Our previous work showed that Drosophila glypican Dlp binds WNT palmitoleate in a hydrophobic pocket to maintain solubility. Is this conserved in vertebrate glypicans — and how important is lipid binding in vivo? Until now, no endogenous separation-of-function allele existed to test this.

further contributes to the imbalance between excitation and inhibition.
-Synaptogenic Factors: Astrocytes secrete molecules like thrombospondins, hevin, and glypicans that promote synapse formation. In ASD, "reactive" astrocytes (A1 phenotype)
induced by inflammatory signals produce fewer synapses

🛑 Are you using glypican antibodies to study brain development, neurodegeneration, cancer biology or cell signaling? 🛑 IPI has recombinant antibodies to GPC1-6 and we want you to know about them!

So, what’s amazing about our anti-glypicans?

IPI just released new glypican antibodies (GPCs1-6) — but what’s a glypican anyway?

Read our explainer to find out! Link in bio.
buff.ly/LezYIdl

The role of glypicans in the nervous system is still being uncovered. In this preprint, researchers @hopkinsmedicine.bsky.social @oneneurojhu.org show GPC6 plays a role in nuclear pore complex integrity and TDP-43 nuclear function, with potential to impact neurological function ➡️

Looking for #glypican, #integrin or #epitopetag antibodies? Browse our #antibody catalog and order today ➡️➡️
proteininnovation.org/glypican-ant...

In a recent review paper out of the NIH, Hsi-En Tsao and Mitchell Ho detail the modulatory role of #glypicans in #Wntsignaling & underscore the need for better blueprints of glypican/Wnt/Fzd complexes. Check out their mini review 📝 onlinelibrary.wiley.com/doi/full/10....

IPI's Deb Moshinsky presented at #SLAS2025 today, outlining our high-throughput SPR testing (using #CarterraLSA), application testing, and cross-reactivity analysis. We’ve applied in our exploration of #neuroscience related #antibodies, including anti- #Glypicans 1-6. Nice work, Deb! 🧑‍🔬

Looking for glypican antibodies? We’ve got GPCs 1, 3 & 4 for you! Browse our antibody catalog and order today ➡️➡️ https://buff.ly/3PsYbe6

Ever wonder how signals are passed between growth factors during synapse development? It’s possible #glypicans are involved. Their structure & positioning let them “soak up signaling proteins from outside the cell,” says Adrian Salic @harvardcellbio.bsky.social. Learn more! https://buff.ly/49HFPPK

Find out more about the glypican family on our blog! proteininnovation.org/2024/11/glyp...

Antibody alert 📣📣 We’ve released new #recombinantantibodies targeting #glypican family members GPC1, GPC3 and GPC4! Browse our collection & order today! #proteinscience #antibodies proteininnovation.org/glypican-ant...

2/3 The twist: despite being heavily glycosylated, both glypicans act exclusively through their CORE PROTEINS — not their heparan sulfate GAG chains. This challenges a long-standing dogma in the proteoglycan field! 🔬

RRID:SCR_006457 was used by the authors of the Genetics paper "Drosophila Glypicans Regulate Follicle Stem Cell Maintenance and Niche Competition". We appreciate the author's support of reproducibility. #STMpublishing #RRID

Glypicans, complete! We now have recombinant antibodies targeting GPC1–6, giving researchers full coverage of this key family. Thanks to our partners at IPI! Extensive characterization available:
https://twp.ai/4ispyb

Glypicans (gpc) act in many developmental signaling pathways as coreceptor, decoy regulater of ligand diffusion Bause M #EuroEvoDevo

Nakato, E., Kamimura, K., Knudsen, C., Masutani, S., Takemura, M., Hayashi, Y., Akiyama, T., Nakato, H. (2023). Differential heparan sulfate dependency of the #Drosophila glypicans. J Biol Chem, 300(1):105544 www.jbc.org/article/S002...