Okay, even I, a geology enthusiast, am genuinely impressed by this! New DNA treatment lowered bad cholesterol by 47% in mice and PCSK9 protein by 87% in liver cells with just one injection. No statins needed!
DNA treatment cuts bad cholesterol by nearly 50% without statins
Researchers from the University of Barcelona and the University of Oregon have developed a new DNA-based treatment that targets the PCSK9 protein, which is linked to high LDL cholesterol and atheroscl
www.sciencedaily.com
September 12, 2026 at 6:04 PM
Okay, even I, a geology enthusiast, am genuinely impressed by this! New DNA treatment lowered bad cholesterol by 47% in mice and PCSK9 protein by 87% in liver cells with just one injection. No statins needed!
Most genome editing work to date has been DNA based. A new paper out today assessed a single dose of epigenetic editing (thru PCSK9) for marked (~70%) and durable reduction of LDL cholesterol [in non-human primates]
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels - Nature Medicine
Epigenetic editing of PCSK9 in the liver, designed to induce DNA methylation and silence gene expression, achieved long-lasting reductions in LDL cholesterol levels in both transgenic mice expressing ...
www.nature.com
February 10, 2025 at 4:01 PM
Most genome editing work to date has been DNA based. A new paper out today assessed a single dose of epigenetic editing (thru PCSK9) for marked (~70%) and durable reduction of LDL cholesterol [in non-human primates]
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Breaking News: The company Merck said it had created a powerful new cholesterol pill that could be a more affordable alternative to other treatments.
Merck PCSK9 Pill Results Point to Extremely Low Cholesterol Future
The drug targets the PCSK9 protein, and could give millions of people a more affordable option to reduce their heart disease risk.
nyti.ms
November 8, 2025 at 8:07 PM
Breaking News: The company Merck said it had created a powerful new cholesterol pill that could be a more affordable alternative to other treatments.
In statements Trump made regarding his recent physical, the Dr. reportedly said his "...cholesterol is well controlled."
That almost certainly means he is taking a statin or one of the newer PCSK9 inhibitors.
The average person with "controlled cholesterol" likely has heart disease.
That almost certainly means he is taking a statin or one of the newer PCSK9 inhibitors.
The average person with "controlled cholesterol" likely has heart disease.
April 14, 2025 at 5:17 AM
In statements Trump made regarding his recent physical, the Dr. reportedly said his "...cholesterol is well controlled."
That almost certainly means he is taking a statin or one of the newer PCSK9 inhibitors.
The average person with "controlled cholesterol" likely has heart disease.
That almost certainly means he is taking a statin or one of the newer PCSK9 inhibitors.
The average person with "controlled cholesterol" likely has heart disease.
Wouldn't have guessed that a PCSK9 blocker (used for LDL cholesterol lowering) might someday be indicated to prevent breast cancer in individuals with a common genomic variant
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
December 11, 2024 at 10:58 PM
Wouldn't have guessed that a PCSK9 blocker (used for LDL cholesterol lowering) might someday be indicated to prevent breast cancer in individuals with a common genomic variant
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer
www.nature.com/articles/s41...
Massive congratulations to @rushika-perera.bsky.social Lab!!
www.nature.com/articles/s41...
Massive congratulations to @rushika-perera.bsky.social Lab!!
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer - Nature
PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-hig...
www.nature.com
May 21, 2025 at 4:22 PM
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer
www.nature.com/articles/s41...
Massive congratulations to @rushika-perera.bsky.social Lab!!
www.nature.com/articles/s41...
Massive congratulations to @rushika-perera.bsky.social Lab!!
new out in Nature today www.nature.com/articles/s41...
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer - Nature
PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-hig...
www.nature.com
May 21, 2025 at 4:09 PM
new out in Nature today www.nature.com/articles/s41...
- Cardiovascular diseases, silencing proteins like PCSK9 that raise cholesterol
- Cancers, by silencing proteins that help tumour cells grow, survive, metabolize, metastasize, or resist treatment
- and more!
- Cancers, by silencing proteins that help tumour cells grow, survive, metabolize, metastasize, or resist treatment
- and more!
October 2, 2026 at 1:45 PM
- Cardiovascular diseases, silencing proteins like PCSK9 that raise cholesterol
- Cancers, by silencing proteins that help tumour cells grow, survive, metabolize, metastasize, or resist treatment
- and more!
- Cancers, by silencing proteins that help tumour cells grow, survive, metabolize, metastasize, or resist treatment
- and more!
