Eu sou portador de uma doença autoimune hiper rara chamada Hemoglobinúria Paroxística Noturna, uma doença que afeta 1 a cada 10 milhões de habitantes.
Essa doença destrói os glóbulos vermelhos, e caso não seja tratada, pode evoluir para trombose, derrame, e até mesmo morte.
Essa doença destrói os glóbulos vermelhos, e caso não seja tratada, pode evoluir para trombose, derrame, e até mesmo morte.
October 6, 2026 at 5:37 PM
Eu sou portador de uma doença autoimune hiper rara chamada Hemoglobinúria Paroxística Noturna, uma doença que afeta 1 a cada 10 milhões de habitantes.
Essa doença destrói os glóbulos vermelhos, e caso não seja tratada, pode evoluir para trombose, derrame, e até mesmo morte.
Essa doença destrói os glóbulos vermelhos, e caso não seja tratada, pode evoluir para trombose, derrame, e até mesmo morte.
Eu sou portador de uma doença autoimune hiper rara chamada Hemoglobinúria Paroxística Noturna, uma doença que afeta 1 a cada 10 milhões de habitantes.
Essa doença destrói os glóbulos vermelhos, e caso não seja tratada, pode evoluir para trombose, derrame, e até mesmo morte.
Essa doença destrói os glóbulos vermelhos, e caso não seja tratada, pode evoluir para trombose, derrame, e até mesmo morte.
Sim, o clima está pesado. Mas ninguém tem que baixar a cabeça, ninguém tem que desistir de nada. Esses caras não podem controlar nosso coração.
EPISÓDIO 100% LIVRE DE CHORAMINGO.
Tem muito o que fazer até o 2º turno. Bora?
O Vira está aqui. O Vira está com você.
www.youtube.com/watch?v=6882...
EPISÓDIO 100% LIVRE DE CHORAMINGO.
Tem muito o que fazer até o 2º turno. Bora?
O Vira está aqui. O Vira está com você.
www.youtube.com/watch?v=6882...
October 6, 2026 at 5:32 PM
Eu sou portador de uma doença autoimune hiper rara chamada Hemoglobinúria Paroxística Noturna, uma doença que afeta 1 a cada 10 milhões de habitantes.
Essa doença destrói os glóbulos vermelhos, e caso não seja tratada, pode evoluir para trombose, derrame, e até mesmo morte.
Essa doença destrói os glóbulos vermelhos, e caso não seja tratada, pode evoluir para trombose, derrame, e até mesmo morte.
Hematuria is the most visible sign in IgA nephropathy, yet our risk models ignore it. In 441 biopsy-proven IgAN patients, dipstick hemoglobinuria tracked active lesions (OR 2.28); proteinuria tracked chronic damage. With Mayo Clinic, Kidney Int 2026: doi.org/10.1016/j.kint.2026.07.021
October 5, 2026 at 8:36 PM
Hematuria is the most visible sign in IgA nephropathy, yet our risk models ignore it. In 441 biopsy-proven IgAN patients, dipstick hemoglobinuria tracked active lesions (OR 2.28); proteinuria tracked chronic damage. With Mayo Clinic, Kidney Int 2026: doi.org/10.1016/j.kint.2026.07.021
Eu sou portador de uma doença autoimune hiper rara chamada Hemoglobinúria Paroxística Noturna, uma doença que afeta 1 a cada 10 milhões de habitantes.
Essa doença destrói os glóbulos vermelhos, e caso não seja tratada, pode evoluir para trombose, derrame, e até mesmo morte.
Essa doença destrói os glóbulos vermelhos, e caso não seja tratada, pode evoluir para trombose, derrame, e até mesmo morte.
October 9, 2026 at 8:26 AM
Eu sou portador de uma doença autoimune hiper rara chamada Hemoglobinúria Paroxística Noturna, uma doença que afeta 1 a cada 10 milhões de habitantes.
Essa doença destrói os glóbulos vermelhos, e caso não seja tratada, pode evoluir para trombose, derrame, e até mesmo morte.
Essa doença destrói os glóbulos vermelhos, e caso não seja tratada, pode evoluir para trombose, derrame, e até mesmo morte.
A hemoglobinúria paroxística noturna (HPN) é uma condição rara resultante de uma mutação adquirida que afeta a ativação do sistema complemento (parte importante do sistema imunológico) e compromete a função das células do sangue.
May 1, 2025 at 4:17 PM
A hemoglobinúria paroxística noturna (HPN) é uma condição rara resultante de uma mutação adquirida que afeta a ativação do sistema complemento (parte importante do sistema imunológico) e compromete a função das células do sangue.
