New research identifies Galectin-3 as a key regulator of neural development, establishing its contribution to brain growth.
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/46mJrGO
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/46mJrGO
September 5, 2025 at 10:39 PM
New research identifies Galectin-3 as a key regulator of neural development, establishing its contribution to brain growth.
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/46mJrGO
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/46mJrGO
➡️ Die Ergebnisse zeigen, dass Galectin-9 und Artemin bei LC mit ME/CFS assoziiert sind.
➡️ Die Studie bringt Galectin-9 mit einer Dysregulation des Immunsystems bei LC in Verbindung.
➡️ CD71+ erythroide Zellen werden als Quelle von Artemin bei LC definiert.
➡️ Die Studie bringt Galectin-9 mit einer Dysregulation des Immunsystems bei LC in Verbindung.
➡️ CD71+ erythroide Zellen werden als Quelle von Artemin bei LC definiert.
May 28, 2024 at 8:55 PM
➡️ Die Ergebnisse zeigen, dass Galectin-9 und Artemin bei LC mit ME/CFS assoziiert sind.
➡️ Die Studie bringt Galectin-9 mit einer Dysregulation des Immunsystems bei LC in Verbindung.
➡️ CD71+ erythroide Zellen werden als Quelle von Artemin bei LC definiert.
➡️ Die Studie bringt Galectin-9 mit einer Dysregulation des Immunsystems bei LC in Verbindung.
➡️ CD71+ erythroide Zellen werden als Quelle von Artemin bei LC definiert.
und Galectin-3-Expressionsniveau beurteilt und bewertet. Die SARS-CoV-2-Gruppe wies eine signifikante Epithelschuppung, umfangreiche Gewebeschäden (P < 0,0001), einen verminderten Mucingehalt, erhöhte Apoptose (P = 0,0279) und Pyroptose (P = 0,0265) sowie eine reduzierte
June 23, 2025 at 7:24 PM
und Galectin-3-Expressionsniveau beurteilt und bewertet. Die SARS-CoV-2-Gruppe wies eine signifikante Epithelschuppung, umfangreiche Gewebeschäden (P < 0,0001), einen verminderten Mucingehalt, erhöhte Apoptose (P = 0,0279) und Pyroptose (P = 0,0265) sowie eine reduzierte
We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network.
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens
Shivcharan et al. report that endosomal damage sensing by the danger receptor galectin-8
licenses noncanonical inflammasome activation and pyroptosis during intracellular
bacterial infections in human...
www.cell.com
July 17, 2025 at 12:12 PM
We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network.
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
Galectin-3-Expression (P = 0,0211) auf. Die parietalen Zellen wiesen eine ausgeprägte strukturelle Schädigung und eine starke SARS-CoV-2-Positivität auf, was ihre Anfälligkeit und ihre potenzielle Rolle bei der Dysfunktion des Magens während der Infektion unterstreicht.
June 23, 2025 at 7:24 PM
Galectin-3-Expression (P = 0,0211) auf. Die parietalen Zellen wiesen eine ausgeprägte strukturelle Schädigung und eine starke SARS-CoV-2-Positivität auf, was ihre Anfälligkeit und ihre potenzielle Rolle bei der Dysfunktion des Magens während der Infektion unterstreicht.
3️⃣ There’s also gut barrier dysfunction - meaning particles from the gut leak into the bloodstream, fueling inflammation.
Markers like Galectin-9, Reelin, and Artemin (linked to pain and brain fog) were higher, especially in women.
Markers like Galectin-9, Reelin, and Artemin (linked to pain and brain fog) were higher, especially in women.
November 8, 2025 at 11:47 AM
3️⃣ There’s also gut barrier dysfunction - meaning particles from the gut leak into the bloodstream, fueling inflammation.
Markers like Galectin-9, Reelin, and Artemin (linked to pain and brain fog) were higher, especially in women.
