some random tid bits from the Demos poll #politas
of the 3 biggest parties
18-29 yr olds - Grns have highest %
Post Grad Qual - Grns have highest %
Didn't finish y12 - Grns have lowest % (by long shot)
of the 3 biggest parties
18-29 yr olds - Grns have highest %
Post Grad Qual - Grns have highest %
Didn't finish y12 - Grns have lowest % (by long shot)
July 14, 2025 at 5:01 AM
some random tid bits from the Demos poll #politas
of the 3 biggest parties
18-29 yr olds - Grns have highest %
Post Grad Qual - Grns have highest %
Didn't finish y12 - Grns have lowest % (by long shot)
of the 3 biggest parties
18-29 yr olds - Grns have highest %
Post Grad Qual - Grns have highest %
Didn't finish y12 - Grns have lowest % (by long shot)
Delighted to share some wonderful work by our recent grad Matthew Aguirre on theoretical models of GRNs, and what eQTL data can teach us about these!
Thrilled to share the second half of my PhD work here!
We show how data on expression quantitative trait loci (eQTL) relates to the structure of gene regulatory networks (GRN). Much of the GRN / eQTL picture is unmapped, but what we do have says a lot… (1/)
doi.org/10.1101/2025...
We show how data on expression quantitative trait loci (eQTL) relates to the structure of gene regulatory networks (GRN). Much of the GRN / eQTL picture is unmapped, but what we do have says a lot… (1/)
doi.org/10.1101/2025...
August 22, 2025 at 9:35 PM
Delighted to share some wonderful work by our recent grad Matthew Aguirre on theoretical models of GRNs, and what eQTL data can teach us about these!
In this case, it's perfectly plausible that Labour will lose seats in the North to Reform at a future election, but - on current polls - it will do so more due to losing progressive voters to the LDs and Grns than by losing voters to Reform.
April 13, 2025 at 10:22 AM
In this case, it's perfectly plausible that Labour will lose seats in the North to Reform at a future election, but - on current polls - it will do so more due to losing progressive voters to the LDs and Grns than by losing voters to Reform.
Some good tactical intentions there from LDs and Grns!
June 5, 2026 at 7:20 AM
Some good tactical intentions there from LDs and Grns!
We present Gene Regulatory nETwork Analsyis (GRETA), a framework to infer, compare and evaluate gene regulatory networks #GRNs. With it, we have benchmarked multimodal and unimodal GRN inference methods. Check the results here 👇
Paper: doi.org/10.1101/2024.12.20.629764
Code: github.com/saezlab/greta
Paper: doi.org/10.1101/2024.12.20.629764
Code: github.com/saezlab/greta
December 23, 2024 at 8:43 AM
We present Gene Regulatory nETwork Analsyis (GRETA), a framework to infer, compare and evaluate gene regulatory networks #GRNs. With it, we have benchmarked multimodal and unimodal GRN inference methods. Check the results here 👇
Paper: doi.org/10.1101/2024.12.20.629764
Code: github.com/saezlab/greta
Paper: doi.org/10.1101/2024.12.20.629764
Code: github.com/saezlab/greta
How can we organize current theoretical approaches for developmental biology - from information to dynamical systems & GRNs - into a common framework?
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
November 10, 2025 at 6:46 AM
How can we organize current theoretical approaches for developmental biology - from information to dynamical systems & GRNs - into a common framework?
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
Even in Labour vs Reform contests, where the nature of swing means Labour to Reform defections count double, the electoral strength/cost of losses to LDs and Grns is now ~66% higher than that of losses to Reform.
October 21, 2025 at 11:45 AM
Even in Labour vs Reform contests, where the nature of swing means Labour to Reform defections count double, the electoral strength/cost of losses to LDs and Grns is now ~66% higher than that of losses to Reform.
Absolutely colossal night of success for the Lib Dems.
In the 10 byelections, the LDs have gained from the CONs, GRNs, INDs and LAB, with a narrow loss to REF by 31 votes in Babergh.
Scoreboard: LD 7, REF 1, CON 1, IND 1.
I assume the media will cover this as breathlessly as every opinion poll?
In the 10 byelections, the LDs have gained from the CONs, GRNs, INDs and LAB, with a narrow loss to REF by 31 votes in Babergh.
Scoreboard: LD 7, REF 1, CON 1, IND 1.
I assume the media will cover this as breathlessly as every opinion poll?