Nephrology Image
Renal hemosiderosis in paroxysmal nocturnal hemoglobinuria
doi.org/10.1016/j.kint.2025.12.033
#NephSky #MedSky
Renal hemosiderosis in paroxysmal nocturnal hemoglobinuria
doi.org/10.1016/j.kint.2025.12.033
#NephSky #MedSky
July 14, 2026 at 5:28 PM
Nephrology Image
Renal hemosiderosis in paroxysmal nocturnal hemoglobinuria
doi.org/10.1016/j.kint.2025.12.033
#NephSky #MedSky
Renal hemosiderosis in paroxysmal nocturnal hemoglobinuria
doi.org/10.1016/j.kint.2025.12.033
#NephSky #MedSky
The anti-vaccine lobby is currently working to manufacture an account of a vaccine injury that is completely baseless:
vaxopedia.org/2024/09/18/a...
This link from @aboutpediatrics.bsky.social explains, but I wanted to offer a bit more detail on paroxysmal nocturnal hemoglobinuria (PNH). 🧵
vaxopedia.org/2024/09/18/a...
This link from @aboutpediatrics.bsky.social explains, but I wanted to offer a bit more detail on paroxysmal nocturnal hemoglobinuria (PNH). 🧵
https://vaxopedia.org/2024…
September 20, 2024 at 11:22 AM
The anti-vaccine lobby is currently working to manufacture an account of a vaccine injury that is completely baseless:
vaxopedia.org/2024/09/18/a...
This link from @aboutpediatrics.bsky.social explains, but I wanted to offer a bit more detail on paroxysmal nocturnal hemoglobinuria (PNH). 🧵
vaxopedia.org/2024/09/18/a...
This link from @aboutpediatrics.bsky.social explains, but I wanted to offer a bit more detail on paroxysmal nocturnal hemoglobinuria (PNH). 🧵
🩸 Paroxysmal nocturnal hemoglobinuria (PNH):
Lack of GPI anchors ➡️ lack of CD55 & CD59 ➡️ unregulated complement activity ➡️ Triad: hemolysis, thrombosis, bone marrow failure (cytopenias)
#MedSky #IMsky #hemesky #PNH #thrombosis #theInternAtWork
Lack of GPI anchors ➡️ lack of CD55 & CD59 ➡️ unregulated complement activity ➡️ Triad: hemolysis, thrombosis, bone marrow failure (cytopenias)
#MedSky #IMsky #hemesky #PNH #thrombosis #theInternAtWork
November 26, 2024 at 3:22 AM
🩸 Paroxysmal nocturnal hemoglobinuria (PNH):
Lack of GPI anchors ➡️ lack of CD55 & CD59 ➡️ unregulated complement activity ➡️ Triad: hemolysis, thrombosis, bone marrow failure (cytopenias)
#MedSky #IMsky #hemesky #PNH #thrombosis #theInternAtWork
Lack of GPI anchors ➡️ lack of CD55 & CD59 ➡️ unregulated complement activity ➡️ Triad: hemolysis, thrombosis, bone marrow failure (cytopenias)
#MedSky #IMsky #hemesky #PNH #thrombosis #theInternAtWork
Renal hemosiderosis in paroxysmal nocturnal hemoglobinuria - Kidney International www.kidney-international.org/article/S008...
Renal hemosiderosis in paroxysmal nocturnal hemoglobinuria
A middle-aged man presented with >10 years of intermittent dark-colored urine. Laboratory
tests showed hemoglobin, 112 g/l; serum creatinine, 75.7 μmol/l; and elevated lactate
dehydrogenase, 26.88 μka...
www.kidney-international.org
March 14, 2026 at 6:06 PM
Renal hemosiderosis in paroxysmal nocturnal hemoglobinuria - Kidney International www.kidney-international.org/article/S008...
Never understood why this was hemoglobinuria month but here we are anyway.
March 2, 2025 at 1:35 AM
Never understood why this was hemoglobinuria month but here we are anyway.