Markers like Galectin-9, Reelin, and Artemin (linked to pain and brain fog) were higher, especially in women.
From Prof Hiroshi Yasuda regarding the blood of LC patients & inflammation :
threadreaderapp.com/thread/18512...
#LongCovid #inflammation
threadreaderapp.com/thread/18512...
#LongCovid #inflammation
![FYI, "In the blood of the long COVID patients, the team [at the University of Alberta] found higher levels of various proteins related to systemic inflammation—especially galectin-9 and artemin..
higher levels of galectin-9 in patients are associated with increased inflammation and brain fog.. higher levels of artemin are associated with widespread pain, more severe pain and cognitive impairment..
galectin-9 is shed by stressed neutrophils—the most abundant white blood cells—in long COVID patients.
This released galectin-9 can promote chronic inflammation by affecting various immune cells..
long COVID dysregulates the production of red blood cells, which results in an abundance of immature red blood cells in the blood of these patients.
Normally, immature red blood cells are present in the bone marrow but not in the blood of healthy people.
It is these immature red blood cells in the blood that suppress the immune system and contribute to the elevation of artemin in the plasma of long-COVID patients."
'Studies pinpoint immune cells and proteins linked to long COVID'](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:li6aqouldc2xdd6ohr3tfukn/bafkreife4cvtrsdtfsnnhemi6lxft3nrndtrqx2bxprih6ccv56i6lbl3a)
October 29, 2024 at 7:01 PM
From Prof Hiroshi Yasuda regarding the blood of LC patients & inflammation :
threadreaderapp.com/thread/18512...
#LongCovid #inflammation
threadreaderapp.com/thread/18512...
#LongCovid #inflammation
New athero paper! We only played a minor part but very happy for our @ipekresearch.bsky.social collaborators that this is out now:
www.atherosclerosis-journal.com/article/S002...
www.atherosclerosis-journal.com/article/S002...
Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation
Atherosclerosis is a chronic immunometabolic disease driven by lipid accumulation
and immune cell infiltration. Macrophages and T cells play key roles throughout plaque
development. Galectin-1 (Gal-1)...
www.atherosclerosis-journal.com
December 13, 2025 at 9:00 AM
New athero paper! We only played a minor part but very happy for our @ipekresearch.bsky.social collaborators that this is out now:
www.atherosclerosis-journal.com/article/S002...
www.atherosclerosis-journal.com/article/S002...
Galectin-9 is an immunotherapy target for modifying regulatory and exhausted T-cells in CLL
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
August 7, 2025 at 7:01 PM
Galectin-9 is an immunotherapy target for modifying regulatory and exhausted T-cells in CLL
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
Repost of our paper published in 2024 showing protective retinal #microglia in retinal degenerative disease hubs.la/Q02j8cMC0.
Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2 | Journal of Experimental Medicine | Rockefeller University Press
hubs.la
November 18, 2024 at 1:08 AM
Repost of our paper published in 2024 showing protective retinal #microglia in retinal degenerative disease hubs.la/Q02j8cMC0.
“Galectin-3 restrains T cell-driven inflammation in the testis and epididymis”
This study advances the understanding of the mechanisms underlying immune-mediated male #Infertility ⤵️
www.nature.com/articles/s41...
This study advances the understanding of the mechanisms underlying immune-mediated male #Infertility ⤵️
www.nature.com/articles/s41...
September 29, 2026 at 10:29 AM
“Galectin-3 restrains T cell-driven inflammation in the testis and epididymis”
This study advances the understanding of the mechanisms underlying immune-mediated male #Infertility ⤵️
www.nature.com/articles/s41...
This study advances the understanding of the mechanisms underlying immune-mediated male #Infertility ⤵️
www.nature.com/articles/s41...
