Great balls of fibronectin! 😍
November 11, 2024 at 6:29 AM
Great balls of fibronectin! 😍
The GRC on Fibronectin, Integrins and Related Molecules earlier this month was a fantastic meeting.
Good work @tanentzapflab.bsky.social and @sarawickstrom.bsky.social for organising.
www.grc.org/fibronectin-...
Good work @tanentzapflab.bsky.social and @sarawickstrom.bsky.social for organising.
www.grc.org/fibronectin-...
May 23, 2025 at 11:16 AM
The GRC on Fibronectin, Integrins and Related Molecules earlier this month was a fantastic meeting.
Good work @tanentzapflab.bsky.social and @sarawickstrom.bsky.social for organising.
www.grc.org/fibronectin-...
Good work @tanentzapflab.bsky.social and @sarawickstrom.bsky.social for organising.
www.grc.org/fibronectin-...
Thanks for an amazing meeting GRC Fibronectin, integrins and related molecules @sarawickstrom.bsky.social and Guy
May 8, 2025 at 7:05 AM
Thanks for an amazing meeting GRC Fibronectin, integrins and related molecules @sarawickstrom.bsky.social and Guy
A reminder to colleagues interested in Cell-Matrix adhesion & anything ECM related that registration is now open for the Fibronectin, Integrins & related molecules Gordon Research Conference. Incredible list speakers! incredible location! it will 🔥 🔥 🔥 Please join us! www.grc.org/fibronectin-...
2025 Fibronectin, Integrins and Related Molecules Conference GRC
The 2025 Gordon Research Conference on Fibronectin, Integrins and Related Molecules will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 22, 2025 at 4:54 AM
A reminder to colleagues interested in Cell-Matrix adhesion & anything ECM related that registration is now open for the Fibronectin, Integrins & related molecules Gordon Research Conference. Incredible list speakers! incredible location! it will 🔥 🔥 🔥 Please join us! www.grc.org/fibronectin-...
Honored to have been elected with Patrick Caswell @mcrcellmatrix.bsky.social co-chair of the 2029 Gordon Research Conference on Fibronectin, Integrins, and Related Molecules!
We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!
We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!
May 12, 2025 at 1:18 PM
Honored to have been elected with Patrick Caswell @mcrcellmatrix.bsky.social co-chair of the 2029 Gordon Research Conference on Fibronectin, Integrins, and Related Molecules!
We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!
We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1
December 3, 2024 at 9:18 AM
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1
A cryosection immunofluorescence image of a Xenopus embryo showing fibronectin in 🔵, DAPI in ⚪, and Sox9 - a marker of the neural crest in 🟠.
Image credit: Kai Weissenbruch from UCL
#FluorescenceFriday #devbio
Image credit: Kai Weissenbruch from UCL
#FluorescenceFriday #devbio
August 1, 2025 at 1:43 PM
A cryosection immunofluorescence image of a Xenopus embryo showing fibronectin in 🔵, DAPI in ⚪, and Sox9 - a marker of the neural crest in 🟠.
Image credit: Kai Weissenbruch from UCL
#FluorescenceFriday #devbio
Image credit: Kai Weissenbruch from UCL
#FluorescenceFriday #devbio
For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...
2025 Fibronectin, Integrins and Related Molecules (GRS) Seminar GRC
The 2025 Gordon Research Seminar on Fibronectin, Integrins and Related Molecules (GRS) will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 20, 2025 at 11:17 AM
For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...
November 15, 2024 at 4:52 PM
Happy #FluorescenceFriday to those who celebrate! Here's another beautiful quail neural tube and somites, imaged by Dr Siew Zhuan Tan. That fibronectin is on fire! ❤️🔥 🧪 👩🔬 #devbio
November 14, 2024 at 11:17 PM
Happy #FluorescenceFriday to those who celebrate! Here's another beautiful quail neural tube and somites, imaged by Dr Siew Zhuan Tan. That fibronectin is on fire! ❤️🔥 🧪 👩🔬 #devbio
Indirect immunostaining of HeLa cells with Fibronectin 🟣 and alpha-Tubulin 🟢.
