So exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this!
And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social!
www.cell.com/developmenta...
And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social!
www.cell.com/developmenta...
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Inge et al. show that human endoderm originates from two converging developmental
routes with distinct dynamics and efficiencies yet similar developmental potential.
Combinatorial activin and BMP4 sig...
www.cell.com
December 2, 2025 at 1:47 PM
So exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this!
And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social!
www.cell.com/developmenta...
And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social!
www.cell.com/developmenta...
Really exciting to see our new review published!
This review explores the evolutionary history of the extra-embryonic endoderm, an evolutionarily ancient tissue co-opted to form the yolk sac, and explores how in vitro models are uncovering its biology.
Check it out here: doi.org/10.1242/dev....
This review explores the evolutionary history of the extra-embryonic endoderm, an evolutionarily ancient tissue co-opted to form the yolk sac, and explores how in vitro models are uncovering its biology.
Check it out here: doi.org/10.1242/dev....
The vertebrate yolk sac: evolutionary origins and current advances in in vitro models
Summary: This Review examines the evolutionary history of the extra-embryonic endoderm, an evolutionarily ancient tissue co-opted to form the yolk sac, and explores how in vitro models are uncovering ...
doi.org
April 30, 2026 at 11:20 AM
Really exciting to see our new review published!
This review explores the evolutionary history of the extra-embryonic endoderm, an evolutionarily ancient tissue co-opted to form the yolk sac, and explores how in vitro models are uncovering its biology.
Check it out here: doi.org/10.1242/dev....
This review explores the evolutionary history of the extra-embryonic endoderm, an evolutionarily ancient tissue co-opted to form the yolk sac, and explores how in vitro models are uncovering its biology.
Check it out here: doi.org/10.1242/dev....
June 4, 2024 at 10:08 AM
#NCB2024
In June, Meissner & co reported a lineage-tracing strategy to track #extraembryonic gut #endoderm cells over development; showed these cells are eventually eliminated in a p53-dependent manner and neighboring embryonic cells clear their remnants.
www.nature.com/articles/s41...
In June, Meissner & co reported a lineage-tracing strategy to track #extraembryonic gut #endoderm cells over development; showed these cells are eventually eliminated in a p53-dependent manner and neighboring embryonic cells clear their remnants.
www.nature.com/articles/s41...
Extraembryonic gut endoderm cells undergo programmed cell death during development - Nature Cell Biology
Batki, Hetzel et al. report a lineage-tracing strategy to track extraembryonic gut endoderm cells over development. They find that these cells are eventually eliminated in a p53-dependent manner and n...
www.nature.com
December 18, 2024 at 10:23 PM
#NCB2024
In June, Meissner & co reported a lineage-tracing strategy to track #extraembryonic gut #endoderm cells over development; showed these cells are eventually eliminated in a p53-dependent manner and neighboring embryonic cells clear their remnants.
www.nature.com/articles/s41...
In June, Meissner & co reported a lineage-tracing strategy to track #extraembryonic gut #endoderm cells over development; showed these cells are eventually eliminated in a p53-dependent manner and neighboring embryonic cells clear their remnants.
www.nature.com/articles/s41...
The church of the holy trinity: endoderm, mesoderm and ectoderm!
September 16, 2025 at 3:04 PM
The church of the holy trinity: endoderm, mesoderm and ectoderm!
Thrilled to share our work using live imaging to understand how Epiblast (future embryo proper) and Primitive Endoderm (future extraembryonic tissues) cell fates segregate in the preimplantation mouse embryo. Gargantuan effort led by amazing @rpkimyip.bsky.social, David Denberg and Denis Faerberg!
August 2, 2025 at 7:31 PM
Thrilled to share our work using live imaging to understand how Epiblast (future embryo proper) and Primitive Endoderm (future extraembryonic tissues) cell fates segregate in the preimplantation mouse embryo. Gargantuan effort led by amazing @rpkimyip.bsky.social, David Denberg and Denis Faerberg!
Thrilled to share our Human Endoderm-derived Organoid Cell Atlas (HEOCA). We compare organoids with primary tissues, assess culture strategies, and explore disease models. In collaboration with Lennard Halle, supervised by
@graycamplab.bsky.social, @fabiantheis.bsky.social & @TreutleinLab. @IHB.
@graycamplab.bsky.social, @fabiantheis.bsky.social & @TreutleinLab. @IHB.
Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: nature.com/articles/s41... Lead by @quanxu.bsky.social, in collaboration with Lennard Halle and @fabiantheis.bsky.social
An integrated transcriptomic cell atlas of human endoderm-derived organoids - Nature Genetics
The human endoderm-derived organoid cell atlas (HEOCA) presents an integrative analysis of single-cell transcriptomes across different conditions, sources and protocols. It compares cell types and sta...
nature.com
May 13, 2025 at 4:51 AM
Thrilled to share our Human Endoderm-derived Organoid Cell Atlas (HEOCA). We compare organoids with primary tissues, assess culture strategies, and explore disease models. In collaboration with Lennard Halle, supervised by
@graycamplab.bsky.social, @fabiantheis.bsky.social & @TreutleinLab. @IHB.
