In @eclinicalmed.bsky.social
Dose-dependent efficacy & renal safety of pemafibrate versus fenofibrate in patients with metabolic dysfunction-associated steatotic liver disease (#MASLD) & hypertriglyceridemia: a multicenter randomized controlled, open label trial www.thelancet.com/journals/ecl....
Dose-dependent efficacy & renal safety of pemafibrate versus fenofibrate in patients with metabolic dysfunction-associated steatotic liver disease (#MASLD) & hypertriglyceridemia: a multicenter randomized controlled, open label trial www.thelancet.com/journals/ecl....
Dose-dependent efficacy and renal safety of pemafibrate versus fenofibrate in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and hypertriglyceridemia: a multicenter ran...
Pemafibrate demonstrated greater reductions in ALT levels than fenofibrate, with a
notable dose–response relationship and favorable safety profile, suggesting therapeutic
potential for patients with M...
www.thelancet.com
October 7, 2026 at 7:06 AM
In @eclinicalmed.bsky.social
Dose-dependent efficacy & renal safety of pemafibrate versus fenofibrate in patients with metabolic dysfunction-associated steatotic liver disease (#MASLD) & hypertriglyceridemia: a multicenter randomized controlled, open label trial www.thelancet.com/journals/ecl....
Dose-dependent efficacy & renal safety of pemafibrate versus fenofibrate in patients with metabolic dysfunction-associated steatotic liver disease (#MASLD) & hypertriglyceridemia: a multicenter randomized controlled, open label trial www.thelancet.com/journals/ecl....
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury | Science Translational Medicine www.science.org/doi/10.1126/...
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury
Aged cranial bone marrow–derived monocytes fuel chronic neuroinflammation after traumatic brain injury, a process reversed by fenofibrate.
www.science.org
October 6, 2026 at 12:13 PM
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury | Science Translational Medicine www.science.org/doi/10.1126/...
Why Fenofibrate attenuates peripheral neuropathic pain by suppressing neuroinflammation matters more than you think.
#fenofibrateattenuates #gym #dna #yeet #coherance #science #metacognition #cellular #frequency #logic #workout #second
#fenofibrateattenuates #gym #dna #yeet #coherance #science #metacognition #cellular #frequency #logic #workout #second
October 4, 2026 at 10:00 AM
Why Fenofibrate attenuates peripheral neuropathic pain by suppressing neuroinflammation matters more than you think.
#fenofibrateattenuates #gym #dna #yeet #coherance #science #metacognition #cellular #frequency #logic #workout #second
#fenofibrateattenuates #gym #dna #yeet #coherance #science #metacognition #cellular #frequency #logic #workout #second
An invasion of immune cells from skull bone marrow triggers inflammation that drives cognitive and mood decline with age in adults with chronic TBI, shows work that also identifies #fenofibrate as a promising therapy in a pilot trial. #ScienceTranslationalMedicine https://scim.ag/4ddo126
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury
Aged cranial bone marrow–derived monocytes fuel chronic neuroinflammation after traumatic brain injury, a process reversed by fenofibrate.
scim.ag
October 1, 2026 at 3:00 PM
An invasion of immune cells from skull bone marrow triggers inflammation that drives cognitive and mood decline with age in adults with chronic TBI, shows work that also identifies #fenofibrate as a promising therapy in a pilot trial. #ScienceTranslationalMedicine https://scim.ag/4ddo126
An invasion of immune cells from skull bone marrow triggers inflammation that drives cognitive and mood decline with age in adults with chronic traumatic brain injury, shows work that also identifies fenofibrate as a promising therapy in a pilot trial.
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury
Aged cranial bone marrow–derived monocytes fuel chronic neuroinflammation after traumatic brain injury, a process reversed by fenofibrate.
scim.ag
October 1, 2026 at 2:36 PM
An invasion of immune cells from skull bone marrow triggers inflammation that drives cognitive and mood decline with age in adults with chronic traumatic brain injury, shows work that also identifies fenofibrate as a promising therapy in a pilot trial.
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury
Zhichao Lu et al.
www.science.org/doi/10.1126/...
Zhichao Lu et al.
www.science.org/doi/10.1126/...
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury
Aged cranial bone marrow–derived monocytes fuel chronic neuroinflammation after traumatic brain injury, a process reversed by fenofibrate.
www.science.org
September 30, 2026 at 11:58 PM
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury
Zhichao Lu et al.
www.science.org/doi/10.1126/...
Zhichao Lu et al.
www.science.org/doi/10.1126/...