PCSK9 global KO or siRNA PCSK9 ameliorated #AbdominalAorticAneurysm in hyperlipidemic hypertensive Apoe SA/SA🐭
A PCSK9-Sirt1 axis
PCSK9 detected in👤🐭aortic macrophages
Intravital imaging of femoral vein➡️leukocyte adhesion
#ATVB 2024 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
A PCSK9-Sirt1 axis
PCSK9 detected in👤🐭aortic macrophages
Intravital imaging of femoral vein➡️leukocyte adhesion
#ATVB 2024 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
Disruption of PCSK9 Suppresses Inflammation and Attenuates Abdominal Aortic Aneurysm Formation | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: Abdominal aortic aneurysm (AAA) is a chronic vascular inflammatory disease without
effective medications. PCSK9 (proprotein convertase subtilisin/kexin 9), a serine
protease from the propr...
www.ahajournals.org
November 27, 2024 at 8:00 PM
PCSK9 global KO or siRNA PCSK9 ameliorated #AbdominalAorticAneurysm in hyperlipidemic hypertensive Apoe SA/SA🐭
A PCSK9-Sirt1 axis
PCSK9 detected in👤🐭aortic macrophages
Intravital imaging of femoral vein➡️leukocyte adhesion
#ATVB 2024 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
A PCSK9-Sirt1 axis
PCSK9 detected in👤🐭aortic macrophages
Intravital imaging of femoral vein➡️leukocyte adhesion
#ATVB 2024 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
Nature research paper: PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer
https://go.nature.com/3Zx70cb
https://go.nature.com/3Zx70cb
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer - Nature
PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-high cells preferring the lung.
go.nature.com
May 22, 2025 at 7:19 PM
Nature research paper: PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer
https://go.nature.com/3Zx70cb
https://go.nature.com/3Zx70cb
A commonly inherited genetic variant of human PCSK9 drives breast cancer metastasis and associates with reduced patient survival in @cellcellpress.bsky.social PCSK9 drives pro-metastatic gene expression by repressing LRP1. Anti-PCSK9 antibody suppresses Br mets.
sciencedirect.com/science/arti...
sciencedirect.com/science/arti...
A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
Identifying patients at risk for metastatic relapse is a critical medical need. We identified a common missense germline variant in proprotein convert…
https://sciencedirect.com/science/article/pii/S0092867424013266?via%3Dihub……tweetorial
December 9, 2024 at 7:39 PM
A commonly inherited genetic variant of human PCSK9 drives breast cancer metastasis and associates with reduced patient survival in @cellcellpress.bsky.social PCSK9 drives pro-metastatic gene expression by repressing LRP1. Anti-PCSK9 antibody suppresses Br mets.
sciencedirect.com/science/arti...
sciencedirect.com/science/arti...
#SABCS24 #bcsm #OncSky #MedSky
📣 A germline variant in PCSK9 (V474I) is assoc w/ #breastcancer survival & causally drives mets (targets tumoral LRP1 & induces somatic pro-mets gene expression).
PCSK9 inhibition (used to ⬇️ cholesterol) ⬇️ mets.
@oncoalert.bsky.social
www.cell.com/cell/abstrac...
📣 A germline variant in PCSK9 (V474I) is assoc w/ #breastcancer survival & causally drives mets (targets tumoral LRP1 & induces somatic pro-mets gene expression).
PCSK9 inhibition (used to ⬇️ cholesterol) ⬇️ mets.
@oncoalert.bsky.social
www.cell.com/cell/abstrac...
A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
Characterization of a common germline variant in PCSK9 unveils a hereditary basis underlying breast cancer metastasis and suggests that PCSK9 inhibition therapy could be a promising strategy for breast cancer metastasis prevention.
www.cell.com
December 13, 2024 at 5:36 PM
#SABCS24 #bcsm #OncSky #MedSky
📣 A germline variant in PCSK9 (V474I) is assoc w/ #breastcancer survival & causally drives mets (targets tumoral LRP1 & induces somatic pro-mets gene expression).
PCSK9 inhibition (used to ⬇️ cholesterol) ⬇️ mets.
@oncoalert.bsky.social
www.cell.com/cell/abstrac...
📣 A germline variant in PCSK9 (V474I) is assoc w/ #breastcancer survival & causally drives mets (targets tumoral LRP1 & induces somatic pro-mets gene expression).
PCSK9 inhibition (used to ⬇️ cholesterol) ⬇️ mets.
@oncoalert.bsky.social
www.cell.com/cell/abstrac...