Kickoff meeting for the
🌌Galectin-3 targeted antifungal prophylaxis in ICU influenza (GALActIC)🌌
eppermed.eu project at UZLeuven
Incredibly productive meeting with the Galactic team @agocarvalho.bsky.social @simonfeys.bsky.social @msgerc.bsky.social @ishamycology.bsky.social
🌌Galectin-3 targeted antifungal prophylaxis in ICU influenza (GALActIC)🌌
eppermed.eu project at UZLeuven
Incredibly productive meeting with the Galactic team @agocarvalho.bsky.social @simonfeys.bsky.social @msgerc.bsky.social @ishamycology.bsky.social
February 5, 2025 at 9:34 AM
Kickoff meeting for the
🌌Galectin-3 targeted antifungal prophylaxis in ICU influenza (GALActIC)🌌
eppermed.eu project at UZLeuven
Incredibly productive meeting with the Galactic team @agocarvalho.bsky.social @simonfeys.bsky.social @msgerc.bsky.social @ishamycology.bsky.social
🌌Galectin-3 targeted antifungal prophylaxis in ICU influenza (GALActIC)🌌
eppermed.eu project at UZLeuven
Incredibly productive meeting with the Galactic team @agocarvalho.bsky.social @simonfeys.bsky.social @msgerc.bsky.social @ishamycology.bsky.social
Glyco27 has been great so far! Gaby Rabinovich received the Hakomori Award and I had the chance to present our lab latest results regarding galectin binding. I am deeply thanked to the organization for honouring me with a travel award to be here 💫💪 #Glyco27 @glyconet.bsky.social
May 29, 2025 at 4:48 PM
Glyco27 has been great so far! Gaby Rabinovich received the Hakomori Award and I had the chance to present our lab latest results regarding galectin binding. I am deeply thanked to the organization for honouring me with a travel award to be here 💫💪 #Glyco27 @glyconet.bsky.social
Checking Galectin-3 spots reveals just how much your cells truly care for you. Beautiful evenings spent at the microscope with @stedet.bsky.social
November 26, 2024 at 9:14 PM
Checking Galectin-3 spots reveals just how much your cells truly care for you. Beautiful evenings spent at the microscope with @stedet.bsky.social
Growth factors trigger receptor desialylation at the plasma membrane, galectin binding and subsequent endocytosis.
=> A proton pump driven glycoswitch @naturecellbiology.bsky.social :
rdcu.be/eaLM9
#glycotime, @institutcurie.bsky.social, @cnrs.fr, @inserm.fr, #NIH, #CellBiol, #Cancer
=> A proton pump driven glycoswitch @naturecellbiology.bsky.social :
rdcu.be/eaLM9
#glycotime, @institutcurie.bsky.social, @cnrs.fr, @inserm.fr, #NIH, #CellBiol, #Cancer
February 22, 2025 at 10:31 PM
Growth factors trigger receptor desialylation at the plasma membrane, galectin binding and subsequent endocytosis.
=> A proton pump driven glycoswitch @naturecellbiology.bsky.social :
rdcu.be/eaLM9
#glycotime, @institutcurie.bsky.social, @cnrs.fr, @inserm.fr, #NIH, #CellBiol, #Cancer
=> A proton pump driven glycoswitch @naturecellbiology.bsky.social :
rdcu.be/eaLM9
#glycotime, @institutcurie.bsky.social, @cnrs.fr, @inserm.fr, #NIH, #CellBiol, #Cancer
Session 1 of #DACHEV2026: Edit Buzás on a stress-induced switch in EV biogenesis, @merypipis.bsky.social on adipocyte-derived EVs, Allegra Angenendt on kinesins in ectosome cargo loading, and flash talks on cilia-dependent EV cargo, EV binding in Zika virus infection, and galectin-3. #ASEV #SwissEV
September 29, 2026 at 9:50 AM
Session 1 of #DACHEV2026: Edit Buzás on a stress-induced switch in EV biogenesis, @merypipis.bsky.social on adipocyte-derived EVs, Allegra Angenendt on kinesins in ectosome cargo loading, and flash talks on cilia-dependent EV cargo, EV binding in Zika virus infection, and galectin-3. #ASEV #SwissEV
"Enteroendocrine cells displayed heightened activity. SARS-CoV-2 infection caused significant damage to gastric epithelial and parietal cells through inflammatory, apoptotic, and pyroptotic mechanisms, likely exacerbated by reduced Galectin-3 expression"
June 26, 2025 at 9:47 AM
"Enteroendocrine cells displayed heightened activity. SARS-CoV-2 infection caused significant damage to gastric epithelial and parietal cells through inflammatory, apoptotic, and pyroptotic mechanisms, likely exacerbated by reduced Galectin-3 expression"
Istanbul researchers studied 20 transgenic mice and found that SARS-CoV-2 directly damages stomach tissue, especially parietal cells, triggering apoptosis and pyroptosis while depleting protective Galectin-3.
