Turrell et al. show that, in young mice, low-level PDGF-C expression maintains dormancy of disseminated tumor cells, but, in aged or fibrotic lungs, the PDGF-C-high environment promotes proliferation,...

Proteínas recombinantes BMP-7 e PDGF-BB foram utilizadas pela primeira vez como terapia contra a osteoporose em modelos animais, que tiveram fortalecimento da estrutura óssea deficiente

Molecular biology; Neuroscience; Pharmacology

Thyroid eye disease (TED) is characterized by fibroblast-driven inflammation and extracellular matrix expansion, which contribute to orbital congestio…

Adult stem cells often reside in specialized niches that they exit upon injury. Here they show that in Drosophila, after damage the gut-associated trachea produces the PDGF-VEGF-related ligand Pvf1, which acts as a guidance cue directing ISC migration toward injury sites.

Highlighted Article: PDGF signaling from hepatic stellate cells promotes re-differentiation of bipotential progenitor cell during zebrafish biliary-mediated liver regeneration.

Proteínas recombinantes BMP-7 e PDGF-BB foram utilizadas pela primeira vez como terapia contra a osteoporose em modelos animais, que tiveram fortalecimento da estrutura óssea deficiente

Alport syndrome is an inherited kidney disease, which can lead to glomerulosclerosis and fibrosis, as well as end-stage kidney disease in children and adults. Platelet-derived growth factor-D (PDGF-D)...

Adipocytes exhibit surprising plasticity, but the regulation of adipocyte-to-fibroblast transition is not well characterized. Yao et al. show that PDGF signaling in adipocytes promotes adipocyte-to-fibroblast transitions in wound healing and supports angiogenesis and re-epithelialization. Transdifferentiated adipocytes persist as fibroblasts after wound healing, in contrast with transient dedifferentiation during physiological remodeling.