Best news ever- I have finally earned my PhD in Neuroscience!!🧠 My thesis was completed in the lab of Dr. Gregory Corder @flybottleescape.bsky.social & is titled: “Opioidergic Organization of the Nociceptive Medial Thalamus & A Behavioral Model of Placebo Analgesia”
July 29, 2026 at 4:25 PM
Best news ever- I have finally earned my PhD in Neuroscience!!🧠 My thesis was completed in the lab of Dr. Gregory Corder @flybottleescape.bsky.social & is titled: “Opioidergic Organization of the Nociceptive Medial Thalamus & A Behavioral Model of Placebo Analgesia”
⚡️🧠A nociceptive amygdala-striatal pathway modulating affective-motivational pain
Now published on the cover of Science Advances @science.org
Check it out 👇
www.science.org/doi/10.1126/...
Now published on the cover of Science Advances @science.org
Check it out 👇
www.science.org/doi/10.1126/...
July 23, 2025 at 6:52 PM
⚡️🧠A nociceptive amygdala-striatal pathway modulating affective-motivational pain
Now published on the cover of Science Advances @science.org
Check it out 👇
www.science.org/doi/10.1126/...
Now published on the cover of Science Advances @science.org
Check it out 👇
www.science.org/doi/10.1126/...
excited to see current Kash Lab postdoc Jess Wojick's paper out from her PhD in @flybottleescape.bsky.social lab !!! congrats Jess and Greg!!!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A nociceptive amygdala-striatal pathway modulating affective-motivational pain
A nociceptive basolateral amygdala–to–nucleus accumbens shell circuit contributes to pain unpleasantness in chronic pain.
www.science.org
July 23, 2025 at 6:10 PM
excited to see current Kash Lab postdoc Jess Wojick's paper out from her PhD in @flybottleescape.bsky.social lab !!! congrats Jess and Greg!!!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Do flies feel pain?
Spooky new preprint from our lab on the cells and circuits that mediate nociceptive behaviors in adult Drosophila, led by graduate student (and newly minted PhD!) @jonesjes.bsky.social.
🪰⚡👻🎃
www.biorxiv.org/content/10.1...
Spooky new preprint from our lab on the cells and circuits that mediate nociceptive behaviors in adult Drosophila, led by graduate student (and newly minted PhD!) @jonesjes.bsky.social.
🪰⚡👻🎃
www.biorxiv.org/content/10.1...
October 29, 2025 at 6:56 PM
Do flies feel pain?
Spooky new preprint from our lab on the cells and circuits that mediate nociceptive behaviors in adult Drosophila, led by graduate student (and newly minted PhD!) @jonesjes.bsky.social.
🪰⚡👻🎃
www.biorxiv.org/content/10.1...
Spooky new preprint from our lab on the cells and circuits that mediate nociceptive behaviors in adult Drosophila, led by graduate student (and newly minted PhD!) @jonesjes.bsky.social.
🪰⚡👻🎃
www.biorxiv.org/content/10.1...
Chickens also have TRPA1 receptors, which would suggest that they *might* also feel a burning/unpleasant sensation from those same chemicals.
pubmed.ncbi.nlm.nih.gov/24398321/
pubmed.ncbi.nlm.nih.gov/24398321/
Heat and noxious chemical sensor, chicken TRPA1, as a target of bird repellents and identification of its structural determinants by multispecies functional comparison - PubMed
Nociceptive receptors enable animals to sense tissue-damaging stimuli, thus playing crucial roles in survival. Due to evolutionary diversification, responses of nociceptive receptors to specific stimuli can vary among species. Multispecies functional comparisons of nociceptive receptors help elucida …
pubmed.ncbi.nlm.nih.gov
February 27, 2026 at 1:46 AM
Chickens also have TRPA1 receptors, which would suggest that they *might* also feel a burning/unpleasant sensation from those same chemicals.
pubmed.ncbi.nlm.nih.gov/24398321/
pubmed.ncbi.nlm.nih.gov/24398321/
Even just looking at images of nature changes our brain and can reduce physical pain, a new study by @maxsteininger.bsky.social and colleagues finds!