October 17, 2025 at 11:20 AM
Absolutely colossal night of success for the Lib Dems.
In the 10 byelections, the LDs have gained from the CONs, GRNs, INDs and LAB, with a narrow loss to REF by 31 votes in Babergh.
Scoreboard: LD 7, REF 1, CON 1, IND 1.
I assume the media will cover this as breathlessly as every opinion poll?
In the 10 byelections, the LDs have gained from the CONs, GRNs, INDs and LAB, with a narrow loss to REF by 31 votes in Babergh.
Scoreboard: LD 7, REF 1, CON 1, IND 1.
I assume the media will cover this as breathlessly as every opinion poll?
The Virtual Cell is biologists' Golem, story-told with whatever the latest technology happens to be.
(PPIs, metabolic networks, ODEs, ChIP-Seq GRNs, LLMs, ...)
(PPIs, metabolic networks, ODEs, ChIP-Seq GRNs, LLMs, ...)
December 27, 2025 at 2:51 PM
The Virtual Cell is biologists' Golem, story-told with whatever the latest technology happens to be.
(PPIs, metabolic networks, ODEs, ChIP-Seq GRNs, LLMs, ...)
(PPIs, metabolic networks, ODEs, ChIP-Seq GRNs, LLMs, ...)
Worth reiterating that Tories now like Reform more than LD and particularly Green voters like Labour. Given that there are typically more Cons than LDs/Grns in the seats likely to be Lab vs Reform, the tactical voting arithmetic has changed massively in the last few months.
Labour voters are now as likely to see the Greens favourably as the Labour Party
Among 2024 Labour voters
Greens: 61% favourable (-1 from 13-14 Apr)
Labour: 59% (-7)
Lib Dems: 54% (-1)
Reform UK: 18% (+9)
Conservatives: 6% (+2)
yougov.co.uk/politics/art...
Among 2024 Labour voters
Greens: 61% favourable (-1 from 13-14 Apr)
Labour: 59% (-7)
Lib Dems: 54% (-1)
Reform UK: 18% (+9)
Conservatives: 6% (+2)
yougov.co.uk/politics/art...
May 17, 2025 at 7:26 AM
Worth reiterating that Tories now like Reform more than LD and particularly Green voters like Labour. Given that there are typically more Cons than LDs/Grns in the seats likely to be Lab vs Reform, the tactical voting arithmetic has changed massively in the last few months.
#NACC Jnt Committee
Dr Helen Haines, Ind & Sen Shoebridge, Grns doing a great job here
Great questions
Nowhere near enough time
Take-out from this is Mark Dreyfus' #NACC legislation is fucking useless
Which was deliberate bcuz he ignored our warnings, he ignored everyone's warnings
🐝
#auspol
Dr Helen Haines, Ind & Sen Shoebridge, Grns doing a great job here
Great questions
Nowhere near enough time
Take-out from this is Mark Dreyfus' #NACC legislation is fucking useless
Which was deliberate bcuz he ignored our warnings, he ignored everyone's warnings
🐝
#auspol
November 22, 2024 at 3:34 AM
Some side notes here: The pool of potential future defectors from Labour is massively skewed. Just 5% of still Labour-ers see Reform as a potential vote, while around half are open to voting LD or Green. Even among Labour to DKs, twice as many would consider LD or Grns than Reform.
August 9, 2025 at 3:21 PM
Some side notes here: The pool of potential future defectors from Labour is massively skewed. Just 5% of still Labour-ers see Reform as a potential vote, while around half are open to voting LD or Green. Even among Labour to DKs, twice as many would consider LD or Grns than Reform.
Thesis deposited, finally! 🥳 It’s been a long but fascinating journey 😄 The defense is on 10th February and open if you'd like to attend. Stay tuned in the coming weeks for a preprint with some intriguing insights about multimodal gene regulatory networks (GRNs) #GRN
November 25, 2024 at 1:47 PM
Thesis deposited, finally! 🥳 It’s been a long but fascinating journey 😄 The defense is on 10th February and open if you'd like to attend. Stay tuned in the coming weeks for a preprint with some intriguing insights about multimodal gene regulatory networks (GRNs) #GRN
With regards to GRNs...We find that interneurons alter their identity when apposed to different pyramidal neurons (Wu et al. Biorxiv 2024). How do surface signals alter TF expression to change GRNs? Linking this will explain a lot of how cortical circuits are so precise!