@graycamplab.bsky.social, @fabiantheis.bsky.social & @TreutleinLab. @IHB.
Transcription ahead of chromatin regulation?
Activation in endoderm occurs prior to K27me3 removal, plus much more. A tribute to our amazing collaborators
@wbickmor.bsky.social and the amazing Rob Illingworth, without whom this data would have gathered dust!
journals.plos.org/plosgenetics...
Activation in endoderm occurs prior to K27me3 removal, plus much more. A tribute to our amazing collaborators
@wbickmor.bsky.social and the amazing Rob Illingworth, without whom this data would have gathered dust!
journals.plos.org/plosgenetics...
February 2, 2025 at 1:48 PM
Transcription ahead of chromatin regulation?
Activation in endoderm occurs prior to K27me3 removal, plus much more. A tribute to our amazing collaborators
@wbickmor.bsky.social and the amazing Rob Illingworth, without whom this data would have gathered dust!
journals.plos.org/plosgenetics...
Activation in endoderm occurs prior to K27me3 removal, plus much more. A tribute to our amazing collaborators
@wbickmor.bsky.social and the amazing Rob Illingworth, without whom this data would have gathered dust!
journals.plos.org/plosgenetics...
⭐️ A transgenic hydra labeling the endoderm and ectoderm of two column ends regenerating.🔬📸 Credit: Raisa Bailon-Zambrano from the University of Colorado Anschutz Medical Campus taken during the 2021 MBL Embryology Course
#FluorescenceFriday #devbio #Embryology 🪸
#FluorescenceFriday #devbio #Embryology 🪸
May 15, 2026 at 6:02 PM
⭐️ A transgenic hydra labeling the endoderm and ectoderm of two column ends regenerating.🔬📸 Credit: Raisa Bailon-Zambrano from the University of Colorado Anschutz Medical Campus taken during the 2021 MBL Embryology Course
#FluorescenceFriday #devbio #Embryology 🪸
#FluorescenceFriday #devbio #Embryology 🪸
New work from our labs (with @itsthewoolab.bsky.social). Congratulations to soon-to-be Dr. Tu, who convinced us that Met was simply too juicy a target to ignore when it comes to controlling endoderm migration. #zebrafish, #endoderm.
New preprint alert! Led by @qsb-uc-merced.bsky.social grad student Po-Shu Tu from my and Stefan Materna's labs, we found that the receptor tyrosine kinase Met is required for directional migration of #endoderm cells in #zebrafish. But — plot twist! — Met's canonical ligand HGF is dispensable.
www.biorxiv.org
May 6, 2026 at 6:03 PM
New work from our labs (with @itsthewoolab.bsky.social). Congratulations to soon-to-be Dr. Tu, who convinced us that Met was simply too juicy a target to ignore when it comes to controlling endoderm migration. #zebrafish, #endoderm.
2/
Hieu is staying in the lab to finish out some interesting work he started during his graduate work, looking at Bmp and Fgf signaling in endoderm and facial development.
Hieu is staying in the lab to finish out some interesting work he started during his graduate work, looking at Bmp and Fgf signaling in endoderm and facial development.
March 17, 2026 at 10:07 PM
2/
Hieu is staying in the lab to finish out some interesting work he started during his graduate work, looking at Bmp and Fgf signaling in endoderm and facial development.
Hieu is staying in the lab to finish out some interesting work he started during his graduate work, looking at Bmp and Fgf signaling in endoderm and facial development.
The first two integrated HCA Organoid Cell Atlases, from brain and endoderm tissues, are available on the HCA Data Portal. Congratulations to all involved! 🖥️ 🧬 data.humancellatlas.org/hca-bio-netw...
April 28, 2025 at 4:21 PM
The first two integrated HCA Organoid Cell Atlases, from brain and endoderm tissues, are available on the HCA Data Portal. Congratulations to all involved! 🖥️ 🧬 data.humancellatlas.org/hca-bio-netw...
Reading because it looks fascinating & fundamental.
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation: Developmental Cell www.cell.com/developmenta... 🧪
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation: Developmental Cell www.cell.com/developmenta... 🧪
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Inge et al. show that human endoderm originates from two converging developmental
routes with distinct dynamics and efficiencies yet similar developmental potential.
Combinatorial activin and BMP4 sig...
www.cell.com
September 15, 2025 at 8:20 PM
Reading because it looks fascinating & fundamental.
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation: Developmental Cell www.cell.com/developmenta... 🧪
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation: Developmental Cell www.cell.com/developmenta... 🧪