Nature exposure induces analgesic effects by acting on nociception-related neural processing - Nature Communications
Virtual nature exposure reduces self-reported pain and is associated with decreased brain responses linked to somatosensory and nociceptive processing, providing new insights into the underlying mecha...
www.nature.com
March 17, 2025 at 1:02 PM
Even just looking at images of nature changes our brain and can reduce physical pain, a new study by @maxsteininger.bsky.social and colleagues finds!
The nociceptive flexion reflex is interesting.
Basically, you've got a reflex that involuntarily contracts a muscle away from a painful stimulus, before the signal reaches your brain.
Basically, you've got a reflex that involuntarily contracts a muscle away from a painful stimulus, before the signal reaches your brain.
April 10, 2024 at 4:30 AM
The nociceptive flexion reflex is interesting.
Basically, you've got a reflex that involuntarily contracts a muscle away from a painful stimulus, before the signal reaches your brain.
Basically, you've got a reflex that involuntarily contracts a muscle away from a painful stimulus, before the signal reaches your brain.
HOWZAT!!!
JCI - Sensory neuron–expressed FGF13 controls nociceptive signaling in diabetic neuropathy models www.jci.org/articles/vie...
JCI - Sensory neuron–expressed FGF13 controls nociceptive signaling in diabetic neuropathy models www.jci.org/articles/vie...
JCI -
Sensory neuron–expressed FGF13 controls nociceptive signaling in diabetic neuropathy models
www.jci.org
July 15, 2025 at 6:26 PM
HOWZAT!!!
JCI - Sensory neuron–expressed FGF13 controls nociceptive signaling in diabetic neuropathy models www.jci.org/articles/vie...
JCI - Sensory neuron–expressed FGF13 controls nociceptive signaling in diabetic neuropathy models www.jci.org/articles/vie...
Nature research paper: Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis
https://go.nature.com/4k4leKo
https://go.nature.com/4k4leKo
Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis - Nature
Functional connectivity between gastric cancer cells and sensory neurons offers a potential therapeutic target.
go.nature.com
February 19, 2025 at 8:30 PM
Nature research paper: Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis
https://go.nature.com/4k4leKo
https://go.nature.com/4k4leKo
Latest work out of the Prescott Lab on #pain sensitivity in different (nociceptive vs. non-nociceptive) afferents. 🔦
Quantifying the contribution of somatosensory afferent types and changes therein to pain sensitivity using transcutaneous optogenetic stimulation in behaving mice https://www.biorxiv.org/content/10.1101/2024.12.13.628414v1
December 23, 2024 at 4:37 PM
Latest work out of the Prescott Lab on #pain sensitivity in different (nociceptive vs. non-nociceptive) afferents. 🔦
whatever doesn’t kill you will make your nociceptive pathways stronger
November 13, 2025 at 1:19 AM
whatever doesn’t kill you will make your nociceptive pathways stronger
Empathy and kindness are becoming rather rare traits these days. There is nothing more important than treating each other like the finite mortal short-lived nociceptive beings we are. A life lived in apathy feels so much shorter and far too cold.
Try to love more while you live.
Try to love more while you live.
September 3, 2025 at 5:41 AM
Empathy and kindness are becoming rather rare traits these days. There is nothing more important than treating each other like the finite mortal short-lived nociceptive beings we are. A life lived in apathy feels so much shorter and far too cold.
Try to love more while you live.
Try to love more while you live.
Bee venom is used to treat many diseases and exhibits anti-inflammatory, anti-bacterial, antimutagenic, radioprotective, anti-nociceptive immunity promoting, hepatocyte protective and anti-cancer activity.
Science or war? Advancement or regression? Health or disease? All on the line, Nov 3rd, 2026.
Science or war? Advancement or regression? Health or disease? All on the line, Nov 3rd, 2026.
