Happy to share our new study on the functional reprogramming of neutrophils in the brain tumor microenvironment by hypoxia-driven lactylation
@theaacr.bsky.social
@wistar.org
@moffittnews.bsky.social
@theaacr.bsky.social
@wistar.org
@moffittnews.bsky.social
March 2, 2025 at 3:24 PM
Happy to share our new study on the functional reprogramming of neutrophils in the brain tumor microenvironment by hypoxia-driven lactylation
@theaacr.bsky.social
@wistar.org
@moffittnews.bsky.social
@theaacr.bsky.social
@wistar.org
@moffittnews.bsky.social
Chemical #priming of #hypoxia responses via PLANT #CYSTEINE OXIDASE inhibition improves #flooding tolerance
academic.oup.com/plphys/artic...
#PlantScience @plantphys.bsky.social @aspbofficial.bsky.social @planteditors.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
academic.oup.com/plphys/artic...
#PlantScience @plantphys.bsky.social @aspbofficial.bsky.social @planteditors.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
Chemical priming of hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves flooding tolerance
Abstract. Extreme flooding driven by climate change demands strategies to enhance plant tolerance to low-oxygen stress. We investigated the ability of bioa
academic.oup.com
October 6, 2026 at 1:57 PM
Chemical #priming of #hypoxia responses via PLANT #CYSTEINE OXIDASE inhibition improves #flooding tolerance
academic.oup.com/plphys/artic...
#PlantScience @plantphys.bsky.social @aspbofficial.bsky.social @planteditors.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
academic.oup.com/plphys/artic...
#PlantScience @plantphys.bsky.social @aspbofficial.bsky.social @planteditors.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
The #ClimateEmergency and #NatureCrisis are intimately interlinked.
"Low oxygen levels coupled with faster deoxygenation make tropical rivers more vulnerable to hypoxia events."
phys.org/news/2026-05...
"Low oxygen levels coupled with faster deoxygenation make tropical rivers more vulnerable to hypoxia events."
phys.org/news/2026-05...
Tropical rivers emerge as biggest oxygen-loss hotspots in a warming world
According to a study published in Science Advances on May 15, global rivers are undergoing widespread and sustained deoxygenation driven by climate warming, among which tropical rivers are the most vu...
phys.org
May 17, 2026 at 10:43 AM
The #ClimateEmergency and #NatureCrisis are intimately interlinked.
"Low oxygen levels coupled with faster deoxygenation make tropical rivers more vulnerable to hypoxia events."
phys.org/news/2026-05...
"Low oxygen levels coupled with faster deoxygenation make tropical rivers more vulnerable to hypoxia events."
phys.org/news/2026-05...
Today the feature is on ROS and R-loops - Hypoxia-driven non-damaging ROS levels lead to R-loop formation. The authors show that ROS-R loop-H3K9Me2 is a key axis regulating chromatin structure and the response to hypoxia. #redoxepigenetics academic.oup.com/nar/article/...
Validate User
academic.oup.com
November 28, 2024 at 11:35 AM
Today the feature is on ROS and R-loops - Hypoxia-driven non-damaging ROS levels lead to R-loop formation. The authors show that ROS-R loop-H3K9Me2 is a key axis regulating chromatin structure and the response to hypoxia. #redoxepigenetics academic.oup.com/nar/article/...
Now online in Cancer Discovery: Functional Reprogramming of Neutrophils within the Brain Tumor Microenvironment by Hypoxia-Driven Histone Lactylation - by Alessio Ugolini, Filippo Veglia, and colleagues doi.org/10.1158/2159... @wistar.org
March 3, 2025 at 6:26 PM
Now online in Cancer Discovery: Functional Reprogramming of Neutrophils within the Brain Tumor Microenvironment by Hypoxia-Driven Histone Lactylation - by Alessio Ugolini, Filippo Veglia, and colleagues doi.org/10.1158/2159... @wistar.org
Big day for our team: our pheochromocytoma and paraganglioma (PPGL) organoid paper is now up on bioRxiv!
This was a tour de force across 6 institutions, 37 authors, building patient-derived organoids from 35 PPGL patients /🧵
🔗 www.biorxiv.org/content/10.1...
This was a tour de force across 6 institutions, 37 authors, building patient-derived organoids from 35 PPGL patients /🧵
🔗 www.biorxiv.org/content/10.1...
Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas
Pheochromocytomas and paragangliomas (PPGLs) are rare chromaffin cell-derived neuroendocrine tumors of sympathetic (catecholamine-producing) or parasympathetic (nonsecretory) origin, frequently driven...
www.biorxiv.org
August 26, 2025 at 8:34 PM
Big day for our team: our pheochromocytoma and paraganglioma (PPGL) organoid paper is now up on bioRxiv!