New pre-print: "PCSK9 and breast cancer survival: a Mendelian Randomization study" www.medrxiv.org/content/10.1... led by Janne Pott. Brief thread:
PCSK9 and breast cancer survival: a Mendelian Randomization study
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is well known for its causal effects on the lipid metabolism. A recent study identified an association between rs562556 within PCSK9 a...
www.medrxiv.org
October 7, 2025 at 8:59 AM
New pre-print: "PCSK9 and breast cancer survival: a Mendelian Randomization study" www.medrxiv.org/content/10.1... led by Janne Pott. Brief thread:
A newly published paper examines the connection between a #PCSK9 gain-of-function mutation and breast cancer metastasis development. An excellent read! PCSK9’s role beyond lipid regulation. #CardioSky
A commonly inherited genetic variant of human PCSK9 drives breast cancer metastasis and associates with reduced patient survival in @cellcellpress.bsky.social PCSK9 drives pro-metastatic gene expression by repressing LRP1. Anti-PCSK9 antibody suppresses Br mets.
sciencedirect.com/science/arti...
sciencedirect.com/science/arti...
A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
Identifying patients at risk for metastatic relapse is a critical medical need. We identified a common missense germline variant in proprotein convert…
https://sciencedirect.com/science/article/pii/S0092867424013266?via%3Dihub……tweetorial
December 10, 2024 at 4:40 PM
A newly published paper examines the connection between a #PCSK9 gain-of-function mutation and breast cancer metastasis development. An excellent read! PCSK9’s role beyond lipid regulation. #CardioSky
#Atherosclerosis
Smooth Muscle Cell PCSK9 transgenic🐭
👉Ferroptosis (⏫Iron deposit ⏫4HNE ⏫PTGS2 ⏬GPX4)
👉Plaque instability
PCSK9 binds to YAP1 for lysosomal degradation▶️
⏬NUPR1 (ferroptosis suppressor)
Cadd4 - a PCSK9 PROTAC
⏫Lesion stability
Research 2025
spj.science.org/doi/full/10....
Smooth Muscle Cell PCSK9 transgenic🐭
👉Ferroptosis (⏫Iron deposit ⏫4HNE ⏫PTGS2 ⏬GPX4)
👉Plaque instability
PCSK9 binds to YAP1 for lysosomal degradation▶️
⏬NUPR1 (ferroptosis suppressor)
Cadd4 - a PCSK9 PROTAC
⏫Lesion stability
Research 2025
spj.science.org/doi/full/10....
December 28, 2025 at 1:07 PM
#Atherosclerosis
Smooth Muscle Cell PCSK9 transgenic🐭
👉Ferroptosis (⏫Iron deposit ⏫4HNE ⏫PTGS2 ⏬GPX4)
👉Plaque instability
PCSK9 binds to YAP1 for lysosomal degradation▶️
⏬NUPR1 (ferroptosis suppressor)
Cadd4 - a PCSK9 PROTAC
⏫Lesion stability
Research 2025
spj.science.org/doi/full/10....
Smooth Muscle Cell PCSK9 transgenic🐭
👉Ferroptosis (⏫Iron deposit ⏫4HNE ⏫PTGS2 ⏬GPX4)
👉Plaque instability
PCSK9 binds to YAP1 for lysosomal degradation▶️
⏬NUPR1 (ferroptosis suppressor)
Cadd4 - a PCSK9 PROTAC
⏫Lesion stability
Research 2025
spj.science.org/doi/full/10....
A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor. #Cell
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
December 10, 2024 at 11:02 AM
A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor. #Cell
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Once again, the 🧬 predicted the trial results. PCSK9 inhibition to prevent abdominal aortic aneurysms #CardioSky #GWAS
November 17, 2024 at 1:49 PM
Once again, the 🧬 predicted the trial results. PCSK9 inhibition to prevent abdominal aortic aneurysms #CardioSky #GWAS
Non-Hepatic #PCSK9 #Obesity
Higher PCSK9 in aortic #SmoothMuscleCell from Obese (vs Lean) Zucker rats
Depending on ERK1/2, PKC & NAPDH oxidase
Any secreted PCSK9 from SMCs? How SMC-derived PCSK9 impacts atherogenesis?
#IJMS_MDPI 2025
www.mdpi.com/1422-0067/26...
Higher PCSK9 in aortic #SmoothMuscleCell from Obese (vs Lean) Zucker rats
Depending on ERK1/2, PKC & NAPDH oxidase
Any secreted PCSK9 from SMCs? How SMC-derived PCSK9 impacts atherogenesis?
#IJMS_MDPI 2025
www.mdpi.com/1422-0067/26...
February 15, 2025 at 8:24 PM
Non-Hepatic #PCSK9 #Obesity
Higher PCSK9 in aortic #SmoothMuscleCell from Obese (vs Lean) Zucker rats
Depending on ERK1/2, PKC & NAPDH oxidase
Any secreted PCSK9 from SMCs? How SMC-derived PCSK9 impacts atherogenesis?