May 23, 2026 at 12:06 AM
Bee venom is used to treat many diseases and exhibits anti-inflammatory, anti-bacterial, antimutagenic, radioprotective, anti-nociceptive immunity promoting, hepatocyte protective and anti-cancer activity.
Science or war? Advancement or regression? Health or disease? All on the line, Nov 3rd, 2026.
Science or war? Advancement or regression? Health or disease? All on the line, Nov 3rd, 2026.
#GastroEdPick Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis @nature.com www.nature.com/articles/s41...
Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis - Nature
Functional connectivity between gastric cancer cells and sensory neurons offers a potential therapeutic target.
www.nature.com
March 3, 2025 at 9:55 AM
#GastroEdPick Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis @nature.com www.nature.com/articles/s41...
Excited for my first USASP (US Association for the Study of Pain) conference! I present my poster on nociceptive processing in the medial thalamus during the Tuesday morning session (poster A12)- hope to see you there! #USASP2026 #painresearch #neuroskyence
March 23, 2026 at 6:30 PM
Excited for my first USASP (US Association for the Study of Pain) conference! I present my poster on nociceptive processing in the medial thalamus during the Tuesday morning session (poster A12)- hope to see you there! #USASP2026 #painresearch #neuroskyence
A preprint from my lab @yalepharm.bsky.social: doi.org/10.1101/2025...
show molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling, using #singleMolecule #microscopy, #cryoEM, #electrophysiology, #signaling, offering a clear blueprint to target this long sought-after pathway!
show molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling, using #singleMolecule #microscopy, #cryoEM, #electrophysiology, #signaling, offering a clear blueprint to target this long sought-after pathway!
A painless nerve growth factor variant uncouples nociceptive and neurotrophic TrkA signaling
Nerve growth factor (NGF) binding to the receptor tyrosine kinase, TrkA, drives neurotrophic signaling essential for neuronal development and survival. This interaction simultaneously drives periphera...
doi.org
December 15, 2025 at 10:04 PM
A preprint from my lab @yalepharm.bsky.social: doi.org/10.1101/2025...
show molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling, using #singleMolecule #microscopy, #cryoEM, #electrophysiology, #signaling, offering a clear blueprint to target this long sought-after pathway!
show molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling, using #singleMolecule #microscopy, #cryoEM, #electrophysiology, #signaling, offering a clear blueprint to target this long sought-after pathway!
🆕📝 New publication in @jphysiol.bsky.social “Non-homogeneous distribution of inhibitory inputs among motor units in response to nociceptive stimulation at moderate contraction intensity”
🔗 doi.org/10.1113/JP28...
@univcotedazur.bsky.social @simonavrillon.bsky.social @agencerecherche.bsky.social
🔗 doi.org/10.1113/JP28...
@univcotedazur.bsky.social @simonavrillon.bsky.social @agencerecherche.bsky.social
Non‐homogeneous distribution of inhibitory inputs among motor units in response to nociceptive stimulation at moderate contraction intensity
Abstract figure legend We combined experimental data and in silico models to investigate the contribution of inhibitory and neuromodulatory inputs to motor unit behaviour in response to nociceptive s....
doi.org
June 1, 2025 at 6:30 AM
🆕📝 New publication in @jphysiol.bsky.social “Non-homogeneous distribution of inhibitory inputs among motor units in response to nociceptive stimulation at moderate contraction intensity”
🔗 doi.org/10.1113/JP28...
@univcotedazur.bsky.social @simonavrillon.bsky.social @agencerecherche.bsky.social
🔗 doi.org/10.1113/JP28...