This was a tour de force across 6 institutions, 37 authors, building patient-derived organoids from 35 PPGL patients /🧵
🔗 www.biorxiv.org/content/10.1...
This was a tour de force across 6 institutions, 37 authors, building patient-derived organoids from 35 PPGL patients /🧵
🔗 www.biorxiv.org/content/10.1...
Congratulations to Jodie, her paper is out in BMC Genomics identifying robust RT-qPCR reference genes for studying changes in gene expression in response to hypoxia in breast cancer.
Great working with her, Will & @bridgekatherine.bsky.social on this. link.springer.com/article/10.1... 1/2
Great working with her, Will & @bridgekatherine.bsky.social on this. link.springer.com/article/10.1... 1/2
Identification of robust RT-qPCR reference genes for studying changes in gene expression in response to hypoxia in breast cancer cell lines - BMC Genomics
Hypoxia is common in breast tumours and is linked to therapy resistance and advanced disease. To understand hypoxia-driven breast cancer progression, RT-qPCR is a widely used technique to quantify tra...
link.springer.com
January 21, 2025 at 4:57 PM
Congratulations to Jodie, her paper is out in BMC Genomics identifying robust RT-qPCR reference genes for studying changes in gene expression in response to hypoxia in breast cancer.
Great working with her, Will & @bridgekatherine.bsky.social on this. link.springer.com/article/10.1... 1/2
Great working with her, Will & @bridgekatherine.bsky.social on this. link.springer.com/article/10.1... 1/2
doi.org/10.1093/plph... Chemical priming of hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves flooding tolerance - by @paolotriozzi.bsky.social @emilyflashman.bsky.social @theplantlab.bsky.social
#plantscience
#plantscience
Chemical priming of hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves flooding tolerance
Abstract. Extreme flooding driven by climate change demands strategies to enhance plant tolerance to low-oxygen stress. We investigated the ability of bioa
doi.org
July 17, 2026 at 9:23 PM
doi.org/10.1093/plph... Chemical priming of hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves flooding tolerance - by @paolotriozzi.bsky.social @emilyflashman.bsky.social @theplantlab.bsky.social
#plantscience
#plantscience
www.sciencedirect.com/science/arti... Climate-driven decline in water level causes earlier onset of hypoxia in a subtropical reservoir
Climate-driven decline in water level causes earlier onset of hypoxia in a subtropical reservoir
Hypoxia, especially in the bottom water, is occurring in deep and stratified reservoirs worldwide, threatening aquatic biodiversity, ecosystem functio…
www.sciencedirect.com
December 2, 2024 at 2:58 PM
www.sciencedirect.com/science/arti... Climate-driven decline in water level causes earlier onset of hypoxia in a subtropical reservoir
Hypoxia-driven lncRNA SHIELD promotes GPX4 translation and protects against ferroptosis in hepatocellular carcinoma
Hypoxia-driven lncRNA SHIELD promotes GPX4 translation and protects against ferroptosis in hepatocellular carcinoma
Liu et al. identify the hypoxia-induced lncRNA SHIELD that protects cancer cells from ferroptosis by enhancing the translation of a key antioxidant enzyme. The study links hypoxic adaptation to ferroptosis resistance and suggests a potential therapeutic strategy to overcome sorafenib resistance in liver cancer.
dlvr.it
June 6, 2026 at 3:19 PM
Hypoxia-driven lncRNA SHIELD promotes GPX4 translation and protects against ferroptosis in hepatocellular carcinoma
Chemical #priming of #hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves #flooding tolerance
academic.oup.com/plphys/artic...
#PlantScience @plantphys.bsky.social @aspbofficial.bsky.social @planteditors.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
academic.oup.com/plphys/artic...
#PlantScience @plantphys.bsky.social @aspbofficial.bsky.social @planteditors.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
Chemical priming of hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves flooding tolerance
Abstract. Extreme flooding driven by climate change demands strategies to enhance plant tolerance to low-oxygen stress. We investigated the ability of bioa
academic.oup.com
September 21, 2026 at 2:37 PM
Chemical #priming of #hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves #flooding tolerance
academic.oup.com/plphys/artic...
#PlantScience @plantphys.bsky.social @aspbofficial.bsky.social @planteditors.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
academic.oup.com/plphys/artic...
