#miRNA-mediated
LightNews LightNews
healthcare-global.bsky.social
www.nature.com/articles/s41...
Decoding miRNA-Mediated Immunoregulation in SARS-CoV-2, HBV, HIV, and HSV Infections - Genes & Immunity
Genes & Immunity - Decoding miRNA-Mediated Immunoregulation in SARS-CoV-2, HBV, HIV, and HSV Infections
www.nature.com
January 20, 2026 at 3:43 PM
dijiang319.bsky.social
In this week's @science.org from @lucksmith.bsky.social and colleagues @mskcancercenter.bsky.social | Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
#RNA #microRNA #miRNA #siRNA #argonaute🧬🧪
www.science.org/doi/10.1126/...
Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
microRNAs (miRNAs) and small interfering RNAs (siRNAs) are 21- to 22-nucleotide RNAs that guide Argonaute-class effectors to targets for repression. In this work, we uncover 5-aminolevulinic acid synt...
www.science.org
December 20, 2024 at 5:14 PM
karinajouravleva.bsky.social
Happy to see our study out! We define the sequence determinants for miRNA-target interactions in flies and provide a foundation for improving computational prediction of miRNA-mediated regulation in Drosophila.
www.nature.com/articles/s41...
#miRNA, @natcomms.nature.com, @rti-umasschan.bsky.social
Biochemical principles of miRNA targeting in flies - Nature Communications
MicroRNAs guide Argonaute proteins to repress gene expression. Here, the authors define the binding rules for five Drosophila miRNAs, showing a narrow preference for canonical seed sites and identifyi...
www.nature.com
February 6, 2026 at 8:39 AM
edrybicki.bsky.social
Decoding miRNA-Mediated Immunoregulation in SARS-CoV-2, HBV, HIV, and HSV Infections | Genes & Immunity
Decoding miRNA-Mediated Immunoregulation in SARS-CoV-2, HBV, HIV, and HSV Infections | Genes & Immunity
Eukaryotic cells regulate gene expression through multiple checkpoints, including post-transcriptional mechanisms mediated by microRNAs (miRNAs). These small non-coding RNAs inhibit translation by binding to target mRNAs, often within a complex regulatory network involving other RNA species such...
www.nature.com
January 21, 2026 at 11:01 AM
sigtrans-sttt.bsky.social
Single-cell #Multiomics reveals that #TNBC-derived #Exosomes reshape T cells through regulatory and dysfunctional states, #miRNA-mediated immune suppression, and distinct γδ and αβ TCR clonotypic expansions.

#STTT #OpenAccess: doi.org/10.1038/s413...
Single-cell multiomics reveals exosome-mediated reprogramming and clonotypic remodeling of T cells in triple-negative breast cancer
September 26, 2026 at 3:45 PM
biorxiv-genomic.bsky.social
Transposable element-mediated co-option drives the evolution of the miRNA regulatory system in Oryza AA-genome species https://www.biorxiv.org/content/10.64898/2026.01.18.700148v1
January 21, 2026 at 1:31 PM
atranscendedman.bsky.social
Researchers at Ege University reviewed over 100 studies and found that miRNAs like miR-21, miR-146a, miR-150, and miR-155 control immune responses in SARS-CoV-2, HBV, HIV, and HSV by targeting core pathways like NF-κB and JAK-STAT.

www.nature.com/articles/s41...
Decoding miRNA-Mediated Immunoregulation in SARS-CoV-2, HBV, HIV, and HSV Infections - Genes & Immunity
Genes & Immunity - Decoding miRNA-Mediated Immunoregulation in SARS-CoV-2, HBV, HIV, and HSV Infections
www.nature.com
January 20, 2026 at 2:17 PM
milofasken.bsky.social
Nice review on #miRNA by the Narry Kim lab!
#RNA #RNAsky