This may underlie COVID-19 gastric symptoms.
link.springer.com/article/10.1...
This may underlie COVID-19 gastric symptoms.
link.springer.com/article/10.1...
SARS-CoV-2 causes gastric damage: structural and ultrastructural evaluation - Journal of Molecular Histology
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infects the gastrointestinal tract; however, its effects on the stomach and underlying mechanisms remain unknown. The presence of ACE2 (ang...
link.springer.com
June 23, 2025 at 4:26 PM
Istanbul researchers studied 20 transgenic mice and found that SARS-CoV-2 directly damages stomach tissue, especially parietal cells, triggering apoptosis and pyroptosis while depleting protective Galectin-3.
This may underlie COVID-19 gastric symptoms.
link.springer.com/article/10.1...
This may underlie COVID-19 gastric symptoms.
link.springer.com/article/10.1...
und pyroptotische Mechanismen, die wahrscheinlich durch eine verringerte Galectin-3-Expression und die daraus resultierende Beeinträchtigung des Magenschutzes noch verstärkt wurden. Diese Schädigung kann die Anfälligkeit für Sekundärinfektionen wie H. pylori erhöhen und könnte zu
June 23, 2025 at 7:25 PM
und pyroptotische Mechanismen, die wahrscheinlich durch eine verringerte Galectin-3-Expression und die daraus resultierende Beeinträchtigung des Magenschutzes noch verstärkt wurden. Diese Schädigung kann die Anfälligkeit für Sekundärinfektionen wie H. pylori erhöhen und könnte zu
Also check out the awesome posters of the Mahal Lab on Tuesday (on multiple sclerosis) and Thursday ( on lectin specificities and miRNA regulation of Galectin 1 and OGT) #Glyco27 #proudoflab @giaglyco.bsky.social
May 26, 2025 at 9:30 PM
Also check out the awesome posters of the Mahal Lab on Tuesday (on multiple sclerosis) and Thursday ( on lectin specificities and miRNA regulation of Galectin 1 and OGT) #Glyco27 #proudoflab @giaglyco.bsky.social
Key to the high aggressiveness of pancreatic cancer
There may be a cure for Pancreatic Cancer rather shortly. It appears there is a new protein called Galectin-1 inside the nuclei of fibroblasts. This protein causes proliferation of aggressive cancer cells.
There may be a cure for Pancreatic Cancer rather shortly. It appears there is a new protein called Galectin-1 inside the nuclei of fibroblasts. This protein causes proliferation of aggressive cancer cells.
Key to the high aggressiveness of pancreatic cancer identified
Pancreatic cancer is one of the most aggressive cancers and has one of the lowest survival rates—only 10% after five years. One of the factors contributing to its aggressiveness is its tumor microenvi...
search.app
April 17, 2025 at 1:19 AM
Key to the high aggressiveness of pancreatic cancer
There may be a cure for Pancreatic Cancer rather shortly. It appears there is a new protein called Galectin-1 inside the nuclei of fibroblasts. This protein causes proliferation of aggressive cancer cells.