@univcotedazur.bsky.social @simonavrillon.bsky.social @agencerecherche.bsky.social
#Rhododendron buds! Did you know that the leaves contain phenolic acids reported to have anti-inflammatory and anti-nociceptive activities. In Nepal the flowers are used to make a juice beneficial to the whole system. 🌿
April 12, 2024 at 9:15 AM
#Rhododendron buds! Did you know that the leaves contain phenolic acids reported to have anti-inflammatory and anti-nociceptive activities. In Nepal the flowers are used to make a juice beneficial to the whole system. 🌿
Gastric cancer hijacks nociceptive neurons to fuel tumor growth and metastasis, revealing a potential therapeutic target in cancer–nerve interactions #GastricCancer #Sensoryneuron
Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis - Nature
Functional connectivity between gastric cancer cells and sensory neurons offers a potential therapeutic target.
www.nature.com
March 14, 2025 at 7:40 PM
Gastric cancer hijacks nociceptive neurons to fuel tumor growth and metastasis, revealing a potential therapeutic target in cancer–nerve interactions #GastricCancer #Sensoryneuron
Excessive mechanosensation via PIEZO1 in bladder epithelial cells drives chronic pain from E. coli infections. IL-6 signaling boosts this process, linking stress to persistent sensory dysfunction. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #RNA 🧪
Excessive epithelial mechanosensation drives nociceptive innervation and chronic bladder pain via the PIEZO1-SLC7A11-glutamate axis
Cell Press article: Excessive epithelial mechanosensation drives nociceptive innervation and chronic bladder pain via the PIEZO1-SLC7A11-glutamate axis
www.cell.com
September 28, 2026 at 10:00 AM
Excessive mechanosensation via PIEZO1 in bladder epithelial cells drives chronic pain from E. coli infections. IL-6 signaling boosts this process, linking stress to persistent sensory dysfunction. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #RNA 🧪
Placebo treatment affects brain systems related to affective and cognitive processes, but not nociceptive pain www.biorxiv.org/content/10.1... 🧠🟦
October 2, 2023 at 8:37 PM
Placebo treatment affects brain systems related to affective and cognitive processes, but not nociceptive pain www.biorxiv.org/content/10.1... 🧠🟦
So excited to have been part of this work from the Corder lab! Congrats to Jess and the whole team.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A nociceptive amygdala-striatal pathway modulating affective-motivational pain
A nociceptive basolateral amygdala–to–nucleus accumbens shell circuit contributes to pain unpleasantness in chronic pain.
www.science.org
July 24, 2025 at 12:25 AM
So excited to have been part of this work from the Corder lab! Congrats to Jess and the whole team.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Well before the sensory signals hit the brain, they communicate with motor neurons.
Go above a certain nociceptive/thermal threshold, and they tell the motor neurons to fire.
Go above a certain nociceptive/thermal threshold, and they tell the motor neurons to fire.
April 10, 2024 at 4:30 AM
Well before the sensory signals hit the brain, they communicate with motor neurons.
Go above a certain nociceptive/thermal threshold, and they tell the motor neurons to fire.
Go above a certain nociceptive/thermal threshold, and they tell the motor neurons to fire.
Proprioceptors, though non-nociceptive, express ASIC3 and mediate acid-induced hyperalgesia, linking them to #sngception in both mice and humans 🐁 🚶♀️ 🚶♀️ #Proprioception #ASIC3 https://buff.ly/3Xhs6Ku
February 24, 2025 at 5:00 PM
Proprioceptors, though non-nociceptive, express ASIC3 and mediate acid-induced hyperalgesia, linking them to #sngception in both mice and humans 🐁 🚶♀️ 🚶♀️ #Proprioception #ASIC3 https://buff.ly/3Xhs6Ku
Köster, Stiehl, @lampertlab.bsky.social and colleagues characterize eight sodium channel subtypes relevant to #nociception and use a computer model to simulate the response of two types of nociceptive nerve fibers. https://buff.ly/4hku7gH
#Biophysics #Neuroscience #IonChannels
#Biophysics #Neuroscience #IonChannels
January 21, 2025 at 5:17 PM
Köster, Stiehl, @lampertlab.bsky.social and colleagues characterize eight sodium channel subtypes relevant to #nociception and use a computer model to simulate the response of two types of nociceptive nerve fibers. https://buff.ly/4hku7gH
#Biophysics #Neuroscience #IonChannels
#Biophysics #Neuroscience #IonChannels