DAPI 🔵
#FluorescenceFriday
DAPI 🔵
#FluorescenceFriday
May 15, 2026 at 1:05 PM
Indirect immunostaining of HeLa cells with Fibronectin 🟣 and alpha-Tubulin 🟢.
DAPI 🔵
#FluorescenceFriday
DAPI 🔵
#FluorescenceFriday
Modulation of fibronectin extracellular matrix enhances anti-tumor efficacy of immune checkpoint blockade @cp-cellrepmed.bsky.social @genentech.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
September 8, 2025 at 8:33 PM
Modulation of fibronectin extracellular matrix enhances anti-tumor efficacy of immune checkpoint blockade @cp-cellrepmed.bsky.social @genentech.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Saddened to learn of the death of Richard Hynes. A giant of cell biology, Richard made a massive contribution to extracellular matrix and cancer biology - in particular early work on fibronectin en.wikipedia.org/wiki/Richard...
Richard Hynes - Wikipedia
en.wikipedia.org
January 10, 2026 at 10:15 PM
Saddened to learn of the death of Richard Hynes. A giant of cell biology, Richard made a massive contribution to extracellular matrix and cancer biology - in particular early work on fibronectin en.wikipedia.org/wiki/Richard...
Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease idp.nature.com/authorize?re...
Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease - Nature Aging
Bhattarai, Yilmaz and colleagues identify astrocyte-derived fibronectin as a key driver of blood–brain barrier dysfunction in Alzheimer’s disease, linking APOE ε4 and amyloid pathology to vascular dam...
idp.nature.com
September 14, 2026 at 9:21 AM
Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease idp.nature.com/authorize?re...
Fibronectin, a key component of the vessel wall, triggers smooth muscle cells to release collagen-rich extracellular vesicles that guide their movement during vessel repair and atherosclerosis.
buff.ly/YOkDI4a
buff.ly/YOkDI4a
October 12, 2025 at 10:02 AM
Fibronectin, a key component of the vessel wall, triggers smooth muscle cells to release collagen-rich extracellular vesicles that guide their movement during vessel repair and atherosclerosis.
buff.ly/YOkDI4a
buff.ly/YOkDI4a
Finally, out in print: "Mesodermal fibronectin controls cell shape, polarity, and mechanotransduction in the second heart field during cardiac outflow tract development."
www.cell.com/developmenta...
www.cell.com/developmenta...
January 9, 2025 at 9:54 PM
Finally, out in print: "Mesodermal fibronectin controls cell shape, polarity, and mechanotransduction in the second heart field during cardiac outflow tract development."
www.cell.com/developmenta...
www.cell.com/developmenta...
Absolute privilege to chair the Fibronectin, Integrins and related molecules GRC with @tanentzapflab.bsky.social Great community, fantastic science and lots of fun 🤩
May 10, 2025 at 6:05 PM
Absolute privilege to chair the Fibronectin, Integrins and related molecules GRC with @tanentzapflab.bsky.social Great community, fantastic science and lots of fun 🤩
#MicroscopyMonday 🔬 MBL Research Scientist @ryliewalsh.bsky.social imaged this chick embryo, labeled with DAPI (a DNA stain) and fibronectin (a glycoprotein), on the MBL's stage-scanning line confocal microscope.
Specimen courtesy Panos Oikonomou, Columbia Univ.
www.youtube.com/watch?v=jAUo...
Specimen courtesy Panos Oikonomou, Columbia Univ.
www.youtube.com/watch?v=jAUo...
Cleared chick embryo labeled with DAPI and fibronectin
YouTube video by Marine Biological Laboratory
www.youtube.com
March 24, 2025 at 4:36 PM
#MicroscopyMonday 🔬 MBL Research Scientist @ryliewalsh.bsky.social imaged this chick embryo, labeled with DAPI (a DNA stain) and fibronectin (a glycoprotein), on the MBL's stage-scanning line confocal microscope.
Specimen courtesy Panos Oikonomou, Columbia Univ.
www.youtube.com/watch?v=jAUo...
Specimen courtesy Panos Oikonomou, Columbia Univ.
www.youtube.com/watch?v=jAUo...