March 11, 2025 at 12:11 AM
With regards to GRNs...We find that interneurons alter their identity when apposed to different pyramidal neurons (Wu et al. Biorxiv 2024). How do surface signals alter TF expression to change GRNs? Linking this will explain a lot of how cortical circuits are so precise!
📊 Ref lead of 2pts, Grns in second
Westminster voting intention
REF: 23% (-1)
GRN: 21% (+4)
CON: 16% (-2)
LAB: 16% (-2)
LDEM: 14% (-)
via @YouGov, 01 - 02 Mar
Chgs. w/ 22 Feb
👇 Read this
www.newstatesman.com/politics/uk-...
Westminster voting intention
REF: 23% (-1)
GRN: 21% (+4)
CON: 16% (-2)
LAB: 16% (-2)
LDEM: 14% (-)
via @YouGov, 01 - 02 Mar
Chgs. w/ 22 Feb
👇 Read this
www.newstatesman.com/politics/uk-...
Britain Elects | Substack
Cutting through the noise with Ben Walker. Click to read Britain Elects, a Substack publication with thousands of subscribers.
britainelects.com
March 3, 2026 at 9:13 AM
📊 Ref lead of 2pts, Grns in second
Westminster voting intention
REF: 23% (-1)
GRN: 21% (+4)
CON: 16% (-2)
LAB: 16% (-2)
LDEM: 14% (-)
via @YouGov, 01 - 02 Mar
Chgs. w/ 22 Feb
👇 Read this
www.newstatesman.com/politics/uk-...
Westminster voting intention
REF: 23% (-1)
GRN: 21% (+4)
CON: 16% (-2)
LAB: 16% (-2)
LDEM: 14% (-)
via @YouGov, 01 - 02 Mar
Chgs. w/ 22 Feb
👇 Read this
www.newstatesman.com/politics/uk-...
Excited to share our RegVelo paper in Cell
www.cell.com/cell/fulltex...
We unify RNA velocity + GRNs into one model → better OOD prediction of perturbations (e.g. gene KOs), with examples incl. neural crest KO predictions 🔬
Big thanks to W Wang, Z Hu & T Sauka-Spengler 🙏
www.cell.com/cell/fulltex...
We unify RNA velocity + GRNs into one model → better OOD prediction of perturbations (e.g. gene KOs), with examples incl. neural crest KO predictions 🔬
Big thanks to W Wang, Z Hu & T Sauka-Spengler 🙏
May 12, 2026 at 7:42 AM
Excited to share our RegVelo paper in Cell
www.cell.com/cell/fulltex...
We unify RNA velocity + GRNs into one model → better OOD prediction of perturbations (e.g. gene KOs), with examples incl. neural crest KO predictions 🔬
Big thanks to W Wang, Z Hu & T Sauka-Spengler 🙏
www.cell.com/cell/fulltex...
We unify RNA velocity + GRNs into one model → better OOD prediction of perturbations (e.g. gene KOs), with examples incl. neural crest KO predictions 🔬
Big thanks to W Wang, Z Hu & T Sauka-Spengler 🙏
📣 New pre-print from the lab:
👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM
📝 Read the #BioRxiv here:
doi.org/10.1101/2025...
👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM
📝 Read the #BioRxiv here:
doi.org/10.1101/2025...
May 21, 2025 at 8:55 AM
📣 New pre-print from the lab:
👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM
📝 Read the #BioRxiv here:
doi.org/10.1101/2025...
👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM
📝 Read the #BioRxiv here:
doi.org/10.1101/2025...
And finally, we have It out! Do not miss It, If you are into early eye development, GRNs, and eye malformations. Thanks to Javier Macho and the rest of the authors for a terrific job.
February 2, 2026 at 8:23 PM
And finally, we have It out! Do not miss It, If you are into early eye development, GRNs, and eye malformations. Thanks to Javier Macho and the rest of the authors for a terrific job.
Our brilliant PhD students are at #SMBE2026 !