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury | Science Translational Medicine www.science.org/doi/10.1126/... 🧪
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury
Aged cranial bone marrow–derived monocytes fuel chronic neuroinflammation after traumatic brain injury, a process reversed by fenofibrate.
www.science.org
September 30, 2026 at 10:39 PM
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury | Science Translational Medicine www.science.org/doi/10.1126/... 🧪
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury: www.science.org/doi/10.1126/... 🌎🧪 #Medsky #Neuroskyence
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury
Aged cranial bone marrow–derived monocytes fuel chronic neuroinflammation after traumatic brain injury, a process reversed by fenofibrate.
www.science.org
September 30, 2026 at 7:52 PM
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury: www.science.org/doi/10.1126/... 🌎🧪 #Medsky #Neuroskyence
Fenofibrate may slow established diabetic retinopathy, but it did not clearly prevent retinopathy before it began. Our evidence-led summary explains what the new meta-analysis found. https://livingdiabetes.com/fenofibrate-diabetic-retinopathy-meta-analysis/ #Diabetes #EyeHealth
Fenofibrate and Diabetic Retinopathy
Fenofibrate and Diabetic Retinopathy
livingdiabetes.com
September 30, 2026 at 4:27 PM
Fenofibrate may slow established diabetic retinopathy, but it did not clearly prevent retinopathy before it began. Our evidence-led summary explains what the new meta-analysis found. https://livingdiabetes.com/fenofibrate-diabetic-retinopathy-meta-analysis/ #Diabetes #EyeHealth
You’re lucky! Mine never stops, if it’s not cholesterol he’s not interested. I refused statins but he didn’t give up and so I’m now on fenofibrate which seems ok.
September 29, 2026 at 9:34 AM
You’re lucky! Mine never stops, if it’s not cholesterol he’s not interested. I refused statins but he didn’t give up and so I’m now on fenofibrate which seems ok.
And meanwhile, my allegedly world-class cardiologist doesn't understand the difference between a fibrate and a fenofibrate, so she's not going to write a prescription for something that would work. And I can ask AI all this in minutes.
September 28, 2026 at 10:06 PM
And meanwhile, my allegedly world-class cardiologist doesn't understand the difference between a fibrate and a fenofibrate, so she's not going to write a prescription for something that would work. And I can ask AI all this in minutes.
I’ve always refused them. I’m on a different thing now, Fenofibrate which I am taking. Mine isn’t actually that high but my GP is obsessed with it! I’m having the special lung scan next week to check for lung cancer. I’ve had it done twice already as I took part in research for it.
September 18, 2026 at 7:10 AM
I’ve always refused them. I’m on a different thing now, Fenofibrate which I am taking. Mine isn’t actually that high but my GP is obsessed with it! I’m having the special lung scan next week to check for lung cancer. I’ve had it done twice already as I took part in research for it.
✨💊 New (to us) drug added to the PBC indication of the Hepatology Drug Interaction checker: fenofibrate. AASLD recommends using fibrates in patients with an inadequate response to ursodeoxycholic acid.
September 17, 2026 at 9:04 AM
✨💊 New (to us) drug added to the PBC indication of the Hepatology Drug Interaction checker: fenofibrate. AASLD recommends using fibrates in patients with an inadequate response to ursodeoxycholic acid.
Today on the solient show: Is she tanking kidney stones, or is this kidney pain one of the MANY horrible side effects of Fenofibrate? Stay tuned!
September 15, 2026 at 10:18 PM
Today on the solient show: Is she tanking kidney stones, or is this kidney pain one of the MANY horrible side effects of Fenofibrate? Stay tuned!
A pharmacokinetics-informed ODE extrapolates long-term fenofibrate transcriptomic responses https://www.biorxiv.org/content/10.64898/2026.08.25.746919v1
August 25, 2026 at 1:01 PM
A pharmacokinetics-informed ODE extrapolates long-term fenofibrate transcriptomic responses https://www.biorxiv.org/content/10.64898/2026.08.25.746919v1
A pharmacokinetics-informed ODE extrapolates long-term fenofibrate transcriptomic responses https://www.biorxiv.org/content/10.64898/2026.08.25.746919v1
August 25, 2026 at 1:01 PM
A pharmacokinetics-informed ODE extrapolates long-term fenofibrate transcriptomic responses https://www.biorxiv.org/content/10.64898/2026.08.25.746919v1
We used the puriFlash®5.250 to purify 5 active ingredients found in OTC & prescription drugs including caffeine, glafenine, ketoprofen, flavone, & fenofibrate. The compounds were then confirmed using the expression® #CompactMassSpec #Purification bit.ly/36h4myZ
August 24, 2026 at 4:55 PM
We used the puriFlash®5.250 to purify 5 active ingredients found in OTC & prescription drugs including caffeine, glafenine, ketoprofen, flavone, & fenofibrate. The compounds were then confirmed using the expression® #CompactMassSpec #Purification bit.ly/36h4myZ
Ophthopedia Update: Association of fenofibrate use with progression of ocular disease in individuals with diabetes: Background/aims
Fenofibrates may slow progression of diabetic retinopathy (DR). This study used the large international TriNetX database to… #Ophthalmology #Ophthotwitter #BJO