#IJMS_MDPI 2025
www.mdpi.com/1422-0067/26...
Higher PCSK9 in aortic #SmoothMuscleCell from Obese (vs Lean) Zucker rats
Depending on ERK1/2, PKC & NAPDH oxidase
Any secreted PCSK9 from SMCs? How SMC-derived PCSK9 impacts atherogenesis?
#IJMS_MDPI 2025
www.mdpi.com/1422-0067/26...
Despite the intense research, very few mutations are specific of metastatic cells. However, mew research @cellpress.bsky.social shows that most of us carry a variant in PCSK9 that promotes metastasis www.cell.com/cell/abstrac...
December 14, 2024 at 5:38 AM
Despite the intense research, very few mutations are specific of metastatic cells. However, mew research @cellpress.bsky.social shows that most of us carry a variant in PCSK9 that promotes metastasis www.cell.com/cell/abstrac...
Non-hepatic #PCSK9
PCSK9 targets LRP2/Megalin to lysosomal degradation in renal proximal tubule cells
Megalin mediates PCSK9 uptake in renal epithelium
PCSK9 KO🐭 or Alirocumab in WT or nephrotic Nphs2-/-🐭
⏫renal Megalin & LDLR
⏬ #Proteinuria
#KidneyInt 2023
www.sciencedirect.com/science/arti...
PCSK9 targets LRP2/Megalin to lysosomal degradation in renal proximal tubule cells
Megalin mediates PCSK9 uptake in renal epithelium
PCSK9 KO🐭 or Alirocumab in WT or nephrotic Nphs2-/-🐭
⏫renal Megalin & LDLR
⏬ #Proteinuria
#KidneyInt 2023
www.sciencedirect.com/science/arti...
July 21, 2025 at 11:49 AM
Non-hepatic #PCSK9
PCSK9 targets LRP2/Megalin to lysosomal degradation in renal proximal tubule cells
Megalin mediates PCSK9 uptake in renal epithelium
PCSK9 KO🐭 or Alirocumab in WT or nephrotic Nphs2-/-🐭
⏫renal Megalin & LDLR
⏬ #Proteinuria
#KidneyInt 2023
www.sciencedirect.com/science/arti...
PCSK9 targets LRP2/Megalin to lysosomal degradation in renal proximal tubule cells
Megalin mediates PCSK9 uptake in renal epithelium
PCSK9 KO🐭 or Alirocumab in WT or nephrotic Nphs2-/-🐭
⏫renal Megalin & LDLR
⏬ #Proteinuria
#KidneyInt 2023
www.sciencedirect.com/science/arti...
We'll be seeing a lot more of this—epigenetic editing—in the future
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Epigenetic editing of PCSK9 for a durable reduction in cholesterol - Nature Medicine
A sustained decrease in low-density lipoprotein cholesterol (LDL-C) is key to reducing the risk of atherosclerotic cardiovascular disease; however, achieving this goal can be hampered by low adherence...
www.nature.com
February 25, 2025 at 6:04 PM
We'll be seeing a lot more of this—epigenetic editing—in the future
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Today, siRNA drugs are largely used to treat liver diseases, partly because that’s the easiest starting point.
And they are extremely effective at it. One example is for cholesterol: siRNA drugs reduce PCSK9 levels by around 70%, reducing cholesterol levels by 50-60%, beyond the effect of statins.
And they are extremely effective at it. One example is for cholesterol: siRNA drugs reduce PCSK9 levels by around 70%, reducing cholesterol levels by 50-60%, beyond the effect of statins.
October 2, 2026 at 1:45 PM
Today, siRNA drugs are largely used to treat liver diseases, partly because that’s the easiest starting point.
And they are extremely effective at it. One example is for cholesterol: siRNA drugs reduce PCSK9 levels by around 70%, reducing cholesterol levels by 50-60%, beyond the effect of statins.
And they are extremely effective at it. One example is for cholesterol: siRNA drugs reduce PCSK9 levels by around 70%, reducing cholesterol levels by 50-60%, beyond the effect of statins.
Biocatalysts can build big molecules. A team at Merck & Co. developed a suite of enzymes that stitch together their oral PCSK9 inhibitor enlicitide. My latest for @cenmag.bsky.social
cen.acs.org/pharmaceutic...
#chemsky
cen.acs.org/pharmaceutic...
#chemsky
May 7, 2026 at 6:24 PM
Biocatalysts can build big molecules. A team at Merck & Co. developed a suite of enzymes that stitch together their oral PCSK9 inhibitor enlicitide. My latest for @cenmag.bsky.social
cen.acs.org/pharmaceutic...
#chemsky
cen.acs.org/pharmaceutic...
#chemsky