#jci
The Journal of Controversial Ideas is a cautionary tale of what happens when academic freedom is conflated with free speech. Most journals would be too embarrassed to publish the exceptionally poor scholarship the JCI repeatedly platforms, but at the JCI “controversy” matters, not scientific merit
October 27, 2025 at 10:09 PM
JCI Insight - Human pegivirus alters brain and blood immune and transcriptomic profiles of patients with Parkinson’s disease insight.jci.org/articles/vie...
JCI Insight - Human pegivirus alters brain and blood immune and transcriptomic profiles of patients with Parkinson’s disease
insight.jci.org
July 10, 2025 at 8:32 PM
Pleased to share and briefly highlight our new manuscript just published 𝘑𝘊𝘐 𝘐𝘯𝘴𝘪𝘨𝘩𝘵 (a short🧵)

"A STING-adjuvanted outer membrane vesicle nanoparticle vaccine protects against lethal 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘢𝘦𝘳𝘶𝘨𝘪𝘯𝘰𝘴𝘢 pneumonia"

🔗 doi.org/10.1172/jci....
September 11, 2025 at 2:37 AM
Cövid is Bad JuJu for kidneys... Even mild disease matters‼️

Get your renal function reviewed following infection 🙏🏻

doi.org/10.1172/jci....
JCI Insight - Levels of circulating kidney injury markers and IL-10 identify non-critically ill patients with COVID-19 at risk of death
doi.org
February 7, 2026 at 9:42 PM
JCI - A vaccine against cytomegalovirus: how close are we? www.jci.org/articles/vie...
JCI - A vaccine against cytomegalovirus: how close are we?
www.jci.org
January 2, 2025 at 5:32 PM
This work is finally online as in-press preview!

JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy
www.jci.org
August 19, 2025 at 4:55 PM
JCI - Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition www.jci.org/articles/vie... 🧪
Shared on BSKY directly from the JCI website!
JCI - Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition
www.jci.org
November 24, 2024 at 6:56 AM
Many clinical studies have shown reduced cancer risk in people with diabetes of obesity taking GLP-1 family of drugs. A new JCI piece makes the case these drugs should be studied to reduce cancer in people without metabolic disease jci.org/articles/vie...
November 3, 2025 at 7:08 PM
For those still peddling the bullshit that Covid is just fine and dandy for kids?

Start here: 🤬🤬

insight.jci.org/articles/vie...
JCI Insight - Pediatric long COVID is characterized by myeloid CCR6 suppression and immune dysregulation
insight.jci.org
April 3, 2026 at 11:59 PM
The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation @jci-insight.bsky.social
insight.jci.org/articles/vie...
March 4, 2025 at 9:27 PM
Very important paper out by George Liu's team in JCI this week: "Pathobiont-driven antibody sialylation through IL-10 undermines vaccination" www.jci.org/articles/vie...

Here is my commentary on it: www.jci.org/articles/vie...
JCI - Pathobiont-driven antibody sialylation through IL-10 undermines vaccination
www.jci.org
December 18, 2024 at 5:18 PM
I just posted about the viral cause of MS yesterday (EBV), and today I saw this article that provides some evidence that Parkinson’s Disease may also be caused by a virus—human pegivirus.
JCI Insight - Human pegivirus alters brain and blood immune and transcriptomic profiles of patients with Parkinson’s disease
insight.jci.org
July 9, 2025 at 10:53 PM
Blood-clotting complications in pediatric pneumonia infection can be life threatening. Huang et al. discover neutrophils promote thrombosis in pneumonia caused by Mycoplasma pneumoniae via NET-mediated endothelial activation involving TLR2 and JAK–STAT3 signaling: doi.org/10.1172/jci....
September 28, 2026 at 4:05 PM
JCI - PINK1 is a target of T cell responses in Parkinson's disease www.jci.org/articles/vie...
December 17, 2024 at 7:02 PM
JCI - Ferroptosis of select skin epithelial cells initiates and maintains chronic systemic immune-mediated psoriatic disease www.jci.org/articles/vie...
November 22, 2024 at 4:12 PM
Early antiviral CD4+ and CD8+ T cells are associated with upper airway clearance of SARS-CoV-2
@jci-insight.bsky.social
insight.jci.org/articles/vie...
December 23, 2024 at 3:27 AM
By DNA sequencing we reveal that large mutated clones are common in #atherosclerosis.

Often >10% of cells carry the same #mutation ⚡and must share a common ancestral cell.

Our initial findings are published in JCI Insight today:
insight.jci.org/articles/vie...

@jci-insight.bsky.social
@sdu.dk
May 22, 2025 at 7:32 PM
A tribute to Stuart Kornfeld, pioneering #glycotime scientist whose work on mannose-6-phosphate receptor lysosomal trafficking (among many other contributions) was highly influential to our work 🫡

www.jci.org/articles/vie...
JCI - A tribute to Stuart A. Kornfeld (1936–2025)
www.jci.org
January 3, 2026 at 3:08 AM
JCI Insight - Map2k6 is a potent genetic modifier of arterial rupture in vascular Ehlers-Danlos syndrome mice insight.jci.org/articles/vie...
JCI Insight - Map2k6 is a potent genetic modifier of arterial rupture in vascular Ehlers-Danlos syndrome mice
insight.jci.org
January 24, 2025 at 1:15 AM
Ya estamos prestando nuestro apoyo desde la Base Antártica Española Juan Carlos I, en pleno corazón de la Isla Livingston 🇦🇶❄️🐧
#UTM #JCI #AEMET #CienciaPolar
January 22, 2026 at 6:21 AM
JCI: ICE agent filmed in a viral clip declaring “We don’t need a warrant, bro” before roughing someone up has been identified as Rutgers grad Amir Zayed.

Zayed is originally from North Bergen, NJ & has been documented kidnapping people across the state. jerseycounterinfo.noblogs.org/nj-ice-agent...
NJ ICE Agent: Amir Zayed of North Jersey – Jersey Counter-Info
jerseycounterinfo.noblogs.org
February 19, 2026 at 1:51 AM
Thrilled to share our newly published work in JCI Insight! insight.jci.org/articles/vie...
March 6, 2026 at 4:25 AM
JCI - The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17 www.jci.org/articles/vie...
May 15, 2025 at 10:57 AM
IL-1β Signaling modulates T follicular helper and regulatory cells in human lymphoid tissues
insight.jci.org/articles/vie...
@jci-insight.bsky.social
JCI Insight - IL-1β Signaling modulates T follicular helper and regulatory cells in human lymphoid tissues
insight.jci.org
May 21, 2025 at 2:50 AM
New #JCI paper: Impaired hydrogen sulfide biosynthesis underlies eccentric contraction-induced force loss in dystrophin-deficient skeletal muscle. #MyoBlue tinyurl.com/mvczd94
JCI - Impaired hydrogen sulfide biosynthesis underlies eccentric contraction-induced force loss in dystrophin-deficient skeletal muscle
tinyurl.com
January 14, 2025 at 5:49 PM