Fenofibrates may slow progression of diabetic retinopathy (DR). This study used the large international TriNetX database to… #Ophthalmology #Ophthotwitter #BJO
Association of fenofibrate use with progression of ocular disease in individuals with diabetes
Background/aims
Fenofibrates may slow progression of diabetic retinopathy (DR). This study used the large international TriNetX database to evaluate progression of retinopathy and development of cataracts, primary open angle glaucoma (POAG) and diabetic macular oedema (DME) in patients with diabetes with and without fenofibrate use.Methods
In this retrospective cohort study, ICD10 codes and RxNorm were used to identify patients in the TriNetX database aged ≥18 years with a diagnosis of diabetes mellitus (DM), with mild or moderate non-proliferative diabetic retinopathy (NPDR) and with and without fenofibrate use from December 2014 through December 2024. ORs were calculated to analyse the proportion of individuals with mild or moderate NPDR using fenofibrate who developed vision-threatening DR (VTDR, defined as severe NPDR or proliferative DR), cataracts, POAG or DME compared with those not taking fenofibrate. Those with cataracts, POAG or DME at baseline were excluded from their respective outcomes analyses.Results
After propensity score matching, 4316, 4200, 4073 and 4571 individuals prescribed fenofibrate were compared with the same number who were not prescribed fenofibrate for progression to VTDR, cataract, POAG or DME, respectively. The ORs for DR progression (OR 0.528, 95% CI 0.333 to 0.838; p=0.0059), cataract (OR 0.585, 95% CI 0.441 to 0.774; p=0.0002) and DME (OR 0.316, 95% CI 0.243 to 0.411; p
dlvr.it
August 21, 2026 at 4:44 PM
Ophthopedia Update: Association of fenofibrate use with progression of ocular disease in individuals with diabetes: Background/aims
Fenofibrates may slow progression of diabetic retinopathy (DR). This study used the large international TriNetX database to… #Ophthalmology #Ophthotwitter #BJO
Fenofibrates may slow progression of diabetic retinopathy (DR). This study used the large international TriNetX database to… #Ophthalmology #Ophthotwitter #BJO
I’m really worried about trying fenofibrate. I apparently have statin intolerance but I also can’t seem to tolerate statin alternatives either, which this is one of them. With this med, it’ll be the fifth cholesterol med they’ll have tried me on, and all of them have made me sicker & haven’t helped.
August 19, 2026 at 3:57 AM
I’m really worried about trying fenofibrate. I apparently have statin intolerance but I also can’t seem to tolerate statin alternatives either, which this is one of them. With this med, it’ll be the fifth cholesterol med they’ll have tried me on, and all of them have made me sicker & haven’t helped.
I think this is probably why I have a fenofibrate rx tbh
July 20, 2026 at 2:56 PM
I think this is probably why I have a fenofibrate rx tbh
Looked up fenofibrate in Wikipedia (a great source for info on prescription drugs), and it's apparently quite old and generic, though doesn't affect exactly the same cholesterol versions as the statins do. Not sure it's price but probably not super high.
(The injectable is fairly new and pricey.)
(The injectable is fairly new and pricey.)
July 19, 2026 at 6:26 AM
Looked up fenofibrate in Wikipedia (a great source for info on prescription drugs), and it's apparently quite old and generic, though doesn't affect exactly the same cholesterol versions as the statins do. Not sure it's price but probably not super high.
(The injectable is fairly new and pricey.)
(The injectable is fairly new and pricey.)
i think i read about that fenofibrate one. the issue for us in the US is just affordability though, everything is ridiculously expensive. like unimaginably.
July 19, 2026 at 6:02 AM
i think i read about that fenofibrate one. the issue for us in the US is just affordability though, everything is ridiculously expensive. like unimaginably.
It's the first oral one of that particular type,
but there are other non-statin cholesterol drugs like fenofibrate, as well as new weekly injectables like Repatha.
but there are other non-statin cholesterol drugs like fenofibrate, as well as new weekly injectables like Repatha.
July 19, 2026 at 5:55 AM
It's the first oral one of that particular type,
but there are other non-statin cholesterol drugs like fenofibrate, as well as new weekly injectables like Repatha.
but there are other non-statin cholesterol drugs like fenofibrate, as well as new weekly injectables like Repatha.
Non-gout drugs that may lower uric acid – losartan, amlodipine, ACE inhibitors, fenofibrate, atorvastatin, leflunomide, vitamin C, estrogen, and high-dose ASA.
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For more gout content, follow our Gout: More than Flares campaign at buff.ly/nDrUL6C,
July 10, 2026 at 8:15 PM
Non-gout drugs that may lower uric acid – losartan, amlodipine, ACE inhibitors, fenofibrate, atorvastatin, leflunomide, vitamin C, estrogen, and high-dose ASA.
For more gout content, follow our Gout: More than Flares campaign at buff.ly/nDrUL6C,
For more gout content, follow our Gout: More than Flares campaign at buff.ly/nDrUL6C,