A 3-year-old boy with chemotherapy-resistant metastatic hepatoblastoma had complete regression lasting at least 12 months after two infusions of glypican-3–specific CAR T cells coexpressing interle...

Glypicans are a family of highly conserved proteoglycans crucial for regulating cell signaling during development. Researchers rely on glypican antibodies to st

We evaluate the effects in humans of interleukin-15 co-expression on glypican-3 (GPC3) chimeric antigen receptor (CAR) T cells and demonstrate that IL-15 increases the expansion, intratumoural su...

Highly specific recombinant glypican (GPC) antibodies, validated for Flow cytometry and Immunofluorescence applications. Buy with Addgene!

Glypicans are a family of highly conserved proteoglycans crucial for regulating cell signaling during development. Researchers rely on glypican antibodies to st

Find unique recombinant antibodies targeting families of cell surface and secreted proteins from a collaboration between Addgene and IPI.

Interleukin-15 (IL-15) promotes the survival of T lymphocytes and enhances the antitumour properties of chimeric antigen receptor (CAR) T cells in preclinical models of solid neoplasms in which CAR T cells have limited efficacy1–4. Glypican-3 (GPC3) is expressed in a group of solid cancers5–10, and here we report the evaluation in humans of the effects of IL-15 co-expression on GPC3-expressing CAR T cells (hereafter GPC3 CAR T cells). Cohort 1 patients ( NCT02905188 and NCT02932956 ) received GPC3 CAR T cells, which were safe but produced no objective antitumour responses and reached peak expansion at 2 weeks. Cohort 2 patients ( NCT05103631 and NCT04377932 ) received GPC3 CAR T cells that co-expressed IL-15 (15.CAR), which mediated significantly increased cell expansion and induced a disease control rate of 66% and antitumour response rate of 33%. Infusion of 15.CAR T cells was associated with increased incidence of cytokine release syndrome, which was controlled with IL-1/IL-6 blocka

Nature - We evaluate the effects in humans of interleukin-15 co-expression on glypican-3 (GPC3) chimeric antigen receptor (CAR) T cells and demonstrate that IL-15 increases the expansion,...

A 3-year-old boy with chemotherapy-resistant metastatic hepatoblastoma had complete regression lasting at least 12 months after two infusions of glypican-3–specific CAR T cells coexpressing interle...

Find unique recombinant antibodies targeting families of cell surface and secreted proteins from a collaboration between Addgene and IPI.

The extracellular matrix plays critical roles in orchestrating cell communication and behaviors in response to various extracellular signals. It is...

Nature - We evaluate the effects in humans of interleukin-15 co-expression on glypican-3 (GPC3) chimeric antigen receptor (CAR) T cells and demonstrate that IL-15 increases the expansion,...

We evaluate the effects in humans of interleukin-15 co-expression on glypican-3 (GPC3) chimeric antigen receptor (CAR) T cells and demonstrate that IL-15 increases the expansion, intratumoural su...

Bosworth et al. demonstrate that astrocyte-expressed glypican 5 regulates glutamatergic synapse maturation and stabilization in the developing cortex, identifying a role for this factor in astrocytes in sculpting developing neural circuits.

Hundreds of millions of years before humans evolved, a family of proteins came to be — first in worms, next in flies, then in mammals. The proteins,