Iptacopan monotherapy enhances patient quality of life while reducing healthcare costs compared to standard treatments for paroxysmal nocturnal hemoglobinuria.
by Ito S, Chetlapalli K (...) Goshua G et 6 al. in Blood #MedSky
📖 read the article:
by Ito S, Chetlapalli K (...) Goshua G et 6 al. in Blood #MedSky
📖 read the article:
Cost-effectiveness of iptacopan for paroxysmal nocturnal hemoglobinuria
Key PointsIptacopan monotherapy is cost saving for anti-C5–treated patients with suboptimal response vs continuation of C5 inhibitors.Improved quality of l
ashpublications.org
January 11, 2025 at 8:31 AM
Iptacopan monotherapy enhances patient quality of life while reducing healthcare costs compared to standard treatments for paroxysmal nocturnal hemoglobinuria.
by Ito S, Chetlapalli K (...) Goshua G et 6 al. in Blood #MedSky
📖 read the article:
by Ito S, Chetlapalli K (...) Goshua G et 6 al. in Blood #MedSky
📖 read the article:
es un día demasiado especial como para tener...no sé, hemoglobinuria paroxística nocturna
December 31, 2024 at 9:02 AM
es un día demasiado especial como para tener...no sé, hemoglobinuria paroxística nocturna
March hemoglobinuria anyone?
Open up your copy of Lanzkowsky's and give this one a like!
Open up your copy of Lanzkowsky's and give this one a like!
Never understood why this was hemoglobinuria month but here we are anyway.
March 2, 2025 at 1:49 AM
March hemoglobinuria anyone?
Open up your copy of Lanzkowsky's and give this one a like!
Open up your copy of Lanzkowsky's and give this one a like!
Excellent thread on the working of the complement system, how deficiency in some of its components results in paroxysmal nocturnal hemoglobinuria (PNH) +/- renders you susceptible to infections. #ImmunoSky #IDSky #MedSky #Microsky
The anti-vaccine lobby is currently working to manufacture an account of a vaccine injury that is completely baseless:
vaxopedia.org/2024/09/18/a...
This link from @aboutpediatrics.bsky.social explains, but I wanted to offer a bit more detail on paroxysmal nocturnal hemoglobinuria (PNH). 🧵
vaxopedia.org/2024/09/18/a...
This link from @aboutpediatrics.bsky.social explains, but I wanted to offer a bit more detail on paroxysmal nocturnal hemoglobinuria (PNH). 🧵
https://vaxopedia.org/2024…
September 20, 2024 at 11:47 AM
Excellent thread on the working of the complement system, how deficiency in some of its components results in paroxysmal nocturnal hemoglobinuria (PNH) +/- renders you susceptible to infections. #ImmunoSky #IDSky #MedSky #Microsky
These findings are indicative of intravascular hemolysis with hemoglobinuria. Immunohistochemical staining for hemoglobin and myoglobin is of utmost importance, given that the morphologic features of these two forms of cast nephropathy are indistinguishable. (4/4)
#renalpath #nephropath
#renalpath #nephropath
November 13, 2024 at 4:33 PM
These findings are indicative of intravascular hemolysis with hemoglobinuria. Immunohistochemical staining for hemoglobin and myoglobin is of utmost importance, given that the morphologic features of these two forms of cast nephropathy are indistinguishable. (4/4)
#renalpath #nephropath
#renalpath #nephropath
Hemoglobinuria-associated acute kidney injury in hemolytic uremic syndrome without renal thrombotic microangiopathy
#nephsky #nephrology
link.springer.com/article/10.1...
#nephsky #nephrology
link.springer.com/article/10.1...
Hemoglobinuria-associated acute kidney injury in hemolytic uremic syndrome without renal thrombotic microangiopathy - BMC Nephrology
Background Hemolytic uremic syndrome (HUS) is classically defined by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI) and is most often associated with r...
link.springer.com
March 20, 2026 at 9:49 AM
Hemoglobinuria-associated acute kidney injury in hemolytic uremic syndrome without renal thrombotic microangiopathy
#nephsky #nephrology
link.springer.com/article/10.1...
#nephsky #nephrology
link.springer.com/article/10.1...
Dipstick hemoglobinuria is associated with histologic markers of active disease in #IgAN and may provide clinically relevant information to complement current assessment of disease activity in #IgAN ca. 2026
#Nephpearls #RKDSummit #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/42628835/
#Nephpearls #RKDSummit #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/42628835/
September 26, 2026 at 6:28 PM
Dipstick hemoglobinuria is associated with histologic markers of active disease in #IgAN and may provide clinically relevant information to complement current assessment of disease activity in #IgAN ca. 2026
#Nephpearls #RKDSummit #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/42628835/
#Nephpearls #RKDSummit #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/42628835/
A multi-center cohort study evaluated hemoglobinuria as a marker of inflammation in IgA nephropathy
#openaccess
buff.ly/kjkqZxT
#openaccess
buff.ly/kjkqZxT
A multi-center cohort study evaluated hemoglobinuria as a marker of inflammation in IgA nephropathy
Hematuria is a hallmark clinical manifestation of IgA nephropathy (IgAN) and largely reflects underlying glomerular inflammation. Despite this, current guidelines prioritize proteinuria and estimated…
www.kidney-international.org
August 30, 2026 at 1:00 PM
A multi-center cohort study evaluated hemoglobinuria as a marker of inflammation in IgA nephropathy
#openaccess
buff.ly/kjkqZxT
#openaccess
buff.ly/kjkqZxT
A multi-center cohort study evaluated hemoglobinuria as a marker of inflammation in IgA nephropathy.