#PlantScience @plantphys.bsky.social @aspbofficial.bsky.social @planteditors.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
Hypoxia-induced pulmonary hypertension is driven by interstitial macrophages, revealing potential therapeutic targets for treatment.
by Kumar R, Nolan K (...) Graham BB et 20 al. in J Clin Invest #MedSky
📖 read the article: https://www.jci.org/articles/view/176865
by Kumar R, Nolan K (...) Graham BB et 20 al. in J Clin Invest #MedSky
📖 read the article: https://www.jci.org/articles/view/176865
February 8, 2025 at 2:51 AM
Hypoxia-induced pulmonary hypertension is driven by interstitial macrophages, revealing potential therapeutic targets for treatment.
by Kumar R, Nolan K (...) Graham BB et 20 al. in J Clin Invest #MedSky
📖 read the article: https://www.jci.org/articles/view/176865
by Kumar R, Nolan K (...) Graham BB et 20 al. in J Clin Invest #MedSky
📖 read the article: https://www.jci.org/articles/view/176865
Esteban Ballestar’s lab studied LPS-driven activation under hypoxia here. They’re more inflammatory, contrary to what was thought
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the immunosuppressive effects of the tumor microenvironment
Activation under hypoxia boosts immunogenic properties of macrophages with protective potential in cancer.
www.science.org
June 7, 2025 at 1:38 PM
Esteban Ballestar’s lab studied LPS-driven activation under hypoxia here. They’re more inflammatory, contrary to what was thought
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
a) We saw that NCLX activation in acute hypoxia is driven by an increase in soluble matrix Ca2+.
Where does Ca2+ come from?
¡Surprise!😃
Ca2+ is already inside the mitochondrial matrix, in calcium phosphate granules that are dissolved in hypoxia (due to acidification) releasing soluble Ca2+
Where does Ca2+ come from?
¡Surprise!😃
Ca2+ is already inside the mitochondrial matrix, in calcium phosphate granules that are dissolved in hypoxia (due to acidification) releasing soluble Ca2+
November 22, 2024 at 12:35 PM
a) We saw that NCLX activation in acute hypoxia is driven by an increase in soluble matrix Ca2+.
Where does Ca2+ come from?
¡Surprise!😃
Ca2+ is already inside the mitochondrial matrix, in calcium phosphate granules that are dissolved in hypoxia (due to acidification) releasing soluble Ca2+
Where does Ca2+ come from?
¡Surprise!😃
Ca2+ is already inside the mitochondrial matrix, in calcium phosphate granules that are dissolved in hypoxia (due to acidification) releasing soluble Ca2+
#TEsky Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia doi.org/10.1002/advs...
Transposable Element–Driven <i>PIEZO</i> Mutation Enhances Locust Flight in Plateau Hypoxia
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro- and microevolution in locusts, our results showed that thousands of TE inser...
doi.org
July 29, 2026 at 7:14 PM
#TEsky Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia doi.org/10.1002/advs...
2/ 🌍 Applied to the Human Lung Cell Atlas (HLCA), DRVI uncovers dozens of distinct biological processes, such as
• Cellular stress responses
• Hypoxia-driven reactions in tumor-adjacent cells
• Rare states like migratory DCs & IFI27+ macrophages.
• Cellular stress responses
• Hypoxia-driven reactions in tumor-adjacent cells
• Rare states like migratory DCs & IFI27+ macrophages.
November 20, 2024 at 2:29 PM
2/ 🌍 Applied to the Human Lung Cell Atlas (HLCA), DRVI uncovers dozens of distinct biological processes, such as
• Cellular stress responses
• Hypoxia-driven reactions in tumor-adjacent cells
• Rare states like migratory DCs & IFI27+ macrophages.
• Cellular stress responses
• Hypoxia-driven reactions in tumor-adjacent cells
• Rare states like migratory DCs & IFI27+ macrophages.
Our new paper is out in Neuro-Oncology! Targeting hypoxia-driven histone lactylation in myeloid cells synergizes with CD137 agonism to expand effector-like exhausted CD8+ T cells in glioblastoma academic.oup.com/neuro-oncolo...
Targeting hypoxia-driven histone lactylation in myeloid cells synergizes with CD137 agonism to expand effector-like exhausted CD8+ T cells in glioblastoma
AbstractBackground. Overwhelming presence of immunoregulatory myeloid cells and dysfunctional T cells is a major barrier to effective immunotherapies in gl
academic.oup.com
October 8, 2026 at 11:29 AM
Our new paper is out in Neuro-Oncology! Targeting hypoxia-driven histone lactylation in myeloid cells synergizes with CD137 agonism to expand effector-like exhausted CD8+ T cells in glioblastoma academic.oup.com/neuro-oncolo...
Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis https://www.biorxiv.org/content/10.1101/2025.03.20.644292v1
March 24, 2025 at 5:15 AM
Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis https://www.biorxiv.org/content/10.1101/2025.03.20.644292v1
Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis https://www.biorxiv.org/content/10.1101/2025.03.20.644292v1
March 24, 2025 at 5:15 AM
Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis https://www.biorxiv.org/content/10.1101/2025.03.20.644292v1
EBV-driven B-cell transformation under germinal center hypoxia requires external unsaturated fatty acids
www.researchsquare.com/article/rs-6...
www.researchsquare.com/article/rs-6...
April 26, 2025 at 2:26 AM
EBV-driven B-cell transformation under germinal center hypoxia requires external unsaturated fatty acids
www.researchsquare.com/article/rs-6...
www.researchsquare.com/article/rs-6...
Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas https://www.biorxiv.org/content/10.1101/2025.08.22.671868v1
August 23, 2025 at 7:48 AM
Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas https://www.biorxiv.org/content/10.1101/2025.08.22.671868v1
Angiogenesis: How New Blood Vessels Shape Health, Healing and Cancer
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Angiogenesis #HIF-1α #Hypoxia #VEGF #VEGFinhibitors
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Angiogenesis #HIF-1α #Hypoxia #VEGF #VEGFinhibitors
Angiogenesis: How New Blood Vessels Shape Health, Healing and Cancer - OncoDaily
Angiogenesis, driven by VEGF and HIF-1α, forms blood vessels in healing, cancer, and ischemia—balancing pro- and anti-angiogenic signals shapes tumor growth and metastasis.
oncodaily.com
May 16, 2025 at 10:38 PM
Angiogenesis: How New Blood Vessels Shape Health, Healing and Cancer
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Angiogenesis #HIF-1α #Hypoxia #VEGF #VEGFinhibitors
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Angiogenesis #HIF-1α #Hypoxia #VEGF #VEGFinhibitors
🧬❄️ RNA Modifications Newsletter - Jan 2026 is out!
RNA mods, ribosome remodeling, codon effects, nanopore detection, translation under stress - winter edition
❄️🧫From hypoxia-driven rRNA methylation to tRNA-linked virulence and ribosome structure.
#RNAsky #RNAbiology #Ribosome #microsky
RNA mods, ribosome remodeling, codon effects, nanopore detection, translation under stress - winter edition
❄️🧫From hypoxia-driven rRNA methylation to tRNA-linked virulence and ribosome structure.
#RNAsky #RNAbiology #Ribosome #microsky
RNA Modifications Newsletter - January 1st, 2026 - Winter Edition ❄️
Issue #7 - Happy new year!
rnamodifupdates.substack.com
January 2, 2026 at 10:43 AM
🧬❄️ RNA Modifications Newsletter - Jan 2026 is out!
RNA mods, ribosome remodeling, codon effects, nanopore detection, translation under stress - winter edition
❄️🧫From hypoxia-driven rRNA methylation to tRNA-linked virulence and ribosome structure.
#RNAsky #RNAbiology #Ribosome #microsky
RNA mods, ribosome remodeling, codon effects, nanopore detection, translation under stress - winter edition
❄️🧫From hypoxia-driven rRNA methylation to tRNA-linked virulence and ribosome structure.
#RNAsky #RNAbiology #Ribosome #microsky
Chemical priming of hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves flooding tolerance (Francesco Fioriti , Rocco Pierpaolo Germano , Noemi La Monaca , et al) doi.org/10.1093/plph... #PlantScience @aspbofficial
Chemical priming of hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves flooding tolerance
Abstract. Extreme flooding driven by climate change demands strategies to enhance plant tolerance to low-oxygen stress. We investigated the ability of bioa
doi.org
September 18, 2026 at 6:11 PM
Chemical priming of hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves flooding tolerance (Francesco Fioriti , Rocco Pierpaolo Germano , Noemi La Monaca , et al) doi.org/10.1093/plph... #PlantScience @aspbofficial
How do mitochondria adapt to low oxygen? Our study in @commsbio.nature.com reveals a coordinated downregulation of OXPHOS genes in nuclear & mitochondrial genomes. We found that the mtDNA response is driven by increased RNA polymerase pausing. doi.org/10.1038/s420... #MitoNuclear
Hypoxia leads to reduced mito-nuclear gene expression and increased mtDNA transcriptional pausing in human cells - Communications Biology
Hypoxia induces a common coordinated reduction of mitochondrial and nuclear OXPHOS gene expression across diverse human cell lines, accompanied by an increased level of mtDNA transcriptional pausing.
doi.org
February 9, 2026 at 2:47 PM
How do mitochondria adapt to low oxygen? Our study in @commsbio.nature.com reveals a coordinated downregulation of OXPHOS genes in nuclear & mitochondrial genomes. We found that the mtDNA response is driven by increased RNA polymerase pausing. doi.org/10.1038/s420... #MitoNuclear