www.nature.com/articles/s41...
The biogenesis and regulation of animal microRNAs - Nature Reviews Molecular Cell Biology
MicroRNAs (miRNAs) are small non-coding RNAs that induce RNA silencing. Advances in high-throughput and structural studies have provided new insights into animal miRNA biogenesis mediated by RNA–prote...
www.nature.com
December 22, 2024 at 10:05 AM
biorxivpreprint.bsky.social
A programmable mRNA platform for miRNA detection via miRNA-mRNA2 triplex-mediated ribosomal frameshifting https://www.biorxiv.org/content/10.1101/2025.11.24.690164v1
November 25, 2025 at 3:02 AM
sshadan.bsky.social
@nature, researchers describe an RNA-RNA-mediated arm-race between fungal pathogens and their plant hosts. Specifically, they show that a fungal lncRNA weakens host immunity by sequestering a protective rice miRNA.
shorturl.at/mIuvy
A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence - Nature
A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.
shorturl.at
May 21, 2026 at 5:52 PM
faezehjame.bsky.social
So pleased to see my third Ph.D. work is now online in #JBC, we identified #miRNA-mediated #sialylation through #CMAS #gene-regulation📣🎊
March 21, 2025 at 1:58 AM
biorxivpreprint.bsky.social
Evidence of target-mediated miRNA degradation in Drosophila ovarian cell culture https://www.biorxiv.org/content/10.1101/2023.08.30.555489v1
Evidence of target-mediated miRNA degradation in Drosophila ovarian cell culture https://www.biorxiv.org/content/10.1101/2023.08.30.555489v1
Target-mediated miRNA degradation (TDMD) is a recently discovered process of post-transcriptional re
www.biorxiv.org
August 31, 2023 at 4:21 AM
biorxiv-plants.bsky.social
An extensive forward genetic screen identifies the HWS-AGO1 axis as pivotal for target mimicry-mediated miRNA degradation in Arabidopsis https://www.biorxiv.org/content/10.1101/2025.11.08.687406v1
November 10, 2025 at 10:05 PM
blackinneuro.bsky.social
Also this afternoon, Bonita Powell (Johns Hopkins University) will present on ‘Understanding HSV-1 host miRNA-mediated mechanisms of post-transcriptional gene regulation in the CNS’.

#BlackInSTEM #BlackInNeuro #SfN23 🧪
Bonita Powell, Johns Hopkins University | 2-3PM | PSTR136.10 / J5 Understanding HSV-1 host miRNA-mediated mechanisms of post-transcriptional gene regulation in the CNS Herpes Simplex Virus 1 (HSV-1) infects 50-80% of the United States population. HSV-1 establishes latency in sensory neurons for the host's lifetime but can sporadically reactivate. In some instances, reactivated HSV-1 can enter the central nervous system and cause lethal disorders. Latency and reactivation are controlled by pronounced changes in expression of the viral genome, with latency characterized by lifelong retention of the HSV-1 genome in a predominantly 'silent' state with the exception of one highly expressed region encoding the Latency Associated Transcript (LAT). The HSV-1 genome encodes 18 precursor microRNAs (miRNAs). Both host and HSV-1 encoded miRNAs are implicated in post-transcriptional regulatory roles governing state transitions between HSV-1 latency and reactivation. However, the gene regulatory in
November 12, 2023 at 4:42 PM
biorxiv-cancer.bsky.social
Hypoxia inducible factors drive miRNA-mediated downregulation of L2HGDH and HIF1A in clear cell renal cancer independent of 14q deletion https://www.biorxiv.org/content/10.1101/2024.12.01.625494v1
Hypoxia inducible factors drive miRNA-mediated downregulation of L2HGDH and HIF1A in clear cell renal cancer independent of 14q deletion https://www.biorxiv.org/content/10.1101/2024.12.01.625494v1
Clear cell renal cell carcinoma (ccRCC) is characterized by pseudohypoxic signaling as well as metab
www.biorxiv.org
December 4, 2024 at 10:48 AM
fjobrien.bsky.social
Our latest @tissueengdublin.bsky.social paper in Bioactive Materials on a new #bioactive #biomaterial for #woundhealing showing how scaffold-mediated miRNA-155 inhibition promotes regenerative macrophage polarisation to direct chronic wound healing.
www.sciencedirect.com/science/arti...
Scaffold-mediated miRNA-155 inhibition promotes regenerative macrophage polarisation leading to anti-inflammatory, angiogenic and neurogenic responses for wound healing
Chronic wounds represent a significant clinical challenge due to persistent inflammation and impaired nerve regeneration that delay healing. Conventio…
www.sciencedirect.com
February 27, 2026 at 10:01 AM
cp-cellrepmethods.bsky.social
Cellular-state control using ribozyme-scaffolded miRNA-sensing and CRISPR-mediated actuation
Cellular-state control using ribozyme-scaffolded miRNA-sensing and CRISPR-mediated actuation
Kang and Bleris utilize an miRNA-directed CRISPR platform to convert endogenous miRNA signatures into state-specific response. Dual-sgRNA constructs with ribozyme scaffolds restrict effector activation to defined states. In an EMT model, the system filters heterogeneous populations to selectively eliminate mesenchymal cells.
dlvr.it
April 7, 2026 at 6:50 PM
mattmuscleguy.bsky.social
New #MolTherapy paper: Development of an AAV-delivered microRNA gene therapy for Myotonic Dystrophy Type 1. #Myoblue tinyurl.com/mrjrue3f
Development of an AAV-delivered microRNA gene therapy for Myotonic Dystrophy Type 1
An AAV-mediated gene therapy for myotonic dystrophy type 1 using a novel muscle-tropic capsid and promoter to express a DMPK-targeting miRNA effectively reduces DMPK expression and nuclear RNA foci, a...
tinyurl.com
September 4, 2025 at 4:25 PM
lucksmith.bsky.social
yay, just in time for the weekend!! ankur garg in joshua-tor lab, stunning series of Microprocessor structures with different pri-let-7s, as well as SRSF3! renfu shang and i were fortunate to participate in this wonderful story @MolecularCell ... more to come!