#nephsky #nephrology
www.kidney-international.org/article/S008...
#nephsky #nephrology
www.kidney-international.org/article/S008...
A multi-center cohort study evaluated hemoglobinuria as a marker of inflammation in IgA nephropathy
Hematuria is a hallmark clinical manifestation of IgA nephropathy (IgAN) and largely
reflects underlying glomerular inflammation. Despite this, current guidelines prioritize
proteinuria and estimated ...
www.kidney-international.org
August 21, 2026 at 10:55 AM
A multi-center cohort study evaluated hemoglobinuria as a marker of inflammation in IgA nephropathy.
#nephsky #nephrology
www.kidney-international.org/article/S008...
#nephsky #nephrology
www.kidney-international.org/article/S008...
Paroxysmal nocturnal hemoglobinuria masquerading as hemolytic uremic syndrome: a Case Report
#nephsky
www.frontiersin.org/journals/med...
#nephsky
www.frontiersin.org/journals/med...
Frontiers | Paroxysmal nocturnal hemoglobinuria masquerading as hemolytic uremic syndrome: a Case Report
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disorder of intravascular hemolysis caused by a somatic mutation in the gene responsible for gly...
www.frontiersin.org
August 1, 2025 at 3:33 AM
Paroxysmal nocturnal hemoglobinuria masquerading as hemolytic uremic syndrome: a Case Report
#nephsky
www.frontiersin.org/journals/med...
#nephsky
www.frontiersin.org/journals/med...
A young adult female patient was diagnosed with #AcuteTubularNecrosis with underlying paroxysmal nocturnal hemoglobinuria (#PNH), highlighting how renal involvement may be an initial manifestation of PNH.
Read more: https://bit.ly/3NQIUq5
#RareDisease #MedSky
Read more: https://bit.ly/3NQIUq5
#RareDisease #MedSky
Case Report: Acute Tubular Necrosis With Underlying PNH
A patient was eventually diagnosed with PNH, with acute tubular necrosis as her initial clinical symptom.
bit.ly
February 3, 2026 at 8:50 PM
A young adult female patient was diagnosed with #AcuteTubularNecrosis with underlying paroxysmal nocturnal hemoglobinuria (#PNH), highlighting how renal involvement may be an initial manifestation of PNH.
Read more: https://bit.ly/3NQIUq5
#RareDisease #MedSky
Read more: https://bit.ly/3NQIUq5
#RareDisease #MedSky
Chronic HEMOYLISIS can cause IRON deposition in the kidney (hemosiderosis).
Like in Paroxysmal nocturnal hemoglobinuria (uncontrolled complement-mediated hemolysis).
—Triad
-Chronic hemolytic anemia (hemoglobinuria)
-Pancytopenia
-Thrombosis at atypical sites
Like in Paroxysmal nocturnal hemoglobinuria (uncontrolled complement-mediated hemolysis).
—Triad
-Chronic hemolytic anemia (hemoglobinuria)
-Pancytopenia
-Thrombosis at atypical sites
March 6, 2025 at 7:05 PM
Chronic HEMOYLISIS can cause IRON deposition in the kidney (hemosiderosis).
Like in Paroxysmal nocturnal hemoglobinuria (uncontrolled complement-mediated hemolysis).
—Triad
-Chronic hemolytic anemia (hemoglobinuria)
-Pancytopenia
-Thrombosis at atypical sites
Like in Paroxysmal nocturnal hemoglobinuria (uncontrolled complement-mediated hemolysis).
—Triad
-Chronic hemolytic anemia (hemoglobinuria)
-Pancytopenia
-Thrombosis at atypical sites
Tomorrow's #RareDiseaseDay. Up until a decade ago, there was no treatment for paroxysmal nocturnal hemoglobinuria. Even now, those treatments are less than ideal. Empaveli, the drug that I take, costs $40,000 a month.
#chronicillness #disability #science
#chronicillness #disability #science
February 27, 2025 at 7:09 PM
Tomorrow's #RareDiseaseDay. Up until a decade ago, there was no treatment for paroxysmal nocturnal hemoglobinuria. Even now, those treatments are less than ideal. Empaveli, the drug that I take, costs $40,000 a month.
#chronicillness #disability #science
#chronicillness #disability #science