🧪To the science feed you go... if you like #neutrophil #metabolism #metastasis #UPP1 #Uracil #fibronectin, then you are in for a treat 👇
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate
in the lung where they inhibit CD8+ T cells, promote fibr...
www.embopress.org
July 23, 2025 at 9:13 PM
🧪To the science feed you go... if you like #neutrophil #metabolism #metastasis #UPP1 #Uracil #fibronectin, then you are in for a treat 👇
Thanks to @tanentzapflab.bsky.social & @sarawickstrom.bsky.social, chairs of an excellent Fibronectin, Integrins & Related Molecules GRC & to @martina-lerche.bsky.social & @mchastney.bsky.social for chairing the GRS. We look forward to Kairbaan Hodivala-Dilke & Tom Barker's 2027 meeting!
May 8, 2025 at 12:06 PM
Thanks to @tanentzapflab.bsky.social & @sarawickstrom.bsky.social, chairs of an excellent Fibronectin, Integrins & Related Molecules GRC & to @martina-lerche.bsky.social & @mchastney.bsky.social for chairing the GRS. We look forward to Kairbaan Hodivala-Dilke & Tom Barker's 2027 meeting!
Congratulations to Pat Caswell (@integrintraffic.bsky.social) & Alexandra Naba (@matrisome.bsky.social) who will be vice-chairs of the 2027 Fibronectin, Integrins & Related Molecules GRC and chairs of the 2029 meeting!
May 8, 2025 at 12:09 PM
Congratulations to Pat Caswell (@integrintraffic.bsky.social) & Alexandra Naba (@matrisome.bsky.social) who will be vice-chairs of the 2027 Fibronectin, Integrins & Related Molecules GRC and chairs of the 2029 meeting!
Fibronectin glomerulopathy
🔸Massive fibronectin deposits
🔸AD mutation FN1
🔸MPGN-like pattern
🔸Silver-neg, PAS+, trichrome-red
🔸EM: Homogeneous granular + variable fibrils
🔸IF/IHC strongly + fibronectin
🔸renal-limited
(1/2) more below
#renalpath #pathsky #nephsky
🔸Massive fibronectin deposits
🔸AD mutation FN1
🔸MPGN-like pattern
🔸Silver-neg, PAS+, trichrome-red
🔸EM: Homogeneous granular + variable fibrils
🔸IF/IHC strongly + fibronectin
🔸renal-limited
(1/2) more below
#renalpath #pathsky #nephsky
August 6, 2025 at 3:18 AM
Fibronectin glomerulopathy
🔸Massive fibronectin deposits
🔸AD mutation FN1
🔸MPGN-like pattern
🔸Silver-neg, PAS+, trichrome-red
🔸EM: Homogeneous granular + variable fibrils
🔸IF/IHC strongly + fibronectin
🔸renal-limited
(1/2) more below
#renalpath #pathsky #nephsky
🔸Massive fibronectin deposits
🔸AD mutation FN1
🔸MPGN-like pattern
🔸Silver-neg, PAS+, trichrome-red
🔸EM: Homogeneous granular + variable fibrils
🔸IF/IHC strongly + fibronectin
🔸renal-limited
(1/2) more below
#renalpath #pathsky #nephsky
Currently at the GRC on Fibronectin, Integrins & Related Molecules in Barga, Italy. Sad to see so little US participation, and particularly to see speakers cancel. Current US Government policy is harming scientific progress and hopefully it will be reversed.
May 5, 2025 at 12:29 PM
Currently at the GRC on Fibronectin, Integrins & Related Molecules in Barga, Italy. Sad to see so little US participation, and particularly to see speakers cancel. Current US Government policy is harming scientific progress and hopefully it will be reversed.
This week's #FluorescenceFriday, we'll be treated with one of the classical models of #devbio, the neural crest cells. Here is a beautiful video of neural crest cells with GFP-tagged focal adhesion kinase (🔵) and LifeAct-RFP (🟣) migrating on a Fibronectin matrix.
📹: Adam Shellard
📹: Adam Shellard
November 14, 2025 at 5:45 PM
This week's #FluorescenceFriday, we'll be treated with one of the classical models of #devbio, the neural crest cells. Here is a beautiful video of neural crest cells with GFP-tagged focal adhesion kinase (🔵) and LifeAct-RFP (🟣) migrating on a Fibronectin matrix.
📹: Adam Shellard
📹: Adam Shellard