www.sciencedirect.com/science/arti...
The structural landscape of Microprocessor-mediated processing of pri-let-7 miRNAs
MicroRNA (miRNA) biogenesis is initiated upon cleavage of a primary miRNA (pri-miRNA) hairpin by the Microprocessor (MP), composed of the Drosha RNase…
www.sciencedirect.com
October 4, 2024 at 10:18 PM
lisaheinke.bsky.social
I'm about to shut down my computer and won't turn it back on again until next year, which I'm very excited about 🤭 before I go, here's our latest NRMCB Review:

"The biogenesis and regulation of animal microRNAs" by Narry Kim and colleagues.

🔗 go.nature.com/3VMUl2U
The biogenesis and regulation of animal microRNAs - Nature Reviews Molecular Cell Biology
MicroRNAs (miRNAs) are small non-coding RNAs that induce RNA silencing. Advances in high-throughput and structural studies have provided new insights into animal miRNA biogenesis mediated by RNA–prote...
go.nature.com
December 20, 2024 at 1:24 PM
insect-science.bsky.social
A #parasitic wasp suppresses host pupation by #microRNA-mediated transcriptional silencing of OfE93
onlinelibrary.wiley.com/doi/10.1111/...
A parasitic wasp suppresses host pupation by microRNA‐mediated transcriptional silencing of OfE93
Parasitism by Macrocentrus cingulum induces miR-281a-5p upregulation in the host Ostrinia furnacalis larvae, which suppresses OfE93 expression and arrests pupation. This finding reveals a miRNA-media...
onlinelibrary.wiley.com
January 27, 2026 at 1:14 PM
frommlab.bsky.social
Curious new preprint on tdmd of microRNAs in Drosophila. www.biorxiv.org/content/10.1...
An endogenous cluster of target-directed microRNA degradation sites induces decay of distinct microRNA families
While much is known about miRNA biogenesis and canonical miRNA targeting, relatively less is understood about miRNA decay. The major miRNA decay pathway in metazoans is mediated through target-directe...
www.biorxiv.org
December 17, 2024 at 12:47 PM
jxbotany.bsky.social
🌱 RESEARCH 🌱

AGO1 is essential for Cu-deficiency responses but is sensitive to oxidative stress. FeSOD1 interacts with and protects AGO1 from superoxide radical-induced degradation, preserving miRNA-mediated gene silencing pathways - Tomassi et al.

🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪
Copper (Cu) deficiency compromises plant growth and limits crop productivity. Plants respond to Cu scarcity by activating the expression of several miRNAs, known as Cu-miRNAs, which degrade mRNAs from various cuproproteins to conserve Cu. Cu-miRNAs, like most plant miRNAs, associate with ARGONAUTE 1 (AGO1), the primary effector protein of miRNA-mediated gene silencing pathways, whose function is typically modulated by interacting proteins acting as cofactors. However, how AGO1 is regulated and functions under Cu deficiency remains unknown. Here, we searched for AGO1 interactors in Arabidopsis thaliana plants expressing a functional AGO1 protein tagged with the Twin-Strep-tag (TST) polypeptide, grown under Cu-sufficient or Cu-deficient conditions. TST–AGO1 complexes were affinity purified, and proteins were identified using tandem MS. Interestingly, the iron superoxide dismutase 1 (FeSOD1) encoded by FSD1 was enriched in TST–AGO1 complexes purified from plants grown under Cu deficiency.
November 18, 2025 at 9:47 AM
biorxiv-devbio.bsky.social
Biosensor capability of the endometrium is mediated in part, by altered miRNA cargo from conceptus-derived extracellular vesicles. https://www.biorxiv.org/content/10.1101/2023.10.27.564369v1
Biosensor capability of the endometrium is mediated in part, by altered miRNA cargo from conceptus-derived extracellular vesicles. https://www.biorxiv.org/content/10.1101/2023.10.27.564369v1
We tested the hypothesis that the biosensor capability of the endometrium is mediated in part, by th
www.biorxiv.org
October 29, 2023 at 2:30 PM
ribonucleicacids.bsky.social
ALAS1 acts as an inhibitor of the miRNA pathway in the cytoplasm. Normally ALAS1 acts in mitos in heme synthesis. Great work from @lucksmith.bsky.social

www.science.org/doi/10.1126/...
Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
microRNAs (miRNAs) and small interfering RNAs (siRNAs) are 21- to 22-nucleotide RNAs that guide Argonaute-class effectors to targets for repression. In this work, we uncover 5-aminolevulinic acid synt...
www.science.org
January 3, 2025 at 10:09 PM