S22: P334 Rachel Carboni with snMultiomics
S22: P339 @xindih.bsky.social with epistasis vs modularity in GRNs (w/ @fishcongen.bsky.social)
S22: talk at 17:45 @jennisiren.bsky.social with GxE in gene expression (w/ main sup @pyhatanja.bsky.social)
S22: P334 Rachel Carboni with snMultiomics
S22: P339 @xindih.bsky.social with epistasis vs modularity in GRNs (w/ @fishcongen.bsky.social)
S22: talk at 17:45 @jennisiren.bsky.social with GxE in gene expression (w/ main sup @pyhatanja.bsky.social)
#SMBE2026
S22: Evolution of gene regulation: insights from novel molecular and statistical approaches
🗓️ Wed Jul 1, 1:20pm - Part 1
🗓️ Wed Jul 1, 3:50pm - Part 2
🔗 smbe2026.org/programme
S22: Evolution of gene regulation: insights from novel molecular and statistical approaches
🗓️ Wed Jul 1, 1:20pm - Part 1
🗓️ Wed Jul 1, 3:50pm - Part 2
🔗 smbe2026.org/programme
June 24, 2026 at 8:32 AM
Our brilliant PhD students are at #SMBE2026 !
S22: P334 Rachel Carboni with snMultiomics
S22: P339 @xindih.bsky.social with epistasis vs modularity in GRNs (w/ @fishcongen.bsky.social)
S22: talk at 17:45 @jennisiren.bsky.social with GxE in gene expression (w/ main sup @pyhatanja.bsky.social)
S22: P334 Rachel Carboni with snMultiomics
S22: P339 @xindih.bsky.social with epistasis vs modularity in GRNs (w/ @fishcongen.bsky.social)
S22: talk at 17:45 @jennisiren.bsky.social with GxE in gene expression (w/ main sup @pyhatanja.bsky.social)
ALP majority forces nothing.
Gillard minority govt was the nearest the ALP has been to its values and grassroots members since Whitlam, because the INDs & GRNs forced it.
Gillard minority govt was the nearest the ALP has been to its values and grassroots members since Whitlam, because the INDs & GRNs forced it.
April 7, 2025 at 6:45 AM
ALP majority forces nothing.
Gillard minority govt was the nearest the ALP has been to its values and grassroots members since Whitlam, because the INDs & GRNs forced it.
Gillard minority govt was the nearest the ALP has been to its values and grassroots members since Whitlam, because the INDs & GRNs forced it.
Well they took their time getting there didn't they. You know I'd love to see Lab, Lib Dems & Grns put togther an official European campaign group that makes the case for EU membership on a day to day basis.
May 16, 2026 at 4:20 PM
Well they took their time getting there didn't they. You know I'd love to see Lab, Lib Dems & Grns put togther an official European campaign group that makes the case for EU membership on a day to day basis.
The dream of the 1970s Posse Comitatus is alive in Texas! The next step is the abolition of the Federal Reserve and the federal income tax.
June 29, 2025 at 11:00 PM
The dream of the 1970s Posse Comitatus is alive in Texas! The next step is the abolition of the Federal Reserve and the federal income tax.
So this is an interesting question that deserves a serious answer.
To summarise:
The political argument is that the LDs have a very different political history to the Greens, and a merger wouldn't work.
The electoral argument is that they can win where the Grns/Lab can't.
To summarise:
The political argument is that the LDs have a very different political history to the Greens, and a merger wouldn't work.
The electoral argument is that they can win where the Grns/Lab can't.
British politics knowers: what is the added value of the LibDems at this point? Why not just fold themselves into the Greens? (I've always been an LibDems booster, but the Greens clearly have more momentum).
Two thirds (66%) of Labour and Lib Dem voters in Gorton and Denton said they would be prepared to switch to the Greens if they were most likely to beat Reform, compared to just 41% of Green and Lib Dem voters who said they would switch to Labour in order to defeat Farage’s party.
February 25, 2026 at 2:08 PM
So this is an interesting question that deserves a serious answer.
To summarise:
The political argument is that the LDs have a very different political history to the Greens, and a merger wouldn't work.
The electoral argument is that they can win where the Grns/Lab can't.
To summarise:
The political argument is that the LDs have a very different political history to the Greens, and a merger wouldn't work.
The electoral argument is that they can win where the Grns/Lab can't.
Also reminder that the weMERFISH paper has an accompanying paper by Jialin @jialinliu.bsky.social from where the RNAseq and ATACpeaks come from, and many, many more cool findings like these menàge-a-six GRNs for differentiation 🐟🧪
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 13, 2026 at 12:03 PM
Also reminder that the weMERFISH paper has an accompanying paper by Jialin @jialinliu.bsky.social from where the RNAseq and ATACpeaks come from, and many, many more cool findings like these menàge-a-six GRNs for differentiation 🐟🧪
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