There may be a cure for Pancreatic Cancer rather shortly. It appears there is a new protein called Galectin-1 inside the nuclei of fibroblasts. This protein causes proliferation of aggressive cancer cells.
Just started a new med/supplement (a galectin-3 inhibitor) - it’s chewable but I’m supposed to let it dissolve in my mouth and HOLY GROSSNESS. Yuck yuck yuck yuck yuck #LongCovid
December 30, 2025 at 4:15 AM
Just started a new med/supplement (a galectin-3 inhibitor) - it’s chewable but I’m supposed to let it dissolve in my mouth and HOLY GROSSNESS. Yuck yuck yuck yuck yuck #LongCovid
University of Alberta, 20 participants, found Long COVID with ME/CFS reshapes the immune system with more exhausted T cells, weaker NK cells, and fewer MAIT and gamma delta T cells, linked to Galectin 9 and TIM 3.
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
Frontiers | Single-cell analysis reveals immune remodeling of monocytes, NK cells, T cell exhaustion, and Galectin-9–associated depletion of gamma delta and mucosal-associated invariant T cells in Lon...
IntroductionThe cellular mechanisms underlying Long COVID (LC) associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remain poorly unde...
www.frontiersin.org
March 13, 2026 at 3:58 PM
University of Alberta, 20 participants, found Long COVID with ME/CFS reshapes the immune system with more exhausted T cells, weaker NK cells, and fewer MAIT and gamma delta T cells, linked to Galectin 9 and TIM 3.
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
"… revealing widespread transcriptional remodeling across both innate and adaptive immune compartments."
"Mechanistically, we identify Galectin-9–TIM-3 interaction as a potential pathway driving ɣ𝛿 and MAIT cell depletion in LC."
#MECFS #LongCovid #GDTcells
www.frontiersin.org/journals/imm...
"Mechanistically, we identify Galectin-9–TIM-3 interaction as a potential pathway driving ɣ𝛿 and MAIT cell depletion in LC."
#MECFS #LongCovid #GDTcells
www.frontiersin.org/journals/imm...
Frontiers | Single-cell analysis reveals immune remodeling of monocytes, NK cells, T cell exhaustion, and Galectin-9–associated depletion of gamma delta and mucosal-associated invariant T cells in Lon...
IntroductionThe cellular mechanisms underlying Long COVID (LC) associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remain poorly unde...
www.frontiersin.org
February 25, 2026 at 9:00 AM
"… revealing widespread transcriptional remodeling across both innate and adaptive immune compartments."
"Mechanistically, we identify Galectin-9–TIM-3 interaction as a potential pathway driving ɣ𝛿 and MAIT cell depletion in LC."
#MECFS #LongCovid #GDTcells
www.frontiersin.org/journals/imm...
"Mechanistically, we identify Galectin-9–TIM-3 interaction as a potential pathway driving ɣ𝛿 and MAIT cell depletion in LC."
#MECFS #LongCovid #GDTcells
www.frontiersin.org/journals/imm...
Cells undergoing ferroptosis secrete Galectin-13, which binds to CD44 and inhibits plasma membrane localization of SLC7A11 in neighboring cells, thereby accelerating neighboring cell death and promoting ferroptosis propagation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation - Nature Chemical Biology
Cells undergoing ferroptosis secrete Galectin-13, which binds to CD44 and inhibits the plasma membrane localization of SLC7A11 in neighboring cells, thereby accelerating neighboring cell death and pro...
www.nature.com
April 17, 2025 at 4:22 PM
Cells undergoing ferroptosis secrete Galectin-13, which binds to CD44 and inhibits plasma membrane localization of SLC7A11 in neighboring cells, thereby accelerating neighboring cell death and promoting ferroptosis propagation
www.nature.com/articles/s41...
www.nature.com/articles/s41...